Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Atypical Lung Carcinoid when undergoing chemotherapy or when you determine you have a genetic risk for developing Atypical Lung Carcinoid because of PPM1D and ASXL1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Atypical Lung Carcinoid which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Date” or “Include fruit Lemon in my diet” or “Should I reduce consumption of vegetable Beetroot” or “Can I take Curcumin and Cissus supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ATYPICAL LUNG CARCINOID, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Atypical Lung Carcinoid is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR ATYPICAL LUNG CARCINOID, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Atypical Lung Carcinoid
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Atypical Lung Carcinoid from cBioPortal. The patients enrolled in the studies for Atypical Lung Carcinoid are in ages between 11 to 93 with an average age of 67. 42.0% of males and 58.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 3571; the top genes with mutations and other abnormalities for Atypical Lung Carcinoid include genes DNMT3A, TET2, PPM1D, ASXL1 and TP53. The occurrence frequency distribution for these genes respectively is 40.2%, 12.4%, 7.1%, 6.9% and 3.6%. These tumor genetic details of Atypical Lung Carcinoid are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Atypical Lung Carcinoid.
Significance of Nutrition for Atypical Lung Carcinoid
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Atypical Lung Carcinoid. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Date includes active ingredients Quercetin, Apigenin, Lupeol, Beta-sitosterol, Ferulic Acid and others. And Lemon contains active ingredients D-limonene, Modified Citrus Pectin, Vitamin C, Auraptene, Oleic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Atypical Lung Carcinoid, activation or inhibition of selected biochemical pathways like Cell Cycle, MAPK Signaling, Oncogenic Cancer Epigenetics, DNA Repair plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Atypical Lung Carcinoid, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ATYPICAL LUNG CARCINOID – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Atypical Lung Carcinoid undergoing chemotherapy treatment
In Atypical Lung Carcinoid – the genes DNMT3A, TET2, PPM1D, ASXL1 and TP53 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Atypical Lung Carcinoid are Cell Cycle, MAPK Signaling, PI3K-AKT-MTOR Signaling and others. Lanreotide is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, MAPK Signaling, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Fava Bean?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Genistein, Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Fava Bean are Quercetin, Daidzein, Butein, Genistein, Beta-sitosterol and others.
Genistein can manipulate biochemical pathways Growth Factor Signaling, Cell Cycle and WNT Beta Catenin Signaling. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and Angiogenesis.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Epicatechin has biological action on biochemical pathways Angiogenesis. And so on.
When treating Atypical Lung Carcinoid with chemotherapy Lanreotide – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Vitamin A and Epicatechin in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Genistein and Beta-sitosterol contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR ATYPICAL LUNG CARCINOID ON TREATMENT WITH CHEMOTHERAPY LANREOTIDE FOR SOME CONDITIONS.
Eat more vegetables, Jicama or Beetroot?
Vegetables are an important part of many diets. The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin A, Vitamin B3, Folic Acid among others. While the active ingredients contained in Beetroot are Vitamin E, Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Growth Factor Signaling, Cell Cycle and WNT Beta Catenin Signaling. Beta-carotene has biological action on biochemical pathways Oncogenic Cancer Epigenetics, Angiogenesis and WNT Beta Catenin Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling and Angiogenesis. And so on.
When treating Atypical Lung Carcinoid with chemotherapy Lanreotide – Foods like Jicama are recommended compared to Beetroot. This is because the active ingredients Vitamin A and Linoleic Acid in Beetroot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-carotene contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER BEETROOT FOR ATYPICAL LUNG CARCINOID ON TREATMENT WITH CHEMOTHERAPY LANREOTIDE FOR SOME CONDITIONS.
Eat more fruits, Lemon or Date?
Fruits are an important part of many diets. The active ingredients contained in Lemon are D-limonene, Modified Citrus Pectin, Vitamin C, Auraptene, Oleic Acid among others. While the active ingredients contained in Date are Quercetin, Apigenin, Lupeol, Beta-sitosterol, Ferulic Acid and others.
D-limonene can manipulate biochemical pathways Growth Factor Signaling, Cell Cycle and MAPK Signaling. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Apigenin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Atypical Lung Carcinoid with chemotherapy Lanreotide – Foods like Lemon are recommended compared to Date. This is because the active ingredients Apigenin and Vitamin A in Date interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients D-limonene and Vitamin C contained in Lemon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: LEMON IS RECOMMENDED OVER DATE FOR ATYPICAL LUNG CARCINOID ON TREATMENT WITH CHEMOTHERAPY LANREOTIDE FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Delphinidin, Oleic Acid, Linolenic Acid, Cianidanol among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Folic Acid, Lecithin and others.
