Foods for Follicular Dendritic Cell Sarcoma!

Introduction

Foods for Follicular Dendritic Cell Sarcoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Follicular dendritic cells (FDCs) are a type of immune cell found within lymphoid follicles that play a role in supporting B cell activation and antibody production. Pathology outlines provide important insights into the characteristics and features of follicular dendritic cell sarcoma (FDCS), a rare cancer arising from FDCs. Differentiating FDCs from conventional dendritic cells is important to understand their unique functions. Histologically, FDCs can be identified based on specific markers. FDCs interact with B cells within lymphoid follicles, contributing to the generation of an immune response. Sarcoma originating from FDCs, known as follicular dendritic cell sarcoma, is a rare malignancy that can involve various organs. Accurate diagnosis is facilitated through histopathology examination, and proper coding using the ICD-10 system ensures accurate documentation. Prognosis and survival rates for FDCS depend on various factors including tumor stage, location, and extent of metastasis. Treatment options for FDCS typically involve a multidisciplinary approach, including surgery, radiation therapy, and chemotherapy, tailored to the individual case. Recognizing the symptoms and distinguishing FDCS from other cancers is crucial. Ongoing research and advancements in treatments, such as targeted therapies, aim to improve outcomes for individuals with FDCS. Awareness and understanding of FDCS can aid in early detection and prompt treatment intervention.

For Follicular Dendritic Cell Sarcoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Follicular Dendritic Cell Sarcoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Follicular Dendritic Cell Sarcoma?

For example does it matter if vegetable Green Bell Pepper is consumed more compared to American Pokeweed? Does it make any difference if fruit Pummelo is preferred over Blackberry? Also if similar choices are made for nuts/seeds like Butternut over Common Hazelnut and for pulses like Broad Bean over Pigeon Pea. And if what I eat matters – then how does one identify foods which are recommended for Follicular Dendritic Cell Sarcoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Follicular Dendritic Cell Sarcoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Allicin, Chlorogenic Acid, Formononetin, Lycopene. And Blackberry contains active ingredients Quercetin, Rutin, Ellagic Acid, Linalool, Myricetin and possibly others.

A common mistake made when deciding and choosing foods to eat for Follicular Dendritic Cell Sarcoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Follicular Dendritic Cell Sarcoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Follicular Dendritic Cell Sarcoma?

Personalized nutrition for cancers like Follicular Dendritic Cell Sarcoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Follicular Dendritic Cell Sarcoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Follicular Dendritic Cell Sarcoma

All cancers like Follicular Dendritic Cell Sarcoma can be characterized by a unique set of biochemical pathways – the signature pathways. Biochemical pathways like JAK-STAT Signaling, TGFB Signaling, Growth Factor Signaling, NFKB Signaling are part of the signature definition of Follicular Dendritic Cell Sarcoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Follicular Dendritic Cell Sarcoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Follicular Dendritic Cell Sarcoma when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

ALK, B2M, EPHA3, EPHB1 and KMT2A are the top ranked reported genes for Follicular Dendritic Cell Sarcoma. ALK is reported in 33.3 % of the representative patients across all clinical trials. And B2M is reported in 33.3 %. The combined population patient data cover ages from to . 100.0 % of the patient data are identified as men. The Follicular Dendritic Cell Sarcoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Follicular Dendritic Cell Sarcoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GREEN BELL PEPPER or AMERICAN POKEWEED?

Vegetable Green Bell Pepper contains many active ingredients or bioactives such as Quercetin, Allicin, Capsaicin, Chlorogenic Acid, Formononetin. These active ingredients manipulate various biochemical pathways like JAK-STAT Signaling, TGFB Signaling and NFKB Signaling and others. Green Bell Pepper is recommended for Follicular Dendritic Cell Sarcoma when ongoing cancer treatment is Radiation. This is because Green Bell Pepper modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable American Pokeweed are Quercetin, Allicin, Chlorogenic Acid, Formononetin, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like NFKB Signaling and TGFB Signaling and others. American Pokeweed is not recommended for Follicular Dendritic Cell Sarcoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GREEN BELL PEPPER IS RECOMMENDED OVER AMERICAN POKEWEED FOR Follicular Dendritic Cell Sarcoma AND TREATMENT Radiation.

Choose Fruit BLACKBERRY or PUMMELO?

