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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Thymoma?

Aug 10, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Thymoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Thymoma because of HDAC4 and MUC16 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Thymoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Apricot” or “Include fruit Rowanberry in my diet” or “Should I reduce consumption of vegetable Lotus” or “Can I take Thunder God and Mulberry supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO THYMOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Thymoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR THYMOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Thymoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Thymoma from cBioPortal. The patients enrolled in the studies for Thymoma are in ages between 17 to 84 with an average age of 60. 52.7% of males and 47.3% of females were the distribution of gender in these clinical studies. From a patient sample size of 148; the top genes with mutations and other abnormalities for Thymoma include genes MUC16, RYR2, HDAC4, MYH14 and NRAS. The occurrence frequency distribution for these genes respectively is 5.9%, 3.7%, 3.0%, 2.2% and 2.2%. These tumor genetic details of Thymoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Thymoma.

Significance of Nutrition for Thymoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Thymoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Apricot includes active ingredients Quercetin, Salicylic Acid, Modified Citrus Pectin, Beta-sitosterol, Linolenic Acid and others. And Rowanberry contains active ingredients Quercetin, Chlorogenic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Thymoma, activation or inhibition of selected biochemical pathways like Extracellular Matrix Remodelling, MAPK Signaling, Small Molecule Transport, RAS-RAF Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Thymoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR THYMOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Thymoma undergoing chemotherapy treatment

In Thymoma – the genes MUC16, RYR2, HDAC4, MYH14 and NRAS have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Thymoma are Extracellular Matrix Remodelling, MAPK Signaling, PI3K-AKT-MTOR Signaling and others. Paclitaxel is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Extracellular Matrix Remodelling, MAPK Signaling, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Vitamin C, Genistein, Oleic Acid, Vitamin A and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Carbohydrate Metabolism, Adherens junction and Cell Cycle.

Vitamin A can manipulate biochemical pathways NFKB Signaling and Focal Adhesion. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Extracellular Matrix Remodelling. And so on.

When treating Thymoma with chemotherapy Paclitaxel – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Vitamin A and Oleic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR THYMOMA ON TREATMENT WITH CHEMOTHERAPY PACLITAXEL FOR SOME CONDITIONS.

Eat more vegetables, Kohlrabi or Lotus?

Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Beta-sitosterol, Linolenic Acid, Vitamin C, Indole-3-carbinol, Brassinin among others. While the active ingredients contained in Lotus are Quercetin, Fisetin, Beta-sitosterol, Linolenic Acid, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Carbohydrate Metabolism and Apoptosis. Brassinin has biological action on biochemical pathways NFKB Signaling, Extracellular Matrix Remodelling and Adherens junction.

Fisetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. Vitamin B3 has biological action on biochemical pathways Angiogenesis and PI3K-AKT-MTOR Signaling. And so on.

When treating Thymoma with chemotherapy Paclitaxel – Foods like Kohlrabi are recommended compared to Lotus. This is because the active ingredients Fisetin and Vitamin B3 in Lotus interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Brassinin contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER LOTUS FOR THYMOMA ON TREATMENT WITH CHEMOTHERAPY PACLITAXEL FOR SOME CONDITIONS.

Which Foods are Recommended for Thymoma?

Eat more fruits, Rowanberry or Apricot?

Fruits are an important part of many diets. The active ingredients contained in Rowanberry are Quercetin, Chlorogenic Acid among others. While the active ingredients contained in Apricot are Quercetin, Salicylic Acid, Modified Citrus Pectin, Beta-sitosterol, Linolenic Acid and others.

Chlorogenic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Quercetin has biological action on biochemical pathways Carbohydrate Metabolism, Extracellular Matrix Remodelling and Adherens junction.

Rutin can manipulate biochemical pathways WNT Beta Catenin Signaling, Focal Adhesion and Microtubule Dynamics. Epicatechin has biological action on biochemical pathways Angiogenesis. And so on.