Vitamin E can manipulate biochemical pathways Growth Factor Signaling, Cell Cycle and MAPK Signaling. Delphinidin has biological action on biochemical pathways Angiogenesis, PI3K-AKT-MTOR Signaling and Growth Factor Signaling.
Lecithin can manipulate biochemical pathways Angiogenesis, MAPK Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Atypical Lung Carcinoid with chemotherapy Lanreotide – Foods like Pecan Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Delphinidin contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER BRAZIL NUT FOR ATYPICAL LUNG CARCINOID ON TREATMENT WITH CHEMOTHERAPY LANREOTIDE FOR SOME CONDITIONS.
Foods for Genetic Risk of Atypical Lung Carcinoid
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. PPM1D and ASXL1 are two genes whose abnormalities are risk factors for Atypical Lung Carcinoid. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Atypical Lung Carcinoid can be used as a guide for coming up with a recommended personalized nutrition plan. For Atypical Lung Carcinoid gene PPM1D has causative impact on biological pathways like DNA Repair. And ASXL1 has a causative impact on biological pathways like Oncogenic Cancer Epigenetics and Suppressive Histone Methylation. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like PPM1D and ASXL1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes PPM1D and ASXL1 should be avoided.
Eat more pulses, Mung Bean or Common Bean?
The active ingredients contained in Mung Bean are Vitamin C, Stigmasterol, Linolenic Acid, Quercetin, Vitexin among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Linolenic Acid, Ferulic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Suppressive Histone Methylation and MYC Signaling. Stigmasterol has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and Apoptosis.
Pelargonidin can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Atypical Lung Carcinoid due to abnormalities in genes PPM1D and ASXL1 – Foods like Mung Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Stigmasterol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF ATYPICAL LUNG CARCINOID DUE TO GENES PPM1D AND ASXL1
Eat more vegetables, Cassava or Heart Of Palm?
The active ingredients contained in Cassava are Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Heart Of Palm are Vitamin C, Palmitic Acid, Vitamin A, Folic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Suppressive Histone Methylation and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, Cell Cycle Checkpoints and Apoptosis.
Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics and mRNA Splicing. Folic Acid has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.
For genetic risk of Atypical Lung Carcinoid due to abnormalities in genes PPM1D and ASXL1 – Foods like Cassava are recommended compared to Heart Of Palm. This is because the active ingredients Palmitic Acid and Folic Acid in Heart Of Palm further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER HEART OF PALM FOR REDUCING THE GENETIC RISK OF ATYPICAL LUNG CARCINOID DUE TO GENES PPM1D AND ASXL1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Graviola?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Graviola are Emodin, Lycopene, Vitamin C, Beta-sitosterol, Daidzein and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Suppressive Histone Methylation and MYC Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, MYC Signaling and Apoptosis.
Fisetin can manipulate biochemical pathways MYC Signaling. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.
For genetic risk of Atypical Lung Carcinoid due to abnormalities in genes PPM1D and ASXL1 – Foods like Feijoa are recommended compared to Graviola. This is because the active ingredients Fisetin and Myricetin in Graviola further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER GRAVIOLA FOR REDUCING THE GENETIC RISK OF ATYPICAL LUNG CARCINOID DUE TO GENES PPM1D AND ASXL1
Eat more nuts, Pistachio or Chestnut?
The active ingredients contained in Pistachio are Beta-sitosterol, Vitamin E, Stigmasterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Chestnut are Vitamin C, Linolenic Acid, Quercetin, Oleic Acid, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, Oncogenic Cancer Epigenetics and Cell Cycle Checkpoints. Vitamin E has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Atypical Lung Carcinoid due to abnormalities in genes PPM1D and ASXL1 – Foods like Pistachio are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Folic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF ATYPICAL LUNG CARCINOID DUE TO GENES PPM1D AND ASXL1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Atypical Lung Carcinoid by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
- Cancer therapy shapes the fitness landscape of clonal hematopoiesis.
- Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Effects of (-)-epicatechin and derivatives on nitric oxide mediated induction of mitochondrial proteins.
- D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- β-Carotene inhibits neuroblastoma cell invasion and metastasis in vitro and in vivo by decreasing level of hypoxia-inducible factor-1α.
- Linoleic acid enhances angiogenesis through suppression of angiostatin induced by plasminogen activator inhibitor 1.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- Identification of new potent phthalazine derivatives with VEGFR-2 and EGFR kinase inhibitory activity.
- New concepts in phospholipase D signaling in inflammation and cancer.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Stigmasterol isolated from marine microalgae Navicula incerta induces apoptosis in human hepatoma HepG2 cells.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.