Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Infiltrating Lobular Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Infiltrating Lobular Carcinoma because of AKT1 and BCL11B gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Infiltrating Lobular Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Watermelon” or “Include fruit Pomegranate in my diet” or “Should I reduce consumption of vegetable Turnip” or “Can I take Goldenseal and Resveratrol supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO INFILTRATING LOBULAR CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Infiltrating Lobular Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR INFILTRATING LOBULAR CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Infiltrating Lobular Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Infiltrating Lobular Carcinoma from cBioPortal. The patients enrolled in the studies for Infiltrating Lobular Carcinoma are in ages between 48 to 63 with an average age of 56.From a patient sample size of 4; the top genes with mutations and other abnormalities for Infiltrating Lobular Carcinoma include genes AKT1, BCL11B, BCOR, CDH1 and CHD4. The occurrence frequency distribution for these genes respectively is 25.0%, 25.0%, 25.0%, 25.0% and 25.0%. These tumor genetic details of Infiltrating Lobular Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Infiltrating Lobular Carcinoma.
Significance of Nutrition for Infiltrating Lobular Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Infiltrating Lobular Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Watermelon includes active ingredients Linolenic Acid, Lycopene, Vitamin C, Cucurbitacin E, Oleic Acid and others. And Pomegranate contains active ingredients Betulinic Acid, Apigenin, Beta-sitosterol, Corilagin, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Infiltrating Lobular Carcinoma, activation or inhibition of selected biochemical pathways like Cytoskeletal Dynamics, Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling, Growth Factor Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Infiltrating Lobular Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR INFILTRATING LOBULAR CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Infiltrating Lobular Carcinoma undergoing chemotherapy treatment
In Infiltrating Lobular Carcinoma – the genes AKT1, BCL11B, BCOR, CDH1 and CHD4 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Infiltrating Lobular Carcinoma are Cytoskeletal Dynamics, Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cytoskeletal Dynamics, Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Lima Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Linolenic Acid, Lupeol, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Lima Bean are Vitamin C, Oleic Acid, Genistein, Linoleic Acid, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Cytoskeletal Dynamics. And so on.
When treating Infiltrating Lobular Carcinoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Lima Bean. This is because the active ingredients Vitamin A and Oleic Acid in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LIMA BEAN FOR INFILTRATING LOBULAR CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Kohlrabi or Turnip?
Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Linolenic Acid, Beta-sitosterol, Vitamin C, Oleic Acid, Brassinin among others. While the active ingredients contained in Turnip are Vitamin C, Sulforaphane, Indole-3-carbinol, Vitamin K, Vitamin A and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and PI3K-AKT-MTOR Signaling. Brassinin has biological action on biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Infiltrating Lobular Carcinoma with chemotherapy Radiation – Foods like Kohlrabi are recommended compared to Turnip. This is because the active ingredients Vitamin A and Folic Acid in Turnip interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Brassinin contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER TURNIP FOR INFILTRATING LOBULAR CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Pomegranate or Watermelon?
Fruits are an important part of many diets. The active ingredients contained in Pomegranate are Betulinic Acid, Apigenin, Beta-sitosterol, Corilagin, Vitamin C among others. While the active ingredients contained in Watermelon are Linolenic Acid, Lycopene, Vitamin C, Cucurbitacin E, Oleic Acid and others.
Betulinic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Hedgehog Signaling and MYC Signaling. Gallic Acid has biological action on biochemical pathways Cytoskeletal Dynamics, PI3K-AKT-MTOR Signaling and Epithelial to Mesenchymal Transition.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Cytoskeletal Dynamics. And so on.
When treating Infiltrating Lobular Carcinoma with chemotherapy Radiation – Foods like Pomegranate are recommended compared to Watermelon. This is because the active ingredients Vitamin A and Oleic Acid in Watermelon interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Gallic Acid contained in Pomegranate support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER WATERMELON FOR INFILTRATING LOBULAR CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Walnut or Pumpkin Seeds?
