Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Fibroblastic Myofibroblastic Tumor when undergoing chemotherapy or when you determine you have a genetic risk for developing Fibroblastic Myofibroblastic Tumor because of NF1 and ARID1B gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Fibroblastic Myofibroblastic Tumor which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Huckleberry” or “Include fruit Orange in my diet” or “Should I reduce consumption of vegetable Carob” or “Can I take Modified Citrus Pectin and Guggul supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO FIBROBLASTIC MYOFIBROBLASTIC TUMOR, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Fibroblastic Myofibroblastic Tumor is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR FIBROBLASTIC MYOFIBROBLASTIC TUMOR, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Fibroblastic Myofibroblastic Tumor
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Fibroblastic Myofibroblastic Tumor from cBioPortal. 55.6% of males and 44.4% of females were the distribution of gender in these clinical studies. From a patient sample size of 18; the top genes with mutations and other abnormalities for Fibroblastic Myofibroblastic Tumor include genes KMT2C, NF1, ARID1B, FAT1 and KRAS. The occurrence frequency distribution for these genes respectively is 22.2%, 22.2%, 11.1%, 11.1% and 11.1%. These tumor genetic details of Fibroblastic Myofibroblastic Tumor are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Fibroblastic Myofibroblastic Tumor.
Significance of Nutrition for Fibroblastic Myofibroblastic Tumor
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Fibroblastic Myofibroblastic Tumor. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Huckleberry includes active ingredients Quercetin, Resveratrol, Ferulic Acid, Vitamin C, Chlorogenic Acid and others. And Orange contains active ingredients Modified Citrus Pectin, D-limonene, Linalool, Salicylic Acid, Glucaric Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Fibroblastic Myofibroblastic Tumor, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Cell Cycle, Oncogenic Histone Methylation, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Fibroblastic Myofibroblastic Tumor, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR FIBROBLASTIC MYOFIBROBLASTIC TUMOR – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Fibroblastic Myofibroblastic Tumor undergoing chemotherapy treatment
In Fibroblastic Myofibroblastic Tumor – the genes KMT2C, NF1, ARID1B, FAT1 and KRAS have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Fibroblastic Myofibroblastic Tumor are RAS-RAF Signaling, Cell Cycle, Focal Adhesion and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Cell Cycle, Focal Adhesion so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Lima Bean?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Genistein, Linolenic Acid, Beta-sitosterol, Vitamin C, Stigmasterol among others. While the active ingredients contained in Lima Bean are Genistein, Vitamin C, Oleic Acid, Linoleic Acid, Vitamin A and others.
Genistein can manipulate biochemical pathways NFKB Signaling, Cell Cycle and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and NFKB Signaling.
Vitamin A can manipulate biochemical pathways Focal Adhesion. Oleic Acid has biological action on biochemical pathways Focal Adhesion. And so on.
When treating Fibroblastic Myofibroblastic Tumor with chemotherapy Radiation – Foods like Scarlet Bean are recommended compared to Lima Bean. This is because the active ingredients Vitamin A and Oleic Acid in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Genistein and Beta-sitosterol contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER LIMA BEAN FOR FIBROBLASTIC MYOFIBROBLASTIC TUMOR ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Cauliflower or Carob?
Vegetables are an important part of many diets. The active ingredients contained in Cauliflower are Glucaric Acid, Linolenic Acid, Beta-sitosterol, Vitamin C, Brassinin among others. While the active ingredients contained in Carob are Quercetin, Myricetin, Gallic Acid, Phloroglucinol, Palmitic Acid and others.
Glucaric Acid can manipulate biochemical pathways NFKB Signaling, Cell Cycle and MYC Signaling. Brassinin has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and NFKB Signaling.
Palmitic Acid can manipulate biochemical pathways NFKB Signaling and MAPK Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Fibroblastic Myofibroblastic Tumor with chemotherapy Radiation – Foods like Cauliflower are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Folic Acid in Carob interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Brassinin contained in Cauliflower support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CAULIFLOWER IS RECOMMENDED OVER CAROB FOR FIBROBLASTIC MYOFIBROBLASTIC TUMOR ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Orange or Huckleberry?