Fruit Blackberry contains many active ingredients or bioactives such as Quercetin, Rutin, Ellagic Acid, Linalool, Myricetin. These active ingredients manipulate various biochemical pathways like JAK-STAT Signaling, TGFB Signaling and NFKB Signaling and others. Blackberry is recommended for Follicular Dendritic Cell Sarcoma when ongoing cancer treatment is Radiation. This is because Blackberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Allicin, Chlorogenic Acid, Formononetin, Lycopene. These active ingredients manipulate various biochemical pathways like NFKB Signaling and TGFB Signaling and others. Pummelo is not recommended for Follicular Dendritic Cell Sarcoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT BLACKBERRY IS RECOMMENDED OVER PUMMELO FOR Follicular Dendritic Cell Sarcoma AND TREATMENT Radiation.

Choose Nut BUTTERNUT or COMMON HAZELNUT?

Butternut contains many active ingredients or bioactives such as Allicin, Chlorogenic Acid, Formononetin, Lycopene, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like JAK-STAT Signaling and NFKB Signaling and others. Butternut is recommended for Follicular Dendritic Cell Sarcoma when ongoing cancer treatment is Radiation. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in Common Hazelnut are Quercetin, Allicin, Chlorogenic Acid, Formononetin, Lycopene. These active ingredients manipulate various biochemical pathways like TGFB Signaling and NFKB Signaling and others. Common Hazelnut is not recommended for Follicular Dendritic Cell Sarcoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER COMMON HAZELNUT FOR Follicular Dendritic Cell Sarcoma AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Follicular Dendritic Cell Sarcoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable CAULIFLOWER or OKRA?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Formononetin, Lupeol, Daidzein, Phloretin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, RAS-RAF Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Cauliflower is recommended for risk of Follicular Dendritic Cell Sarcoma when associated genetic risk is ALK. This is because Cauliflower increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Okra are Apigenin, Quercetin, Curcumin, Myricetin, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair and PI3K-AKT-MTOR Signaling and others. Okra is not recommended when risk of Follicular Dendritic Cell Sarcoma when associated genetic risk is ALK because it increases the signature pathways of it.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER OKRA FOR ALK GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or PITANGA?

Fruit Red Raspberry contains many active ingredients or bioactives such as Quercetin, Curcumin, Ellagic Acid, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling and EPHRIN Signaling and others. Red Raspberry is recommended for risk of Follicular Dendritic Cell Sarcoma when associated genetic risk is ALK. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pitanga are Apigenin, Quercetin, Curcumin, Myricetin, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair and PI3K-AKT-MTOR Signaling and others. Pitanga is not recommended when risk of Follicular Dendritic Cell Sarcoma when associated genetic risk is ALK because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PITANGA FOR ALK GENETIC RISK OF CANCER.

Choose Nut BLACK WALNUT or CHESTNUT?

Black Walnut contains many active ingredients or bioactives such as Apigenin, Quercetin, Curcumin, Ellagic Acid, Myricetin. These active ingredients manipulate various biochemical pathways like MAPK Signaling, MYC Signaling, Apoptosis and PI3K-AKT-MTOR Signaling and others. Black Walnut is recommended for risk of Follicular Dendritic Cell Sarcoma when associated genetic risk is ALK. This is because Black Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Apigenin, Curcumin, Ellagic Acid, Myricetin, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair and PI3K-AKT-MTOR Signaling and others. Chestnut is not recommended when risk of Follicular Dendritic Cell Sarcoma when associated genetic risk is ALK because it increases the signature pathways of it.

BLACK WALNUT IS RECOMMENDED OVER CHESTNUT FOR ALK GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Follicular Dendritic Cell Sarcoma. Follicular Dendritic Cell Sarcoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Follicular Dendritic Cell Sarcoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Green Bell Pepper contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Follicular Dendritic Cell Sarcoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Msk Impact 2017
• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
• Allicin Inhibits Proliferation and Invasion in Vitro and in Vivo via SHP-1-Mediated STAT3 Signaling in Cholangiocarcinoma.
• Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells–A SAR study.
• Melatonin and vitamin D3 synergistically down-regulate Akt and MDM2 leading to TGFβ-1-dependent growth inhibition of breast cancer cells.
• Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel.
• Geraniol, a component of plant essential oils, sensitizes human colonic cancer cells to 5-Fluorouracil treatment.
• Gallic acid provokes DNA damage and suppresses DNA repair gene expression in human prostate cancer PC-3 cells.