Nuts are an important part of many diets. The active ingredients contained in Walnut are Juglone, Betulinic Acid, Vitamin E, Linolenic Acid, Beta-sitosterol among others. While the active ingredients contained in Pumpkin Seeds are Linolenic Acid, Beta-sitosterol, Gamma-linolenic Acid, Oleic Acid, Stigmasterol and others.
Juglone can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Cucurbitacin I has biological action on biochemical pathways MYC Signaling. And so on.
When treating Infiltrating Lobular Carcinoma with chemotherapy Radiation – Foods like Walnut are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Cucurbitacin I in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Juglone and Beta-sitosterol contained in Walnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: WALNUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR INFILTRATING LOBULAR CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Infiltrating Lobular Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. AKT1 and BCL11B are two genes whose abnormalities are risk factors for Infiltrating Lobular Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Infiltrating Lobular Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Infiltrating Lobular Carcinoma gene AKT1 has causative impact on biological pathways like Autophagy, PI3K-AKT-MTOR Signaling and Angiogenesis. And BCL11B has a causative impact on biological pathways like Chromatin Remodeling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like AKT1 and BCL11B should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes AKT1 and BCL11B should be avoided.
Eat more pulses, Scarlet Bean or Common Bean?
The active ingredients contained in Scarlet Bean are Linolenic Acid, Beta-sitosterol, Oleic Acid, Vitamin C, Stigmasterol among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Linolenic Acid, Delphinidin, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle Checkpoints and MAPK Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Ferulic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
For genetic risk of Infiltrating Lobular Carcinoma due to abnormalities in genes AKT1 and BCL11B – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Vitamin A and Ferulic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF INFILTRATING LOBULAR CARCINOMA DUE TO GENES AKT1 AND BCL11B
Eat more vegetables, Giant Butterbur or Jute?
The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Kaempferol among others. While the active ingredients contained in Jute are Quercetin, Linolenic Acid, Oleic Acid, Vitamin C, Vitamin B3 and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Infiltrating Lobular Carcinoma due to abnormalities in genes AKT1 and BCL11B – Foods like Giant Butterbur are recommended compared to Jute. This is because the active ingredients Vitamin A and Folic Acid in Jute further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER JUTE FOR REDUCING THE GENETIC RISK OF INFILTRATING LOBULAR CARCINOMA DUE TO GENES AKT1 AND BCL11B
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Peach?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Peach are Modified Citrus Pectin, Linolenic Acid, Beta-sitosterol, Oleic Acid, Vitamin C and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Lycopene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Infiltrating Lobular Carcinoma due to abnormalities in genes AKT1 and BCL11B – Foods like Feijoa are recommended compared to Peach. This is because the active ingredients Fisetin and Vitamin A in Peach further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER PEACH FOR REDUCING THE GENETIC RISK OF INFILTRATING LOBULAR CARCINOMA DUE TO GENES AKT1 AND BCL11B
Eat more nuts, Hazelnut or Peanut?
The active ingredients contained in Hazelnut are Vitamin E, Quercetin, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Quercetin, Linolenic Acid, Beta-sitosterol, Oleic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Quercetin has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Infiltrating Lobular Carcinoma due to abnormalities in genes AKT1 and BCL11B – Foods like Hazelnut are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF INFILTRATING LOBULAR CARCINOMA DUE TO GENES AKT1 AND BCL11B
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Infiltrating Lobular Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Brca Broad
- Sequence analysis of mutations and translocations across breast cancer subtypes.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway.
- Gallic acid inhibits gastric cancer cells metastasis and invasive growth via increased expression of RhoB, downregulation of AKT/small GTPase signals and inhibition of NF-κB activity.
- Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Targeted juglone blocks the invasion and metastasis of HPV-positive cervical cancer cells.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Cucurbitacin-I induces hypertrophy in H9c2 cardiomyoblasts through activation of autophagy via MEK/ERK1/2 signaling pathway.
- Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.