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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Colorectal Adenocarcinoma?

Aug 8, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Colorectal Adenocarcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Colorectal Adenocarcinoma because of APC and TOP2A gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Colorectal Adenocarcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Huckleberry” or “Include fruit Persimmon in my diet” or “Should I reduce consumption of vegetable Lotus” or “Can I take D-limonene and Birch supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO COLORECTAL ADENOCARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Colorectal Adenocarcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR COLORECTAL ADENOCARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Colorectal Adenocarcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Colorectal Adenocarcinoma from cBioPortal. The patients enrolled in the studies for Colorectal Adenocarcinoma are in ages between 4 to 95 with an average age of 58. 54.9% of males and 45.1% of females were the distribution of gender in these clinical studies. From a patient sample size of 10227; the top genes with mutations and other abnormalities for Colorectal Adenocarcinoma include genes TP53, APC, KRAS, TOP2A and FBXW7. The occurrence frequency distribution for these genes respectively is 2.8%, 2.7%, 1.8%, 0.9% and 0.8%. These tumor genetic details of Colorectal Adenocarcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Colorectal Adenocarcinoma.

Significance of Nutrition for Colorectal Adenocarcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Colorectal Adenocarcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Huckleberry includes active ingredients Quercetin, Resveratrol, Delphinidin, Vitamin C, Ferulic Acid and others. And Persimmon contains active ingredients Quercetin, Lupeol, Lycopene, Betulinic Acid, Fisetin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Colorectal Adenocarcinoma, activation or inhibition of selected biochemical pathways like Cell Cycle, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Colorectal Adenocarcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Colorectal Adenocarcinoma, activation or inhibition of selected biochemical pathways like Cell Cycle, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR COLORECTAL ADENOCARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Colorectal Adenocarcinoma undergoing chemotherapy treatment

In Colorectal Adenocarcinoma – the genes TP53, APC, KRAS, TOP2A and FBXW7 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Colorectal Adenocarcinoma are Cell Cycle, Growth Factor Signaling, MAPK Signaling and others. Irinotecan is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, Growth Factor Signaling, MAPK Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Oleic Acid, Beta-sitosterol, Linolenic Acid, Vitamin C, Genistein among others. While the active ingredients contained in Pigeon Pea are Oleic Acid, Linolenic Acid, Vitamin C, Genistein, Vitamin A and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle and MYC Signaling.

Genistein can manipulate biochemical pathways Vitamin Metabolism, DNA Repair and Nutrient sensing. Vitamin A has biological action on biochemical pathways TGFB Signaling and Extracellular Matrix Remodelling. And so on.

When treating Colorectal Adenocarcinoma with chemotherapy Irinotecan – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin A in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR COLORECTAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY IRINOTECAN FOR SOME CONDITIONS.

Eat more vegetables, Cassava or Lotus?

Vegetables are an important part of many diets. The active ingredients contained in Cassava are Oleic Acid, Beta-sitosterol, Linolenic Acid, Vitamin C, Vitamin A among others. While the active ingredients contained in Lotus are Quercetin, Fisetin, Oleic Acid, Beta-sitosterol, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Growth Factor Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, DNA Repair and Cell Cycle.

Citric Acid can manipulate biochemical pathways Vitamin Metabolism. Quercetin has biological action on biochemical pathways Vitamin Metabolism. And so on.

When treating Colorectal Adenocarcinoma with chemotherapy Irinotecan – Foods like Cassava are recommended compared to Lotus. This is because the active ingredients Citric Acid and Quercetin in Lotus interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER LOTUS FOR COLORECTAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY IRINOTECAN FOR SOME CONDITIONS.

Which Foods are Recommended for Colorectal Adenocarcinoma?

Eat more fruits, Persimmon or Huckleberry?

Fruits are an important part of many diets. The active ingredients contained in Persimmon are Quercetin, Lupeol, Lycopene, Betulinic Acid, Fisetin among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, Delphinidin, Vitamin C, Ferulic Acid and others.

Lycopene can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle and MYC Signaling.

