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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Gastric Adenocarcinoma?

Aug 8, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Gastric Adenocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Gastric Adenocarcinoma because of ARID1A and CDH1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Gastric Adenocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Pummelo” or “Include fruit Cherimoya in my diet” or “Should I reduce consumption of vegetable Bell Pepper” or “Can I take Dim and Neem Extract supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO GASTRIC ADENOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Gastric Adenocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR GASTRIC ADENOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Gastric Adenocarcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Gastric Adenocarcinoma from cBioPortal. 69.2% of males and 30.8% of females were the distribution of gender in these clinical studies. From a patient sample size of 866; the top genes with mutations and other abnormalities for Gastric Adenocarcinoma include genes TP53, ARID1A, CDH1, FAT4 and FAT3. The occurrence frequency distribution for these genes respectively is 62.9%, 18.6%, 16.3%, 15.1% and 13.8%. These tumor genetic details of Gastric Adenocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Gastric Adenocarcinoma.

Significance of Nutrition for Gastric Adenocarcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Gastric Adenocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Pummelo includes active ingredients Beta-sitosterol, Naringin, Vitamin C, Linolenic Acid, Chlorogenic Acid and others. And Cherimoya contains active ingredients Beta-sitosterol, Vitamin C, Stigmasterol, Linolenic Acid, Oleic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Gastric Adenocarcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Gastric Adenocarcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Gastric Adenocarcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR GASTRIC ADENOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Gastric Adenocarcinoma undergoing chemotherapy treatment

In Gastric Adenocarcinoma – the genes TP53, ARID1A, CDH1, FAT4 and FAT3 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Gastric Adenocarcinoma are RAS-RAF Signaling, mRNA Splicing, Cell Cycle and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, mRNA Splicing, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Fava Bean?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Stigmasterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Fava Bean are Quercetin, Butein, Beta-sitosterol, Daidzein, Cianidanol and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress. Cianidanol has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Gastric Adenocarcinoma with chemotherapy Radiation – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Quercetin and Cianidanol in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR GASTRIC ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Kohlrabi or Bell Pepper?

Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Beta-sitosterol, Brassinin, Vitamin C, Kaempferol, Indole-3-carbinol among others. While the active ingredients contained in Bell Pepper are Vitamin E, Isorhamnetin, Vitamin C, Capsaicin, P-coumaric Acid and others.

Brassinin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and JAK-STAT Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling.

Capsaicin can manipulate biochemical pathways Heat Stress Response, DNA Repair and MAPK Signaling. Vitamin A has biological action on biochemical pathways Extracellular Matrix Remodelling and Focal Adhesion. And so on.

When treating Gastric Adenocarcinoma with chemotherapy Radiation – Foods like Kohlrabi are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Vitamin A in Bell Pepper interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Brassinin and Vitamin C contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER BELL PEPPER FOR GASTRIC ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Which Foods are Recommended for Gastric Adenocarcinoma?

Eat more fruits, Cherimoya or Pummelo?

Fruits are an important part of many diets. The active ingredients contained in Cherimoya are Beta-sitosterol, Vitamin C, Stigmasterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Pummelo are Beta-sitosterol, Naringin, Vitamin C, Linolenic Acid, Chlorogenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Stigmasterol has biological action on biochemical pathways DNA Repair, JAK-STAT Signaling and Cell Cycle.

Naringin can manipulate biochemical pathways Oxidative Stress. Naringenin has biological action on biochemical pathways Heat Stress Response, DNA Repair and Oxidative Stress. And so on.

When treating Gastric Adenocarcinoma with chemotherapy Radiation – Foods like Cherimoya are recommended compared to Pummelo. This is because the active ingredients Naringin and Naringenin in Pummelo interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Stigmasterol contained in Cherimoya support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CHERIMOYA IS RECOMMENDED OVER PUMMELO FOR GASTRIC ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Cianidanol, Delphinidin, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Gallic Acid, Vitamin C, Beta-carotene and others.

Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and DNA Repair. Delphinidin has biological action on biochemical pathways Extracellular Matrix Remodelling, Growth Factor Signaling and MYC Signaling.

Quercetin can manipulate biochemical pathways Oxidative Stress. Gallic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Gastric Adenocarcinoma with chemotherapy Radiation – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Delphinidin contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR GASTRIC ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Gastric Adenocarcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ARID1A and CDH1 are two genes whose abnormalities are risk factors for Gastric Adenocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Gastric Adenocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Gastric Adenocarcinoma gene ARID1A has causative impact on biological pathways like Androgen Signaling and Chromatin Remodeling. And CDH1 has a causative impact on biological pathways like Adherens junction and Epithelial to Mesenchymal Transition. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ARID1A and CDH1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ARID1A and CDH1 should be avoided.

Eat more pulses, Common Pea or Moth Bean?

The active ingredients contained in Common Pea are Beta-sitosterol, Lupeol, Vitamin C, Linolenic Acid, Daidzein among others. While the active ingredients contained in Moth Bean are Beta-sitosterol, Linolenic Acid, Linoleic Acid, Oleic Acid, Stigmasterol and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and WNT Beta Catenin Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.

Linoleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

For genetic risk of Gastric Adenocarcinoma due to abnormalities in genes ARID1A and CDH1 – Foods like Common Pea are recommended compared to Moth Bean. This is because the active ingredients Linoleic Acid and Oleic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF GASTRIC ADENOCARCINOMA DUE TO GENES ARID1A AND CDH1

Eat more vegetables, Cassava or Spinach?

The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Linolenic Acid, Linoleic Acid, Oleic Acid among others. While the active ingredients contained in Spinach are Apigenin, Beta-sitosterol, Vitamin C, Linolenic Acid, Quercetin and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and WNT Beta Catenin Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints.

Apigenin can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

For genetic risk of Gastric Adenocarcinoma due to abnormalities in genes ARID1A and CDH1 – Foods like Cassava are recommended compared to Spinach. This is because the active ingredients Apigenin and Linoleic Acid in Spinach further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER SPINACH FOR REDUCING THE GENETIC RISK OF GASTRIC ADENOCARCINOMA DUE TO GENES ARID1A AND CDH1

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Kiwi or Cranberry?

The active ingredients contained in Kiwi are Vitamin C, Quercetin, Vitamin A, Chlorogenic Acid, Fisetin among others. While the active ingredients contained in Cranberry are Vitamin C, Resveratrol, Hyperoside, P-coumaric Acid, Quercetin and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and WNT Beta Catenin Signaling. Chlorogenic Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Epithelial to Mesenchymal Transition.

Resveratrol can manipulate biochemical pathways P53 Signaling. Ellagic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. And so on.

For genetic risk of Gastric Adenocarcinoma due to abnormalities in genes ARID1A and CDH1 – Foods like Kiwi are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Chlorogenic Acid contained in Kiwi together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: KIWI IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF GASTRIC ADENOCARCINOMA DUE TO GENES ARID1A AND CDH1

Eat more nuts, Hazelnut or Chestnut?

The active ingredients contained in Hazelnut are Linolenic Acid, Vitamin E, Quercetin, Linoleic Acid, Oleic Acid among others. While the active ingredients contained in Chestnut are Vitamin C, Linolenic Acid, Quercetin, Linoleic Acid, Oleic Acid and others.

Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and P53 Signaling. Myricitrin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.

Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

For genetic risk of Gastric Adenocarcinoma due to abnormalities in genes ARID1A and CDH1 – Foods like Hazelnut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Linoleic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Myricitrin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF GASTRIC ADENOCARCINOMA DUE TO GENES ARID1A AND CDH1


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Gastric Adenocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

sample-report


References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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