addonfinal2
What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Osteosarcoma?

Aug 10, 2022

4.8
(21)
Estimated reading time: 15 minutes
Home » Blogs » Which Foods are Recommended for Osteosarcoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Osteosarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Osteosarcoma because of CHEK2 and PPM1D gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Osteosarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Bilberry” or “Include fruit Nance in my diet” or “Should I reduce consumption of vegetable Jute” or “Can I take Birch and Artemisinine supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO OSTEOSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Osteosarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR OSTEOSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Osteosarcoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Osteosarcoma from cBioPortal. The patients enrolled in the studies for Osteosarcoma are in ages between 1 to 93 with an average age of 61. 29.2% of males and 70.8% of females were the distribution of gender in these clinical studies. From a patient sample size of 1453; the top genes with mutations and other abnormalities for Osteosarcoma include genes DNMT3A, PPM1D, TET2, TP53 and CHEK2. The occurrence frequency distribution for these genes respectively is 21.6%, 9.7%, 3.4%, 2.5% and 2.3%. These tumor genetic details of Osteosarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Osteosarcoma.

Significance of Nutrition for Osteosarcoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Osteosarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Bilberry includes active ingredients Quercetin, Resveratrol, Myricetin, Caffeic Acid, Gallic Acid and others. And Nance contains active ingredients Vitamin C, Betulin, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Osteosarcoma, activation or inhibition of selected biochemical pathways like RUNX Signaling, Cell Cycle Checkpoints, Oncogenic Cancer Epigenetics, DNA Repair plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Osteosarcoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Osteosarcoma, activation or inhibition of selected biochemical pathways like RUNX Signaling, Cell Cycle Checkpoints, Oncogenic Cancer Epigenetics, DNA Repair plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR OSTEOSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Osteosarcoma undergoing chemotherapy treatment

In Osteosarcoma – the genes DNMT3A, PPM1D, TET2, TP53 and CHEK2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Osteosarcoma are RUNX Signaling, Cell Cycle Checkpoints, Cell Cycle and others. Dacarbazine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RUNX Signaling, Cell Cycle Checkpoints, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Common Bean?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Stigmasterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Kaempferol, Linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and P53 Signaling.

Apigenin can manipulate biochemical pathways DNA Repair, Oxidative Stress and TWEAK Signaling. Esculin has biological action on biochemical pathways DNA Repair and Oxidative Stress. And so on.

When treating Osteosarcoma with chemotherapy Dacarbazine – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Apigenin and Esculin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR OSTEOSARCOMA ON TREATMENT WITH CHEMOTHERAPY DACARBAZINE FOR SOME CONDITIONS.

Eat more vegetables, Lettuce or Jute?

Vegetables are an important part of many diets. The active ingredients contained in Lettuce are Quercetin, Beta-sitosterol, Vitamin C, Linolenic Acid, Caffeic Acid among others. While the active ingredients contained in Jute are Quercetin, Vitamin C, Kaempferol, Linolenic Acid, Oleic Acid and others.

Vitamin A can manipulate biochemical pathways NFKB Signaling, Apoptosis and Cell Cycle. Vitamin K has biological action on biochemical pathways TWEAK Signaling, MYC Signaling and Cell Cycle Checkpoints.

Quercetin can manipulate biochemical pathways Oxidative Stress. Kaempferol has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Osteosarcoma with chemotherapy Dacarbazine – Foods like Lettuce are recommended compared to Jute. This is because the active ingredients Quercetin and Kaempferol in Jute interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Vitamin K contained in Lettuce support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: LETTUCE IS RECOMMENDED OVER JUTE FOR OSTEOSARCOMA ON TREATMENT WITH CHEMOTHERAPY DACARBAZINE FOR SOME CONDITIONS.

Which Foods are Recommended for Osteosarcoma?

Eat more fruits, Nance or Bilberry?

Fruits are an important part of many diets. The active ingredients contained in Nance are Vitamin C, Betulin, Vitamin A among others. While the active ingredients contained in Bilberry are Quercetin, Resveratrol, Myricetin, Caffeic Acid, Gallic Acid and others.

