addonfinal2
What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Myxofibrosarcoma?

Aug 9, 2022

4.2
(37)
Estimated reading time: 16 minutes
Home » Blogs » Which Foods are Recommended for Myxofibrosarcoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Myxofibrosarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Myxofibrosarcoma because of RYR2 and NF1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Myxofibrosarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Sea Buckthorn” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Endive” or “Can I take Lycopene and Myricetin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MYXOFIBROSARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Myxofibrosarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR MYXOFIBROSARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Myxofibrosarcoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Myxofibrosarcoma from cBioPortal. The patients enrolled in the studies for Myxofibrosarcoma are in ages between 31 to 89 with an average age of 62. 50.7% of males and 49.3% of females were the distribution of gender in these clinical studies. From a patient sample size of 146; the top genes with mutations and other abnormalities for Myxofibrosarcoma include genes TP53, TERT, MUC16, RYR2 and NF1. The occurrence frequency distribution for these genes respectively is 7.6%, 4.8%, 3.8%, 3.8% and 3.8%. These tumor genetic details of Myxofibrosarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Myxofibrosarcoma.

Significance of Nutrition for Myxofibrosarcoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Myxofibrosarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Sea Buckthorn includes active ingredients Isorhamnetin, Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Myxofibrosarcoma, activation or inhibition of selected biochemical pathways like Extracellular Matrix Remodelling, Nutrient sensing, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Myxofibrosarcoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Myxofibrosarcoma, activation or inhibition of selected biochemical pathways like Extracellular Matrix Remodelling, Nutrient sensing, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MYXOFIBROSARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Myxofibrosarcoma undergoing chemotherapy treatment

In Myxofibrosarcoma – the genes TP53, TERT, MUC16, RYR2 and NF1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Myxofibrosarcoma are Extracellular Matrix Remodelling, Nutrient sensing, RAS-RAF Signaling and others. Docetaxel is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Extracellular Matrix Remodelling, Nutrient sensing, RAS-RAF Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Adzuki Bean or Black-eyed Pea?

Pulses are an important part of many diets. The active ingredients contained in Adzuki Bean are Isoliquiritigenin, Genistein, Glucaric Acid, Folic Acid among others. While the active ingredients contained in Black-eyed Pea are Genistein, Linolenic Acid, Daidzein, Vitamin C, Beta-carotene and others.

Glucaric Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Isoliquiritigenin has biological action on biochemical pathways Adherens junction, Microtubule Dynamics and Chemokine Signaling.

Vitamin C can manipulate biochemical pathways Heat Stress Response. Genistein has biological action on biochemical pathways Nutrient sensing. And so on.

When treating Myxofibrosarcoma with chemotherapy Docetaxel – Foods like Adzuki Bean are recommended compared to Black-eyed Pea. This is because the active ingredients Vitamin C and Genistein in Black-eyed Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Isoliquiritigenin contained in Adzuki Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ADZUKI BEAN IS RECOMMENDED OVER BLACK-EYED PEA FOR MYXOFIBROSARCOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.

Eat more vegetables, Kohlrabi or Endive?

Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Brassinin, Beta-sitosterol, Sulforaphane, Indole-3-carbinol, Linolenic Acid among others. While the active ingredients contained in Endive are Quercetin, Linolenic Acid, Vitamin C, Kaempferol, Oleic Acid and others.

Brassinin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Beta-sitosterol has biological action on biochemical pathways Glucocorticoid Signaling, Adherens junction and Microtubule Dynamics.

Vitamin C can manipulate biochemical pathways Heat Stress Response. Vitamin A has biological action on biochemical pathways NFKB Signaling, TGFB Signaling and Focal Adhesion. And so on.

When treating Myxofibrosarcoma with chemotherapy Docetaxel – Foods like Kohlrabi are recommended compared to Endive. This is because the active ingredients Vitamin C and Vitamin A in Endive interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Brassinin and Beta-sitosterol contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER ENDIVE FOR MYXOFIBROSARCOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.

