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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Esophageal Adenosquamous Carcinoma?

Aug 8, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Esophageal Adenosquamous Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Esophageal Adenosquamous Carcinoma because of NOTCH1 and NOTCH4 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Esophageal Adenosquamous Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Passion Fruit” or “Include fruit Feijoa in my diet” or “Should I reduce consumption of vegetable Tomato” or “Can I take Curcumin and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ESOPHAGEAL ADENOSQUAMOUS CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Esophageal Adenosquamous Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ESOPHAGEAL ADENOSQUAMOUS CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Esophageal Adenosquamous Carcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Esophageal Adenosquamous Carcinoma from cBioPortal. From a patient sample size of 5; the top genes with mutations and other abnormalities for Esophageal Adenosquamous Carcinoma include genes TP53, NOTCH1, NOTCH4, BCR and NFE2L2. The occurrence frequency distribution for these genes respectively is 100.0%, 40.0%, 40.0%, 20.0% and 20.0%. These tumor genetic details of Esophageal Adenosquamous Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Esophageal Adenosquamous Carcinoma.

Significance of Nutrition for Esophageal Adenosquamous Carcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Esophageal Adenosquamous Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Passion Fruit includes active ingredients Oleic Acid, Vitamin C, Linolenic Acid, Linoleic Acid, Vitamin A and others. And Feijoa contains active ingredients Vitamin C, Lycopene, Casuarinin, Folic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Esophageal Adenosquamous Carcinoma, activation or inhibition of selected biochemical pathways like Cell Cycle, Growth Factor Signaling, Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Esophageal Adenosquamous Carcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Esophageal Adenosquamous Carcinoma, activation or inhibition of selected biochemical pathways like Cell Cycle, Growth Factor Signaling, Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ESOPHAGEAL ADENOSQUAMOUS CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Esophageal Adenosquamous Carcinoma undergoing chemotherapy treatment

In Esophageal Adenosquamous Carcinoma – the genes TP53, NOTCH1, NOTCH4, BCR and NFE2L2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Esophageal Adenosquamous Carcinoma are Cell Cycle, Growth Factor Signaling, Angiogenesis and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, Growth Factor Signaling, Angiogenesis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Common Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Oleic Acid, Vitamin C among others. While the active ingredients contained in Common Bean are Esculin, Apigenin, Oleic Acid, Vitamin C, Ferulic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Cell Cycle, MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways Oxidative Stress, Angiogenesis and Cell Cycle.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Esculin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Esophageal Adenosquamous Carcinoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Vitamin A and Esculin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR ESOPHAGEAL ADENOSQUAMOUS CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Cabbage or Tomato?

Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Benzyl Isothiocyanate, Beta-sitosterol, Quercetin, Vitamin C, Brassinin among others. While the active ingredients contained in Tomato are Lupeol, Oleic Acid, Vitamin C, Linolenic Acid, Lutein and others.

Vitamin C can manipulate biochemical pathways Cell Cycle, MYC Signaling and PI3K-AKT-MTOR Signaling. Glucaric Acid has biological action on biochemical pathways MYC Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling.

Citric Acid can manipulate biochemical pathways Oxidative Stress. Rutin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Esophageal Adenosquamous Carcinoma with chemotherapy Radiation – Foods like Cabbage are recommended compared to Tomato. This is because the active ingredients Citric Acid and Rutin in Tomato interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CABBAGE IS RECOMMENDED OVER TOMATO FOR ESOPHAGEAL ADENOSQUAMOUS CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Which Foods are Recommended for Esophageal Adenosquamous Carcinoma?

Eat more fruits, Feijoa or Passion Fruit?

Fruits are an important part of many diets. The active ingredients contained in Feijoa are Vitamin C, Lycopene, Casuarinin, Folic Acid among others. While the active ingredients contained in Passion Fruit are Oleic Acid, Vitamin C, Linolenic Acid, Linoleic Acid, Vitamin A and others.

Vitamin C can manipulate biochemical pathways Cell Cycle, MYC Signaling and PI3K-AKT-MTOR Signaling. Lycopene has biological action on biochemical pathways Angiogenesis, MYC Signaling and Cell Cycle.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Esophageal Adenosquamous Carcinoma with chemotherapy Radiation – Foods like Feijoa are recommended compared to Passion Fruit. This is because the active ingredients Vitamin A and Citric Acid in Passion Fruit interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Lycopene contained in Feijoa support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER PASSION FRUIT FOR ESOPHAGEAL ADENOSQUAMOUS CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pumpkin Seeds or Macadamia Nut?

