Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Cutaneous Squamous Cell Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Cutaneous Squamous Cell Carcinoma because of RELN and APOB gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Cutaneous Squamous Cell Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Apricot” or “Include fruit Persimmon in my diet” or “Should I reduce consumption of vegetable Rhubarb” or “Can I take Dim and Neem Extract supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO CUTANEOUS SQUAMOUS CELL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Cutaneous Squamous Cell Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR CUTANEOUS SQUAMOUS CELL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Cutaneous Squamous Cell Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Cutaneous Squamous Cell Carcinoma from cBioPortal. The patients enrolled in the studies for Cutaneous Squamous Cell Carcinoma are in ages between 37 to 93 with an average age of 72. 77.4% of males and 22.6% of females were the distribution of gender in these clinical studies. From a patient sample size of 330; the top genes with mutations and other abnormalities for Cutaneous Squamous Cell Carcinoma include genes RELN, APOB, FAT4, MUC16 and COL11A1. The occurrence frequency distribution for these genes respectively is 17.3%, 15.6%, 15.6%, 14.2% and 13.8%. These tumor genetic details of Cutaneous Squamous Cell Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Cutaneous Squamous Cell Carcinoma.
Significance of Nutrition for Cutaneous Squamous Cell Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Cutaneous Squamous Cell Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Apricot includes active ingredients Quercetin, Beta-sitosterol, Vitamin C, Linolenic Acid, Stigmasterol and others. And Persimmon contains active ingredients Quercetin, Lycopene, Betulinic Acid, Vitamin C, Lupeol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Cutaneous Squamous Cell Carcinoma, activation or inhibition of selected biochemical pathways like Amino Acid Metabolism, Angiogenesis, Extracellular Matrix Remodelling, Small Molecule Transport plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Cutaneous Squamous Cell Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR CUTANEOUS SQUAMOUS CELL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Cutaneous Squamous Cell Carcinoma undergoing chemotherapy treatment
In Cutaneous Squamous Cell Carcinoma – the genes RELN, APOB, FAT4, MUC16 and COL11A1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Cutaneous Squamous Cell Carcinoma are Amino Acid Metabolism, Angiogenesis, PI3K-AKT-MTOR Signaling and others. Fluorouracil is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Amino Acid Metabolism, Angiogenesis, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Black-eyed Pea or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Black-eyed Pea are Daidzein, Vitamin C, Linolenic Acid, Genistein, Vitamin B3 among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Genistein, Linoleic Acid, Oleic Acid and others.
Daidzein can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Oxidative Stress. Vitamin C has biological action on biochemical pathways Adherens junction, MYC Signaling and WNT Beta Catenin Signaling.
Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Vitamin A has biological action on biochemical pathways Focal Adhesion. And so on.
When treating Cutaneous Squamous Cell Carcinoma with chemotherapy Fluorouracil – Foods like Black-eyed Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin A in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Daidzein and Vitamin C contained in Black-eyed Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BLACK-EYED PEA IS RECOMMENDED OVER PIGEON PEA FOR CUTANEOUS SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.
Eat more vegetables, Cassava or Rhubarb?
Vegetables are an important part of many diets. The active ingredients contained in Cassava are Beta-sitosterol, Vitamin C, Linolenic Acid, Linoleic Acid, Oleic Acid among others. While the active ingredients contained in Rhubarb are Quercetin, Rhein, Vitamin C, Vitamin E, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Glucocorticoid Signaling and Microtubule Dynamics.
Rutin can manipulate biochemical pathways Oxidative Stress, Microtubule Dynamics and WNT Beta Catenin Signaling. Quercetin has biological action on biochemical pathways Nucleotide metabolism and Oxidative Stress. And so on.
When treating Cutaneous Squamous Cell Carcinoma with chemotherapy Fluorouracil – Foods like Cassava are recommended compared to Rhubarb. This is because the active ingredients Rutin and Quercetin in Rhubarb interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER RHUBARB FOR CUTANEOUS SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.
Eat more fruits, Persimmon or Apricot?
Fruits are an important part of many diets. The active ingredients contained in Persimmon are Quercetin, Lycopene, Betulinic Acid, Vitamin C, Lupeol among others. While the active ingredients contained in Apricot are Quercetin, Beta-sitosterol, Vitamin C, Linolenic Acid, Stigmasterol and others.
