Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Clear Cell Sarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Clear Cell Sarcoma because of FUS and IRS2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Clear Cell Sarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Sapota” or “Include fruit Graviola in my diet” or “Should I reduce consumption of vegetable Radish” or “Can I take Basil and Indole-3-carbinol supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO CLEAR CELL SARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Clear Cell Sarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR CLEAR CELL SARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Clear Cell Sarcoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Clear Cell Sarcoma from cBioPortal. The patients enrolled in the studies for Clear Cell Sarcoma are in ages between 14 to 14 with an average age of 14. 59.3% of males and 40.7% of females were the distribution of gender in these clinical studies. From a patient sample size of 27; the top genes with mutations and other abnormalities for Clear Cell Sarcoma include genes TERT, TP53, FUS, IRS2 and NRAS. The occurrence frequency distribution for these genes respectively is 25.0%, 12.5%, 12.5%, 12.5% and 12.5%. These tumor genetic details of Clear Cell Sarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Clear Cell Sarcoma.
Significance of Nutrition for Clear Cell Sarcoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Clear Cell Sarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Sapota includes active ingredients Beta-sitosterol, Linolenic Acid, Lycopene, Vitamin C, Oleic Acid and others. And Graviola contains active ingredients Emodin, Vitamin E, Fisetin, Beta-sitosterol, Lycopene and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Clear Cell Sarcoma, activation or inhibition of selected biochemical pathways like Cell Cycle Checkpoints, Apoptosis, MAPK Signaling, Chromatin Remodeling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Clear Cell Sarcoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR CLEAR CELL SARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Clear Cell Sarcoma undergoing chemotherapy treatment
In Clear Cell Sarcoma – the genes TERT, TP53, FUS, IRS2 and NRAS have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Clear Cell Sarcoma are Cell Cycle Checkpoints and others. Ifosfamide is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle Checkpoints so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Soy Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Soy Bean are Vitamin E, Lupeol, Fisetin, Linolenic Acid, Beta-sitosterol and others.
Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints. And so on.
When treating Clear Cell Sarcoma with chemotherapy Ifosfamide – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Aescin and Folic Acid in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR CLEAR CELL SARCOMA ON TREATMENT WITH CHEMOTHERAPY IFOSFAMIDE FOR SOME CONDITIONS.
Eat more vegetables, Rhubarb or Radish?
Vegetables are an important part of many diets. The active ingredients contained in Rhubarb are Emodin, Rhein, Vitamin E, Chrysophanol, Linolenic Acid among others. While the active ingredients contained in Radish are Beta-sitosterol, Linolenic Acid, P-coumaric Acid, Vitamin C, Oleic Acid and others.
Vitamin K can manipulate biochemical pathways Cell Cycle Checkpoints. Emodin has biological action on biochemical pathways Cell Cycle Checkpoints.
Pelargonidin can manipulate biochemical pathways Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints. And so on.
When treating Clear Cell Sarcoma with chemotherapy Ifosfamide – Foods like Rhubarb are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin K and Emodin contained in Rhubarb support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: RHUBARB IS RECOMMENDED OVER RADISH FOR CLEAR CELL SARCOMA ON TREATMENT WITH CHEMOTHERAPY IFOSFAMIDE FOR SOME CONDITIONS.
Eat more fruits, Graviola or Sapota?
Fruits are an important part of many diets. The active ingredients contained in Graviola are Emodin, Vitamin E, Fisetin, Beta-sitosterol, Lycopene among others. While the active ingredients contained in Sapota are Beta-sitosterol, Linolenic Acid, Lycopene, Vitamin C, Oleic Acid and others.
Emodin can manipulate biochemical pathways Cell Cycle Checkpoints. Fisetin has biological action on biochemical pathways Cell Cycle Checkpoints.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints. And so on.
When treating Clear Cell Sarcoma with chemotherapy Ifosfamide – Foods like Graviola are recommended compared to Sapota. This is because the active ingredients Aescin and Folic Acid in Sapota interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Emodin and Fisetin contained in Graviola support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: GRAVIOLA IS RECOMMENDED OVER SAPOTA FOR CLEAR CELL SARCOMA ON TREATMENT WITH CHEMOTHERAPY IFOSFAMIDE FOR SOME CONDITIONS.
Eat more nuts, Hazelnut or Macadamia Nut?
Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Vitamin E, Linolenic Acid, Oleic Acid, Quercetin, Linoleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Folic Acid, Myristic Acid and others.
Vitamin E can manipulate biochemical pathways Cell Cycle Checkpoints. Quercetin has biological action on biochemical pathways Cell Cycle Checkpoints.
Myristic Acid can manipulate biochemical pathways Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints. And so on.
When treating Clear Cell Sarcoma with chemotherapy Ifosfamide – Foods like Hazelnut are recommended compared to Macadamia Nut. This is because the active ingredients Myristic Acid and Folic Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Quercetin contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER MACADAMIA NUT FOR CLEAR CELL SARCOMA ON TREATMENT WITH CHEMOTHERAPY IFOSFAMIDE FOR SOME CONDITIONS.