When treating Thymoma with chemotherapy Paclitaxel – Foods like Rowanberry are recommended compared to Apricot. This is because the active ingredients Rutin and Epicatechin in Apricot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Chlorogenic Acid and Quercetin contained in Rowanberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ROWANBERRY IS RECOMMENDED OVER APRICOT FOR THYMOMA ON TREATMENT WITH CHEMOTHERAPY PACLITAXEL FOR SOME CONDITIONS.

Eat more nuts, Pistachio or Peanut?

Nuts are an important part of many diets. The active ingredients contained in Pistachio are Resveratrol, Beta-sitosterol, Vitamin E, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Beta-sitosterol, Vitamin E, Linolenic Acid, Vitamin C and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Resveratrol has biological action on biochemical pathways Carbohydrate Metabolism, Extracellular Matrix Remodelling and Microtubule Dynamics.

Vitamin A can manipulate biochemical pathways NFKB Signaling and Focal Adhesion. Lecithin has biological action on biochemical pathways JAK-STAT Signaling, MYC Signaling and MAPK Signaling. And so on.

When treating Thymoma with chemotherapy Paclitaxel – Foods like Pistachio are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Resveratrol contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER PEANUT FOR THYMOMA ON TREATMENT WITH CHEMOTHERAPY PACLITAXEL FOR SOME CONDITIONS.

Foods for Genetic Risk of Thymoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. HDAC4 and MUC16 are two genes whose abnormalities are risk factors for Thymoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Thymoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Thymoma gene HDAC4 has causative impact on biological pathways like Oncogenic Cancer Epigenetics, G-protein-coupled Receptor Signaling and DNA Repair. And MUC16 has a causative impact on biological pathways like Post Translation Modification. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like HDAC4 and MUC16 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes HDAC4 and MUC16 should be avoided.

Eat more pulses, Scarlet Bean or Chickpea?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Chickpea are Linolenic Acid, Oleic Acid, Genistein, Vitamin A, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Oleic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Thymoma due to abnormalities in genes HDAC4 and MUC16 – Foods like Scarlet Bean are recommended compared to Chickpea. This is because the active ingredients Oleic Acid and Folic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF THYMOMA DUE TO GENES HDAC4 AND MUC16

Eat more vegetables, Arugula or Carob?

The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Carob are Quercetin, Palmitic Acid, Myricetin, Gallic Acid, Phloroglucinol and others.

Kaempferol can manipulate biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics. Vitamin K has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Palmitic Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Thymoma due to abnormalities in genes HDAC4 and MUC16 – Foods like Arugula are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Folic Acid in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Vitamin K contained in Arugula together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF THYMOMA DUE TO GENES HDAC4 AND MUC16

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Pomegranate or Lemon?

The active ingredients contained in Pomegranate are Apigenin, Betulinic Acid, Beta-sitosterol, Corilagin, Ursolic Acid among others. While the active ingredients contained in Lemon are P-coumaric Acid, D-limonene, Vitamin C, Diosmetin, Hesperidin and others.

Betulinic Acid can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Ursolic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Myrcene can manipulate biochemical pathways Extracellular Matrix Remodelling. Eriodictyol has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

For genetic risk of Thymoma due to abnormalities in genes HDAC4 and MUC16 – Foods like Pomegranate are recommended compared to Lemon. This is because the active ingredients Myrcene and Eriodictyol in Lemon further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Ursolic Acid contained in Pomegranate together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER LEMON FOR REDUCING THE GENETIC RISK OF THYMOMA DUE TO GENES HDAC4 AND MUC16

Eat more nuts, Pine Nut or Acorn?

The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Acorn are Beta-sitosterol, Vitamin C, Vitamin B3, Quercetin, Quercitrin and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.

Vitamin B3 can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Thymoma due to abnormalities in genes HDAC4 and MUC16 – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Vitamin B3 and Folic Acid in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF THYMOMA DUE TO GENES HDAC4 AND MUC16


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Thymoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

sample-report


References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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