Vitamin C can manipulate biochemical pathways NFKB Signaling, Apoptosis and Cell Cycle. Betulin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Delphinidin can manipulate biochemical pathways Oxidative Stress. Chlorogenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Osteosarcoma with chemotherapy Dacarbazine – Foods like Nance are recommended compared to Bilberry. This is because the active ingredients Delphinidin and Chlorogenic Acid in Bilberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Betulin contained in Nance support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: NANCE IS RECOMMENDED OVER BILBERRY FOR OSTEOSARCOMA ON TREATMENT WITH CHEMOTHERAPY DACARBAZINE FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Cianidanol, Linolenic Acid, Oleic Acid, Delphinidin among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Beta-carotene, Vitamin C, Gallic Acid and others.

Vitamin E can manipulate biochemical pathways Inositol Phosphate Signaling, NFKB Signaling and Apoptosis. Cianidanol has biological action on biochemical pathways DNA Repair, TWEAK Signaling and MYC Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress. Beta-carotene has biological action on biochemical pathways MAPK Signaling and Notch Signaling. And so on.

When treating Osteosarcoma with chemotherapy Dacarbazine – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Beta-carotene in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR OSTEOSARCOMA ON TREATMENT WITH CHEMOTHERAPY DACARBAZINE FOR SOME CONDITIONS.

Foods for Genetic Risk of Osteosarcoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CHEK2 and PPM1D are two genes whose abnormalities are risk factors for Osteosarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Osteosarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Osteosarcoma gene CHEK2 has causative impact on biological pathways like DNA Repair and Cell Cycle Checkpoints. And PPM1D has a causative impact on biological pathways like DNA Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CHEK2 and PPM1D should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CHEK2 and PPM1D should be avoided.

Eat more pulses, Winged Bean or Hyacinth Bean?

The active ingredients contained in Winged Bean are Betulinic Acid, Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Hyacinth Bean are Vitamin C, Genistein, Palmitic Acid, Myristic Acid, Folic Acid and others.

Betulinic Acid can manipulate biochemical pathways Hedgehog Signaling, Apoptosis and NFKB Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.

Palmitic Acid can manipulate biochemical pathways NFKB Signaling, Oncogenic Cancer Epigenetics and MAPK Signaling. Myristic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Osteosarcoma due to abnormalities in genes CHEK2 and PPM1D – Foods like Winged Bean are recommended compared to Hyacinth Bean. This is because the active ingredients Palmitic Acid and Myristic Acid in Hyacinth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER HYACINTH BEAN FOR REDUCING THE GENETIC RISK OF OSTEOSARCOMA DUE TO GENES CHEK2 AND PPM1D

Eat more vegetables, Cassava or Celery?

The active ingredients contained in Cassava are Vitamin C, Linolenic Acid, Beta-sitosterol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Celery are Apigenin, Vitamin C, Linolenic Acid, Quercetin, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Cell Cycle Checkpoints and Oncogenic Cancer Epigenetics.

Cynaroside can manipulate biochemical pathways Oncogenic Cancer Epigenetics and MAPK Signaling. Luteolin has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Osteosarcoma due to abnormalities in genes CHEK2 and PPM1D – Foods like Cassava are recommended compared to Celery. This is because the active ingredients Cynaroside and Luteolin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF OSTEOSARCOMA DUE TO GENES CHEK2 AND PPM1D

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Feijoa or Raspberry?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Raspberry are Vitamin C, Resveratrol, Quercetin, Ellagic Acid, Rutin and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways NFKB Signaling, Cell Cycle Checkpoints and MAPK Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.

For genetic risk of Osteosarcoma due to abnormalities in genes CHEK2 and PPM1D – Foods like Feijoa are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF OSTEOSARCOMA DUE TO GENES CHEK2 AND PPM1D

Eat more nuts, Almond or Chestnut?

The active ingredients contained in Almond are Vitamin E, Linolenic Acid, Beta-sitosterol, Stigmasterol, Quercetin among others. While the active ingredients contained in Chestnut are Vitamin C, Linolenic Acid, Quercetin, Oleic Acid, Ellagic Acid and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Apoptosis and MYC Signaling. Vitamin E has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and MAPK Signaling. And so on.

For genetic risk of Osteosarcoma due to abnormalities in genes CHEK2 and PPM1D – Foods like Almond are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF OSTEOSARCOMA DUE TO GENES CHEK2 AND PPM1D


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Osteosarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

sample-report


References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

You can also read this in

How useful was this post?

Click on a star to rate it!

Average rating 4.8 / 5. Vote count: 21

No votes so far! Be the first to rate this post.

As you found this post useful...

Follow us on social media!

We are sorry that this post was not useful for you!

Let us improve this post!

Tell us how we can improve this post?