Nuts are an important part of many diets. The active ingredients contained in Pumpkin Seeds are Beta-sitosterol, Oleic Acid, Stigmasterol, Gamma-linolenic Acid, Linolenic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.

Gamma-linolenic Acid can manipulate biochemical pathways Cell Cycle, Notch Signaling and MYC Signaling. Lecithin has biological action on biochemical pathways Oxidative Stress.

Palmitic Acid can manipulate biochemical pathways Growth Factor Signaling and Cell Cycle. Lauric Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

When treating Esophageal Adenosquamous Carcinoma with chemotherapy Radiation – Foods like Pumpkin Seeds are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Gamma-linolenic Acid and Lecithin contained in Pumpkin Seeds support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PUMPKIN SEEDS IS RECOMMENDED OVER MACADAMIA NUT FOR ESOPHAGEAL ADENOSQUAMOUS CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Esophageal Adenosquamous Carcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NOTCH1 and NOTCH4 are two genes whose abnormalities are risk factors for Esophageal Adenosquamous Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Esophageal Adenosquamous Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Esophageal Adenosquamous Carcinoma gene NOTCH1 has causative impact on biological pathways like Notch Signaling and RUNX Signaling. And NOTCH4 has a causative impact on biological pathways like Notch Signaling, Thyroid Hormone Signaling and Angiogenesis. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NOTCH1 and NOTCH4 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NOTCH1 and NOTCH4 should be avoided.

Eat more pulses, Scarlet Bean or Chickpea?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Chickpea are Oleic Acid, Linolenic Acid, Genistein, Vitamin A, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and Apoptosis.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.

For genetic risk of Esophageal Adenosquamous Carcinoma due to abnormalities in genes NOTCH1 and NOTCH4 – Foods like Scarlet Bean are recommended compared to Chickpea. This is because the active ingredients Vitamin A and Folic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF ESOPHAGEAL ADENOSQUAMOUS CARCINOMA DUE TO GENES NOTCH1 AND NOTCH4

Eat more vegetables, Milk Thistle or Lettuce?

The active ingredients contained in Milk Thistle are Silibinin, Vitamin E, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Lettuce are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Chlorogenic Acid and others.

Silibinin can manipulate biochemical pathways Apoptosis, Notch Signaling and MYC Signaling. Vitamin E has biological action on biochemical pathways Cell Cycle Checkpoints, RUNX Signaling and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.

For genetic risk of Esophageal Adenosquamous Carcinoma due to abnormalities in genes NOTCH1 and NOTCH4 – Foods like Milk Thistle are recommended compared to Lettuce. This is because the active ingredients Vitamin A and Folic Acid in Lettuce further promote the effects of genes on the biochemical pathways. While the active ingredients Silibinin and Vitamin E contained in Milk Thistle together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MILK THISTLE IS RECOMMENDED OVER LETTUCE FOR REDUCING THE GENETIC RISK OF ESOPHAGEAL ADENOSQUAMOUS CARCINOMA DUE TO GENES NOTCH1 AND NOTCH4

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Blueberry or Cloudberry?

The active ingredients contained in Blueberry are Vitamin E, Eugenol, Resveratrol, Vitamin C, Chlorogenic Acid among others. While the active ingredients contained in Cloudberry are Ellagic Acid, Vitamin C, Urolithin B, Vitamin A and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Chlorogenic Acid has biological action on biochemical pathways Notch Signaling, RUNX Signaling and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Esophageal Adenosquamous Carcinoma due to abnormalities in genes NOTCH1 and NOTCH4 – Foods like Blueberry are recommended compared to Cloudberry. This is because the active ingredients Vitamin A and Ellagic Acid in Cloudberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Chlorogenic Acid contained in Blueberry together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: BLUEBERRY IS RECOMMENDED OVER CLOUDBERRY FOR REDUCING THE GENETIC RISK OF ESOPHAGEAL ADENOSQUAMOUS CARCINOMA DUE TO GENES NOTCH1 AND NOTCH4

Eat more nuts, Almond or Peanut?

The active ingredients contained in Almond are Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Peanut are Vitamin E, Rhamnetin, Beta-sitosterol, Oleic Acid, Vitamin C and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Vitamin E has biological action on biochemical pathways Notch Signaling, RUNX Signaling and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.

For genetic risk of Esophageal Adenosquamous Carcinoma due to abnormalities in genes NOTCH1 and NOTCH4 – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Vitamin A and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF ESOPHAGEAL ADENOSQUAMOUS CARCINOMA DUE TO GENES NOTCH1 AND NOTCH4


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Esophageal Adenosquamous Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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