Quercetin can manipulate biochemical pathways Vitamin Metabolism. Resveratrol has biological action on biochemical pathways P53 Signaling and DNA Repair. And so on.

When treating Colorectal Adenocarcinoma with chemotherapy Irinotecan – Foods like Persimmon are recommended compared to Huckleberry. This is because the active ingredients Quercetin and Resveratrol in Huckleberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Vitamin C contained in Persimmon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PERSIMMON IS RECOMMENDED OVER HUCKLEBERRY FOR COLORECTAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY IRINOTECAN FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Oleic Acid, Beta-sitosterol, Linolenic Acid, Vitamin A among others. While the active ingredients contained in Acorn are Quercetin, Gallic Acid, Beta-sitosterol, Beta-carotene, Vitamin C and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin K has biological action on biochemical pathways Cell Cycle, MYC Signaling and Cell Cycle Checkpoints.

Quercetin can manipulate biochemical pathways Vitamin Metabolism. Gallic Acid has biological action on biochemical pathways Vitamin Metabolism. And so on.

When treating Colorectal Adenocarcinoma with chemotherapy Irinotecan – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR COLORECTAL ADENOCARCINOMA ON TREATMENT WITH CHEMOTHERAPY IRINOTECAN FOR SOME CONDITIONS.

Foods for Genetic Risk of Colorectal Adenocarcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. APC and TOP2A are two genes whose abnormalities are risk factors for Colorectal Adenocarcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Colorectal Adenocarcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Colorectal Adenocarcinoma gene APC has causative impact on biological pathways like Angiogenesis and Growth Factor Signaling. And TOP2A has a causative impact on biological pathways like Cell Cycle, Cell Cycle and Post Translation Modification. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like APC and TOP2A should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes APC and TOP2A should be avoided.

Eat more pulses, Mung Bean or Soy Bean?

The active ingredients contained in Mung Bean are Linolenic Acid, Oleic Acid, Vitamin C, Stigmasterol, Vitexin among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Vitamin E, Beta-sitosterol, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Stigmasterol has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Colorectal Adenocarcinoma due to abnormalities in genes APC and TOP2A – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Stigmasterol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF COLORECTAL ADENOCARCINOMA DUE TO GENES APC AND TOP2A

Eat more vegetables, Jicama or Bell Pepper?

The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Bell Pepper are Vitamin E, Linolenic Acid, Oleic Acid, Vitamin C, P-coumaric Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin B3 has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Capsaicin can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.

For genetic risk of Colorectal Adenocarcinoma due to abnormalities in genes APC and TOP2A – Foods like Jicama are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Folic Acid in Bell Pepper further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER BELL PEPPER FOR REDUCING THE GENETIC RISK OF COLORECTAL ADENOCARCINOMA DUE TO GENES APC AND TOP2A

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Kiwi or Grape?

The active ingredients contained in Kiwi are Vitamin C, Quercetin, Fisetin, Chlorogenic Acid, Vitamin A among others. While the active ingredients contained in Grape are Resveratrol, Lupeol, Vitamin E, Pterostilbene, Beta-sitosterol and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Fisetin has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Colorectal Adenocarcinoma due to abnormalities in genes APC and TOP2A – Foods like Kiwi are recommended compared to Grape. This is because the active ingredients Resveratrol and Pelargonidin in Grape further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Fisetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: KIWI IS RECOMMENDED OVER GRAPE FOR REDUCING THE GENETIC RISK OF COLORECTAL ADENOCARCINOMA DUE TO GENES APC AND TOP2A

Eat more nuts, Hazelnut or Peanut?

The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Oleic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Vitamin C and others.

Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Myricitrin has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vanillic Acid has biological action on biochemical pathways MAPK Signaling. And so on.

For genetic risk of Colorectal Adenocarcinoma due to abnormalities in genes APC and TOP2A – Foods like Hazelnut are recommended compared to Peanut. This is because the active ingredients Lecithin and Vanillic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Myricitrin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF COLORECTAL ADENOCARCINOMA DUE TO GENES APC AND TOP2A


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Colorectal Adenocarcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

sample-report


References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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