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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Non-hodgkin Lymphoma?

Aug 10, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Non-hodgkin Lymphoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Non-hodgkin Lymphoma because of RHOA and EP300 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Non-hodgkin Lymphoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Fig” or “Include fruit Orange in my diet” or “Should I reduce consumption of vegetable Chicory” or “Can I take Wheatgrass and Lemon supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO NON-HODGKIN LYMPHOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Non-hodgkin Lymphoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR NON-HODGKIN LYMPHOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Non-hodgkin Lymphoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Non-hodgkin Lymphoma from cBioPortal. The patients enrolled in the studies for Non-hodgkin Lymphoma are in ages between 4 to 57 with an average age of 12. 73.9% of males and 26.1% of females were the distribution of gender in these clinical studies. From a patient sample size of 23; the top genes with mutations and other abnormalities for Non-hodgkin Lymphoma include genes TET2, RHOA, EP300, COL3A1 and IDH2. The occurrence frequency distribution for these genes respectively is 50.0%, 37.5%, 12.5%, 12.5% and 12.5%. These tumor genetic details of Non-hodgkin Lymphoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Non-hodgkin Lymphoma.

Significance of Nutrition for Non-hodgkin Lymphoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Non-hodgkin Lymphoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Fig includes active ingredients Vitamin C, Angelicin, Rutin, Lupeol, Bergapten and others. And Orange contains active ingredients D-limonene, Vitamin C, Linolenic Acid, Vicenin 2, Modified Citrus Pectin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Non-hodgkin Lymphoma, activation or inhibition of selected biochemical pathways like MAPK Signaling, Post Translation Modification, Oncogenic Cancer Epigenetics, Cytoskeletal Dynamics plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Non-hodgkin Lymphoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Non-hodgkin Lymphoma, activation or inhibition of selected biochemical pathways like MAPK Signaling, Post Translation Modification, Oncogenic Cancer Epigenetics, Cytoskeletal Dynamics plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR NON-HODGKIN LYMPHOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Non-hodgkin Lymphoma undergoing chemotherapy treatment

In Non-hodgkin Lymphoma – the genes TET2, RHOA, EP300, COL3A1 and IDH2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Non-hodgkin Lymphoma are MAPK Signaling, Post Translation Modification, Hypoxia and others. Doxorubicin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers MAPK Signaling, Post Translation Modification, Hypoxia so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Yellow Wax Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Vitamin C, Linolenic Acid, Kaempferol, Pelargonidin, Lupeol among others. While the active ingredients contained in Yellow Wax Bean are Vitamin C, Ferulic Acid, Cianidanol, Astragalin, Vitamin A and others.

Vitamin C can manipulate biochemical pathways MAPK Signaling, Oncogenic Cancer Epigenetics and Hypoxia. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Oncogenic Cancer Epigenetics and Hypoxia.

Palmitic Acid can manipulate biochemical pathways NFKB Signaling, Oncogenic Cancer Epigenetics and MAPK Signaling. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling and MAPK Signaling. And so on.

When treating Non-hodgkin Lymphoma with chemotherapy Doxorubicin – Foods like Common Pea are recommended compared to Yellow Wax Bean. This is because the active ingredients Palmitic Acid and Folic Acid in Yellow Wax Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER YELLOW WAX BEAN FOR NON-HODGKIN LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.

Eat more vegetables, Taro or Chicory?

Vegetables are an important part of many diets. The active ingredients contained in Taro are Vitamin C, Linolenic Acid, Stigmasterol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Chicory are Apigenin, Quercetin, Vitamin C, Linolenic Acid, Protocatechuic Acid and others.

Vitamin C can manipulate biochemical pathways MAPK Signaling, Oncogenic Cancer Epigenetics and Hypoxia. Stigmasterol has biological action on biochemical pathways JAK-STAT Signaling and MAPK Signaling.

Esculetin can manipulate biochemical pathways Hypoxia. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling and MAPK Signaling. And so on.

When treating Non-hodgkin Lymphoma with chemotherapy Doxorubicin – Foods like Taro are recommended compared to Chicory. This is because the active ingredients Esculetin and Folic Acid in Chicory interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Stigmasterol contained in Taro support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: TARO IS RECOMMENDED OVER CHICORY FOR NON-HODGKIN LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.

Which Foods are Recommended for Non hodgkin Lymphoma?

Eat more fruits, Orange or Fig?

Fruits are an important part of many diets. The active ingredients contained in Orange are D-limonene, Vitamin C, Linolenic Acid, Vicenin 2, Modified Citrus Pectin among others. While the active ingredients contained in Fig are Vitamin C, Angelicin, Rutin, Lupeol, Bergapten and others.

D-limonene can manipulate biochemical pathways NFKB Signaling, MAPK Signaling and Post Translation Modification. Vitamin C has biological action on biochemical pathways Oncogenic Cancer Epigenetics, Hypoxia and MAPK Signaling.

Lauric Acid can manipulate biochemical pathways NFKB Signaling and MAPK Signaling. Myristic Acid has biological action on biochemical pathways MAPK Signaling. And so on.

