Foods for Tongue Cancer!

Introduction

Foods for Tongue Cancer should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Tongue Cancer does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Tongue Cancer does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Tongue Cancer?

For example does it matter if vegetable Giant Butterbur is consumed more compared to Garden Tomato? Does it make any difference if fruit Elderberry is preferred over Nance? Also if similar choices are made for nuts/seeds like Common Walnut over Chestnut and for pulses like Black-eyed Pea over Pigeon Pea. And if what I eat matters – then how does one identify foods which are recommended for Tongue Cancer and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Tongue Cancer!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Elderberry contains active ingredients Quercetin, Curcumin, Phloretin, Lupeol, Isoliquiritigenin. And Nance contains active ingredients Curcumin, Phloretin, Lupeol, Isoliquiritigenin, Daidzein and possibly others.

A common mistake made when deciding and choosing foods to eat for Tongue Cancer – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Tongue Cancer.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Tongue Cancer?

Personalized nutrition for cancers like Tongue Cancer consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Tongue Cancer biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Tongue Cancer

All cancers like Tongue Cancer can be characterized by a unique set of biochemical pathways – the signature pathways of Tongue Cancer. Biochemical pathways like Amino Acid Metabolism, Angiogenesis, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints are part of the signature definition of Tongue Cancer. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Tongue Cancer need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Tongue Cancer when taking cancer treatment Fluorouracil, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, TERT, CDKN2A, FAT1 and NOTCH1 are the top ranked reported genes for Tongue Cancer. TP53 is reported in 56.8 % of the representative patients across all clinical trials. And TERT is reported in 30.5 %. The combined population patient data cover ages from to . % of the patient data are identified as men. The Tongue Cancer biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Tongue Cancer

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GIANT BUTTERBUR or GARDEN TOMATO?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Phloretin, Lupeol, Isoliquiritigenin, Daidzein. These active ingredients manipulate various biochemical pathways like Adherens junction, Amino Acid Metabolism, P53 Signaling and Focal Adhesion and others. Giant Butterbur is recommended for Tongue Cancer when ongoing cancer treatment is Fluorouracil. This is because Giant Butterbur modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Fluorouracil.

Some of the active ingredients or bioactives in vegetable Garden Tomato are Quercetin, Curcumin, Phloretin, Lupeol, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Microtubule Dynamics and Oxidative Stress and others. Garden Tomato is not recommended for Tongue Cancer when ongoing cancer treatment is Fluorouracil because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER GARDEN TOMATO FOR Tongue Cancer AND TREATMENT Fluorouracil.

Choose Fruit NANCE or ELDERBERRY?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Phloretin, Lupeol, Isoliquiritigenin, Daidzein. These active ingredients manipulate various biochemical pathways like Adherens junction, Hypoxia and P53 Signaling and others. Nance is recommended for Tongue Cancer when ongoing cancer treatment is Fluorouracil. This is because Nance modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Fluorouracil.

Some of the active ingredients or bioactives in fruit Elderberry are Quercetin, Curcumin, Phloretin, Lupeol, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, Microtubule Dynamics and Oxidative Stress and others. Elderberry is not recommended for Tongue Cancer when ongoing cancer treatment is Fluorouracil because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT NANCE IS RECOMMENDED OVER ELDERBERRY FOR Tongue Cancer AND TREATMENT Fluorouracil.

Choose Nut COMMON WALNUT or CHESTNUT?

Common Walnut contains many active ingredients or bioactives such as Quercetin, Ellagic Acid, Curcumin, Phloretin, Lupeol. These active ingredients manipulate various biochemical pathways like Cell Cycle, Adherens junction, Focal Adhesion and Epithelial to Mesenchymal Transition and others. Common Walnut is recommended for Tongue Cancer when ongoing cancer treatment is Fluorouracil. This is because Common Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Fluorouracil.

Some of the active ingredients or bioactives in Chestnut are Ellagic Acid, Curcumin, Phloretin, Lupeol, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Oxidative Stress and Netrin Signaling and others. Chestnut is not recommended for Tongue Cancer when ongoing cancer treatment is Fluorouracil because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON WALNUT IS RECOMMENDED OVER CHESTNUT FOR Tongue Cancer AND TREATMENT Fluorouracil.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Tongue Cancer or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CAULIFLOWER or MEXICAN GROUNDCHERRY?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Lupeol, Formononetin, Daidzein, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, MAPK Signaling and MYC Signaling and others. Cauliflower is recommended for risk of Tongue Cancer when associated genetic risk is CDKN2A. This is because Cauliflower increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Mexican Groundcherry are Apigenin, Curcumin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and Oncogenic Cancer Epigenetics and others. Mexican Groundcherry is not recommended when risk of Tongue Cancer when associated genetic risk is CDKN2A because it increases the signature pathways of it.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER MEXICAN GROUNDCHERRY FOR CDKN2A GENETIC RISK OF CANCER.

Choose Fruit SOUR CHERRY or PUMMELO?

Fruit Sour Cherry contains many active ingredients or bioactives such as Apigenin, Curcumin, Quercetin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling and others. Sour Cherry is recommended for risk of Tongue Cancer when associated genetic risk is CDKN2A. This is because Sour Cherry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Quercetin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and Cell Cycle Checkpoints and others. Pummelo is not recommended when risk of Tongue Cancer when associated genetic risk is CDKN2A because it increases the signature pathways of it.

FRUIT SOUR CHERRY IS RECOMMENDED OVER PUMMELO FOR CDKN2A GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Formononetin, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle, MAPK Signaling, P53 Signaling and Angiogenesis and others. Butternut is recommended for risk of Tongue Cancer when associated genetic risk is CDKN2A. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Curcumin, Quercetin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Stem Cell Signaling and Oncogenic Cancer Epigenetics and others. European Chestnut is not recommended when risk of Tongue Cancer when associated genetic risk is CDKN2A because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR CDKN2A GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Tongue Cancer. Tongue Cancer patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Tongue Cancer, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Giant Butterbur contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Tongue Cancer?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Daidzein effect on hormone refractory prostate cancer in vitro and in vivo compared to genistein and soy extract: potentiation of radiotherapy.
• The apple polyphenol phloretin inhibits breast cancer cell migration and proliferation via inhibition of signals by type 2 glucose transporter.
• Negative regulation of signal transducer and activator of transcription-3 signalling cascade by lupeol inhibits growth and induces apoptosis in hepatocellular carcinoma cells.
• Effects and significance of formononetin on expression levels of HIF-1α and VEGF in mouse cervical cancer tissue.
• In vitro and in vivo antitumor activity of neochlorogenic acid in human gastric carcinoma cells are complemented with ROS generation, loss of mitochondrial membrane potential and apoptosis induction.
• Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel.