Foods for Desmoplastic Nodular Medulloblastoma!

Introduction

Foods for Desmoplastic Nodular Medulloblastoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

For Desmoplastic Nodular Medulloblastoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Desmoplastic Nodular Medulloblastoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Desmoplastic Nodular Medulloblastoma?

For example does it matter if vegetable Wild Carrot is consumed more compared to Yam? Does it make any difference if fruit Fox Grape is preferred over European Cranberry? Also if similar choices are made for nuts/seeds like Common Walnut over European Chestnut and for pulses like Broad Bean over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Desmoplastic Nodular Medulloblastoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Desmoplastic Nodular Medulloblastoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Fox Grape contains active ingredients Apigenin, Curcumin, Luteolin, Quercetin, Daidzein. And European Cranberry contains active ingredients Apigenin, Curcumin, Luteolin, Quercetin, Ellagic Acid and possibly others.

A common mistake made when deciding and choosing foods to eat for Desmoplastic Nodular Medulloblastoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Desmoplastic Nodular Medulloblastoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Desmoplastic Nodular Medulloblastoma?

Personalized nutrition for cancers like Desmoplastic Nodular Medulloblastoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Desmoplastic Nodular Medulloblastoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Desmoplastic Nodular Medulloblastoma

All cancers like Desmoplastic Nodular Medulloblastoma can be characterized by a unique set of biochemical pathways – the signature pathways of Desmoplastic Nodular Medulloblastoma. Biochemical pathways like Cell Cycle, Growth Factor Signaling, MAPK Signaling, G-protein-coupled Receptor Signaling are part of the signature definition of Desmoplastic Nodular Medulloblastoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Desmoplastic Nodular Medulloblastoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Desmoplastic Nodular Medulloblastoma when taking cancer treatment Irinotecan, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

PTCH1, DDX3X, KMT2D, PRKAR1A and TCF4 are the top ranked reported genes for Desmoplastic Nodular Medulloblastoma. PTCH1 is reported in 33.3 % of the representative patients across all clinical trials. And DDX3X is reported in 25.9 %. The combined population patient data cover ages from 2 to 39. 57.1 % of the patient data are identified as men. The Desmoplastic Nodular Medulloblastoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Desmoplastic Nodular Medulloblastoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable WILD CARROT or YAM?

Vegetable Wild Carrot contains many active ingredients or bioactives such as Apigenin, Curcumin, Luteolin, Quercetin, Chrysin. These active ingredients manipulate various biochemical pathways like NFKB Signaling, Cell Cycle, PI3K-AKT-MTOR Signaling and Apoptosis and others. Wild Carrot is recommended for Desmoplastic Nodular Medulloblastoma when ongoing cancer treatment is Irinotecan. This is because Wild Carrot modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Irinotecan.

Some of the active ingredients or bioactives in vegetable Yam are Apigenin, Curcumin, Luteolin, Daidzein, Salicylic Acid. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and TGFB Signaling and others. Yam is not recommended for Desmoplastic Nodular Medulloblastoma when ongoing cancer treatment is Irinotecan because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE WILD CARROT IS RECOMMENDED OVER YAM FOR Desmoplastic Nodular Medulloblastoma AND TREATMENT Irinotecan.

Choose Fruit EUROPEAN CRANBERRY or FOX GRAPE?

Fruit European Cranberry contains many active ingredients or bioactives such as Apigenin, Curcumin, Luteolin, Quercetin, Ellagic Acid. These active ingredients manipulate various biochemical pathways like TGFB Signaling, NFKB Signaling, Cell Cycle and P53 Signaling and others. European Cranberry is recommended for Desmoplastic Nodular Medulloblastoma when ongoing cancer treatment is Irinotecan. This is because European Cranberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Irinotecan.

Some of the active ingredients or bioactives in fruit Fox Grape are Apigenin, Curcumin, Luteolin, Quercetin, Daidzein. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and TGFB Signaling and others. Fox Grape is not recommended for Desmoplastic Nodular Medulloblastoma when ongoing cancer treatment is Irinotecan because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT EUROPEAN CRANBERRY IS RECOMMENDED OVER FOX GRAPE FOR Desmoplastic Nodular Medulloblastoma AND TREATMENT Irinotecan.

Choose Nut COMMON WALNUT or EUROPEAN CHESTNUT?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Ellagic Acid, Daidzein, Salicylic Acid. These active ingredients manipulate various biochemical pathways like TGFB Signaling, NFKB Signaling, Cell Cycle and P53 Signaling and others. Common Walnut is recommended for Desmoplastic Nodular Medulloblastoma when ongoing cancer treatment is Irinotecan. This is because Common Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Irinotecan.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Curcumin, Luteolin, Quercetin, Ellagic Acid. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and TGFB Signaling and others. European Chestnut is not recommended for Desmoplastic Nodular Medulloblastoma when ongoing cancer treatment is Irinotecan because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON WALNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Desmoplastic Nodular Medulloblastoma AND TREATMENT Irinotecan.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Desmoplastic Nodular Medulloblastoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or MALABAR SPINACH?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Myricetin, Lupeol, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Angiogenesis, PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and P53 Signaling and others. Giant Butterbur is recommended for risk of Desmoplastic Nodular Medulloblastoma when associated genetic risk is DDX3X. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Malabar Spinach are Curcumin, Apigenin, Quercetin, Myricetin, Lupeol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and MAPK Signaling and others. Malabar Spinach is not recommended when risk of Desmoplastic Nodular Medulloblastoma when associated genetic risk is DDX3X because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER MALABAR SPINACH FOR DDX3X GENETIC RISK OF CANCER.

Choose Fruit NANCE or PUMMELO?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Apigenin, Myricetin, Lupeol, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Angiogenesis, PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and P53 Signaling and others. Nance is recommended for risk of Desmoplastic Nodular Medulloblastoma when associated genetic risk is DDX3X. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Curcumin, Apigenin, Quercetin, Lupeol, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and others. Pummelo is not recommended when risk of Desmoplastic Nodular Medulloblastoma when associated genetic risk is DDX3X because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER PUMMELO FOR DDX3X GENETIC RISK OF CANCER.

Choose Nut COMMON HAZELNUT or CHESTNUT?

Common Hazelnut contains many active ingredients or bioactives such as Curcumin, Quercetin, Myricetin, Lupeol, Isoliquiritigenin. These active ingredients manipulate various biochemical pathways like Angiogenesis, PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and P53 Signaling and others. Common Hazelnut is recommended for risk of Desmoplastic Nodular Medulloblastoma when associated genetic risk is DDX3X. This is because Common Hazelnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Curcumin, Apigenin, Ellagic Acid, Myricetin, Lupeol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and others. Chestnut is not recommended when risk of Desmoplastic Nodular Medulloblastoma when associated genetic risk is DDX3X because it increases the signature pathways of it.

COMMON HAZELNUT IS RECOMMENDED OVER CHESTNUT FOR DDX3X GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Desmoplastic Nodular Medulloblastoma. Desmoplastic Nodular Medulloblastoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Desmoplastic Nodular Medulloblastoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Wild Carrot contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Desmoplastic Nodular Medulloblastoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

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• Geraniol, a component of plant essential oils, sensitizes human colonic cancer cells to 5-Fluorouracil treatment.
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