Which Foods are Recommended for Synovial Sarcoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Synovial Sarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Synovial Sarcoma because of PIK3R1 and SETD2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Synovial Sarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Apricot” or “Include fruit Cherimoya in my diet” or “Should I reduce consumption of vegetable Spinach” or “Can I take Guggul and Thunder God supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SYNOVIAL SARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Synovial Sarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR SYNOVIAL SARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Synovial Sarcoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Synovial Sarcoma from cBioPortal. The patients enrolled in the studies for Synovial Sarcoma are in ages between 20 to 72 with an average age of 30. 48.5% of males and 51.5% of females were the distribution of gender in these clinical studies. From a patient sample size of 164; the top genes with mutations and other abnormalities for Synovial Sarcoma include genes PIK3R1, SETD2, ATRX, ABL1 and ADCY2. The occurrence frequency distribution for these genes respectively is 2.7%, 2.7%, 2.7%, 1.4% and 1.4%. These tumor genetic details of Synovial Sarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Synovial Sarcoma.

Synovial sarcoma is a cancer that develops in different types of soft tissues, such as muscles or ligaments, and accounts for 5% – 10% of soft tissue tumors. It is often found in the arm, leg, or foot, and near joints such as wrist or ankle. It can also form in the soft tissues in the lung or abdomen. A third of the patients with synovial sarcoma are diagnosed under the age of 30 and it is predominant in males. Approximately 800 new cases of synovial sarcoma occur in the United States each year, and this is the third most common soft-tissue tumor in adolescents and young adults. Symptoms caused by synovial sarcoma depend on where the tumor develops. Synovial sarcoma is often first noticed as a painless lump, but if it is near a nerve, it might cause pain or numbness as it grows. Treatment modalities for synovial sarcoma include surgery, radiation therapy and chemotherapy, the latter being used when synovial sarcoma cannot be completely removed by surgery or when it has spread. Synovial sarcoma has been reported to have a high likelihood of spread (metastasis). 5-year survival rate of synovial sarcoma is 50-60%, however, advances in oncologic therapy, particularly development of biologic treatments such as monoclonal antibodies, may improve survival rates. In addition, the right nutrition (foods and natural supplements) aligned to the treatment may support and enhance the patients’ well-being. (Ref: https://emedicine.medscape.com/article/1257131-overview; https://my.clevelandclinic.org/health/diseases/22012-synovial-sarcoma)

Significance of Nutrition for Synovial Sarcoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Synovial Sarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Apricot includes active ingredients Quercetin, Beta-sitosterol, Modified Citrus Pectin, Vitamin C, Salicylic Acid and others. And Cherimoya contains active ingredients Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Synovial Sarcoma, activation or inhibition of selected biochemical pathways like Amino Acid Metabolism, MAPK Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Synovial Sarcoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SYNOVIAL SARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Synovial Sarcoma undergoing chemotherapy treatment

In Synovial Sarcoma – the genes PIK3R1, SETD2, ATRX, ABL1 and ADCY2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Synovial Sarcoma are Amino Acid Metabolism, MAPK Signaling, Adherens junction and others. Fluorouracil is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Amino Acid Metabolism, MAPK Signaling, Adherens junction so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Fava Bean?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Genistein, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Fava Bean are Daidzein, Quercetin, Caffeic Acid, Beta-sitosterol, P-coumaric Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and MYC Signaling. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, P53 Signaling and Vitamin D Signaling.

Quercetin can manipulate biochemical pathways Hypoxia. Genistein has biological action on biochemical pathways DNA Repair. And so on.

When treating Synovial Sarcoma with chemotherapy Fluorouracil – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Quercetin and Genistein in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR SYNOVIAL SARCOMA ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.

Eat more vegetables, Mexican Groundcherry or Spinach?

Vegetables are an important part of many diets. The active ingredients contained in Mexican Groundcherry are Vitamin C, Vitamin B3 among others. While the active ingredients contained in Spinach are Apigenin, Quercetin, Beta-sitosterol, Vitamin C, Kaempferol and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and MYC Signaling. Vitamin B3 has biological action on biochemical pathways P53 Signaling, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.

Apigenin can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Vitamin D Signaling and DNA Repair. Quercetin has biological action on biochemical pathways Hypoxia. And so on.

