Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Lip And Oral Cavity Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Lip And Oral Cavity Cancer because of CDKN2A and NOTCH1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Lip And Oral Cavity Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Lemon in my diet” or “Should I reduce consumption of vegetable Endive” or “Can I take Dim and Guggul supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO LIP AND ORAL CAVITY CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Lip And Oral Cavity Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR LIP AND ORAL CAVITY CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Lip And Oral Cavity Cancer
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Lip And Oral Cavity Cancer from cBioPortal. The patients enrolled in the studies for Lip And Oral Cavity Cancer are in ages between 26 to 99 with an average age of 55. 71.0% of males and 29.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 220; the top genes with mutations and other abnormalities for Lip And Oral Cavity Cancer include genes TP53, TERT, CDKN2A, NOTCH1 and PIK3CA. The occurrence frequency distribution for these genes respectively is 34.4%, 32.0%, 14.8%, 12.3% and 8.2%. These tumor genetic details of Lip And Oral Cavity Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Lip And Oral Cavity Cancer.
Significance of Nutrition for Lip And Oral Cavity Cancer
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Lip And Oral Cavity Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cranberry includes active ingredients Quercetin, Resveratrol, Ellagic Acid, Hyperoside, Myricetin and others. And Lemon contains active ingredients D-limonene, Hesperidin, Oleic Acid, Modified Citrus Pectin, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Lip And Oral Cavity Cancer, activation or inhibition of selected biochemical pathways like Apoptosis, Chromatin Remodeling, Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Lip And Oral Cavity Cancer, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR LIP AND ORAL CAVITY CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Lip And Oral Cavity Cancer undergoing chemotherapy treatment
In Lip And Oral Cavity Cancer – the genes TP53, TERT, CDKN2A, NOTCH1 and PIK3CA have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Lip And Oral Cavity Cancer are Apoptosis, Chromatin Remodeling, Angiogenesis and others. Trabectedin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Apoptosis, Chromatin Remodeling, Angiogenesis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Common Bean?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Oleic Acid, Vitamin C, Ferulic Acid and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Chromatin Remodeling and DNA Repair. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and P53 Signaling.
Apigenin can manipulate biochemical pathways DNA Repair and PI3K-AKT-MTOR Signaling. Esculin has biological action on biochemical pathways DNA Repair. And so on.
When treating Lip And Oral Cavity Cancer with chemotherapy Trabectedin – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Apigenin and Esculin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR LIP AND ORAL CAVITY CANCER ON TREATMENT WITH CHEMOTHERAPY TRABECTEDIN FOR SOME CONDITIONS.
Eat more vegetables, Cabbage or Endive?
Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Quercetin, Benzyl Isothiocyanate, Isorhamnetin, Beta-sitosterol, Brassinin among others. While the active ingredients contained in Endive are Quercetin, Oleic Acid, Vitamin C, Kaempferol, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Cell Cycle, MYC Signaling and P53 Signaling. Glucaric Acid has biological action on biochemical pathways NFKB Signaling, Apoptosis and Cell Survival.
Quercetin can manipulate biochemical pathways DNA Repair. Linoleic Acid has biological action on biochemical pathways Angiogenesis. And so on.
When treating Lip And Oral Cavity Cancer with chemotherapy Trabectedin – Foods like Cabbage are recommended compared to Endive. This is because the active ingredients Quercetin and Linoleic Acid in Endive interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CABBAGE IS RECOMMENDED OVER ENDIVE FOR LIP AND ORAL CAVITY CANCER ON TREATMENT WITH CHEMOTHERAPY TRABECTEDIN FOR SOME CONDITIONS.
Eat more fruits, Lemon or Cranberry?
Fruits are an important part of many diets. The active ingredients contained in Lemon are D-limonene, Hesperidin, Oleic Acid, Modified Citrus Pectin, Vitamin C among others. While the active ingredients contained in Cranberry are Quercetin, Resveratrol, Ellagic Acid, Hyperoside, Myricetin and others.
D-limonene can manipulate biochemical pathways NFKB Signaling, Apoptosis and Growth Factor Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and P53 Signaling.
Quercetin can manipulate biochemical pathways DNA Repair. Resveratrol has biological action on biochemical pathways P53 Signaling and DNA Repair. And so on.
When treating Lip And Oral Cavity Cancer with chemotherapy Trabectedin – Foods like Lemon are recommended compared to Cranberry. This is because the active ingredients Quercetin and Resveratrol in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients D-limonene and Vitamin C contained in Lemon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: LEMON IS RECOMMENDED OVER CRANBERRY FOR LIP AND ORAL CAVITY CANCER ON TREATMENT WITH CHEMOTHERAPY TRABECTEDIN FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Pumpkin Seeds?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Cianidanol, Linolenic Acid, Delphinidin among others. While the active ingredients contained in Pumpkin Seeds are Beta-sitosterol, Oleic Acid, Linolenic Acid, Salicylic Acid, Stigmasterol and others.
