Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Low-grade Serous Ovarian Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Low-grade Serous Ovarian Cancer because of RUNX1 and EIF1AX gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Low-grade Serous Ovarian Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Huckleberry” or “Include fruit Blueberry in my diet” or “Should I reduce consumption of vegetable Bell Pepper” or “Can I take Spirulina and Cardamom supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO LOW-GRADE SEROUS OVARIAN CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Low-grade Serous Ovarian Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR LOW-GRADE SEROUS OVARIAN CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Low-grade Serous Ovarian Cancer
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Low-grade Serous Ovarian Cancer from cBioPortal. From a patient sample size of 122; the top genes with mutations and other abnormalities for Low-grade Serous Ovarian Cancer include genes TP53, KRAS, RUNX1, EIF1AX and NRAS. The occurrence frequency distribution for these genes respectively is 8.1%, 8.1%, 5.4%, 5.4% and 5.4%. These tumor genetic details of Low-grade Serous Ovarian Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Low-grade Serous Ovarian Cancer.
Significance of Nutrition for Low-grade Serous Ovarian Cancer
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Low-grade Serous Ovarian Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Huckleberry includes active ingredients Resveratrol, Quercetin, Vitamin C, Ferulic Acid, P-coumaric Acid and others. And Blueberry contains active ingredients Resveratrol, Quercetin, Vitamin C, Cianidanol, Vitamin E and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Low-grade Serous Ovarian Cancer, activation or inhibition of selected biochemical pathways like Oncogenic Cancer Epigenetics, Suppressive Histone Methylation, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Low-grade Serous Ovarian Cancer, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR LOW-GRADE SEROUS OVARIAN CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Low-grade Serous Ovarian Cancer undergoing chemotherapy treatment
In Low-grade Serous Ovarian Cancer – the genes TP53, KRAS, RUNX1, EIF1AX and NRAS have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Low-grade Serous Ovarian Cancer are Oncogenic Cancer Epigenetics, Suppressive Histone Methylation, Chromatin Remodeling and others. Pembrolizumab is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Oncogenic Cancer Epigenetics, Suppressive Histone Methylation, Chromatin Remodeling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Vitamin C, Daidzein, Linolenic Acid, Beta-sitosterol among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Genistein, Linoleic Acid and others.
Vitamin C can manipulate biochemical pathways Suppressive Histone Methylation, MYC Signaling and WNT Beta Catenin Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and MYC Signaling.
Genistein can manipulate biochemical pathways Chromatin Remodeling and DNA Repair. Folic Acid has biological action on biochemical pathways MYC Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Low-grade Serous Ovarian Cancer with chemotherapy Pembrolizumab – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Folic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR LOW-GRADE SEROUS OVARIAN CANCER ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Eat more vegetables, Arrowroot or Bell Pepper?
Vegetables are an important part of many diets. The active ingredients contained in Arrowroot are Protocatechuic Acid, Quercetin, Vitamin C, Beta-carotene, Chlorogenic Acid among others. While the active ingredients contained in Bell Pepper are Vitamin C, Linolenic Acid, Isorhamnetin, Vitamin E, Oleic Acid and others.
Protocatechuic Acid can manipulate biochemical pathways MYC Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways Suppressive Histone Methylation, DNA Repair and WNT Beta Catenin Signaling.
Capsaicin can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways MYC Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Low-grade Serous Ovarian Cancer with chemotherapy Pembrolizumab – Foods like Arrowroot are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Folic Acid in Bell Pepper interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Protocatechuic Acid and Quercetin contained in Arrowroot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER BELL PEPPER FOR LOW-GRADE SEROUS OVARIAN CANCER ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Eat more fruits, Blueberry or Huckleberry?
Fruits are an important part of many diets. The active ingredients contained in Blueberry are Resveratrol, Quercetin, Vitamin C, Cianidanol, Vitamin E among others. While the active ingredients contained in Huckleberry are Resveratrol, Quercetin, Vitamin C, Ferulic Acid, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways Suppressive Histone Methylation, MYC Signaling and WNT Beta Catenin Signaling. Cianidanol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.
