Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Mouth Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Mouth Cancer because of CDKN2A and FAT1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Mouth Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Sapota” or “Include fruit Persimmon in my diet” or “Should I reduce consumption of vegetable Garland Chrysanthemum” or “Can I take Dim and Birch supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MOUTH CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Mouth Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR MOUTH CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Mouth Cancer
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Mouth Cancer from cBioPortal. The top genes with mutations and other abnormalities for Mouth Cancer include genes TP53, TERT, CDKN2A, FAT1 and NOTCH1. The occurrence frequency distribution for these genes respectively is 56.8%, 30.5%, 22.3%, 19.5% and 19.5%. These tumor genetic details of Mouth Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Mouth Cancer.
Significance of Nutrition for Mouth Cancer
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Mouth Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Sapota includes active ingredients Vitamin C, Lycopene, Beta-sitosterol, Linolenic Acid, Gallic Acid and others. And Persimmon contains active ingredients Quercetin, Betulinic Acid, Vitamin C, Lupeol, Lycopene and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Mouth Cancer, activation or inhibition of selected biochemical pathways like Amino Acid Metabolism, Angiogenesis, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Mouth Cancer, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MOUTH CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Mouth Cancer undergoing chemotherapy treatment
In Mouth Cancer – the genes TP53, TERT, CDKN2A, FAT1 and NOTCH1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Mouth Cancer are Amino Acid Metabolism, Angiogenesis, PI3K-AKT-MTOR Signaling and others. Fluorouracil is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Amino Acid Metabolism, Angiogenesis, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid, Vitamin A and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Microtubule Dynamics and WNT Beta Catenin Signaling.
Vitamin A can manipulate biochemical pathways Focal Adhesion. Genistein has biological action on biochemical pathways DNA Repair and Oxidative Stress. And so on.
When treating Mouth Cancer with chemotherapy Fluorouracil – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Vitamin A and Genistein in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR MOUTH CANCER ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.
Eat more vegetables, Cabbage or Garland Chrysanthemum?
Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Quercetin, Benzyl Isothiocyanate, Vitamin C, Isorhamnetin, Beta-sitosterol among others. While the active ingredients contained in Garland Chrysanthemum are Vitamin C, Vitamin A, Folic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and MYC Signaling. Glucaric Acid has biological action on biochemical pathways NFKB Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways Focal Adhesion. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and Vitamin D Signaling. And so on.
When treating Mouth Cancer with chemotherapy Fluorouracil – Foods like Cabbage are recommended compared to Garland Chrysanthemum. This is because the active ingredients Vitamin A and Folic Acid in Garland Chrysanthemum interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CABBAGE IS RECOMMENDED OVER GARLAND CHRYSANTHEMUM FOR MOUTH CANCER ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.
Eat more fruits, Persimmon or Sapota?
Fruits are an important part of many diets. The active ingredients contained in Persimmon are Quercetin, Betulinic Acid, Vitamin C, Lupeol, Lycopene among others. While the active ingredients contained in Sapota are Vitamin C, Lycopene, Beta-sitosterol, Linolenic Acid, Gallic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and MYC Signaling. Lycopene has biological action on biochemical pathways NFKB Signaling, Microtubule Dynamics and WNT Beta Catenin Signaling.
Vitamin A can manipulate biochemical pathways Focal Adhesion. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Mouth Cancer with chemotherapy Fluorouracil – Foods like Persimmon are recommended compared to Sapota. This is because the active ingredients Vitamin A and Citric Acid in Sapota interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Lycopene contained in Persimmon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PERSIMMON IS RECOMMENDED OVER SAPOTA FOR MOUTH CANCER ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Cianidanol, Oleic Acid, Delphinidin among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Beta-sitosterol, Gallic Acid, Beta-carotene and others.
Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and DNA Repair. Cianidanol has biological action on biochemical pathways Microtubule Dynamics, MYC Signaling and P53 Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress. Gallic Acid has biological action on biochemical pathways Vitamin D Signaling and Oxidative Stress. And so on.
When treating Mouth Cancer with chemotherapy Fluorouracil – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR MOUTH CANCER ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.
Foods for Genetic Risk of Mouth Cancer
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CDKN2A and FAT1 are two genes whose abnormalities are risk factors for Mouth Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Mouth Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Mouth Cancer gene CDKN2A has causative impact on biological pathways like Cell Cycle Checkpoints and Cell Cycle. And FAT1 has a causative impact on biological pathways like Cytoskeletal Dynamics and Adherens junction. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CDKN2A and FAT1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CDKN2A and FAT1 should be avoided.
Eat more pulses, Common Pea or Common Bean?
The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Linolenic Acid, Vitamin C, Ferulic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Cell Cycle. And so on.
For genetic risk of Mouth Cancer due to abnormalities in genes CDKN2A and FAT1 – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Vitamin A and Pelargonidin in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF MOUTH CANCER DUE TO GENES CDKN2A AND FAT1
Eat more vegetables, Jicama or Beetroot?
The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin A, Vitamin B3, Folic Acid among others. While the active ingredients contained in Beetroot are Vitamin E, Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Beta-carotene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Oncogenic Cancer Epigenetics.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. And so on.
For genetic risk of Mouth Cancer due to abnormalities in genes CDKN2A and FAT1 – Foods like Jicama are recommended compared to Beetroot. This is because the active ingredients Vitamin A and Folic Acid in Beetroot further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER BEETROOT FOR REDUCING THE GENETIC RISK OF MOUTH CANCER DUE TO GENES CDKN2A AND FAT1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Kiwi or Cranberry?
The active ingredients contained in Kiwi are Vitamin C, Quercetin, Fisetin, Vitamin A, Chlorogenic Acid among others. While the active ingredients contained in Cranberry are Hyperoside, Vitamin C, Ellagic Acid, Resveratrol, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Fisetin has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Cell Cycle.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
For genetic risk of Mouth Cancer due to abnormalities in genes CDKN2A and FAT1 – Foods like Kiwi are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Fisetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: KIWI IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF MOUTH CANCER DUE TO GENES CDKN2A AND FAT1
Eat more nuts, Hazelnut or Chestnut?
The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Oleic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Chestnut are Linolenic Acid, Vitamin C, Ellagic Acid, Oleic Acid, Quercetin and others.
Vitamin E can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Myricitrin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Mouth Cancer due to abnormalities in genes CDKN2A and FAT1 – Foods like Hazelnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Vitamin A in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Myricitrin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF MOUTH CANCER DUE TO GENES CDKN2A AND FAT1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Mouth Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
- Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines.
- Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- (+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-alpha in LPS-stimulated macrophages.
- Small-molecule inhibitors of NADPH oxidase 4.
- Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Effects of β-carotene on Expression of Selected MicroRNAs, Histone Acetylation, and DNA Methylation in Colon Cancer Stem Cells.
- Myricitrin blocks activation of NF-κB and MAPK signaling pathways to protect nigrostriatum neuron in LPS-stimulated mice.
- Fisetin: a dietary antioxidant for health promotion.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.