Vitamin E can manipulate biochemical pathways NFKB Signaling, Apoptosis and DNA Repair. Cianidanol has biological action on biochemical pathways Cell Survival, MYC Signaling and P53 Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Angiogenesis. Vitamin B3 has biological action on biochemical pathways DNA Repair, PI3K-AKT-MTOR Signaling and Angiogenesis. And so on.
When treating Lip And Oral Cavity Cancer with chemotherapy Trabectedin – Foods like Pecan Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Vitamin B3 in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR LIP AND ORAL CAVITY CANCER ON TREATMENT WITH CHEMOTHERAPY TRABECTEDIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Lip And Oral Cavity Cancer
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CDKN2A and NOTCH1 are two genes whose abnormalities are risk factors for Lip And Oral Cavity Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Lip And Oral Cavity Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Lip And Oral Cavity Cancer gene CDKN2A has causative impact on biological pathways like Cell Cycle Checkpoints and Cell Cycle. And NOTCH1 has a causative impact on biological pathways like Notch Signaling and RUNX Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CDKN2A and NOTCH1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CDKN2A and NOTCH1 should be avoided.
Eat more pulses, Common Pea or Soy Bean?
The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Soy Bean are Vitamin E, Lupeol, Beta-sitosterol, Daidzein, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Apoptosis.
Lecithin can manipulate biochemical pathways MYC Signaling. Aescin has biological action on biochemical pathways Cell Cycle Checkpoints and Cell Cycle. And so on.
For genetic risk of Lip And Oral Cavity Cancer due to abnormalities in genes CDKN2A and NOTCH1 – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Lecithin and Aescin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF LIP AND ORAL CAVITY CANCER DUE TO GENES CDKN2A AND NOTCH1
Eat more vegetables, Milk Thistle or Radish?
The active ingredients contained in Milk Thistle are Vitamin E, Silibinin, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Radish are Beta-sitosterol, P-coumaric Acid, Linolenic Acid, Quercetin, Vitamin C and others.
Silibinin can manipulate biochemical pathways Apoptosis, Cell Cycle and Notch Signaling. Vitamin E has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.
Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Cell Cycle. Folic Acid has biological action on biochemical pathways P53 Signaling, Apoptosis and MYC Signaling. And so on.
For genetic risk of Lip And Oral Cavity Cancer due to abnormalities in genes CDKN2A and NOTCH1 – Foods like Milk Thistle are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Silibinin and Vitamin E contained in Milk Thistle together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MILK THISTLE IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF LIP AND ORAL CAVITY CANCER DUE TO GENES CDKN2A AND NOTCH1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Roselle or Raspberry?
The active ingredients contained in Roselle are Vitamin E, Beta-sitosterol, Linolenic Acid, Stigmasterol, Vitamin C among others. While the active ingredients contained in Raspberry are Quercetin, Ellagic Acid, Vitamin C, Salicylic Acid, Gallic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, Cell Cycle and Notch Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
For genetic risk of Lip And Oral Cavity Cancer due to abnormalities in genes CDKN2A and NOTCH1 – Foods like Roselle are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Beta-sitosterol contained in Roselle together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ROSELLE IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF LIP AND ORAL CAVITY CANCER DUE TO GENES CDKN2A AND NOTCH1
Eat more nuts, Almond or Peanut?
The active ingredients contained in Almond are Vitamin E, Beta-sitosterol, Linolenic Acid, Stigmasterol, Quercetin among others. While the active ingredients contained in Peanut are Vitamin E, Beta-sitosterol, Rhamnetin, Linolenic Acid, Ferulic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Vitamin E has biological action on biochemical pathways Notch Signaling, P53 Signaling and Cell Cycle Checkpoints.
Lecithin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.
For genetic risk of Lip And Oral Cavity Cancer due to abnormalities in genes CDKN2A and NOTCH1 – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF LIP AND ORAL CAVITY CANCER DUE TO GENES CDKN2A AND NOTCH1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Lip And Oral Cavity Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Mixed Allen 2018
- Pan-cancer analysis of whole genomes.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Induction of apoptosis by calcium D-glucarate in 7,12-dimethyl benz [a] anthracene-exposed mouse skin.
- Linoleic acid enhances angiogenesis through suppression of angiostatin induced by plasminogen activator inhibitor 1.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- (+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-alpha in LPS-stimulated macrophages.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Resveratrol modulates tumor cell proliferation and protein translation via SIRT1-dependent AMPK activation.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.