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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Intrahepatic Cholangiocarcinoma?

Aug 10, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Intrahepatic Cholangiocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Intrahepatic Cholangiocarcinoma because of BAP1 and HLA-A gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Intrahepatic Cholangiocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Apricot” or “Include fruit Cherimoya in my diet” or “Should I reduce consumption of vegetable Okra” or “Can I take Neem Extract and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO INTRAHEPATIC CHOLANGIOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Intrahepatic Cholangiocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR INTRAHEPATIC CHOLANGIOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Intrahepatic Cholangiocarcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Intrahepatic Cholangiocarcinoma from cBioPortal. The patients enrolled in the studies for Intrahepatic Cholangiocarcinoma are in ages between 29 to 86 with an average age of 59. 54.2% of males and 45.8% of females were the distribution of gender in these clinical studies. From a patient sample size of 1495; the top genes with mutations and other abnormalities for Intrahepatic Cholangiocarcinoma include genes BAP1, IDH1, HLA-A, ACVR2A and MUC16. The occurrence frequency distribution for these genes respectively is 2.1%, 2.1%, 1.5%, 1.2% and 1.1%. These tumor genetic details of Intrahepatic Cholangiocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Intrahepatic Cholangiocarcinoma.

Significance of Nutrition for Intrahepatic Cholangiocarcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Intrahepatic Cholangiocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Apricot includes active ingredients Quercetin, Beta-sitosterol, Modified Citrus Pectin, Linolenic Acid, Salicylic Acid and others. And Cherimoya contains active ingredients Beta-sitosterol, Linolenic Acid, Vitamin C, Stigmasterol, Oleic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Intrahepatic Cholangiocarcinoma, activation or inhibition of selected biochemical pathways like Post Translation Modification, RAS-RAF Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Intrahepatic Cholangiocarcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Intrahepatic Cholangiocarcinoma, activation or inhibition of selected biochemical pathways like Post Translation Modification, RAS-RAF Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR INTRAHEPATIC CHOLANGIOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Intrahepatic Cholangiocarcinoma undergoing chemotherapy treatment

In Intrahepatic Cholangiocarcinoma – the genes BAP1, IDH1, HLA-A, ACVR2A and MUC16 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Intrahepatic Cholangiocarcinoma are Post Translation Modification, RAS-RAF Signaling, mRNA Splicing and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Post Translation Modification, RAS-RAF Signaling, mRNA Splicing so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Linolenic Acid, Vitamin C, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Vitamin C, Oleic Acid, Genistein, Linoleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling.

Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Vitamin A has biological action on biochemical pathways Extracellular Matrix Remodelling, Notch Signaling and Focal Adhesion. And so on.

When treating Intrahepatic Cholangiocarcinoma with chemotherapy Radiation – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin A in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR INTRAHEPATIC CHOLANGIOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Cassava or Okra?

Vegetables are an important part of many diets. The active ingredients contained in Cassava are Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Okra are Quercetin, Beta-sitosterol, Linolenic Acid, Salicylic Acid, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Glucocorticoid Signaling and Oxidative Stress.

Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling, Notch Signaling and Focal Adhesion. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Intrahepatic Cholangiocarcinoma with chemotherapy Radiation – Foods like Cassava are recommended compared to Okra. This is because the active ingredients Vitamin A and Quercetin in Okra interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER OKRA FOR INTRAHEPATIC CHOLANGIOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Which Foods are Recommended for Intrahepatic Cholangiocarcinoma?

Eat more fruits, Cherimoya or Apricot?

Fruits are an important part of many diets. The active ingredients contained in Cherimoya are Beta-sitosterol, Linolenic Acid, Vitamin C, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Apricot are Quercetin, Beta-sitosterol, Modified Citrus Pectin, Linolenic Acid, Salicylic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Stigmasterol has biological action on biochemical pathways DNA Repair, JAK-STAT Signaling and Cell Cycle.