Which Foods are Recommended for Myxofibrosarcoma?

Eat more fruits, Partridgeberry or Sea Buckthorn?

Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Sea Buckthorn are Isorhamnetin, Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid and others.

Resveratrol can manipulate biochemical pathways Carbohydrate Metabolism, NFKB Signaling and Apoptosis. Beta-sitosterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Glucocorticoid Signaling and Adherens junction.

Vitamin C can manipulate biochemical pathways Heat Stress Response. Vitamin A has biological action on biochemical pathways NFKB Signaling, TGFB Signaling and Focal Adhesion. And so on.

When treating Myxofibrosarcoma with chemotherapy Docetaxel – Foods like Partridgeberry are recommended compared to Sea Buckthorn. This is because the active ingredients Vitamin C and Vitamin A in Sea Buckthorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER SEA BUCKTHORN FOR MYXOFIBROSARCOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Brazil Nut?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Folic Acid, Lecithin and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle, MYC Signaling and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways NFKB Signaling, Chemokine Signaling and JAK-STAT Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Extracellular Matrix Remodelling. And so on.

When treating Myxofibrosarcoma with chemotherapy Docetaxel – Foods like Pine Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Oleic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER BRAZIL NUT FOR MYXOFIBROSARCOMA ON TREATMENT WITH CHEMOTHERAPY DOCETAXEL FOR SOME CONDITIONS.

Foods for Genetic Risk of Myxofibrosarcoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. RYR2 and NF1 are two genes whose abnormalities are risk factors for Myxofibrosarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Myxofibrosarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Myxofibrosarcoma gene RYR2 has causative impact on biological pathways like G-protein-coupled Receptor Signaling and G-protein-coupled Receptor Signaling. And NF1 has a causative impact on biological pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like RYR2 and NF1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes RYR2 and NF1 should be avoided.

Eat more pulses, Common Pea or Soy Bean?

The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Soy Bean are Quercetin, Lupeol, Daidzein, Vitamin E, Beta-sitosterol and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lupeol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Myxofibrosarcoma due to abnormalities in genes RYR2 and NF1 – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Lupeol contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF MYXOFIBROSARCOMA DUE TO GENES RYR2 AND NF1

Eat more vegetables, Jicama or Celery?

The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Vitamin C, Linolenic Acid, Oleic Acid and others.

Beta-carotene can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin B3 has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Cynaroside can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Luteolin has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Myxofibrosarcoma due to abnormalities in genes RYR2 and NF1 – Foods like Jicama are recommended compared to Celery. This is because the active ingredients Cynaroside and Luteolin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-carotene and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF MYXOFIBROSARCOMA DUE TO GENES RYR2 AND NF1

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Feijoa or Cranberry?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Ellagic Acid, Resveratrol, Quercetin, Hyperoside, Vitamin C and others.

Lycopene can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Casuarinin has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.

For genetic risk of Myxofibrosarcoma due to abnormalities in genes RYR2 and NF1 – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Myricetin in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Lycopene and Casuarinin contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF MYXOFIBROSARCOMA DUE TO GENES RYR2 AND NF1

Eat more nuts, Almond or Acorn?

The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Beta-carotene, Quercitrin and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Vitamin B2 can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Myxofibrosarcoma due to abnormalities in genes RYR2 and NF1 – Foods like Almond are recommended compared to Acorn. This is because the active ingredients Vitamin B2 and Folic Acid in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF MYXOFIBROSARCOMA DUE TO GENES RYR2 AND NF1


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Myxofibrosarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

sample-report


References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

You can also read this in

How useful was this post?

Click on a star to rate it!

Average rating 4.2 / 5. Vote count: 37

No votes so far! Be the first to rate this post.

As you found this post useful...

Follow us on social media!

We are sorry that this post was not useful for you!

Let us improve this post!

Tell us how we can improve this post?