Foods for Low-grade Serous Ovarian Cancer!

Introduction

Foods for Low-grade Serous Ovarian Cancer should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Low-grade Serous Ovarian Cancer does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Low-grade Serous Ovarian Cancer does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Low-grade Serous Ovarian Cancer?

For example does it matter if vegetable New Zealand Spinach is consumed more compared to Spinach? Does it make any difference if fruit Pummelo is preferred over Pomegranate? Also if similar choices are made for nuts/seeds like Butternut over Cashew Nut and for pulses like Gram Bean over Lima Bean. And if what I eat matters – then how does one identify foods which are recommended for Low-grade Serous Ovarian Cancer and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Low-grade Serous Ovarian Cancer!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Curcumin, Apigenin, Lycopene, Formononetin, Lupeol. And Pomegranate contains active ingredients Curcumin, Apigenin, Formononetin, Lupeol, Phloretin and possibly others.

A common mistake made when deciding and choosing foods to eat for Low-grade Serous Ovarian Cancer – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Low-grade Serous Ovarian Cancer.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Low-grade Serous Ovarian Cancer?

Personalized nutrition for cancers like Low-grade Serous Ovarian Cancer consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Low-grade Serous Ovarian Cancer biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Low-grade Serous Ovarian Cancer

All cancers like Low-grade Serous Ovarian Cancer can be characterized by a unique set of biochemical pathways – the signature pathways of Low-grade Serous Ovarian Cancer. Biochemical pathways like Cell Cycle Checkpoints, Apoptosis, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Low-grade Serous Ovarian Cancer. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Low-grade Serous Ovarian Cancer need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Low-grade Serous Ovarian Cancer when taking cancer treatment Cisplatin, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, KRAS, RUNX1, EIF1AX and NRAS are the top ranked reported genes for Low-grade Serous Ovarian Cancer. TP53 is reported in 8.1 % of the representative patients across all clinical trials. And KRAS is reported in 8.1 %. The combined population patient data cover ages from to . 0.0 % of the patient data are identified as men. The Low-grade Serous Ovarian Cancer biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Low-grade Serous Ovarian Cancer

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable NEW ZEALAND SPINACH or SPINACH?

Vegetable New Zealand Spinach contains many active ingredients or bioactives such as Curcumin, Apigenin, Lycopene, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, DNA Repair, Cell Cycle Checkpoints and MYC Signaling and others. New Zealand Spinach is recommended for Low-grade Serous Ovarian Cancer when ongoing cancer treatment is Cisplatin. This is because New Zealand Spinach modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cisplatin.

Some of the active ingredients or bioactives in vegetable Spinach are Curcumin, Apigenin, Lupeol, Formononetin, Phloretin. These active ingredients manipulate various biochemical pathways like MAPK Signaling and WNT Beta Catenin Signaling and others. Spinach is not recommended for Low-grade Serous Ovarian Cancer when ongoing cancer treatment is Cisplatin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE NEW ZEALAND SPINACH IS RECOMMENDED OVER SPINACH FOR Low-grade Serous Ovarian Cancer AND TREATMENT Cisplatin.

Choose Fruit POMEGRANATE or PUMMELO?

Fruit Pomegranate contains many active ingredients or bioactives such as Curcumin, Apigenin, Formononetin, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling, Apoptosis and PI3K-AKT-MTOR Signaling and others. Pomegranate is recommended for Low-grade Serous Ovarian Cancer when ongoing cancer treatment is Cisplatin. This is because Pomegranate modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cisplatin.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Apigenin, Lycopene, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and WNT Beta Catenin Signaling and others. Pummelo is not recommended for Low-grade Serous Ovarian Cancer when ongoing cancer treatment is Cisplatin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT POMEGRANATE IS RECOMMENDED OVER PUMMELO FOR Low-grade Serous Ovarian Cancer AND TREATMENT Cisplatin.

Choose Nut BUTTERNUT or CASHEW NUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Lycopene, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, DNA Repair, Cell Cycle Checkpoints and MYC Signaling and others. Butternut is recommended for Low-grade Serous Ovarian Cancer when ongoing cancer treatment is Cisplatin. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cisplatin.

Some of the active ingredients or bioactives in Cashew Nut are Curcumin, Formononetin, Lupeol, Phloretin, Protocatechuic Acid. These active ingredients manipulate various biochemical pathways like MAPK Signaling and PI3K-AKT-MTOR Signaling and others. Cashew Nut is not recommended for Low-grade Serous Ovarian Cancer when ongoing cancer treatment is Cisplatin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER CASHEW NUT FOR Low-grade Serous Ovarian Cancer AND TREATMENT Cisplatin.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Low-grade Serous Ovarian Cancer or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CAULIFLOWER or JERUSALEM ARTICHOKE?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Delphinidin, Isoliquiritigenin, Formononetin, Catechol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, JAK-STAT Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Cauliflower is recommended for risk of Low-grade Serous Ovarian Cancer when associated genetic risk is EIF1AX. This is because Cauliflower increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Jerusalem Artichoke are Curcumin, Delphinidin, Apigenin, Myricetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling and others. Jerusalem Artichoke is not recommended when risk of Low-grade Serous Ovarian Cancer when associated genetic risk is EIF1AX because it increases the signature pathways of it.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER JERUSALEM ARTICHOKE FOR EIF1AX GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or STAR FRUIT?

Fruit Red Raspberry contains many active ingredients or bioactives such as Ellagic Acid, Quercetin, Curcumin, Delphinidin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling and others. Red Raspberry is recommended for risk of Low-grade Serous Ovarian Cancer when associated genetic risk is EIF1AX. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Star Fruit are Curcumin, Delphinidin, Apigenin, Myricetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling and others. Star Fruit is not recommended when risk of Low-grade Serous Ovarian Cancer when associated genetic risk is EIF1AX because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER STAR FRUIT FOR EIF1AX GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Quercetin, Curcumin, Delphinidin, Myricetin, Lycopene. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling and others. Common Hazelnut is recommended for risk of Low-grade Serous Ovarian Cancer when associated genetic risk is EIF1AX. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Ellagic Acid, Curcumin, Delphinidin, Apigenin, Myricetin. These active ingredients manipulate various biochemical pathways like MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling and others. Chestnut is not recommended when risk of Low-grade Serous Ovarian Cancer when associated genetic risk is EIF1AX because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR EIF1AX GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Low-grade Serous Ovarian Cancer. Low-grade Serous Ovarian Cancer patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Low-grade Serous Ovarian Cancer, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like New Zealand Spinach contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Low-grade Serous Ovarian Cancer?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

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