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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Synovial Sarcoma!

Jul 31, 2023

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Introduction

Foods for Synovial Sarcoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Synovial cell sarcoma is a rare and aggressive form of soft tissue cancer that commonly occurs in the soft tissue, such as mucle or ligaments and often found in the arm, leg, or foot, and near joints such as the wrist or ankle. It arises from the synovial cells, which are responsible for lubricating the joints. Symptoms can vary depending on the location but may include pain, swelling, and a palpable mass. Early diagnosis and prompt treatment are crucial for improving outcomes. Synovial sarcoma can rarely metastasize to the lungs, resulting in lung cancer. Treatment options for synovial cell sarcoma typically involve a combination of surgery, chemotherapy, and radiation therapy. Comprehensive management may involve specialized treatments tailored to the unique needs of each individual, particularly in cases involving synovial sarcoma of the foot. The survival rate for synovial sarcoma varies depending on factors like stage, treatment response, and individual characteristics such as the location of the tumor, if the cancer has spread to other parts of the body. The five-year survival rate ranges from 36%-76% for people diagnosed with synovial sarcoma and the chances of survival are better if the tumor is completely removed and there is no recurrence or metastasis.



For Synovial Sarcoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Synovial Sarcoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Synovial Sarcoma?

For example does it matter if vegetable Giant Butterbur is consumed more compared to Red Bell Pepper? Does it make any difference if fruit Pummelo is preferred over Pomegranate? Also if similar choices are made for nuts/seeds like Common Walnut over European Chestnut and for pulses like Adzuki Bean over Lima Bean. And if what I eat matters – then how does one identify foods which are recommended for Synovial Sarcoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Synovial Sarcoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Synovial Sarcoma can be characterized by a unique set of biochemical pathways - the signature pathways of Synovial Sarcoma. Biochemical pathways like Cell Cycle, Notch Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Synovial Sarcoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Apigenin, Curcumin, Lupeol, Lycopene, Naringin. And Pomegranate contains active ingredients Apigenin, Curcumin, Lupeol, Naringin, Beta-sitosterol and possibly others.

A common mistake made when deciding and choosing foods to eat for Synovial Sarcoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Synovial Sarcoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Synovial Sarcoma?

Personalized nutrition for cancers like Synovial Sarcoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Synovial Sarcoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Synovial Sarcoma

All cancers like Synovial Sarcoma can be characterized by a unique set of biochemical pathways – the signature pathways of Synovial Sarcoma. Biochemical pathways like Cell Cycle, Notch Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Synovial Sarcoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Synovial Sarcoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Synovial Sarcoma when taking cancer treatment Cisplatin, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

PIK3R1, SETD2, ATRX, ABL1 and ADCY2 are the top ranked reported genes for Synovial Sarcoma. PIK3R1 is reported in 2.7 % of the representative patients across all clinical trials. And SETD2 is reported in 2.7 %. The combined population patient data cover ages from 20 to 72. 48.5 % of the patient data are identified as men. The Synovial Sarcoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Synovial Sarcoma!

Food and Supplements for Synovial Sarcoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GIANT BUTTERBUR or RED BELL PEPPER?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Lycopene, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle, P53 Signaling, Cell Cycle Checkpoints and MYC Signaling and others. Giant Butterbur is recommended for Synovial Sarcoma when ongoing cancer treatment is Cisplatin. This is because Giant Butterbur modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cisplatin.

Some of the active ingredients or bioactives in vegetable Red Bell Pepper are Curcumin, Lupeol, Lycopene, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like DNA Repair and MAPK Signaling and others. Red Bell Pepper is not recommended for Synovial Sarcoma when ongoing cancer treatment is Cisplatin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER RED BELL PEPPER FOR Synovial Sarcoma AND TREATMENT Cisplatin.

Choose Fruit POMEGRANATE or PUMMELO?

