Foods for Chondroblastoma!

Introduction

Foods for Chondroblastoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Chondroblastoma is a rare type of benign bone tumor that primarily affects young individuals. It is characterized by distinct features visible in radiology and detailed in pathology outlines. The tumor commonly occurs in the epiphyses of long bones, with frequent sites including the femur, knee, humerus, and hip. Chondroblastoma of the foot is less common but can occur.

Radiologically, chondroblastoma presents unique features that help in differentiating it from other bone lesions. The tumor typically appears as a lytic lesion, often with well-defined edges and possible calcification. In diagnosing chondroblastoma, radiological assessment is crucial to distinguish it from other similar conditions like chondrosarcoma and osteochondroma.

Treatment for chondroblastoma usually involves surgery, which can range from curettage (scraping the tumor out of the bone) to more extensive procedures, depending on the tumor’s size and location. In some cases, adjuvant therapies like cryotherapy may be used during surgery to minimize recurrence. The role of non-surgical treatments, such as chemotherapy, is limited due to the benign nature of the tumor.

Symptoms of chondroblastoma include pain, swelling, and limited joint movement, depending on the tumor’s location. Orthopedic resources like OrthoBullets provide comprehensive information about the clinical presentation, diagnosis, and management of chondroblastoma, making them valuable for both practitioners and students.

The prognosis for chondroblastoma is generally good, especially when diagnosed early and treated appropriately. However, the possibility of recurrence, especially in larger or aggressively treated tumors, necessitates regular follow-up and monitoring after treatment.

For Chondroblastoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Chondroblastoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Chondroblastoma?

For example does it matter if vegetable Brussel Sprouts is consumed more compared to Broccoli? Does it make any difference if fruit Pummelo is preferred over Rabbiteye Blueberry? Also if similar choices are made for nuts/seeds like Japanese Walnut over European Chestnut and for pulses like Broad Bean over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Chondroblastoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Chondroblastoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Quercetin, Curcumin, Delphinidin, Caffeic Acid, Lycopene. And Rabbiteye Blueberry contains active ingredients Quercetin, Eugenol, Linalool, Ferulic Acid, Gallic Acid and possibly others.

A common mistake made when deciding and choosing foods to eat for Chondroblastoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Chondroblastoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Chondroblastoma?

Personalized nutrition for cancers like Chondroblastoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Chondroblastoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Characteristics of cancers like Chondroblastoma

All cancers like Chondroblastoma can be characterized by a unique set of biochemical pathways – the signature pathways of Chondroblastoma. Biochemical pathways like Extracellular Matrix Remodelling, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, Notch Signaling are part of the signature definition of Chondroblastoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Chondroblastoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Chondroblastoma when taking cancer treatment Radiation, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

GABRR2, CDH5, MET, JAG1 and MATK are the top ranked reported genes for Chondroblastoma. GABRR2 is reported in 12.5 % of the representative patients across all clinical trials. And CDH5 is reported in 12.5 %. The combined population patient data cover ages from to . 87.5 % of the patient data are identified as men. The Chondroblastoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Food and Supplements for Chondroblastoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable BRUSSEL SPROUTS or BROCCOLI?

Vegetable Brussel Sprouts contains many active ingredients or bioactives such as Sulforaphane, Curcumin, Delphinidin, Isoliquiritigenin, Daidzein. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Brussel Sprouts is recommended for Chondroblastoma when ongoing cancer treatment is Radiation. This is because Brussel Sprouts modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in vegetable Broccoli are Quercetin, Alpha Lipoic Acid, Resveratrol, Sulforaphane, Curcumin. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling and PI3K-AKT-MTOR Signaling and others. Broccoli is not recommended for Chondroblastoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE BRUSSEL SPROUTS IS RECOMMENDED OVER BROCCOLI FOR Chondroblastoma AND TREATMENT Radiation.

Choose Fruit RABBITEYE BLUEBERRY or PUMMELO?

