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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Desmoid Tumor?

Aug 7, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Desmoid Tumor when undergoing chemotherapy or when you determine you have a genetic risk for developing Desmoid Tumor because of CTNNB1 and HIPK1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Desmoid Tumor which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Fig” or “Include fruit Blackberry in my diet” or “Should I reduce consumption of vegetable Heart Of Palm” or “Can I take Neem Extract and Alpha Lipoic Acid supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO DESMOID TUMOR, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Desmoid Tumor is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR DESMOID TUMOR, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Desmoid Tumor

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Desmoid Tumor from cBioPortal. The patients enrolled in the studies for Desmoid Tumor are in ages between 24 to 56 with an average age of 40. 42.9% of males and 57.1% of females were the distribution of gender in these clinical studies. From a patient sample size of 21; the top genes with mutations and other abnormalities for Desmoid Tumor include genes CTNNB1, HIPK1, COL4A3, APC and KDM5B. The occurrence frequency distribution for these genes respectively is 76.5%, 5.9%, 5.9%, 5.9% and 5.9%. These tumor genetic details of Desmoid Tumor are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Desmoid Tumor.

Significance of Nutrition for Desmoid Tumor

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Desmoid Tumor. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Fig includes active ingredients Psoralen, Angelicin, Beta-sitosterol, Lupeol, Vitamin C and others. And Blackberry contains active ingredients Ellagic Acid, Cianidanol, Quercetin, Myricetin, Urolithin B and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Desmoid Tumor, activation or inhibition of selected biochemical pathways like Growth Factor Signaling, MAPK Signaling, Epithelial to Mesenchymal Transition, Adherens junction plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Desmoid Tumor, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Desmoid Tumor, activation or inhibition of selected biochemical pathways like Growth Factor Signaling, MAPK Signaling, Epithelial to Mesenchymal Transition, Adherens junction plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR DESMOID TUMOR – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Desmoid Tumor undergoing chemotherapy treatment

In Desmoid Tumor – the genes CTNNB1, HIPK1, COL4A3, APC and KDM5B have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Desmoid Tumor are Growth Factor Signaling, MAPK Signaling, Epithelial to Mesenchymal Transition and others. Cyclophosphamide is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Growth Factor Signaling, MAPK Signaling, Epithelial to Mesenchymal Transition so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Bean or Lentils?

Pulses are an important part of many diets. The active ingredients contained in Common Bean are Gamma-linolenic Acid, Delphinidin, Linolenic Acid, Oleic Acid, Apigenin among others. While the active ingredients contained in Lentils are Ellagic Acid, Daidzein, Linolenic Acid, Oleic Acid, Isoliquiritigenin and others.

Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling. Gamma-linolenic Acid has biological action on biochemical pathways Growth Factor Signaling, MAPK Signaling and Epithelial to Mesenchymal Transition.

Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Desmoid Tumor with chemotherapy Cyclophosphamide – Foods like Common Bean are recommended compared to Lentils. This is because the active ingredients Ellagic Acid and Oleic Acid in Lentils interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Gamma-linolenic Acid contained in Common Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON BEAN IS RECOMMENDED OVER LENTILS FOR DESMOID TUMOR ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.

Eat more vegetables, Lettuce or Heart Of Palm?

Vegetables are an important part of many diets. The active ingredients contained in Lettuce are Quercetin, Linolenic Acid, Oleic Acid, Beta-sitosterol, Caffeic Acid among others. While the active ingredients contained in Heart Of Palm are Vitamin C, Vitamin A, Folic Acid, Palmitic Acid and others.

Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling.

Palmitic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Growth Factor Signaling and MAPK Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MAPK Signaling. And so on.

When treating Desmoid Tumor with chemotherapy Cyclophosphamide – Foods like Lettuce are recommended compared to Heart Of Palm. This is because the active ingredients Palmitic Acid and Folic Acid in Heart Of Palm interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Vitamin K contained in Lettuce support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: LETTUCE IS RECOMMENDED OVER HEART OF PALM FOR DESMOID TUMOR ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.

Which Foods are Recommended for Desmoid Tumor?

Eat more fruits, Blackberry or Fig?

Fruits are an important part of many diets. The active ingredients contained in Blackberry are Ellagic Acid, Cianidanol, Quercetin, Myricetin, Urolithin B among others. While the active ingredients contained in Fig are Psoralen, Angelicin, Beta-sitosterol, Lupeol, Vitamin C and others.

Cianidanol can manipulate biochemical pathways Growth Factor Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Scopoletin has biological action on biochemical pathways Epithelial to Mesenchymal Transition, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Lauric Acid can manipulate biochemical pathways Growth Factor Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways MAPK Signaling. And so on.

When treating Desmoid Tumor with chemotherapy Cyclophosphamide – Foods like Blackberry are recommended compared to Fig. This is because the active ingredients Lauric Acid and Myristic Acid in Fig interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Cianidanol and Scopoletin contained in Blackberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: BLACKBERRY IS RECOMMENDED OVER FIG FOR DESMOID TUMOR ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.