Fruits are an important part of many diets. The active ingredients contained in Orange are Modified Citrus Pectin, D-limonene, Linalool, Salicylic Acid, Glucaric Acid among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, Ferulic Acid, Vitamin C, Chlorogenic Acid and others.
D-limonene can manipulate biochemical pathways NFKB Signaling, Cell Cycle and MYC Signaling. Glucaric Acid has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.
Resveratrol can manipulate biochemical pathways DNA Repair. Pelargonidin has biological action on biochemical pathways MYC Signaling, NFKB Signaling and Cell Cycle. And so on.
When treating Fibroblastic Myofibroblastic Tumor with chemotherapy Radiation – Foods like Orange are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients D-limonene and Glucaric Acid contained in Orange support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ORANGE IS RECOMMENDED OVER HUCKLEBERRY FOR FIBROBLASTIC MYOFIBROBLASTIC TUMOR ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Linolenic Acid, Beta-sitosterol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Rhamnetin, Ferulic Acid, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Cell Cycle. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and NFKB Signaling.
Vitamin A can manipulate biochemical pathways Focal Adhesion. Lecithin has biological action on biochemical pathways MYC Signaling, NFKB Signaling and MAPK Signaling. And so on.
When treating Fibroblastic Myofibroblastic Tumor with chemotherapy Radiation – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR FIBROBLASTIC MYOFIBROBLASTIC TUMOR ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Fibroblastic Myofibroblastic Tumor
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NF1 and ARID1B are two genes whose abnormalities are risk factors for Fibroblastic Myofibroblastic Tumor. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Fibroblastic Myofibroblastic Tumor can be used as a guide for coming up with a recommended personalized nutrition plan. For Fibroblastic Myofibroblastic Tumor gene NF1 has causative impact on biological pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling. And ARID1B has a causative impact on biological pathways like Androgen Signaling and Chromatin Remodeling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NF1 and ARID1B should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NF1 and ARID1B should be avoided.
Eat more pulses, Winged Bean or Soy Bean?
The active ingredients contained in Winged Bean are Betulinic Acid, Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Beta-sitosterol, Vitamin E, Quercetin and others.
Betulinic Acid can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Fibroblastic Myofibroblastic Tumor due to abnormalities in genes NF1 and ARID1B – Foods like Winged Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF FIBROBLASTIC MYOFIBROBLASTIC TUMOR DUE TO GENES NF1 AND ARID1B
Eat more vegetables, Giant Butterbur or Endive?
The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Melatonin, Vitamin B3, Kaempferol among others. While the active ingredients contained in Endive are Quercetin, Vitamin C, Linolenic Acid, Oleic Acid, Kaempferol and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Quercetin can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Fibroblastic Myofibroblastic Tumor due to abnormalities in genes NF1 and ARID1B – Foods like Giant Butterbur are recommended compared to Endive. This is because the active ingredients Quercetin and Folic Acid in Endive further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER ENDIVE FOR REDUCING THE GENETIC RISK OF FIBROBLASTIC MYOFIBROBLASTIC TUMOR DUE TO GENES NF1 AND ARID1B
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Strawberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Strawberry are Ellagic Acid, Lupeol, Beta-sitosterol, Vitamin C, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.
Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Fibroblastic Myofibroblastic Tumor due to abnormalities in genes NF1 and ARID1B – Foods like Feijoa are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF FIBROBLASTIC MYOFIBROBLASTIC TUMOR DUE TO GENES NF1 AND ARID1B
Eat more nuts, Pecan Nut or Acorn?
The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Cianidanol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Acorn are Beta-sitosterol, Quercetin, Vitamin C, Beta-carotene, Quercitrin and others.
Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Cianidanol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Quercetin can manipulate biochemical pathways DNA Repair. Beta-carotene has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Fibroblastic Myofibroblastic Tumor due to abnormalities in genes NF1 and ARID1B – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Beta-carotene in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF FIBROBLASTIC MYOFIBROBLASTIC TUMOR DUE TO GENES NF1 AND ARID1B
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Fibroblastic Myofibroblastic Tumor by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pan Origimed 2020
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.