Rutin can manipulate biochemical pathways Oxidative Stress, Oncogenic Cancer Epigenetics and Focal Adhesion. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Intrahepatic Cholangiocarcinoma with chemotherapy Radiation – Foods like Cherimoya are recommended compared to Apricot. This is because the active ingredients Rutin and Citric Acid in Apricot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Stigmasterol contained in Cherimoya support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CHERIMOYA IS RECOMMENDED OVER APRICOT FOR INTRAHEPATIC CHOLANGIOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Gallic Acid, Vitamin C, Beta-carotene and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle, MYC Signaling and PI3K-AKT-MTOR Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress. Gallic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Intrahepatic Cholangiocarcinoma with chemotherapy Radiation – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR INTRAHEPATIC CHOLANGIOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Intrahepatic Cholangiocarcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. BAP1 and HLA-A are two genes whose abnormalities are risk factors for Intrahepatic Cholangiocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Intrahepatic Cholangiocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Intrahepatic Cholangiocarcinoma gene BAP1 has causative impact on biological pathways like DNA Repair. And HLA-A has a causative impact on biological pathways like Interferon Signaling and Antigen Presentation. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like BAP1 and HLA-A should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes BAP1 and HLA-A should be avoided.

Eat more pulses, Mung Bean or Common Bean?

The active ingredients contained in Mung Bean are Quercetin, Kaempferol, Genistein, Oleic Acid, Vitamin C among others. While the active ingredients contained in Common Bean are Apigenin, Kaempferol, Esculin, Genistein, Oleic Acid and others.

Kaempferol can manipulate biochemical pathways RAS-RAF Signaling, Cell Cycle Checkpoints and Hypoxia. Vitamin C has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways RAS-RAF Signaling, MYC Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Intrahepatic Cholangiocarcinoma due to abnormalities in genes BAP1 and HLA-A – Foods like Mung Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Vitamin C contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF INTRAHEPATIC CHOLANGIOCARCINOMA DUE TO GENES BAP1 AND HLA-A

Eat more vegetables, Jicama or Carob?

The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Carob are Quercetin, Myricetin, Phloroglucinol, Gallic Acid, Palmitic Acid and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Beta-carotene has biological action on biochemical pathways Oncogenic Cancer Epigenetics, Hypoxia and MYC Signaling.

Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics, Energy Metabolism and PI3K-AKT-MTOR Signaling. Myricetin has biological action on biochemical pathways Oncogenic Histone Methylation and Oncogenic Cancer Epigenetics. And so on.

For genetic risk of Intrahepatic Cholangiocarcinoma due to abnormalities in genes BAP1 and HLA-A – Foods like Jicama are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Myricetin in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF INTRAHEPATIC CHOLANGIOCARCINOMA DUE TO GENES BAP1 AND HLA-A

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Grape or Strawberry?

The active ingredients contained in Grape are Resveratrol, Lupeol, Oleic Acid, Vitamin C, Vitamin E among others. While the active ingredients contained in Strawberry are Ellagic Acid, Lupeol, Oleic Acid, Vitamin C, Beta-sitosterol and others.

Resveratrol can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways Oncogenic Cancer Epigenetics, Hypoxia and RAS-RAF Signaling.

Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Intrahepatic Cholangiocarcinoma due to abnormalities in genes BAP1 and HLA-A – Foods like Grape are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients Resveratrol and Vitamin C contained in Grape together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GRAPE IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF INTRAHEPATIC CHOLANGIOCARCINOMA DUE TO GENES BAP1 AND HLA-A

Eat more nuts, Almond or Brazil Nut?

The active ingredients contained in Almond are Quercetin, Oleic Acid, Vitamin E, Beta-sitosterol, Linolenic Acid among others. While the active ingredients contained in Brazil Nut are Oleic Acid, Vitamin E, Linolenic Acid, Lecithin, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and Cell Cycle Checkpoints. Vitamin E has biological action on biochemical pathways Hypoxia, PI3K-AKT-MTOR Signaling and MYC Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways RAS-RAF Signaling, Cell Cycle Checkpoints and MYC Signaling. And so on.

For genetic risk of Intrahepatic Cholangiocarcinoma due to abnormalities in genes BAP1 and HLA-A – Foods like Almond are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF INTRAHEPATIC CHOLANGIOCARCINOMA DUE TO GENES BAP1 AND HLA-A


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Intrahepatic Cholangiocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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