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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Chondroblastoma?

Aug 8, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Chondroblastoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Chondroblastoma because of GABRR2 and CDH5 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Chondroblastoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Cherry” or “Include fruit Saskatoon Berry in my diet” or “Should I reduce consumption of vegetable Bottle Gourd” or “Can I take Green Tea and Cissus supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO CHONDROBLASTOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Chondroblastoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR CHONDROBLASTOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Chondroblastoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Chondroblastoma from cBioPortal. 87.5% of males and 12.5% of females were the distribution of gender in these clinical studies. From a patient sample size of 8; the top genes with mutations and other abnormalities for Chondroblastoma include genes GABRR2, CDH5, MET, JAG1 and MATK. The occurrence frequency distribution for these genes respectively is 12.5%, 12.5%, 12.5%, 12.5% and 12.5%. These tumor genetic details of Chondroblastoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Chondroblastoma.

Significance of Nutrition for Chondroblastoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Chondroblastoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Cherry includes active ingredients Quercetin, Beta-sitosterol, Chlorogenic Acid, Isorhamnetin, Vitamin C and others. And Saskatoon Berry contains active ingredients Quercetin, Delphinidin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Chondroblastoma, activation or inhibition of selected biochemical pathways like Extracellular Matrix Remodelling, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, Notch Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Chondroblastoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR CHONDROBLASTOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Chondroblastoma undergoing chemotherapy treatment

In Chondroblastoma – the genes GABRR2, CDH5, MET, JAG1 and MATK have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Chondroblastoma are Extracellular Matrix Remodelling, Growth Factor Signaling, Epithelial to Mesenchymal Transition and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Extracellular Matrix Remodelling, Growth Factor Signaling, Epithelial to Mesenchymal Transition so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Mung Bean or Lima Bean?

Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Glucaric Acid, Linolenic Acid, Genistein among others. While the active ingredients contained in Lima Bean are Vitamin C, Genistein, Oleic Acid, Vitamin A, Linoleic Acid and others.

Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Chondroblastoma with chemotherapy Radiation – Foods like Mung Bean are recommended compared to Lima Bean. This is because the active ingredients Vitamin A and Oleic Acid in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin C contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER LIMA BEAN FOR CHONDROBLASTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Arrowroot or Bottle Gourd?

Vegetables are an important part of many diets. The active ingredients contained in Arrowroot are Quercetin, Chlorogenic Acid, Vanillic Acid, Vitamin C, Protocatechuic Acid among others. While the active ingredients contained in Bottle Gourd are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A and others.

Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. Chlorogenic Acid has biological action on biochemical pathways Extracellular Matrix Remodelling, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Chondroblastoma with chemotherapy Radiation – Foods like Arrowroot are recommended compared to Bottle Gourd. This is because the active ingredients Vitamin A and Oleic Acid in Bottle Gourd interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Chlorogenic Acid contained in Arrowroot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER BOTTLE GOURD FOR CHONDROBLASTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Which Foods are Recommended for Chondroblastoma?

Eat more fruits, Saskatoon Berry or Cherry?

Fruits are an important part of many diets. The active ingredients contained in Saskatoon Berry are Quercetin, Delphinidin among others. While the active ingredients contained in Cherry are Quercetin, Beta-sitosterol, Chlorogenic Acid, Isorhamnetin, Vitamin C and others.

Delphinidin can manipulate biochemical pathways Growth Factor Signaling, PI3K-AKT-MTOR Signaling and Extracellular Matrix Remodelling. Quercetin has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Growth Factor Signaling and PI3K-AKT-MTOR Signaling.

Shikimic Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Pelargonidin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

When treating Chondroblastoma with chemotherapy Radiation – Foods like Saskatoon Berry are recommended compared to Cherry. This is because the active ingredients Shikimic Acid and Pelargonidin in Cherry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Delphinidin and Quercetin contained in Saskatoon Berry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SASKATOON BERRY IS RECOMMENDED OVER CHERRY FOR CHONDROBLASTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Almond or Pumpkin Seeds?

Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Beta-sitosterol, Vitamin E, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Pumpkin Seeds are Beta-sitosterol, Cucurbitacin I, Gamma-linolenic Acid, Linolenic Acid, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways Growth Factor Signaling, Extracellular Matrix Remodelling and Epithelial to Mesenchymal Transition.

Lecithin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Chondroblastoma with chemotherapy Radiation – Foods like Almond are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Oleic Acid in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER PUMPKIN SEEDS FOR CHONDROBLASTOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Chondroblastoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. GABRR2 and CDH5 are two genes whose abnormalities are risk factors for Chondroblastoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Chondroblastoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Chondroblastoma gene GABRR2 has causative impact on biological pathways like Cannabinoid receptor Signaling. And CDH5 has a causative impact on biological pathways like Epithelial to Mesenchymal Transition. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like GABRR2 and CDH5 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes GABRR2 and CDH5 should be avoided.

Eat more pulses, Fava Bean or Common Bean?

The active ingredients contained in Fava Bean are Quercetin, Butein, Caffeic Acid, Daidzein, Beta-sitosterol among others. While the active ingredients contained in Common Bean are Delphinidin, Ferulic Acid, Vitamin C, Gamma-linolenic Acid, Linolenic Acid and others.

Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. Butein has biological action on biochemical pathways Extracellular Matrix Remodelling, RUNX Signaling and Epithelial to Mesenchymal Transition.

Vitamin A can manipulate biochemical pathways Extracellular Matrix Remodelling. Apigenin has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

For genetic risk of Chondroblastoma due to abnormalities in genes GABRR2 and CDH5 – Foods like Fava Bean are recommended compared to Common Bean. This is because the active ingredients Vitamin A and Apigenin in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Butein contained in Fava Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FAVA BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF CHONDROBLASTOMA DUE TO GENES GABRR2 AND CDH5

Eat more vegetables, Cabbage or Squash?

The active ingredients contained in Cabbage are Quercetin, Benzyl Isothiocyanate, Sulforaphane, Delphinidin, Beta-sitosterol among others. While the active ingredients contained in Squash are Ellagic Acid, Beta-sitosterol, Vitamin E, Vitamin C, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling. Glucaric Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling.

Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Vitamin A has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.

For genetic risk of Chondroblastoma due to abnormalities in genes GABRR2 and CDH5 – Foods like Cabbage are recommended compared to Squash. This is because the active ingredients Ellagic Acid and Vitamin A in Squash further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CABBAGE IS RECOMMENDED OVER SQUASH FOR REDUCING THE GENETIC RISK OF CHONDROBLASTOMA DUE TO GENES GABRR2 AND CDH5

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Rowanberry or Strawberry?

The active ingredients contained in Rowanberry are Quercetin, Chlorogenic Acid among others. While the active ingredients contained in Strawberry are Ellagic Acid, Beta-sitosterol, Lupeol, Vitamin C, Linolenic Acid and others.

Chlorogenic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, RUNX Signaling and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways Growth Factor Signaling, Extracellular Matrix Remodelling and Epithelial to Mesenchymal Transition.

Fisetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Ellagic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

For genetic risk of Chondroblastoma due to abnormalities in genes GABRR2 and CDH5 – Foods like Rowanberry are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients Chlorogenic Acid and Quercetin contained in Rowanberry together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ROWANBERRY IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF CHONDROBLASTOMA DUE TO GENES GABRR2 AND CDH5

Eat more nuts, Peanut or Macadamia Nut?

The active ingredients contained in Peanut are Quercetin, Beta-sitosterol, Ferulic Acid, Rhamnetin, Vitamin E among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Lauric Acid, Folic Acid, Palmitic Acid, Myristic Acid and others.

Quercetin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways RUNX Signaling, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling.

Lauric Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Palmitic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Growth Factor Signaling and Extracellular Matrix Remodelling. And so on.

For genetic risk of Chondroblastoma due to abnormalities in genes GABRR2 and CDH5 – Foods like Peanut are recommended compared to Macadamia Nut. This is because the active ingredients Lauric Acid and Palmitic Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Beta-sitosterol contained in Peanut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: PEANUT IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF CHONDROBLASTOMA DUE TO GENES GABRR2 AND CDH5


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Chondroblastoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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