When treating Synovial Sarcoma with chemotherapy Fluorouracil – Foods like Mexican Groundcherry are recommended compared to Spinach. This is because the active ingredients Apigenin and Quercetin in Spinach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Vitamin B3 contained in Mexican Groundcherry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MEXICAN GROUNDCHERRY IS RECOMMENDED OVER SPINACH FOR SYNOVIAL SARCOMA ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.

Eat more fruits, Cherimoya or Apricot?

Fruits are an important part of many diets. The active ingredients contained in Cherimoya are Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Apricot are Quercetin, Beta-sitosterol, Modified Citrus Pectin, Vitamin C, Salicylic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and MYC Signaling. Stigmasterol has biological action on biochemical pathways P53 Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Rutin can manipulate biochemical pathways WNT Beta Catenin Signaling and Oncogenic Cancer Epigenetics. Quercetin has biological action on biochemical pathways Hypoxia. And so on.

When treating Synovial Sarcoma with chemotherapy Fluorouracil – Foods like Cherimoya are recommended compared to Apricot. This is because the active ingredients Rutin and Quercetin in Apricot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Stigmasterol contained in Cherimoya support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CHERIMOYA IS RECOMMENDED OVER APRICOT FOR SYNOVIAL SARCOMA ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.

Eat more nuts, Pistachio or Peanut?

Nuts are an important part of many diets. The active ingredients contained in Pistachio are Beta-sitosterol, Vitamin E, Resveratrol, Vitamin A, Linolenic Acid among others. While the active ingredients contained in Peanut are Quercetin, Beta-sitosterol, Vitamin E, Vitamin C, Rhamnetin and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Adherens junction and MYC Signaling. Vitamin E has biological action on biochemical pathways DNA Repair, Notch Signaling and P53 Signaling.

Quercetin can manipulate biochemical pathways Hypoxia. Vitamin A has biological action on biochemical pathways Focal Adhesion. And so on.

When treating Synovial Sarcoma with chemotherapy Fluorouracil – Foods like Pistachio are recommended compared to Peanut. This is because the active ingredients Quercetin and Vitamin A in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin E contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER PEANUT FOR SYNOVIAL SARCOMA ON TREATMENT WITH CHEMOTHERAPY FLUOROURACIL FOR SOME CONDITIONS.

Foods for Genetic Risk of Synovial Sarcoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. PIK3R1 and SETD2 are two genes whose abnormalities are risk factors for Synovial Sarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Synovial Sarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Synovial Sarcoma gene PIK3R1 has causative impact on biological pathways like Hematopoiesis and Cytokine Signaling. And SETD2 has a causative impact on biological pathways like Oncogenic Histone Methylation. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like PIK3R1 and SETD2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes PIK3R1 and SETD2 should be avoided.

Eat more pulses, Mung Bean or Soy Bean?

The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Oleic Acid, Linolenic Acid, Vitexin among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Quercetin, Vitamin E, Beta-sitosterol and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitexin has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Synovial Sarcoma due to abnormalities in genes PIK3R1 and SETD2 – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitexin contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF SYNOVIAL SARCOMA DUE TO GENES PIK3R1 AND SETD2

Eat more vegetables, Giant Butterbur or Celery?

The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Vitamin A among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Vitamin C, Oleic Acid, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Luteolin can manipulate biochemical pathways MYC Signaling. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Synovial Sarcoma due to abnormalities in genes PIK3R1 and SETD2 – Foods like Giant Butterbur are recommended compared to Celery. This is because the active ingredients Luteolin and Chrysin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF SYNOVIAL SARCOMA DUE TO GENES PIK3R1 AND SETD2

Eat more fruits, Orange or Raspberry?

The active ingredients contained in Orange are D-limonene, Linalool, Modified Citrus Pectin, Vitamin C, Oleic Acid among others. While the active ingredients contained in Raspberry are Ellagic Acid, Quercetin, Resveratrol, Vitamin C, Gallic Acid and others.

D-limonene can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.

For genetic risk of Synovial Sarcoma due to abnormalities in genes PIK3R1 and SETD2 – Foods like Orange are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF SYNOVIAL SARCOMA DUE TO GENES PIK3R1 AND SETD2

Eat more nuts, Almond or Brazil Nut?

The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Lecithin, Folic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin E has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Synovial Sarcoma due to abnormalities in genes PIK3R1 and SETD2 – Foods like Almond are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF SYNOVIAL SARCOMA DUE TO GENES PIK3R1 AND SETD2

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Synovial Sarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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