Foods for Genetic Risk of Clear Cell Sarcoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. FUS and IRS2 are two genes whose abnormalities are risk factors for Clear Cell Sarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Clear Cell Sarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Clear Cell Sarcoma gene FUS has causative impact on biological pathways like mRNA Splicing. And IRS2 has a causative impact on biological pathways like Nutrient sensing, cGMP Signaling and Growth Factor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like FUS and IRS2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes FUS and IRS2 should be avoided.
Eat more pulses, Scarlet Bean or Lima Bean?
The active ingredients contained in Scarlet Bean are Oleic Acid, Linolenic Acid, Vitamin C, Stigmasterol, Beta-sitosterol among others. While the active ingredients contained in Lima Bean are Oleic Acid, Vitamin C, Genistein, Linoleic Acid, Vitamin A and others.
Vitamin C can manipulate biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling. Stigmasterol has biological action on biochemical pathways JAK-STAT Signaling, Cell Cycle Checkpoints and MAPK Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways FOXO Signaling. And so on.
For genetic risk of Clear Cell Sarcoma due to abnormalities in genes FUS and IRS2 – Foods like Scarlet Bean are recommended compared to Lima Bean. This is because the active ingredients Vitamin A and Linoleic Acid in Lima Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Stigmasterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER LIMA BEAN FOR REDUCING THE GENETIC RISK OF CLEAR CELL SARCOMA DUE TO GENES FUS AND IRS2
Eat more vegetables, Artichoke or Bamboo?
The active ingredients contained in Artichoke are Apigenin, Luteolin, Vitamin C, Chlorogenic Acid, Naringenin among others. While the active ingredients contained in Bamboo are Oleic Acid, Protocatechuic Acid, Linolenic Acid, Tricin, Vitamin C and others.
Vitamin K can manipulate biochemical pathways Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Apigenin has biological action on biochemical pathways DNA Repair, JAK-STAT Signaling and MAPK Signaling.
Ferulic Acid can manipulate biochemical pathways DNA Repair. Caffeic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Clear Cell Sarcoma due to abnormalities in genes FUS and IRS2 – Foods like Artichoke are recommended compared to Bamboo. This is because the active ingredients Ferulic Acid and Caffeic Acid in Bamboo further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin K and Apigenin contained in Artichoke together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARTICHOKE IS RECOMMENDED OVER BAMBOO FOR REDUCING THE GENETIC RISK OF CLEAR CELL SARCOMA DUE TO GENES FUS AND IRS2
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Partridgeberry or Roselle?
The active ingredients contained in Partridgeberry are Resveratrol, Stigmasterol, Beta-sitosterol among others. While the active ingredients contained in Roselle are Oleic Acid, Vitamin E, Linolenic Acid, Vitamin C, Stigmasterol and others.
Resveratrol can manipulate biochemical pathways Hippo Signaling, DNA Repair and JAK-STAT Signaling. Stigmasterol has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways FOXO Signaling. And so on.
For genetic risk of Clear Cell Sarcoma due to abnormalities in genes FUS and IRS2 – Foods like Partridgeberry are recommended compared to Roselle. This is because the active ingredients Vitamin A and Linoleic Acid in Roselle further promote the effects of genes on the biochemical pathways. While the active ingredients Resveratrol and Stigmasterol contained in Partridgeberry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER ROSELLE FOR REDUCING THE GENETIC RISK OF CLEAR CELL SARCOMA DUE TO GENES FUS AND IRS2
Eat more nuts, Pine Nut or Peanut?
The active ingredients contained in Pine Nut are Oleic Acid, Vitamin E, Linolenic Acid, Beta-sitosterol, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Oleic Acid, Vitamin E, Linolenic Acid, Vitamin C and others.
Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Lecithin has biological action on biochemical pathways JAK-STAT Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Clear Cell Sarcoma due to abnormalities in genes FUS and IRS2 – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF CLEAR CELL SARCOMA DUE TO GENES FUS AND IRS2
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Clear Cell Sarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Mixed Kunga Msk 2022
- Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Research progress on the anticancer effects of vitamin K2.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- Saturated fatty acids modulate cell response to DNA damage: implication for their role in tumorigenesis.
- Stigmasterol isolated from marine microalgae Navicula incerta induces apoptosis in human hepatoma HepG2 cells.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Role of FoxO1 in FFA-induced oxidative stress in adipocytes.
- Spongiapyridine and related spongians isolated from an Indonesian Spongia sp.
- Legionella pneumophila serogroup 12 pneumonia in a renal transplant recipient: case report and environmental observations.
- Caffeic acid phenethyl ester suppresses androgen receptor signaling and stability via inhibition of phosphorylation on Ser81 and Ser213.
- Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Resveratrol, pterostilbene, and piceatannol in vaccinium berries.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.