Lycopene can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Vitamin C has biological action on biochemical pathways Adherens junction, MYC Signaling and WNT Beta Catenin Signaling.
Rutin can manipulate biochemical pathways Oxidative Stress, Microtubule Dynamics and WNT Beta Catenin Signaling. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Cutaneous Squamous Cell Carcinoma with chemotherapy Fluorouracil – Foods like Persimmon are recommended compared to Apricot. This is because the active ingredients Rutin and Citric Acid in Apricot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Vitamin C contained in Persimmon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PERSIMMON IS RECOMMENDED OVER APRICOT FOR CUTANEOUS SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.
Eat more nuts, Pistachio or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Pistachio are Resveratrol, Beta-sitosterol, Vitamin E, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Peanut are Quercetin, Beta-sitosterol, Vitamin C, Vitamin E, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Resveratrol has biological action on biochemical pathways Microtubule Dynamics, MYC Signaling and Vitamin D Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress and Nucleotide metabolism. Vitamin A has biological action on biochemical pathways Focal Adhesion. And so on.
When treating Cutaneous Squamous Cell Carcinoma with chemotherapy Fluorouracil – Foods like Pistachio are recommended compared to Peanut. This is because the active ingredients Quercetin and Vitamin A in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Resveratrol contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER PEANUT FOR CUTANEOUS SQUAMOUS CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.
Foods for Genetic Risk of Cutaneous Squamous Cell Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. RELN and APOB are two genes whose abnormalities are risk factors for Cutaneous Squamous Cell Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Cutaneous Squamous Cell Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Cutaneous Squamous Cell Carcinoma gene RELN has causative impact on biological pathways like Notch Signaling. And APOB has a causative impact on biological pathways like Focal Adhesion and NFKB Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like RELN and APOB should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes RELN and APOB should be avoided.
Eat more pulses, Lentils or Chickpea?
The active ingredients contained in Lentils are Ellagic Acid, Esculin, Beta-sitosterol, Vitamin C, Daidzein among others. While the active ingredients contained in Chickpea are Oleic Acid, Genistein, Linolenic Acid, Vitamin A, Folic Acid and others.
Ellagic Acid can manipulate biochemical pathways Post Translation Modification, RAS-RAF Signaling and Notch Signaling. Esculin has biological action on biochemical pathways MYC Signaling.
Vitamin A can manipulate biochemical pathways Notch Signaling. Linolenic Acid has biological action on biochemical pathways Complement Cascade. And so on.
For genetic risk of Cutaneous Squamous Cell Carcinoma due to abnormalities in genes RELN and APOB – Foods like Lentils are recommended compared to Chickpea. This is because the active ingredients Vitamin A and Linolenic Acid in Chickpea further promote the effects of genes on the biochemical pathways. While the active ingredients Ellagic Acid and Esculin contained in Lentils together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: LENTILS IS RECOMMENDED OVER CHICKPEA FOR REDUCING THE GENETIC RISK OF CUTANEOUS SQUAMOUS CELL CARCINOMA DUE TO GENES RELN AND APOB
Eat more vegetables, Burdock or Celeriac?
The active ingredients contained in Burdock are Lupeol, Arctigenin, Chlorogenic Acid, Caffeic Acid, Dehydrocostus Lactone among others. While the active ingredients contained in Celeriac are Vitamin C, Oleic Acid, Linolenic Acid, Vitamin K, Linoleic Acid and others.
Chlorogenic Acid can manipulate biochemical pathways MYC Signaling and Extracellular Matrix Remodelling. Caffeic Acid has biological action on biochemical pathways Post Translation Modification, RAS-RAF Signaling and Notch Signaling.
Linolenic Acid can manipulate biochemical pathways Complement Cascade. Linoleic Acid has biological action on biochemical pathways Complement Cascade. And so on.
For genetic risk of Cutaneous Squamous Cell Carcinoma due to abnormalities in genes RELN and APOB – Foods like Burdock are recommended compared to Celeriac. This is because the active ingredients Linolenic Acid and Linoleic Acid in Celeriac further promote the effects of genes on the biochemical pathways. While the active ingredients Chlorogenic Acid and Caffeic Acid contained in Burdock together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: BURDOCK IS RECOMMENDED OVER CELERIAC FOR REDUCING THE GENETIC RISK OF CUTANEOUS SQUAMOUS CELL CARCINOMA DUE TO GENES RELN AND APOB
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Bilberry or Coconut?
