Which Foods are Recommended for Desmoplastic Nodular Medulloblastoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Desmoplastic Nodular Medulloblastoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Desmoplastic Nodular Medulloblastoma because of PTCH1 and DDX3X gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Desmoplastic Nodular Medulloblastoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Watermelon” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Chayote” or “Can I take Cissus and Skullcap supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO DESMOPLASTIC NODULAR MEDULLOBLASTOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Desmoplastic Nodular Medulloblastoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR DESMOPLASTIC NODULAR MEDULLOBLASTOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Desmoplastic Nodular Medulloblastoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Desmoplastic Nodular Medulloblastoma from cBioPortal. The patients enrolled in the studies for Desmoplastic Nodular Medulloblastoma are in ages between 2 to 39 with an average age of 11. 57.1% of males and 42.9% of females were the distribution of gender in these clinical studies. From a patient sample size of 29; the top genes with mutations and other abnormalities for Desmoplastic Nodular Medulloblastoma include genes PTCH1, DDX3X, KMT2D, PRKAR1A and TCF4. The occurrence frequency distribution for these genes respectively is 33.3%, 25.9%, 14.8%, 11.1% and 11.1%. These tumor genetic details of Desmoplastic Nodular Medulloblastoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Desmoplastic Nodular Medulloblastoma.

Significance of Nutrition for Desmoplastic Nodular Medulloblastoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Desmoplastic Nodular Medulloblastoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Watermelon includes active ingredients Lycopene, Cucurbitacin E, Linolenic Acid, Vitamin C, Oleic Acid and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Desmoplastic Nodular Medulloblastoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Cell Cycle, Interferon Signaling, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Desmoplastic Nodular Medulloblastoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR DESMOPLASTIC NODULAR MEDULLOBLASTOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Desmoplastic Nodular Medulloblastoma undergoing chemotherapy treatment

In Desmoplastic Nodular Medulloblastoma – the genes PTCH1, DDX3X, KMT2D, PRKAR1A and TCF4 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Desmoplastic Nodular Medulloblastoma are RAS-RAF Signaling, Cell Cycle, Cytoskeletal Dynamics and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Cell Cycle, Cytoskeletal Dynamics so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Common Bean?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Lupeol, Beta-sitosterol, Kaempferol, Linolenic Acid among others. While the active ingredients contained in Common Bean are Apigenin, P-coumaric Acid, Kaempferol, Linolenic Acid, Genistein and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Chromatin Remodeling and Cell Cycle. Vitamin C has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Hypoxia.

Vitamin A can manipulate biochemical pathways Notch Signaling and Focal Adhesion. Apigenin has biological action on biochemical pathways Heat Stress Response and TGFB Signaling. And so on.

When treating Desmoplastic Nodular Medulloblastoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Vitamin A and Apigenin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR DESMOPLASTIC NODULAR MEDULLOBLASTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Cucumber or Chayote?

Vegetables are an important part of many diets. The active ingredients contained in Cucumber are Fisetin, Caffeic Acid, Lupeol, Beta-sitosterol, Salicylic Acid among others. While the active ingredients contained in Chayote are Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid, Folic Acid and others.

Fisetin can manipulate biochemical pathways NFKB Signaling, Cell Cycle and Notch Signaling. Caffeic Acid has biological action on biochemical pathways Cytoskeletal Dynamics, Chromatin Remodeling and Cell Survival.

Oleic Acid can manipulate biochemical pathways Cytoskeletal Dynamics and Oncogenic Cancer Epigenetics. Linoleic Acid has biological action on biochemical pathways Heat Stress Response and TGFB Signaling. And so on.

When treating Desmoplastic Nodular Medulloblastoma with chemotherapy Radiation – Foods like Cucumber are recommended compared to Chayote. This is because the active ingredients Oleic Acid and Linoleic Acid in Chayote interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Fisetin and Caffeic Acid contained in Cucumber support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CUCUMBER IS RECOMMENDED OVER CHAYOTE FOR DESMOPLASTIC NODULAR MEDULLOBLASTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Partridgeberry or Watermelon?

Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Watermelon are Lycopene, Cucurbitacin E, Linolenic Acid, Vitamin C, Oleic Acid and others.

Resveratrol can manipulate biochemical pathways NFKB Signaling, Cell Cycle and Cell Survival. Beta-sitosterol has biological action on biochemical pathways Chromatin Remodeling, MYC Signaling and Heat Stress Response.

Lycopene can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Vitamin A has biological action on biochemical pathways Notch Signaling and Focal Adhesion. And so on.

When treating Desmoplastic Nodular Medulloblastoma with chemotherapy Radiation – Foods like Partridgeberry are recommended compared to Watermelon. This is because the active ingredients Lycopene and Vitamin A in Watermelon interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER WATERMELON FOR DESMOPLASTIC NODULAR MEDULLOBLASTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Chestnut?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Chestnut are Quercetin, Ellagic Acid, Linolenic Acid, Vitamin C, Gallic Acid and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Chromatin Remodeling and Cell Cycle. Vitamin K has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Inflammation.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Heat Stress Response. Betulin has biological action on biochemical pathways Cytoskeletal Dynamics. And so on.

