Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Gallbladder Adenosquamous Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Gallbladder Adenosquamous Carcinoma because of CUL3 and POLE gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Gallbladder Adenosquamous Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Huckleberry” or “Include fruit Avocado in my diet” or “Should I reduce consumption of vegetable Endive” or “Can I take Dim and Psyllium supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO GALLBLADDER ADENOSQUAMOUS CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Gallbladder Adenosquamous Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR GALLBLADDER ADENOSQUAMOUS CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Gallbladder Adenosquamous Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Gallbladder Adenosquamous Carcinoma from cBioPortal. 60.0% of males and 40.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 5; the top genes with mutations and other abnormalities for Gallbladder Adenosquamous Carcinoma include genes TP53, CUL3, POLE, ARID1B and TERT. The occurrence frequency distribution for these genes respectively is 60.0%, 40.0%, 40.0%, 20.0% and 20.0%. These tumor genetic details of Gallbladder Adenosquamous Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Gallbladder Adenosquamous Carcinoma.
Significance of Nutrition for Gallbladder Adenosquamous Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Gallbladder Adenosquamous Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Huckleberry includes active ingredients Quercetin, Resveratrol, Caffeic Acid, Vitamin C, P-coumaric Acid and others. And Avocado contains active ingredients Quercetin, Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Gallbladder Adenosquamous Carcinoma, activation or inhibition of selected biochemical pathways like Extracellular Matrix Remodelling, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Gallbladder Adenosquamous Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR GALLBLADDER ADENOSQUAMOUS CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Gallbladder Adenosquamous Carcinoma undergoing chemotherapy treatment
In Gallbladder Adenosquamous Carcinoma – the genes TP53, CUL3, POLE, ARID1B and TERT have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Gallbladder Adenosquamous Carcinoma are Extracellular Matrix Remodelling, Growth Factor Signaling, Angiogenesis and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Extracellular Matrix Remodelling, Growth Factor Signaling, Angiogenesis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Fava Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Vitamin C, Delphinidin among others. While the active ingredients contained in Fava Bean are Quercetin, Butein, Daidzein, Beta-sitosterol, Caffeic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Angiogenesis. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Angiogenesis.
Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling. Genistein has biological action on biochemical pathways DNA Repair. And so on.
When treating Gallbladder Adenosquamous Carcinoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Fava Bean. This is because the active ingredients Vitamin A and Genistein in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER FAVA BEAN FOR GALLBLADDER ADENOSQUAMOUS CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Arrowroot or Endive?
Vegetables are an important part of many diets. The active ingredients contained in Arrowroot are Quercetin, Beta-carotene, Vitamin C, Protocatechuic Acid, Vanillic Acid among others. While the active ingredients contained in Endive are Quercetin, Vitamin C, Oleic Acid, Linolenic Acid, Vitamin A and others.
Quercetin can manipulate biochemical pathways NFKB Signaling, Extracellular Matrix Remodelling and DNA Repair. Beta-carotene has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Angiogenesis.
Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling. Folic Acid has biological action on biochemical pathways Growth Factor Signaling, JAK-STAT Signaling and MYC Signaling. And so on.
When treating Gallbladder Adenosquamous Carcinoma with chemotherapy Radiation – Foods like Arrowroot are recommended compared to Endive. This is because the active ingredients Vitamin A and Folic Acid in Endive interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Beta-carotene contained in Arrowroot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER ENDIVE FOR GALLBLADDER ADENOSQUAMOUS CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Avocado or Huckleberry?
Fruits are an important part of many diets. The active ingredients contained in Avocado are Quercetin, Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, Caffeic Acid, Vitamin C, P-coumaric Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Angiogenesis. Quercetin has biological action on biochemical pathways Extracellular Matrix Remodelling, DNA Repair and JAK-STAT Signaling.