The active ingredients contained in Bilberry are Gallic Acid, Quercetin, Resveratrol, Chlorogenic Acid, Caffeic Acid among others. While the active ingredients contained in Coconut are Vitamin E, Beta-sitosterol, Palmitic Acid, Capric Acid, Lauric Acid and others.
Chlorogenic Acid can manipulate biochemical pathways MYC Signaling and Extracellular Matrix Remodelling. Arbutin has biological action on biochemical pathways MYC Signaling.
Palmitic Acid can manipulate biochemical pathways Post Translation Modification. Lauric Acid has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Cutaneous Squamous Cell Carcinoma due to abnormalities in genes RELN and APOB – Foods like Bilberry are recommended compared to Coconut. This is because the active ingredients Palmitic Acid and Lauric Acid in Coconut further promote the effects of genes on the biochemical pathways. While the active ingredients Chlorogenic Acid and Arbutin contained in Bilberry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: BILBERRY IS RECOMMENDED OVER COCONUT FOR REDUCING THE GENETIC RISK OF CUTANEOUS SQUAMOUS CELL CARCINOMA DUE TO GENES RELN AND APOB
Eat more nuts, Acorn or Hazelnut?
The active ingredients contained in Acorn are Gallic Acid, Quercetin, Vitamin C, Beta-sitosterol, Beta-carotene among others. While the active ingredients contained in Hazelnut are Quercetin, Vitamin E, Oleic Acid, Myricitrin, Linolenic Acid and others.
Gallic Acid can manipulate biochemical pathways MYC Signaling, Calcium Signaling and Notch Signaling. Beta-sitosterol has biological action on biochemical pathways MYC Signaling and Calcium Signaling.
Quercetin can manipulate biochemical pathways Complement Cascade. Vitamin A has biological action on biochemical pathways Notch Signaling. And so on.
For genetic risk of Cutaneous Squamous Cell Carcinoma due to abnormalities in genes RELN and APOB – Foods like Acorn are recommended compared to Hazelnut. This is because the active ingredients Quercetin and Vitamin A in Hazelnut further promote the effects of genes on the biochemical pathways. While the active ingredients Gallic Acid and Beta-sitosterol contained in Acorn together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ACORN IS RECOMMENDED OVER HAZELNUT FOR REDUCING THE GENETIC RISK OF CUTANEOUS SQUAMOUS CELL CARCINOMA DUE TO GENES RELN AND APOB
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Cutaneous Squamous Cell Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
- Genomic analysis of metastatic cutaneous squamous cell carcinoma.
- Daidzein effect on hormone refractory prostate cancer in vitro and in vivo compared to genistein and soy extract: potentiation of radiotherapy.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
- Adhesion to the extracellular matrix is positively regulated by retinoic acid in HepG2 cells.
- Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines.
- The mechanism of action of aspartic proteases involves ‘push-pull’ catalysis.
- Beta-sitosterol induces anti-proliferation and apoptosis in human leukemic U937 cells through activation of caspase-3 and induction of Bax/Bcl-2 ratio.
- Thrombin inhibitory activity of some polyphenolic compounds.
- Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition.
- Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
- Esculin exhibited anti-inflammatory activities in vivo and regulated TNF-α and IL-6 production in LPS-stimulated mouse peritoneal macrophages in vitro through MAPK pathway.
- Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex.
- Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway.
- Osteopetrotic (grey-lethal) bone produces collagenase and TIMP in organ culture: regulation by vitamin A.
- Maresin 1 attenuates NAFLD by suppression of endoplasmic reticulum stress via AMPK-SERCA2b pathway.
- Clinical pharmacodynamics of antihistamines.
- Chromatographic separation and electrochemical determination of cholesterol hydroperoxides generated by photodynamic action.
- Gallic acid inhibits migration and invasion in human osteosarcoma U-2 OS cells through suppressing the matrix metalloproteinase-2/-9, protein kinase B (PKB) and PKC signaling pathways.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.