Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Mycosis Fungoides when undergoing chemotherapy or when you determine you have a genetic risk for developing Mycosis Fungoides because of ADA and ADAMTS1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Mycosis Fungoides which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Plum” or “Include fruit Naranjilla in my diet” or “Should I reduce consumption of vegetable Beetroot” or “Can I take Vitamin D3 and Artemisinine supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MYCOSIS FUNGOIDES, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Mycosis Fungoides is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR MYCOSIS FUNGOIDES, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Mycosis Fungoides
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Mycosis Fungoides from cBioPortal. From a patient sample size of 3; the top genes with mutations and other abnormalities for Mycosis Fungoides include genes ADA, ADAMTS1, ANO2, ADRA1D and AKAP9. The occurrence frequency distribution for these genes respectively is 33.3%, 33.3%, 33.3%, 33.3% and 33.3%. These tumor genetic details of Mycosis Fungoides are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Mycosis Fungoides.
Mycosis fungoides is a slowly progressive and chronic disease, a rare form of T-cell lymphoma of the skin. In individuals with mycosis fungoides, the skin becomes infiltrated with plaques and nodules composed of lymphocytes. This disorder can spread to other parts of the body including the liver, spleen, gastrointestinal system, or brain. Mycosis fungoides occurs in adults over 40 years of age and has a predominance in males over females. Symptoms of mycosis fungoides can include flat, scaly patches; thicker raised lesions (plaques); and common skin conditions like eczema or psoriasis along with excessive itching. Mycosis fungoides patients can have long-term remission with treatment, and many may live with minimal or no symptoms for many years. Most patients diagnosed with mycosis fungoides live with early-stage disease and have a normal life span. Treatment for mycosis fungoides include skin directed therapies such as creams, ointments or gels, and systemic therapies with chemotherapy, targeted agents or immunotherapies. Additionally, supportive care with the right nutrition (food and natural supplements) with their inherent bioactives that can interfere with the disease-causing pathways, can enhance patients’ well-being. (Ref: https://www.clfoundation.org/mycosis-fungoides ; https://rarediseases.org/rare-diseases/mycosis-fungoides/ ; Kaufman AE et al, J Eur Acad Dermatol Venereol., 2020)
Significance of Nutrition for Mycosis Fungoides
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Mycosis Fungoides. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Plum includes active ingredients Betulinic Acid, Beta-sitosterol, Vitamin C, Vitamin A, Quercetin and others. And Naranjilla contains active ingredients Beta-carotene, Vitamin A, Zeaxanthin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Mycosis Fungoides, activation or inhibition of selected biochemical pathways like Post Translation Modification, PI3K-AKT-MTOR Signaling, Small Molecule Transport, Extracellular Matrix Remodelling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Mycosis Fungoides, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MYCOSIS FUNGOIDES – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Mycosis Fungoides undergoing chemotherapy treatment
In Mycosis Fungoides – the genes ADA, ADAMTS1, ANO2, ADRA1D and AKAP9 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Mycosis Fungoides are Post Translation Modification, PI3K-AKT-MTOR Signaling, Amino Acid Metabolism and others. Romidepsin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Post Translation Modification, PI3K-AKT-MTOR Signaling, Amino Acid Metabolism so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Lentils?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Vitamin C, Vitamin A, Quercetin, Linoleic Acid, Kaempferol among others. While the active ingredients contained in Lentils are Daidzein, Beta-sitosterol, Vitamin C, Vitamin A, Linoleic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, Vitamin D Signaling and PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways Retinoic Acid Signaling, Amino Acid Metabolism and MYC Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and Vitamin D Signaling. Genistein has biological action on biochemical pathways DNA Repair. And so on.
When treating Mycosis Fungoides with chemotherapy Romidepsin – Foods like Mung Bean are recommended compared to Lentils. This is because the active ingredients Ellagic Acid and Genistein in Lentils interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Vitamin A contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER LENTILS FOR MYCOSIS FUNGOIDES ON TREATMENT WITH CHEMOTHERAPY ROMIDEPSIN FOR SOME CONDITIONS.
Eat more vegetables, Arrowroot or Beetroot?