Fruit Pomegranate contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Naringin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle, Epithelial to Mesenchymal Transition, P53 Signaling and DNA Repair and others. Pomegranate is recommended for Synovial Sarcoma when ongoing cancer treatment is Cisplatin. This is because Pomegranate modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cisplatin.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Lupeol, Lycopene, Naringin. These active ingredients manipulate various biochemical pathways like DNA Repair and WNT Beta Catenin Signaling and others. Pummelo is not recommended for Synovial Sarcoma when ongoing cancer treatment is Cisplatin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT POMEGRANATE IS RECOMMENDED OVER PUMMELO FOR Synovial Sarcoma AND TREATMENT Cisplatin.

Choose Nut COMMON WALNUT or EUROPEAN CHESTNUT?

Common Walnut contains many active ingredients or bioactives such as Curcumin, Lupeol, Beta-sitosterol, Phloretin, Quercetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, Amino Acid Metabolism, P53 Signaling and Inositol Phosphate Signaling and others. Common Walnut is recommended for Synovial Sarcoma when ongoing cancer treatment is Cisplatin. This is because Common Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Cisplatin.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Curcumin, Lupeol, Beta-sitosterol, Phloretin. These active ingredients manipulate various biochemical pathways like DNA Repair, Epithelial to Mesenchymal Transition and WNT Beta Catenin Signaling and others. European Chestnut is not recommended for Synovial Sarcoma when ongoing cancer treatment is Cisplatin because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

COMMON WALNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Synovial Sarcoma AND TREATMENT Cisplatin.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Synovial Sarcoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable BITTER GOURD or BROCCOLI?

Vegetable Bitter Gourd contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Beta-sitosterol, Daidzein. These active ingredients manipulate various biochemical pathways like Apoptosis, P53 Signaling, Cell Cycle Checkpoints and MYC Signaling and others. Bitter Gourd is recommended for risk of Synovial Sarcoma when associated genetic risk is ABL1. This is because Bitter Gourd increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Broccoli are Curcumin, Resveratrol, Quercetin, Lupeol, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Hypoxia and P53 Signaling and others. Broccoli is not recommended when risk of Synovial Sarcoma when associated genetic risk is ABL1 because it increases the signature pathways of it.

VEGETABLE BITTER GOURD IS RECOMMENDED OVER BROCCOLI FOR ABL1 GENETIC RISK OF CANCER.

Choose Fruit NANCE or SWEET ORANGE?

Fruit Nance contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Beta-sitosterol, Daidzein. These active ingredients manipulate various biochemical pathways like Hypoxia, P53 Signaling and MYC Signaling and others. Nance is recommended for risk of Synovial Sarcoma when associated genetic risk is ABL1. This is because Nance increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Sweet Orange are Curcumin, D-limonene, Lupeol, Linalool, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like DAP12 Signaling and Cell Cycle Checkpoints and others. Sweet Orange is not recommended when risk of Synovial Sarcoma when associated genetic risk is ABL1 because it increases the signature pathways of it.

FRUIT NANCE IS RECOMMENDED OVER SWEET ORANGE FOR ABL1 GENETIC RISK OF CANCER.

Choose Nut BLACK WALNUT or MACADAMIA NUT?

Black Walnut contains many active ingredients or bioactives such as Curcumin, Apigenin, Quercetin, Ellagic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like Apoptosis, RAS-RAF Signaling, P53 Signaling and MYC Signaling and others. Black Walnut is recommended for risk of Synovial Sarcoma when associated genetic risk is ABL1. This is because Black Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Macadamia Nut are Curcumin, Apigenin, Lupeol, Beta-sitosterol, Daidzein. These active ingredients manipulate various biochemical pathways like Oncogenic Histone Methylation, PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and MYC Signaling and others. Macadamia Nut is not recommended when risk of Synovial Sarcoma when associated genetic risk is ABL1 because it increases the signature pathways of it.

BLACK WALNUT IS RECOMMENDED OVER MACADAMIA NUT FOR ABL1 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Synovial Sarcoma. Synovial Sarcoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Synovial Sarcoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Giant Butterbur contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Synovial Sarcoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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