When treating Non-hodgkin Lymphoma with chemotherapy Doxorubicin – Foods like Orange are recommended compared to Fig. This is because the active ingredients Lauric Acid and Myristic Acid in Fig interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients D-limonene and Vitamin C contained in Orange support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER FIG FOR NON-HODGKIN LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Peanut?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Linolenic Acid, Vitamin E, Delphinidin, Cianidanol, Oleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin C, Linolenic Acid, Vitamin E, Stigmasterol and others.

Vitamin E can manipulate biochemical pathways MAPK Signaling, NFKB Signaling and Hypoxia. Delphinidin has biological action on biochemical pathways MAPK Signaling, NFKB Signaling and Hypoxia.

Lecithin can manipulate biochemical pathways NFKB Signaling, JAK-STAT Signaling and MAPK Signaling. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling and MAPK Signaling. And so on.

When treating Non-hodgkin Lymphoma with chemotherapy Doxorubicin – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Delphinidin contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR NON-HODGKIN LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Non-hodgkin Lymphoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. RHOA and EP300 are two genes whose abnormalities are risk factors for Non-hodgkin Lymphoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Non-hodgkin Lymphoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Non-hodgkin Lymphoma gene RHOA has causative impact on biological pathways like Cytoskeletal Dynamics, Adherens junction and cGMP Signaling. And EP300 has a causative impact on biological pathways like G-protein-coupled Receptor Signaling and Immune Evasion Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like RHOA and EP300 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes RHOA and EP300 should be avoided.

Eat more pulses, Scarlet Bean or Pigeon Pea?

The active ingredients contained in Scarlet Bean are Oleic Acid, Linolenic Acid, Beta-sitosterol, Vitamin C, Genistein among others. While the active ingredients contained in Pigeon Pea are Oleic Acid, Linolenic Acid, Vitamin C, Genistein, Vitamin A and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling.

Oleic Acid can manipulate biochemical pathways Cytoskeletal Dynamics and Netrin Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Non-hodgkin Lymphoma due to abnormalities in genes RHOA and EP300 – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Oleic Acid and Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF NON-HODGKIN LYMPHOMA DUE TO GENES RHOA AND EP300

Eat more vegetables, Cauliflower or Yardlong Bean?

The active ingredients contained in Cauliflower are Sulforaphane, Oleic Acid, Linolenic Acid, Beta-sitosterol, Glucaric Acid among others. While the active ingredients contained in Yardlong Bean are Oleic Acid, Linolenic Acid, Vitamin C, Vitamin A, Linoleic Acid and others.

Glucaric Acid can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways Oncogenic Cancer Epigenetics, MYC Signaling and PI3K-AKT-MTOR Signaling.

Oleic Acid can manipulate biochemical pathways Cytoskeletal Dynamics and Netrin Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Non-hodgkin Lymphoma due to abnormalities in genes RHOA and EP300 – Foods like Cauliflower are recommended compared to Yardlong Bean. This is because the active ingredients Oleic Acid and Folic Acid in Yardlong Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Glucaric Acid and Vitamin C contained in Cauliflower together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CAULIFLOWER IS RECOMMENDED OVER YARDLONG BEAN FOR REDUCING THE GENETIC RISK OF NON-HODGKIN LYMPHOMA DUE TO GENES RHOA AND EP300

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Mango or Huckleberry?

The active ingredients contained in Mango are Lupeol, Oleic Acid, Linolenic Acid, Beta-sitosterol, Gallic Acid among others. While the active ingredients contained in Huckleberry are Resveratrol, Vitamin C, Caffeic Acid, Quercetin, P-coumaric Acid and others.

Gallic Acid can manipulate biochemical pathways MYC Signaling, Cytoskeletal Dynamics and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways Oncogenic Cancer Epigenetics, MYC Signaling and PI3K-AKT-MTOR Signaling.

Quercetin can manipulate biochemical pathways Cell Junctions. Pelargonidin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Non-hodgkin Lymphoma due to abnormalities in genes RHOA and EP300 – Foods like Mango are recommended compared to Huckleberry. This is because the active ingredients Quercetin and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Gallic Acid and Vitamin C contained in Mango together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MANGO IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF NON-HODGKIN LYMPHOMA DUE TO GENES RHOA AND EP300

Eat more nuts, Almond or Cashew Nut?

The active ingredients contained in Almond are Salicylic Acid, Oleic Acid, Linolenic Acid, Vitamin E, Beta-sitosterol among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Gallic Acid, Vitamin C, Butyric Acid, Vitamin K and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling. Salicylic Acid has biological action on biochemical pathways Histone/Protein Acetylation, RUNX Signaling and MYC Signaling.

Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Non-hodgkin Lymphoma due to abnormalities in genes RHOA and EP300 – Foods like Almond are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Salicylic Acid contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF NON-HODGKIN LYMPHOMA DUE TO GENES RHOA AND EP300


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Non-hodgkin Lymphoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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