Vegetables are an important part of many diets. The active ingredients contained in Arrowroot are Beta-carotene, Vanillic Acid, Vitamin C, Quercetin, Protocatechuic Acid among others. While the active ingredients contained in Beetroot are Vitamin E, Beta-sitosterol, Vitamin C, Vitamin A, Linoleic Acid and others.
Beta-carotene can manipulate biochemical pathways DNA Repair, MYC Signaling and Vitamin D Signaling. Vanillic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Amino Acid Metabolism and MYC Signaling.
Trans-trans-farnesol can manipulate biochemical pathways Retinoic Acid Signaling. Linolenic Acid has biological action on biochemical pathways Vitamin D Signaling and Retinoic Acid Signaling. And so on.
When treating Mycosis Fungoides with chemotherapy Romidepsin – Foods like Arrowroot are recommended compared to Beetroot. This is because the active ingredients Trans-trans-farnesol and Linolenic Acid in Beetroot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-carotene and Vanillic Acid contained in Arrowroot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER BEETROOT FOR MYCOSIS FUNGOIDES ON TREATMENT WITH CHEMOTHERAPY ROMIDEPSIN FOR SOME CONDITIONS.
Eat more fruits, Naranjilla or Plum?
Fruits are an important part of many diets. The active ingredients contained in Naranjilla are Beta-carotene, Vitamin A, Zeaxanthin among others. While the active ingredients contained in Plum are Betulinic Acid, Beta-sitosterol, Vitamin C, Vitamin A, Quercetin and others.
Beta-carotene can manipulate biochemical pathways DNA Repair, MYC Signaling and Vitamin D Signaling. Vitamin A has biological action on biochemical pathways Retinoic Acid Signaling, PI3K-AKT-MTOR Signaling and Amino Acid Metabolism.
Myristic Acid can manipulate biochemical pathways Post Translation Modification. Palmitic Acid has biological action on biochemical pathways MYC Signaling and Post Translation Modification. And so on.
When treating Mycosis Fungoides with chemotherapy Romidepsin – Foods like Naranjilla are recommended compared to Plum. This is because the active ingredients Myristic Acid and Palmitic Acid in Plum interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-carotene and Vitamin A contained in Naranjilla support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: NARANJILLA IS RECOMMENDED OVER PLUM FOR MYCOSIS FUNGOIDES ON TREATMENT WITH CHEMOTHERAPY ROMIDEPSIN FOR SOME CONDITIONS.
Eat more nuts, Pistachio or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Pistachio are Vitamin E, Beta-sitosterol, Vitamin A, Linoleic Acid, Oleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Vitamin D Signaling and PI3K-AKT-MTOR Signaling. Vitamin E has biological action on biochemical pathways DNA Repair, Amino Acid Metabolism and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. Linolenic Acid has biological action on biochemical pathways Vitamin D Signaling and Retinoic Acid Signaling. And so on.
When treating Mycosis Fungoides with chemotherapy Romidepsin – Foods like Pistachio are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Linolenic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER BRAZIL NUT FOR MYCOSIS FUNGOIDES ON TREATMENT WITH CHEMOTHERAPY ROMIDEPSIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Mycosis Fungoides
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ADA and ADAMTS1 are two genes whose abnormalities are risk factors for Mycosis Fungoides. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Mycosis Fungoides can be used as a guide for coming up with a recommended personalized nutrition plan. For Mycosis Fungoides gene ADA has causative impact on biological pathways like Nucleotide metabolism. And ADAMTS1 has a causative impact on biological pathways like Extracellular Matrix Remodelling, Post Translation Modification and Angiogenesis. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ADA and ADAMTS1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ADA and ADAMTS1 should be avoided.
Eat more pulses, Scarlet Bean or Fava Bean?
The active ingredients contained in Scarlet Bean are Vitamin C, Liquiritigenin, Stigmasterol, Genistein, Beta-sitosterol among others. While the active ingredients contained in Fava Bean are Caffeic Acid, Quercetin, Daidzein, Ferulic Acid, Vitamin C and others.
Vitamin C can manipulate biochemical pathways MYC Signaling and MAPK Signaling. Liquiritigenin has biological action on biochemical pathways Extracellular Matrix Remodelling, MYC Signaling and MAPK Signaling.