Eat more nuts, Walnut or Pumpkin Seeds?

Nuts are an important part of many diets. The active ingredients contained in Walnut are Ellagic Acid, Quercetin, Juglone, Vitamin E, Linolenic Acid among others. While the active ingredients contained in Pumpkin Seeds are Gamma-linolenic Acid, Linolenic Acid, Oleic Acid, Beta-sitosterol, Stigmasterol and others.

Juglone can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Growth Factor Signaling and MAPK Signaling. Myricetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Epithelial to Mesenchymal Transition and MAPK Signaling.

Lecithin can manipulate biochemical pathways MAPK Signaling and PI3K-AKT-MTOR Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

When treating Desmoid Tumor with chemotherapy Cyclophosphamide – Foods like Walnut are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Oleic Acid in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Juglone and Myricetin contained in Walnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: WALNUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR DESMOID TUMOR ON TREATMENT WITH CHEMOTHERAPY CYCLOPHOSPHAMIDE FOR SOME CONDITIONS.

Foods for Genetic Risk of Desmoid Tumor

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CTNNB1 and HIPK1 are two genes whose abnormalities are risk factors for Desmoid Tumor. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Desmoid Tumor can be used as a guide for coming up with a recommended personalized nutrition plan. For Desmoid Tumor gene CTNNB1 has causative impact on biological pathways like Adherens junction, Androgen Signaling and Cytoskeletal Dynamics. And HIPK1 has a causative impact on biological pathways like Cell Cycle Checkpoints. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CTNNB1 and HIPK1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CTNNB1 and HIPK1 should be avoided.

Eat more pulses, Common Pea or Fava Bean?

The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Fava Bean are Beta-sitosterol, Daidzein, Quercetin, Ferulic Acid, Linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Adherens junction. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, MYC Signaling and P53 Signaling.

Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

For genetic risk of Desmoid Tumor due to abnormalities in genes CTNNB1 and HIPK1 – Foods like Common Pea are recommended compared to Fava Bean. This is because the active ingredients Oleic Acid and Linoleic Acid in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF DESMOID TUMOR DUE TO GENES CTNNB1 AND HIPK1

Eat more vegetables, Arugula or Carrot?

The active ingredients contained in Arugula are Esculin, Vitamin A, Kaempferol, Vitamin K, Erysolin among others. While the active ingredients contained in Carrot are Lupeol, Beta-sitosterol, Lycopene, Eugenol, D-limonene and others.

Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Adherens junction. Kaempferol has biological action on biochemical pathways WNT Beta Catenin Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Osthole can manipulate biochemical pathways WNT Beta Catenin Signaling and Adherens junction. Luteolin has biological action on biochemical pathways MYC Signaling and WNT Beta Catenin Signaling. And so on.

For genetic risk of Desmoid Tumor due to abnormalities in genes CTNNB1 and HIPK1 – Foods like Arugula are recommended compared to Carrot. This is because the active ingredients Osthole and Luteolin in Carrot further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin A and Kaempferol contained in Arugula together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CARROT FOR REDUCING THE GENETIC RISK OF DESMOID TUMOR DUE TO GENES CTNNB1 AND HIPK1

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Feijoa or Pummelo?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Pummelo are Naringin, Beta-sitosterol, Naringenin, Linolenic Acid, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Adherens junction. Lycopene has biological action on biochemical pathways WNT Beta Catenin Signaling, MYC Signaling and P53 Signaling.

Naringetol can manipulate biochemical pathways WNT Beta Catenin Signaling. Hesperetin has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.

For genetic risk of Desmoid Tumor due to abnormalities in genes CTNNB1 and HIPK1 – Foods like Feijoa are recommended compared to Pummelo. This is because the active ingredients Naringetol and Hesperetin in Pummelo further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER PUMMELO FOR REDUCING THE GENETIC RISK OF DESMOID TUMOR DUE TO GENES CTNNB1 AND HIPK1

Eat more nuts, Brazil Nut or Chestnut?

The active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid among others. While the active ingredients contained in Chestnut are Quercetin, Linolenic Acid, Vitamin C, Oleic Acid, Ellagic Acid and others.

Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and MYC Signaling. Linolenic Acid has biological action on biochemical pathways Adherens junction, WNT Beta Catenin Signaling and P53 Signaling.

Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.

For genetic risk of Desmoid Tumor due to abnormalities in genes CTNNB1 and HIPK1 – Foods like Brazil Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Oleic Acid in Chestnut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Linolenic Acid contained in Brazil Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: BRAZIL NUT IS RECOMMENDED OVER CHESTNUT FOR REDUCING THE GENETIC RISK OF DESMOID TUMOR DUE TO GENES CTNNB1 AND HIPK1


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Desmoid Tumor by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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