Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Pineoblastoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Pineoblastoma because of ATR and DICER1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Pineoblastoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cherry” or “Include fruit Pomegranate in my diet” or “Should I reduce consumption of vegetable Jute” or “Can I take Ginseng and Caffeine supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO PINEOBLASTOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Pineoblastoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR PINEOBLASTOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Pineoblastoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Pineoblastoma from cBioPortal. The patients enrolled in the studies for Pineoblastoma are in ages between 30 to 71 with an average age of 62. 60.0% of males and 40.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 5; the top genes with mutations and other abnormalities for Pineoblastoma include genes ATR, DICER1, ATM, CREBBP and EPHB1. The occurrence frequency distribution for these genes respectively is 44.7%, 13.6%, 13.6%, 13.6% and 11.8%. These tumor genetic details of Pineoblastoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Pineoblastoma.
Significance of Nutrition for Pineoblastoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Pineoblastoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cherry includes active ingredients Chlorogenic Acid, Quercetin, Linolenic Acid, Oleic Acid, Kaempferide and others. And Pomegranate contains active ingredients Ellagic Acid, Gallic Acid, Corilagin, Betulinic Acid, Urolithin B and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Pineoblastoma, activation or inhibition of selected biochemical pathways like RUNX Signaling, MAPK Signaling, DNA Repair, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Pineoblastoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR PINEOBLASTOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Pineoblastoma undergoing chemotherapy treatment
In Pineoblastoma – the genes ATR, DICER1, ATM, CREBBP and EPHB1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Pineoblastoma are RUNX Signaling, MAPK Signaling, Notch Signaling and others. Carboplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RUNX Signaling, MAPK Signaling, Notch Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Linolenic Acid, Oleic Acid, Lupeol, Beta-sitosterol among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Oleic Acid, Vitamin C, Linoleic Acid, Genistein and others.
Beta-sitosterol can manipulate biochemical pathways RUNX Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling and PI3K-AKT-MTOR Signaling.
Genistein can manipulate biochemical pathways DNA Repair. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Pineoblastoma with chemotherapy Carboplatin – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin A in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR PINEOBLASTOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more vegetables, Potato or Jute?
Vegetables are an important part of many diets. The active ingredients contained in Potato are Chlorogenic Acid, Gallic Acid, Linolenic Acid, Oleic Acid, Beta-sitosterol among others. While the active ingredients contained in Jute are Quercetin, Linolenic Acid, Oleic Acid, Vitamin C, Kaempferol and others.
Chlorogenic Acid can manipulate biochemical pathways RUNX Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Gallic Acid has biological action on biochemical pathways DNA Repair, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Pineoblastoma with chemotherapy Carboplatin – Foods like Potato are recommended compared to Jute. This is because the active ingredients Vitamin A and Folic Acid in Jute interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Chlorogenic Acid and Gallic Acid contained in Potato support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: POTATO IS RECOMMENDED OVER JUTE FOR PINEOBLASTOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more fruits, Pomegranate or Cherry?
Fruits are an important part of many diets. The active ingredients contained in Pomegranate are Ellagic Acid, Gallic Acid, Corilagin, Betulinic Acid, Urolithin B among others. While the active ingredients contained in Cherry are Chlorogenic Acid, Quercetin, Linolenic Acid, Oleic Acid, Kaempferide and others.
Gallic Acid can manipulate biochemical pathways DNA Repair, MAPK Signaling and PI3K-AKT-MTOR Signaling. Betulinic Acid has biological action on biochemical pathways Hedgehog Signaling, RUNX Signaling and MAPK Signaling.
Shikimic Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Pelargonidin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Pineoblastoma with chemotherapy Carboplatin – Foods like Pomegranate are recommended compared to Cherry. This is because the active ingredients Shikimic Acid and Pelargonidin in Cherry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Gallic Acid and Betulinic Acid contained in Pomegranate support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER CHERRY FOR PINEOBLASTOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more nuts, Almond or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Vitamin E, Quercetin, Linolenic Acid, Oleic Acid, Beta-sitosterol among others. While the active ingredients contained in Peanut are Vitamin E, Rhamnetin, Quercetin, Linolenic Acid, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways RUNX Signaling and PI3K-AKT-MTOR Signaling. Vitamin E has biological action on biochemical pathways DNA Repair, Notch Signaling and MAPK Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Lecithin has biological action on biochemical pathways MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Pineoblastoma with chemotherapy Carboplatin – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR PINEOBLASTOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Pineoblastoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ATR and DICER1 are two genes whose abnormalities are risk factors for Pineoblastoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Pineoblastoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Pineoblastoma gene ATR has causative impact on biological pathways like DNA Repair, Cell Cycle Checkpoints and DNA Repair. And DICER1 has a causative impact on biological pathways like NFKB Signaling and Apoptosis. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ATR and DICER1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ATR and DICER1 should be avoided.
Eat more pulses, Scarlet Bean or Common Bean?
The active ingredients contained in Scarlet Bean are Genistein, Oleic Acid, Vitamin C, Linolenic Acid, Beta-sitosterol among others. While the active ingredients contained in Common Bean are Apigenin, Delphinidin, Genistein, Esculin, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Ferulic Acid can manipulate biochemical pathways DNA Repair and Growth Factor Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Pineoblastoma due to abnormalities in genes ATR and DICER1 – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Ferulic Acid and Pelargonidin in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF PINEOBLASTOMA DUE TO GENES ATR AND DICER1
Eat more vegetables, Jicama or Celery?
The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Celery are Apigenin, Oleic Acid, Quercetin, Vitamin C, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Vitamin B3 has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and Apoptosis.
Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Pineoblastoma due to abnormalities in genes ATR and DICER1 – Foods like Jicama are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF PINEOBLASTOMA DUE TO GENES ATR AND DICER1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Mulberry or Date?
The active ingredients contained in Mulberry are Resveratrol, Morusin, Deoxynojirimycin among others. While the active ingredients contained in Date are Apigenin, Protocatechuic Acid, Lupeol, Oleic Acid, Quercetin and others.
Morusin can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Deoxynojirimycin has biological action on biochemical pathways Apoptosis.
Quercetin can manipulate biochemical pathways DNA Repair. Ferulic Acid has biological action on biochemical pathways Growth Factor Signaling and DNA Repair. And so on.
For genetic risk of Pineoblastoma due to abnormalities in genes ATR and DICER1 – Foods like Mulberry are recommended compared to Date. This is because the active ingredients Quercetin and Ferulic Acid in Date further promote the effects of genes on the biochemical pathways. While the active ingredients Morusin and Deoxynojirimycin contained in Mulberry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MULBERRY IS RECOMMENDED OVER DATE FOR REDUCING THE GENETIC RISK OF PINEOBLASTOMA DUE TO GENES ATR AND DICER1
Eat more nuts, Pecan Nut or Acorn?
The active ingredients contained in Pecan Nut are Delphinidin, Cianidanol, Vitamin E, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Beta-sitosterol, Quercitrin, Vitamin B3 and others.
Delphinidin can manipulate biochemical pathways Growth Factor Signaling, MYC Signaling and MAPK Signaling. Cianidanol has biological action on biochemical pathways Apoptosis, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Quercetin can manipulate biochemical pathways DNA Repair. Beta-carotene has biological action on biochemical pathways MAPK Signaling and DNA Repair. And so on.
For genetic risk of Pineoblastoma due to abnormalities in genes ATR and DICER1 – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Beta-carotene in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Delphinidin and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF PINEOBLASTOMA DUE TO GENES ATR AND DICER1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Pineoblastoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.