Fruit Rabbiteye Blueberry contains many active ingredients or bioactives such as Quercetin, Eugenol, Linalool, Ferulic Acid, Gallic Acid. These active ingredients manipulate various biochemical pathways like Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Rabbiteye Blueberry is recommended for Chondroblastoma when ongoing cancer treatment is Radiation. This is because Rabbiteye Blueberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Curcumin, Delphinidin, Caffeic Acid, Lycopene. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and Epithelial to Mesenchymal Transition and others. Pummelo is not recommended for Chondroblastoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT RABBITEYE BLUEBERRY IS RECOMMENDED OVER PUMMELO FOR Chondroblastoma AND TREATMENT Radiation.

Choose Nut JAPANESE WALNUT or EUROPEAN CHESTNUT?

Japanese Walnut contains many active ingredients or bioactives such as Ellagic Acid, Myricetin, Curcumin, Delphinidin, Caffeic Acid. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Japanese Walnut is recommended for Chondroblastoma when ongoing cancer treatment is Radiation. This is because Japanese Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Radiation.

Some of the active ingredients or bioactives in European Chestnut are Quercetin, Ellagic Acid, Myricetin, Curcumin, Delphinidin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and Epithelial to Mesenchymal Transition and others. European Chestnut is not recommended for Chondroblastoma when ongoing cancer treatment is Radiation because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

JAPANESE WALNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Chondroblastoma AND TREATMENT Radiation.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Chondroblastoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or TURNIP?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Lycopene, Delphinidin, Lupeol. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints, Epithelial to Mesenchymal Transition and Cytoskeletal Dynamics and others. Giant Butterbur is recommended for risk of Chondroblastoma when associated genetic risk is CDH5. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Turnip are Quercetin, Ellagic Acid, Curcumin, Delphinidin, Lupeol. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling, PI3K-AKT-MTOR Signaling and MYC Signaling and others. Turnip is not recommended when risk of Chondroblastoma when associated genetic risk is CDH5 because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER TURNIP FOR CDH5 GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or SAPODILLA?

Fruit Red Raspberry contains many active ingredients or bioactives such as Quercetin, Ellagic Acid, Curcumin, Delphinidin, Lupeol. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling, Epithelial to Mesenchymal Transition, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling and others. Red Raspberry is recommended for risk of Chondroblastoma when associated genetic risk is CDH5. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Sapodilla are Curcumin, Apigenin, Lycopene, Delphinidin, Lupeol. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Sapodilla is not recommended when risk of Chondroblastoma when associated genetic risk is CDH5 because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER SAPODILLA FOR CDH5 GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or CHESTNUT?

Butternut contains many active ingredients or bioactives such as Curcumin, Apigenin, Lycopene, Delphinidin, Lupeol. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, RAS-RAF Signaling, Epithelial to Mesenchymal Transition and Adherens junction and others. Butternut is recommended for risk of Chondroblastoma when associated genetic risk is CDH5. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Ellagic Acid, Curcumin, Apigenin, Lycopene, Delphinidin. These active ingredients manipulate various biochemical pathways like Extracellular Matrix Remodelling, Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling and others. Chestnut is not recommended when risk of Chondroblastoma when associated genetic risk is CDH5 because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER CHESTNUT FOR CDH5 GENETIC RISK OF CANCER.

In Conclusion

Foods and Supplements chosen are important decisions for cancers like Chondroblastoma. Chondroblastoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Chondroblastoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Brussel Sprouts contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Chondroblastoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.

References

• Msk Impact 2017
• Pan-cancer analysis of whole genomes.
• Myricetin suppresses p21-activated kinase 1 in human breast cancer MCF-7 cells through downstream signaling of the β-catenin pathway.
• Gallic acid, a phenolic compound, exerts anti-angiogenic effects via the PTEN/AKT/HIF-1α/VEGF signaling pathway in ovarian cancer cells.
• Sulforaphane induces apoptosis in rhabdomyosarcoma and restores TRAIL-sensitivity in the aggressive alveolar subtype leading to tumor elimination in mice.
• Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade.
• Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
• Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines.
• https://www.ncbi.nlm.nih.gov/books/NBK536947
• https://my.clevelandclinic.org/health/diseases/22095-chondroblastoma