Resveratrol can manipulate biochemical pathways DNA Repair. Pelargonidin has biological action on biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Low-grade Serous Ovarian Cancer with chemotherapy Pembrolizumab – Foods like Blueberry are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Cianidanol contained in Blueberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BLUEBERRY IS RECOMMENDED OVER HUCKLEBERRY FOR LOW-GRADE SEROUS OVARIAN CANCER ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Linolenic Acid, Cianidanol, Vitamin E, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Brazil Nut are Linolenic Acid, Vitamin E, Oleic Acid, Lecithin, Folic Acid and others.
Cianidanol can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin E has biological action on biochemical pathways DNA Repair, MYC Signaling and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Low-grade Serous Ovarian Cancer with chemotherapy Pembrolizumab – Foods like Pecan Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Cianidanol and Vitamin E contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER BRAZIL NUT FOR LOW-GRADE SEROUS OVARIAN CANCER ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.
Foods for Genetic Risk of Low-grade Serous Ovarian Cancer
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. RUNX1 and EIF1AX are two genes whose abnormalities are risk factors for Low-grade Serous Ovarian Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Low-grade Serous Ovarian Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Low-grade Serous Ovarian Cancer gene RUNX1 has causative impact on biological pathways like NFKB Signaling, RUNX Signaling and TGFB Signaling. And EIF1AX has a causative impact on biological pathways like PI3K-AKT-MTOR Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like RUNX1 and EIF1AX should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes RUNX1 and EIF1AX should be avoided.
Eat more pulses, Mung Bean or Soy Bean?
The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Soy Bean are Lupeol, Quercetin, Daidzein, Vitamin E, Beta-sitosterol and others.
Quercetin can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Low-grade Serous Ovarian Cancer due to abnormalities in genes RUNX1 and EIF1AX – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF LOW-GRADE SEROUS OVARIAN CANCER DUE TO GENES RUNX1 AND EIF1AX
Eat more vegetables, Jicama or Radish?
The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Radish are Quercetin, Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-carotene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and MAPK Signaling. And so on.
For genetic risk of Low-grade Serous Ovarian Cancer due to abnormalities in genes RUNX1 and EIF1AX – Foods like Jicama are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF LOW-GRADE SEROUS OVARIAN CANCER DUE TO GENES RUNX1 AND EIF1AX
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Orange or Cranberry?
The active ingredients contained in Orange are D-limonene, Linalool, Modified Citrus Pectin, Vitamin C, Oleic Acid among others. While the active ingredients contained in Cranberry are Ellagic Acid, Quercetin, Vitamin C, Resveratrol, Hyperoside and others.
D-limonene can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
For genetic risk of Low-grade Serous Ovarian Cancer due to abnormalities in genes RUNX1 and EIF1AX – Foods like Orange are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ORANGE IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF LOW-GRADE SEROUS OVARIAN CANCER DUE TO GENES RUNX1 AND EIF1AX
Eat more nuts, Almond or Peanut?
The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Beta-sitosterol, Vitamin C, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Low-grade Serous Ovarian Cancer due to abnormalities in genes RUNX1 and EIF1AX – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF LOW-GRADE SEROUS OVARIAN CANCER DUE TO GENES RUNX1 AND EIF1AX
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Low-grade Serous Ovarian Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
- Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
- Sequential protooncogene expression in regenerating kidney following acute renal injury.
- Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Naturally occurring phenolic acids modulate TPA-induced activation of EGFR, AP-1, and STATs in mouse epidermis.
- Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.
- Inhibitory effect of tocotrienol on eukaryotic DNA polymerase lambda and angiogenesis.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Effects of β-carotene on Expression of Selected MicroRNAs, Histone Acetylation, and DNA Methylation in Colon Cancer Stem Cells.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.