Resveratrol can manipulate biochemical pathways DNA Repair. Pelargonidin has biological action on biochemical pathways MYC Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Gallbladder Adenosquamous Carcinoma with chemotherapy Radiation – Foods like Avocado are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Avocado support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: AVOCADO IS RECOMMENDED OVER HUCKLEBERRY FOR GALLBLADDER ADENOSQUAMOUS CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Almond or Chestnut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Chestnut are Ellagic Acid, Quercetin, Vitamin C, Gallic Acid, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Angiogenesis. Quercetin has biological action on biochemical pathways Extracellular Matrix Remodelling, DNA Repair and JAK-STAT Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Vitamin A has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.
When treating Gallbladder Adenosquamous Carcinoma with chemotherapy Radiation – Foods like Almond are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Vitamin A in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER CHESTNUT FOR GALLBLADDER ADENOSQUAMOUS CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Gallbladder Adenosquamous Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CUL3 and POLE are two genes whose abnormalities are risk factors for Gallbladder Adenosquamous Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Gallbladder Adenosquamous Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Gallbladder Adenosquamous Carcinoma gene CUL3 has causative impact on biological pathways like Post Translation Modification, Antigen Presentation and Immune Checkpoints. And POLE has a causative impact on biological pathways like Chromatin Remodeling, DNA Repair and Mismatch Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CUL3 and POLE should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CUL3 and POLE should be avoided.
Eat more pulses, Scarlet Bean or Soy Bean?
The active ingredients contained in Scarlet Bean are Vitamin C, Beta-sitosterol, Linolenic Acid, Stigmasterol, Oleic Acid among others. While the active ingredients contained in Soy Bean are Vitamin C, Lupeol, Vitamin E, Daidzein, Beta-sitosterol and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, Oncogenic Cancer Epigenetics and Hypoxia.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Gallbladder Adenosquamous Carcinoma due to abnormalities in genes CUL3 and POLE – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF GALLBLADDER ADENOSQUAMOUS CARCINOMA DUE TO GENES CUL3 AND POLE
Eat more vegetables, Giant Butterbur or Heart Of Palm?
The active ingredients contained in Giant Butterbur are Vitamin C, Beta-sitosterol, Vitamin B3, Melatonin, Kaempferol among others. While the active ingredients contained in Heart Of Palm are Vitamin C, Palmitic Acid, Vitamin A, Folic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, Oncogenic Cancer Epigenetics and Hypoxia.
Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics and Energy Metabolism. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Gallbladder Adenosquamous Carcinoma due to abnormalities in genes CUL3 and POLE – Foods like Giant Butterbur are recommended compared to Heart Of Palm. This is because the active ingredients Palmitic Acid and Folic Acid in Heart Of Palm further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER HEART OF PALM FOR REDUCING THE GENETIC RISK OF GALLBLADDER ADENOSQUAMOUS CARCINOMA DUE TO GENES CUL3 AND POLE
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Grape?
The active ingredients contained in Feijoa are Vitamin C, Lycopene, Casuarinin, Folic Acid among others. While the active ingredients contained in Grape are Vitamin C, Lupeol, Vitamin E, Pterostilbene, Beta-sitosterol and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, Hypoxia and Apoptosis.
Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Gallbladder Adenosquamous Carcinoma due to abnormalities in genes CUL3 and POLE – Foods like Feijoa are recommended compared to Grape. This is because the active ingredients Resveratrol and Pelargonidin in Grape further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER GRAPE FOR REDUCING THE GENETIC RISK OF GALLBLADDER ADENOSQUAMOUS CARCINOMA DUE TO GENES CUL3 AND POLE
Eat more nuts, Hazelnut or Peanut?
The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Quercetin, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin C, Vitamin E, Beta-sitosterol, Linolenic Acid, Rhamnetin and others.
Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Cell Cycle Checkpoints, Oncogenic Cancer Epigenetics and Hypoxia.
Lecithin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.
For genetic risk of Gallbladder Adenosquamous Carcinoma due to abnormalities in genes CUL3 and POLE – Foods like Hazelnut are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF GALLBLADDER ADENOSQUAMOUS CARCINOMA DUE TO GENES CUL3 AND POLE
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Gallbladder Adenosquamous Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pan Origimed 2020
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- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.