Quercetin can manipulate biochemical pathways DNA Repair and Complement Cascade. Ferulic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Mycosis Fungoides due to abnormalities in genes ADA and ADAMTS1 – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Quercetin and Ferulic Acid in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Liquiritigenin contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF MYCOSIS FUNGOIDES DUE TO GENES ADA AND ADAMTS1
Eat more vegetables, Artichoke or Garden Cress?
The active ingredients contained in Artichoke are Apigenin, Vitamin C, Cynaroside, Chlorogenic Acid, Naringenin among others. While the active ingredients contained in Garden Cress are Isorhamnetin, Vitamin E, Vitamin C, Benzyl Isothiocyanate, Stigmasterol and others.
Vitamin K can manipulate biochemical pathways MYC Signaling. Apigenin has biological action on biochemical pathways DNA Repair and MYC Signaling.
Isorhamnetin can manipulate biochemical pathways Small Molecule Transport. Benzyl Isothiocyanate has biological action on biochemical pathways Small Molecule Transport. And so on.
For genetic risk of Mycosis Fungoides due to abnormalities in genes ADA and ADAMTS1 – Foods like Artichoke are recommended compared to Garden Cress. This is because the active ingredients Isorhamnetin and Benzyl Isothiocyanate in Garden Cress further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin K and Apigenin contained in Artichoke together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARTICHOKE IS RECOMMENDED OVER GARDEN CRESS FOR REDUCING THE GENETIC RISK OF MYCOSIS FUNGOIDES DUE TO GENES ADA AND ADAMTS1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Orange or Apricot?
The active ingredients contained in Orange are D-limonene, Modified Citrus Pectin, Linalool, Salicylic Acid, Vitamin C among others. While the active ingredients contained in Apricot are Modified Citrus Pectin, Quercetin, Salicylic Acid, Vitamin C, Stigmasterol and others.
D-limonene can manipulate biochemical pathways MYC Signaling, Small Molecule Transport and MAPK Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling and MAPK Signaling.
Rutin can manipulate biochemical pathways TGFB Signaling and Extracellular Matrix Remodelling. Quercetin has biological action on biochemical pathways DNA Repair and Complement Cascade. And so on.
For genetic risk of Mycosis Fungoides due to abnormalities in genes ADA and ADAMTS1 – Foods like Orange are recommended compared to Apricot. This is because the active ingredients Rutin and Quercetin in Apricot further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ORANGE IS RECOMMENDED OVER APRICOT FOR REDUCING THE GENETIC RISK OF MYCOSIS FUNGOIDES DUE TO GENES ADA AND ADAMTS1
Eat more nuts, Walnut or Peanut?
The active ingredients contained in Walnut are D-limonene, Protocatechuic Acid, Hyperoside, Quercetin, Myricetin among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Vitamin C, Ferulic Acid, Stigmasterol and others.
D-limonene can manipulate biochemical pathways MYC Signaling, Small Molecule Transport and MAPK Signaling. Hyperoside has biological action on biochemical pathways Post Translation Modification, Extracellular Matrix Remodelling and MYC Signaling.
Quercetin can manipulate biochemical pathways DNA Repair and Complement Cascade. Lecithin has biological action on biochemical pathways MYC Signaling and MAPK Signaling. And so on.
For genetic risk of Mycosis Fungoides due to abnormalities in genes ADA and ADAMTS1 – Foods like Walnut are recommended compared to Peanut. This is because the active ingredients Quercetin and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Hyperoside contained in Walnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: WALNUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF MYCOSIS FUNGOIDES DUE TO GENES ADA AND ADAMTS1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Mycosis Fungoides by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
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- Legionella pneumophila serogroup 12 pneumonia in a renal transplant recipient: case report and environmental observations.
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- Research progress on the anticancer effects of vitamin K2.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine.
- Structure-Activity Relationship Study on Isothiocyanates: Comparison of TRPA1-Activating Ability between Allyl Isothiocyanate and Specific Flavor Components of Wasabi, Horseradish, and White Mustard.
- The preventive effects of hyperoside on lung cancer in vitro by inducing apoptosis and inhibiting proliferation through Caspase-3 and P53 signaling pathway.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.