Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Papillary Stomach Adenocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Papillary Stomach Adenocarcinoma because of FN1 and PRDM9 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Papillary Stomach Adenocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Kumquat” or “Include fruit Naranjilla in my diet” or “Should I reduce consumption of vegetable Spinach” or “Can I take Curcumin and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PAPILLARY STOMACH ADENOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Papillary Stomach Adenocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR PAPILLARY STOMACH ADENOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Papillary Stomach Adenocarcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Papillary Stomach Adenocarcinoma from cBioPortal. The patients enrolled in the studies for Papillary Stomach Adenocarcinoma are in ages between 36 to 80 with an average age of 62. 90.9% of males and 9.1% of females were the distribution of gender in these clinical studies. From a patient sample size of 22; the top genes with mutations and other abnormalities for Papillary Stomach Adenocarcinoma include genes TP53, FN1, PRDM9, RYR3 and MUC16. The occurrence frequency distribution for these genes respectively is 45.0%, 15.0%, 15.0%, 15.0% and 15.0%. These tumor genetic details of Papillary Stomach Adenocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Papillary Stomach Adenocarcinoma.
Significance of Nutrition for Papillary Stomach Adenocarcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Papillary Stomach Adenocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Kumquat includes active ingredients Apigenin, Linolenic Acid, Vitamin C, Oleic Acid, Naringenin and others. And Naranjilla contains active ingredients Beta-carotene, Zeaxanthin, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Papillary Stomach Adenocarcinoma, activation or inhibition of selected biochemical pathways like Cell Cycle, RUNX Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Papillary Stomach Adenocarcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PAPILLARY STOMACH ADENOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Papillary Stomach Adenocarcinoma undergoing chemotherapy treatment
In Papillary Stomach Adenocarcinoma – the genes TP53, FN1, PRDM9, RYR3 and MUC16 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Papillary Stomach Adenocarcinoma are Cell Cycle, RUNX Signaling, Notch Signaling and others. Cisplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, RUNX Signaling, Notch Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Vitamin C, Oleic Acid, Vitamin A, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and WNT Beta Catenin Signaling.
Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Linolenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Papillary Stomach Adenocarcinoma with chemotherapy Cisplatin – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Linolenic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR PAPILLARY STOMACH ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more vegetables, Cabbage or Spinach?
Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Benzyl Isothiocyanate, Beta-sitosterol, Quercetin, Isorhamnetin, Brassinin among others. While the active ingredients contained in Spinach are Apigenin, Beta-sitosterol, Quercetin, Linolenic Acid, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Cell Cycle. Glucaric Acid has biological action on biochemical pathways NFKB Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.
Apigenin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, DNA Repair and Oxidative Stress. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Papillary Stomach Adenocarcinoma with chemotherapy Cisplatin – Foods like Cabbage are recommended compared to Spinach. This is because the active ingredients Apigenin and Quercetin in Spinach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CABBAGE IS RECOMMENDED OVER SPINACH FOR PAPILLARY STOMACH ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more fruits, Naranjilla or Kumquat?
Fruits are an important part of many diets. The active ingredients contained in Naranjilla are Beta-carotene, Zeaxanthin, Vitamin A among others. While the active ingredients contained in Kumquat are Apigenin, Linolenic Acid, Vitamin C, Oleic Acid, Naringenin and others.
Beta-carotene can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin A has biological action on biochemical pathways Cell Cycle, MYC Signaling and WNT Beta Catenin Signaling.
Naringenin can manipulate biochemical pathways Oxidative Stress. Naringetol has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.
When treating Papillary Stomach Adenocarcinoma with chemotherapy Cisplatin – Foods like Naranjilla are recommended compared to Kumquat. This is because the active ingredients Naringenin and Naringetol in Kumquat interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-carotene and Vitamin A contained in Naranjilla support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: NARANJILLA IS RECOMMENDED OVER KUMQUAT FOR PAPILLARY STOMACH ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more nuts, Hazelnut or Walnut?
Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Vitamin E, Quercetin, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Walnut are Ellagic Acid, Betulinic Acid, Beta-sitosterol, Vitamin E, Quercetin and others.
Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin A has biological action on biochemical pathways Cell Cycle, MYC Signaling and WNT Beta Catenin Signaling.
Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. Juglone has biological action on biochemical pathways DNA Repair and Oxidative Stress. And so on.
When treating Papillary Stomach Adenocarcinoma with chemotherapy Cisplatin – Foods like Hazelnut are recommended compared to Walnut. This is because the active ingredients Ellagic Acid and Juglone in Walnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Vitamin A contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER WALNUT FOR PAPILLARY STOMACH ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Papillary Stomach Adenocarcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. FN1 and PRDM9 are two genes whose abnormalities are risk factors for Papillary Stomach Adenocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Papillary Stomach Adenocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Papillary Stomach Adenocarcinoma gene FN1 has causative impact on biological pathways like Cytoskeletal Dynamics, Epithelial to Mesenchymal Transition and Focal Adhesion. And PRDM9 has a causative impact on biological pathways like Oncogenic Histone Methylation and Amino Acid Metabolism. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like FN1 and PRDM9 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes FN1 and PRDM9 should be avoided.
