Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Gliosarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Gliosarcoma because of BRAF and RB1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Gliosarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Date” or “Include fruit Rowanberry in my diet” or “Should I reduce consumption of vegetable Endive” or “Can I take Curcumin and Quercetin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO GLIOSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Gliosarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR GLIOSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Gliosarcoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Gliosarcoma from cBioPortal. The patients enrolled in the studies for Gliosarcoma are in ages between 52 to 80 with an average age of 58. 50.0% of males and 50.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 26; the top genes with mutations and other abnormalities for Gliosarcoma include genes TP53, TERT, BRAF, RB1 and PTEN. The occurrence frequency distribution for these genes respectively is 9.1%, 9.1%, 9.1%, 9.1% and 9.1%. These tumor genetic details of Gliosarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Gliosarcoma.
Significance of Nutrition for Gliosarcoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Gliosarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Date includes active ingredients Quercetin, Apigenin, Lupeol, Beta-sitosterol, Protocatechuic Acid and others. And Rowanberry contains active ingredients Quercetin, Chlorogenic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Gliosarcoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Extracellular Matrix Remodelling, PI3K-AKT-MTOR Signaling, Apoptosis plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Gliosarcoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR GLIOSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Gliosarcoma undergoing chemotherapy treatment
In Gliosarcoma – the genes TP53, TERT, BRAF, RB1 and PTEN have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Gliosarcoma are RAS-RAF Signaling, Extracellular Matrix Remodelling, Growth Factor Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Extracellular Matrix Remodelling, Growth Factor Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Common Bean?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Oleic Acid, Vitamin C, Glucaric Acid, Vitexin among others. While the active ingredients contained in Common Bean are Delphinidin, Apigenin, Esculin, Oleic Acid, P-coumaric Acid and others.
Quercetin can manipulate biochemical pathways NFKB Signaling, Extracellular Matrix Remodelling and DNA Repair. Vitamin C has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and Angiogenesis.
Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling. Apigenin has biological action on biochemical pathways DNA Repair and TGFB Signaling. And so on.
When treating Gliosarcoma with chemotherapy Radiation – Foods like Mung Bean are recommended compared to Common Bean. This is because the active ingredients Vitamin A and Apigenin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin C contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER COMMON BEAN FOR GLIOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Arrowroot or Endive?
Vegetables are an important part of many diets. The active ingredients contained in Arrowroot are Quercetin, Protocatechuic Acid, Chlorogenic Acid, Vitamin C, Beta-carotene among others. While the active ingredients contained in Endive are Quercetin, Oleic Acid, Vitamin C, Linolenic Acid, Kaempferol and others.
Quercetin can manipulate biochemical pathways NFKB Signaling, Extracellular Matrix Remodelling and DNA Repair. Protocatechuic Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Angiogenesis.
Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling. Linoleic Acid has biological action on biochemical pathways TGFB Signaling. And so on.
When treating Gliosarcoma with chemotherapy Radiation – Foods like Arrowroot are recommended compared to Endive. This is because the active ingredients Vitamin A and Linoleic Acid in Endive interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Protocatechuic Acid contained in Arrowroot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER ENDIVE FOR GLIOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Rowanberry or Date?
Fruits are an important part of many diets. The active ingredients contained in Rowanberry are Quercetin, Chlorogenic Acid among others. While the active ingredients contained in Date are Quercetin, Apigenin, Lupeol, Beta-sitosterol, Protocatechuic Acid and others.
Chlorogenic Acid can manipulate biochemical pathways NFKB Signaling, Extracellular Matrix Remodelling and MYC Signaling. Quercetin has biological action on biochemical pathways DNA Repair, Growth Factor Signaling and TGFB Signaling.
Apigenin can manipulate biochemical pathways DNA Repair and TGFB Signaling. Vitamin A has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.
When treating Gliosarcoma with chemotherapy Radiation – Foods like Rowanberry are recommended compared to Date. This is because the active ingredients Apigenin and Vitamin A in Date interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Chlorogenic Acid and Quercetin contained in Rowanberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ROWANBERRY IS RECOMMENDED OVER DATE FOR GLIOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Almond or Pumpkin Seeds?
Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Salicylic Acid, Oleic Acid among others. While the active ingredients contained in Pumpkin Seeds are Beta-sitosterol, Salicylic Acid, Oleic Acid, Linolenic Acid, Stigmasterol and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Angiogenesis. Quercetin has biological action on biochemical pathways Extracellular Matrix Remodelling, DNA Repair and Growth Factor Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling. Cucurbitacin I has biological action on biochemical pathways MYC Signaling and NFKB Signaling. And so on.
When treating Gliosarcoma with chemotherapy Radiation – Foods like Almond are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Cucurbitacin I in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER PUMPKIN SEEDS FOR GLIOSARCOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Gliosarcoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. BRAF and RB1 are two genes whose abnormalities are risk factors for Gliosarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Gliosarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Gliosarcoma gene BRAF has causative impact on biological pathways like RAS-RAF Signaling, MAPK Signaling and Antigen Presentation. And RB1 has a causative impact on biological pathways like Cell Cycle Checkpoints, DNA Repair and Cell Cycle. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like BRAF and RB1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes BRAF and RB1 should be avoided.
Eat more pulses, Hyacinth Bean or Moth Bean?
The active ingredients contained in Hyacinth Bean are Palmitic Acid, Vitamin C, Genistein, Folic Acid, Myristic Acid among others. While the active ingredients contained in Moth Bean are Beta-sitosterol, Oleic Acid, Linolenic Acid, Stigmasterol, Linoleic Acid and others.
Palmitic Acid can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Hypoxia.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Gliosarcoma due to abnormalities in genes BRAF and RB1 – Foods like Hyacinth Bean are recommended compared to Moth Bean. This is because the active ingredients Vitamin A and Folic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Palmitic Acid and Vitamin C contained in Hyacinth Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HYACINTH BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF GLIOSARCOMA DUE TO GENES BRAF AND RB1
Eat more vegetables, Cassava or Jute?
The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Jute are Quercetin, Vitamin C, Oleic Acid, Linolenic Acid, Kaempferol and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Gliosarcoma due to abnormalities in genes BRAF and RB1 – Foods like Cassava are recommended compared to Jute. This is because the active ingredients Vitamin A and Folic Acid in Jute further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER JUTE FOR REDUCING THE GENETIC RISK OF GLIOSARCOMA DUE TO GENES BRAF AND RB1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Kiwi or Naranjilla?
The active ingredients contained in Kiwi are Quercetin, Vitamin C, Fisetin, Chlorogenic Acid, Vitamin A among others. While the active ingredients contained in Naranjilla are Zeaxanthin, Beta-carotene, Vitamin A and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Hypoxia.
Beta-carotene can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Gliosarcoma due to abnormalities in genes BRAF and RB1 – Foods like Kiwi are recommended compared to Naranjilla. This is because the active ingredients Beta-carotene and Vitamin A in Naranjilla further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: KIWI IS RECOMMENDED OVER NARANJILLA FOR REDUCING THE GENETIC RISK OF GLIOSARCOMA DUE TO GENES BRAF AND RB1
Eat more nuts, Hazelnut or Peanut?
The active ingredients contained in Hazelnut are Quercetin, Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Beta-sitosterol, Vitamin C, Oleic Acid and others.
Quercetin can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin E has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Hypoxia.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Lecithin has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Gliosarcoma due to abnormalities in genes BRAF and RB1 – Foods like Hazelnut are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin E contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF GLIOSARCOMA DUE TO GENES BRAF AND RB1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Gliosarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Glioma Mskcc 2019
- Genomic Correlates of Disease Progression and Treatment Response in Prospectively Characterized Gliomas.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Chromatographic separation and electrochemical determination of cholesterol hydroperoxides generated by photodynamic action.
- Protocatechuic acid inhibits the growth of ovarian cancer cells by inducing apoptosis and autophagy.
- Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Cucurbitacin-I induces hypertrophy in H9c2 cardiomyoblasts through activation of autophagy via MEK/ERK1/2 signaling pathway.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- β-carotene Inhibits Expression of c-Myc and Cyclin E in Helicobacter pylori-infected Gastric Epithelial Cells.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.