When treating Desmoplastic Nodular Medulloblastoma with chemotherapy Radiation – Foods like Pine Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Betulin in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER CHESTNUT FOR DESMOPLASTIC NODULAR MEDULLOBLASTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Desmoplastic Nodular Medulloblastoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. PTCH1 and DDX3X are two genes whose abnormalities are risk factors for Desmoplastic Nodular Medulloblastoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Desmoplastic Nodular Medulloblastoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Desmoplastic Nodular Medulloblastoma gene PTCH1 has causative impact on biological pathways like G-protein-coupled Receptor Signaling. And DDX3X has a causative impact on biological pathways like Interferon Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like PTCH1 and DDX3X should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes PTCH1 and DDX3X should be avoided.

Eat more pulses, Scarlet Bean or Adzuki Bean?

The active ingredients contained in Scarlet Bean are Genistein, Oleic Acid, Beta-sitosterol, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Adzuki Bean are Genistein, Isoliquiritigenin, Glucaric Acid, Folic Acid and others.

Genistein can manipulate biochemical pathways DNA Repair, MYC Signaling and Cell Cycle Checkpoints. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and MYC Signaling.

Isoliquiritigenin can manipulate biochemical pathways Interferon Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Desmoplastic Nodular Medulloblastoma due to abnormalities in genes PTCH1 and DDX3X – Foods like Scarlet Bean are recommended compared to Adzuki Bean. This is because the active ingredients Isoliquiritigenin and Folic Acid in Adzuki Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Genistein and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER ADZUKI BEAN FOR REDUCING THE GENETIC RISK OF DESMOPLASTIC NODULAR MEDULLOBLASTOMA DUE TO GENES PTCH1 AND DDX3X

Eat more vegetables, Jicama or Beetroot?

The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Beetroot are Oleic Acid, Beta-sitosterol, Vitamin E, Vitamin C, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and Cell Cycle Checkpoints. Vitamin B3 has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Cell Cycle Checkpoints.

Vitamin E can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Desmoplastic Nodular Medulloblastoma due to abnormalities in genes PTCH1 and DDX3X – Foods like Jicama are recommended compared to Beetroot. This is because the active ingredients Vitamin E and Folic Acid in Beetroot further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER BEETROOT FOR REDUCING THE GENETIC RISK OF DESMOPLASTIC NODULAR MEDULLOBLASTOMA DUE TO GENES PTCH1 AND DDX3X

Eat more fruits, Kiwi or Cranberry?

The active ingredients contained in Kiwi are Vitamin C, Quercetin, Fisetin, Chlorogenic Acid, Vitamin A among others. While the active ingredients contained in Cranberry are Resveratrol, Ellagic Acid, Vitamin C, Hyperoside, Myricetin and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and Cell Cycle Checkpoints. Quercetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Oncogenic Cancer Epigenetics.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics and Oncogenic Histone Methylation. And so on.

For genetic risk of Desmoplastic Nodular Medulloblastoma due to abnormalities in genes PTCH1 and DDX3X – Foods like Kiwi are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Myricetin in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: KIWI IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF DESMOPLASTIC NODULAR MEDULLOBLASTOMA DUE TO GENES PTCH1 AND DDX3X

Eat more nuts, Hazelnut or Peanut?

The active ingredients contained in Hazelnut are Oleic Acid, Vitamin E, Linolenic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Peanut are Oleic Acid, Beta-sitosterol, Vitamin E, Vitamin C, Linolenic Acid and others.

Quercetin can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and Cell Cycle Checkpoints. Myricitrin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Vitamin E has biological action on biochemical pathways DNA Repair. And so on.

For genetic risk of Desmoplastic Nodular Medulloblastoma due to abnormalities in genes PTCH1 and DDX3X – Foods like Hazelnut are recommended compared to Peanut. This is because the active ingredients Lecithin and Vitamin E in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Myricitrin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF DESMOPLASTIC NODULAR MEDULLOBLASTOMA DUE TO GENES PTCH1 AND DDX3X

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Desmoplastic Nodular Medulloblastoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Mbl Sickkids 2016
• Pan-cancer analysis of whole genomes.
• Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
• The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
• Adhesion to the extracellular matrix is positively regulated by retinoic acid in HepG2 cells.
• Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
• Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition.
• Fisetin alleviates early brain injury following experimental subarachnoid hemorrhage in rats possibly by suppressing TLR 4/NF-κB signaling pathway.
• Chromatographic separation and electrochemical determination of cholesterol hydroperoxides generated by photodynamic action.
• Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
• Fabrication of size-controlled linoleic acid particles and evaluation of their in-vitro lipotoxicity.
• Research progress on the anticancer effects of vitamin K2.
• Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
• Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors.
• Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells.
• Bis(4-hydroxy-2H-chromen-2-one): synthesis and effects on leukemic cell lines proliferation and NF-κB regulation.
• Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
• Inhibitors of histone demethylases.
• Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells.
• Inhibitory effect of tocotrienol on eukaryotic DNA polymerase lambda and angiogenesis.
• Myricitrin blocks activation of NF-κB and MAPK signaling pathways to protect nigrostriatum neuron in LPS-stimulated mice.
• The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
• HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
• Resveratrol, pterostilbene, and piceatannol in vaccinium berries.
• Fisetin: a dietary antioxidant for health promotion.

• Which Foods are Recommended for Desmoplastic Melanoma?
• Which 3 Foods to Avoid for Medulloblastoma?
• Which Foods are Recommended for Anaplastic Medulloblastoma?
• Which Foods are Recommended for Prostate Small Cell Carcinoma?
• Which Foods are Recommended for Colorectal Adenocarcinoma?