Eat more pulses, Hyacinth Bean or Common Bean?
The active ingredients contained in Hyacinth Bean are Palmitic Acid, Vitamin C, Genistein, Folic Acid, Myristic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Ferulic Acid, Linolenic Acid, Vitamin C and others.
Palmitic Acid can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle, Cell Cycle Checkpoints and Oxidative Stress.
Apigenin can manipulate biochemical pathways Oxidative Stress. Esculin has biological action on biochemical pathways Oxidative Stress. And so on.
For genetic risk of Papillary Stomach Adenocarcinoma due to abnormalities in genes FN1 and PRDM9 – Foods like Hyacinth Bean are recommended compared to Common Bean. This is because the active ingredients Apigenin and Esculin in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Palmitic Acid and Vitamin C contained in Hyacinth Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HYACINTH BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF PAPILLARY STOMACH ADENOCARCINOMA DUE TO GENES FN1 AND PRDM9
Eat more vegetables, Japanese Pumpkin or Chayote?
The active ingredients contained in Japanese Pumpkin are Beta-sitosterol, Vitamin E, Palmitic Acid, Vitamin C, Vitamin A among others. While the active ingredients contained in Chayote are Linolenic Acid, Vitamin C, Linoleic Acid, Oleic Acid, Citric Acid and others.
Palmitic Acid can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin A has biological action on biochemical pathways Extracellular Matrix Remodelling, Cell Cycle and Cell Cycle Checkpoints.
Citric Acid can manipulate biochemical pathways Oxidative Stress. Linolenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
For genetic risk of Papillary Stomach Adenocarcinoma due to abnormalities in genes FN1 and PRDM9 – Foods like Japanese Pumpkin are recommended compared to Chayote. This is because the active ingredients Citric Acid and Linolenic Acid in Chayote further promote the effects of genes on the biochemical pathways. While the active ingredients Palmitic Acid and Vitamin A contained in Japanese Pumpkin together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JAPANESE PUMPKIN IS RECOMMENDED OVER CHAYOTE FOR REDUCING THE GENETIC RISK OF PAPILLARY STOMACH ADENOCARCINOMA DUE TO GENES FN1 AND PRDM9
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Bilberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Bilberry are Quercetin, P-coumaric Acid, Arbutin, Resveratrol, Gallic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Lycopene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Netrin Signaling.
Arbutin can manipulate biochemical pathways Oxidative Stress. Chlorogenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
For genetic risk of Papillary Stomach Adenocarcinoma due to abnormalities in genes FN1 and PRDM9 – Foods like Feijoa are recommended compared to Bilberry. This is because the active ingredients Arbutin and Chlorogenic Acid in Bilberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER BILBERRY FOR REDUCING THE GENETIC RISK OF PAPILLARY STOMACH ADENOCARCINOMA DUE TO GENES FN1 AND PRDM9
Eat more nuts, Pecan Nut or Chestnut?
The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Cianidanol, Linoleic Acid, Oleic Acid among others. While the active ingredients contained in Chestnut are Ellagic Acid, Linolenic Acid, Vitamin C, Quercetin, Linoleic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Cianidanol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Netrin Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Gallic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
For genetic risk of Papillary Stomach Adenocarcinoma due to abnormalities in genes FN1 and PRDM9 – Foods like Pecan Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Gallic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF PAPILLARY STOMACH ADENOCARCINOMA DUE TO GENES FN1 AND PRDM9
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Papillary Stomach Adenocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pancan Pcawg 2020
- Pan-cancer analysis of whole genomes.
- β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial-Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
- Alpha-linolenic acid confers protection on mice renal cells against cisplatin-induced nephrotoxicity.
- β-carotene Inhibits Expression of c-Myc and Cyclin E in Helicobacter pylori-infected Gastric Epithelial Cells.
- Retinoic acid, GABA-ergic, and TGF-beta signaling systems are involved in human cleft palate fibroblast phenotype.
- Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
- Small-molecule inhibitors of NADPH oxidase 4.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Mechanism of Juglone-Induced Cell Cycle Arrest and Apoptosis in Ishikawa Human Endometrial Cancer Cells.
- A redox-resistant sirtuin-1 mutant protects against hepatic metabolic and oxidant stress.
- Anti-oxidative and photo-protective effects of coumarins isolated from Fraxinus chinensis.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Decrease of intracellular ROS by arbutin is associated with apoptosis induction and downregulation of IL-1β and TNF-α in LNCaP; prostate cancer.
- Natural Polyphenol Chlorogenic Acid Protects Against Acetaminophen-Induced Hepatotoxicity by Activating ERK/Nrf2 Antioxidative Pathway.
- Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
- Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.