Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Breast Mixed Ductal And Lobular Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Breast Mixed Ductal And Lobular Carcinoma because of MAP3K1 and AKAP9 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Breast Mixed Ductal And Lobular Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Pummelo” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Spinach” or “Can I take Dim and Alpha Lipoic Acid supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO BREAST MIXED DUCTAL AND LOBULAR CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Breast Mixed Ductal And Lobular Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR BREAST MIXED DUCTAL AND LOBULAR CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Breast Mixed Ductal And Lobular Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Breast Mixed Ductal And Lobular Carcinoma from cBioPortal. The patients enrolled in the studies for Breast Mixed Ductal And Lobular Carcinoma are in ages between 34 to 87 with an average age of 61. 0.4% of males and 99.6% of females were the distribution of gender in these clinical studies. From a patient sample size of 510; the top genes with mutations and other abnormalities for Breast Mixed Ductal And Lobular Carcinoma include genes MAP3K1, AKAP9, NF1, AKT1 and LAMA2. The occurrence frequency distribution for these genes respectively is 8.6%, 3.5%, 3.0%, 3.0% and 3.0%. These tumor genetic details of Breast Mixed Ductal And Lobular Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Breast Mixed Ductal And Lobular Carcinoma.
Significance of Nutrition for Breast Mixed Ductal And Lobular Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Breast Mixed Ductal And Lobular Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Pummelo includes active ingredients Beta-sitosterol, Chlorogenic Acid, Naringin, Hesperetin, Linolenic Acid and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Breast Mixed Ductal And Lobular Carcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, MAPK Signaling, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Breast Mixed Ductal And Lobular Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR BREAST MIXED DUCTAL AND LOBULAR CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Breast Mixed Ductal And Lobular Carcinoma undergoing chemotherapy treatment
In Breast Mixed Ductal And Lobular Carcinoma – the genes MAP3K1, AKAP9, NF1, AKT1 and LAMA2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Breast Mixed Ductal And Lobular Carcinoma are RAS-RAF Signaling, mRNA Splicing, Cell Cycle and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, mRNA Splicing, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Lima Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Beta-sitosterol, Lupeol, Daidzein, Kaempferol, Genistein among others. While the active ingredients contained in Lima Bean are Genistein, Vitamin C, Oleic Acid, Linoleic Acid, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling.
Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Vitamin A has biological action on biochemical pathways Extracellular Matrix Remodelling, TGFB Signaling and Notch Signaling. And so on.
When treating Breast Mixed Ductal And Lobular Carcinoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Lima Bean. This is because the active ingredients Genistein and Vitamin A in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LIMA BEAN FOR BREAST MIXED DUCTAL AND LOBULAR CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Jicama or Spinach?
Vegetables are an important part of many diets. The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Spinach are Quercetin, Apigenin, Beta-sitosterol, Kaempferol, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Cell Cycle and MYC Signaling. Beta-carotene has biological action on biochemical pathways NFKB Signaling, Microtubule Dynamics and DNA Repair.
Apigenin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, DNA Repair and TGFB Signaling. Quercetin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Breast Mixed Ductal And Lobular Carcinoma with chemotherapy Radiation – Foods like Jicama are recommended compared to Spinach. This is because the active ingredients Apigenin and Quercetin in Spinach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-carotene contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER SPINACH FOR BREAST MIXED DUCTAL AND LOBULAR CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Partridgeberry or Pummelo?
Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Pummelo are Beta-sitosterol, Chlorogenic Acid, Naringin, Hesperetin, Linolenic Acid and others.
Resveratrol can manipulate biochemical pathways NFKB Signaling, Microtubule Dynamics and JAK-STAT Signaling. Beta-sitosterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Glucocorticoid Signaling and Oxidative Stress.
Naringin can manipulate biochemical pathways Oxidative Stress. Naringenin has biological action on biochemical pathways Heat Stress Response, DNA Repair and Oxidative Stress. And so on.
When treating Breast Mixed Ductal And Lobular Carcinoma with chemotherapy Radiation – Foods like Partridgeberry are recommended compared to Pummelo. This is because the active ingredients Naringin and Naringenin in Pummelo interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER PUMMELO FOR BREAST MIXED DUCTAL AND LOBULAR CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Macadamia Nut?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle, MYC Signaling and PI3K-AKT-MTOR Signaling.
