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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Gastric Adenocarcinoma!

Aug 4, 2023

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Introduction

Foods for Gastric Adenocarcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Gastric Adenocarcinoma, a type of gastric cancer, is characterized by malignant cells forming in the lining of the stomach, with its pathology outlines and radiology being key in diagnosis. Symptoms can include weight loss, stomach pain, and nausea, often leading to a late diagnosis. The staging of gastric adenocarcinoma, including stage 4, is crucial for determining the prognosis and treatment strategy. Metastasis is a significant concern, impacting the survival rate and overall management of the disease. The ICD-10 coding system provides a standardized classification for gastric adenocarcinoma, essential for medical records and research. Treatment varies from surgery to chemotherapy and radiation, guided by treatment guidelines and influenced by factors like tumor margins and patient health. Gastric adenocarcinoma also occurs in dogs, indicating a need for awareness in veterinary care. Understanding the risk factors and pathophysiology of gastric adenocarcinoma can aid in early detection and prevention, with diet and endoscopy playing roles in both. The term ‘gastric adenocarcinoma’ is often used interchangeably with gastric carcinoma, but they represent distinct entities within gastric cancers, each requiring tailored treatment and management approaches.



For Gastric Adenocarcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Gastric Adenocarcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Gastric Adenocarcinoma?

For example does it matter if vegetable New Zealand Spinach is consumed more compared to White Cabbage? Does it make any difference if fruit Pummelo is preferred over French Plantain? Also if similar choices are made for nuts/seeds like Butternut over Chestnut and for pulses like Gram Bean over Lima Bean. And if what I eat matters – then how does one identify foods which are recommended for Gastric Adenocarcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Gastric Adenocarcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Gastric Adenocarcinoma can be characterized by a unique set of biochemical pathways - the signature pathways of Gastric Adenocarcinoma. Biochemical pathways like RAS-RAF Signaling, mRNA Splicing, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints are part of the signature definition of Gastric Adenocarcinoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Curcumin, Phloretin, Beta-sitosterol, Formononetin. And French Plantain contains active ingredients Quercetin, Myricetin, Curcumin, Phloretin, Beta-sitosterol and possibly others.

A common mistake made when deciding and choosing foods to eat for Gastric Adenocarcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Gastric Adenocarcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Gastric Adenocarcinoma?

Personalized nutrition for cancers like Gastric Adenocarcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Gastric Adenocarcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Gastric Adenocarcinoma

All cancers like Gastric Adenocarcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Gastric Adenocarcinoma. Biochemical pathways like RAS-RAF Signaling, mRNA Splicing, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints are part of the signature definition of Gastric Adenocarcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Gastric Adenocarcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Gastric Adenocarcinoma when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, ARID1A, CDH1, FAT4 and FAT3 are the top ranked reported genes for Gastric Adenocarcinoma. TP53 is reported in 62.9 % of the representative patients across all clinical trials. And ARID1A is reported in 18.6 %. The combined population patient data cover ages from to . 69.2 % of the patient data are identified as men. The Gastric Adenocarcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Gastric Adenocarcinoma!

Food and Supplements for Gastric Adenocarcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable NEW ZEALAND SPINACH or WHITE CABBAGE?

Vegetable New Zealand Spinach contains many active ingredients or bioactives such as Quercetin, Myricetin, Curcumin, Phloretin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Microtubule Dynamics, Hypoxia, NFKB Signaling and PI3K-AKT-MTOR Signaling and others. New Zealand Spinach is recommended for Gastric Adenocarcinoma when ongoing cancer treatment is Radiation. This is because New Zealand Spinach modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable White Cabbage are Quercetin, Curcumin, Phloretin, Beta-sitosterol, Benzyl Isothiocyanate. These active ingredients manipulate various biochemical pathways like Cytoskeletal Dynamics and Oxidative Stress and others. White Cabbage is not recommended for Gastric Adenocarcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE NEW ZEALAND SPINACH IS RECOMMENDED OVER WHITE CABBAGE FOR Gastric Adenocarcinoma AND TREATMENT Radiation.

Choose Fruit FRENCH PLANTAIN or PUMMELO?

Fruit French Plantain contains many active ingredients or bioactives such as Quercetin, Myricetin, Curcumin, Phloretin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Microtubule Dynamics, Hypoxia, NFKB Signaling and PI3K-AKT-MTOR Signaling and others. French Plantain is recommended for Gastric Adenocarcinoma when ongoing cancer treatment is Radiation. This is because French Plantain modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Curcumin, Phloretin, Beta-sitosterol, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair, Heat Stress Response and Oxidative Stress and others. Pummelo is not recommended for Gastric Adenocarcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT FRENCH PLANTAIN IS RECOMMENDED OVER PUMMELO FOR Gastric Adenocarcinoma AND TREATMENT Radiation.

Choose Nut BUTTERNUT or CHESTNUT?

Butternut contains many active ingredients or bioactives such as Myricetin, Curcumin, Phloretin, Beta-sitosterol, Formononetin. These active ingredients manipulate various biochemical pathways like Microtubule Dynamics, DNA Repair, NFKB Signaling and MAPK Signaling and others. Butternut is recommended for Gastric Adenocarcinoma when ongoing cancer treatment is Radiation. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in Chestnut are Ellagic Acid, Myricetin, Curcumin, Phloretin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Heat Stress Response, Stem Cell Signaling and Oxidative Stress and others. Chestnut is not recommended for Gastric Adenocarcinoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER CHESTNUT FOR Gastric Adenocarcinoma AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Gastric Adenocarcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable COMMON MUSHROOM or CHAYOTE?

Vegetable Common Mushroom contains many active ingredients or bioactives such as Vitamin D3, Apigenin, Curcumin, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Hypoxia and PI3K-AKT-MTOR Signaling and others. Common Mushroom is recommended for risk of Gastric Adenocarcinoma when associated genetic risk is ARID1A. This is because Common Mushroom increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Chayote are Apigenin, Curcumin, Lupeol, Phloretin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, TGFB Signaling and PI3K-AKT-MTOR Signaling and others. Chayote is not recommended when risk of Gastric Adenocarcinoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

VEGETABLE COMMON MUSHROOM IS RECOMMENDED OVER CHAYOTE FOR ARID1A GENETIC RISK OF CANCER.

Choose Fruit NANCE or JUJUBE?

Fruit Nance contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Phloretin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Hypoxia and PI3K-AKT-MTOR Signaling and others. Nance is recommended for risk of Gastric Adenocarcinoma when associated genetic risk is ARID1A. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Jujube are Apigenin, Curcumin, Quercetin, Lupeol, Phloretin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, TGFB Signaling and PI3K-AKT-MTOR Signaling and others. Jujube is not recommended when risk of Gastric Adenocarcinoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER JUJUBE FOR ARID1A GENETIC RISK OF CANCER.

Choose Nut COMMON WALNUT or EUROPEAN CHESTNUT?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Lupeol, Ellagic Acid, Phloretin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, Hypoxia, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Common Walnut is recommended for risk of Gastric Adenocarcinoma when associated genetic risk is ARID1A. This is because Common Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Curcumin, Quercetin, Lupeol, Ellagic Acid. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, TGFB Signaling and Stem Cell Signaling and others. European Chestnut is not recommended when risk of Gastric Adenocarcinoma when associated genetic risk is ARID1A because it increases the signature pathways of it.

COMMON WALNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR ARID1A GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Gastric Adenocarcinoma. Gastric Adenocarcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Gastric Adenocarcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like New Zealand Spinach contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Gastric Adenocarcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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