Palmitic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and mRNA Splicing. Lauric Acid has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Breast Mixed Ductal And Lobular Carcinoma with chemotherapy Radiation – Foods like Pine Nut are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER MACADAMIA NUT FOR BREAST MIXED DUCTAL AND LOBULAR CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Breast Mixed Ductal And Lobular Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. MAP3K1 and AKAP9 are two genes whose abnormalities are risk factors for Breast Mixed Ductal And Lobular Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Breast Mixed Ductal And Lobular Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Breast Mixed Ductal And Lobular Carcinoma gene MAP3K1 has causative impact on biological pathways like MAPK Signaling, Angiogenesis and Growth Factor Signaling. And AKAP9 has a causative impact on biological pathways like MAPK Signaling, MAPK Signaling and Cell Cycle. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like MAP3K1 and AKAP9 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes MAP3K1 and AKAP9 should be avoided.
Eat more pulses, Mung Bean or Common Bean?
The active ingredients contained in Mung Bean are Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol, Linoleic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Linolenic Acid, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Stigmasterol has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and MAPK Signaling. And so on.
For genetic risk of Breast Mixed Ductal And Lobular Carcinoma due to abnormalities in genes MAP3K1 and AKAP9 – Foods like Mung Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Stigmasterol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF BREAST MIXED DUCTAL AND LOBULAR CARCINOMA DUE TO GENES MAP3K1 AND AKAP9
Eat more vegetables, Giant Butterbur or Parsnip?
The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Vitamin A among others. While the active ingredients contained in Parsnip are Vitamin C, Linolenic Acid, Oleic Acid, P-coumaric Acid, Bergapten and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Imperatorin can manipulate biochemical pathways Small Molecule Transport. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Breast Mixed Ductal And Lobular Carcinoma due to abnormalities in genes MAP3K1 and AKAP9 – Foods like Giant Butterbur are recommended compared to Parsnip. This is because the active ingredients Imperatorin and Folic Acid in Parsnip further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER PARSNIP FOR REDUCING THE GENETIC RISK OF BREAST MIXED DUCTAL AND LOBULAR CARCINOMA DUE TO GENES MAP3K1 AND AKAP9
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Lemon?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Lemon are Diosmetin, Hesperidin, Vitamin C, Oleic Acid, D-limonene and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Myrcene can manipulate biochemical pathways Small Molecule Transport. Syringin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Breast Mixed Ductal And Lobular Carcinoma due to abnormalities in genes MAP3K1 and AKAP9 – Foods like Feijoa are recommended compared to Lemon. This is because the active ingredients Myrcene and Syringin in Lemon further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER LEMON FOR REDUCING THE GENETIC RISK OF BREAST MIXED DUCTAL AND LOBULAR CARCINOMA DUE TO GENES MAP3K1 AND AKAP9
Eat more nuts, Pecan Nut or Peanut?
The active ingredients contained in Pecan Nut are Vitamin E, Cianidanol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin E, Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid and others.
Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Cianidanol has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Breast Mixed Ductal And Lobular Carcinoma due to abnormalities in genes MAP3K1 and AKAP9 – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF BREAST MIXED DUCTAL AND LOBULAR CARCINOMA DUE TO GENES MAP3K1 AND AKAP9
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Breast Mixed Ductal And Lobular Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Brca Mapk Hp Msk 2021
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- Adhesion to the extracellular matrix is positively regulated by retinoic acid in HepG2 cells.
- Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition.
- The citrus flavonoid naringenin stimulates DNA repair in prostate cancer cells.
- β-Carotene inhibits neuroblastoma cell invasion and metastasis in vitro and in vivo by decreasing level of hypoxia-inducible factor-1α.
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- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- The impact of patients’ severity of illness and age on nursing workload.
- Syringin prevents bone loss in ovariectomized mice via TRAF6 mediated inhibition of NF-κB and stimulation of PI3K/AKT.
- Osthole or imperatorin-mediated facilitation of glutamate release is associated with a synaptic vesicle mobilization in rat hippocampal glutamatergic nerve endings.
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- Resveratrol, pterostilbene, and piceatannol in vaccinium berries.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.