Which Foods are Recommended for Ocular Melanoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Ocular Melanoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Ocular Melanoma because of GNAQ and GNA11 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Ocular Melanoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Quince” or “Include fruit Persimmon in my diet” or “Should I reduce consumption of vegetable Yam” or “Can I take Lavender and Neem Extract supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO OCULAR MELANOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Ocular Melanoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR OCULAR MELANOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Ocular Melanoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Ocular Melanoma from cBioPortal. 52.0% of males and 48.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 255; the top genes with mutations and other abnormalities for Ocular Melanoma include genes GNAQ, GNA11, SF3B1, BAP1 and EIF1AX. The occurrence frequency distribution for these genes respectively is 30.3%, 27.3%, 13.6%, 9.8% and 7.6%. These tumor genetic details of Ocular Melanoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Ocular Melanoma.

Ocular melanoma, also known as intraocular melanoma or uveal melanoma, is a very rare cancer but the most common primary cancer of the eye that affects the pigmented cells of the eye, with an incidence of 5 per million adults. The exact cause of ocular melanoma is unknown, but it has been linked to genetics and sun exposure. The disease can spread to other parts of the body, most commonly the liver, making it a potentially life-threatening condition. Despite this, with early detection and proper treatment, many patients have a good prognosis and long life expectancy. However, ocular melanomas form in the part of the eye that is difficult to detect and they typically do not cause early signs or symptoms. When symptoms occur, they can include sensation or flashes in the vision (floaters), a growing dark spot on the iris, poor blurry vision in one eye or loss of peripheral vision. Surgery is often the first line of treatment for ocular melanoma, and other options such as chemotherapy and radiation may also be used. Optimal nutrition (foods and natural supplements) along with the prescribed treatment and surveillance can improve the prognosis and well-being of adult patients diagnosed with ocular melanoma. (Ref: https://www.mayoclinic.org/diseases-conditions/eye-melanoma/symptoms-causes/syc-20372371; https://www.cancer.org/cancer/eye-cancer/about/key-statistics.html; https://rarediseases.org/rare-diseases/ocular-melanoma/)

Significance of Nutrition for Ocular Melanoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Ocular Melanoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Quince includes active ingredients Vitamin C, Oleic Acid, Chlorogenic Acid, Modified Citrus Pectin, Linoleic Acid and others. And Persimmon contains active ingredients Quercetin, Fisetin, Lupeol, Betulinic Acid, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Ocular Melanoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, G-protein-coupled Receptor Signaling, Platelet aggregation plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Ocular Melanoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR OCULAR MELANOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Ocular Melanoma undergoing chemotherapy treatment

In Ocular Melanoma – the genes GNAQ, GNA11, SF3B1, BAP1 and EIF1AX have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Ocular Melanoma are RAS-RAF Signaling, mRNA Splicing, Cell Cycle and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, mRNA Splicing, Cell Cycle so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Fava Bean?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Vitamin C, Beta-sitosterol, Stigmasterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Fava Bean are Quercetin, Daidzein, Butein, Vitamin C, Beta-sitosterol and others.

Vitamin C can manipulate biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, DNA Repair and Cell Survival.

Quercetin can manipulate biochemical pathways Oxidative Stress. Cianidanol has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Ocular Melanoma with chemotherapy Radiation – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Quercetin and Cianidanol in Fava Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR OCULAR MELANOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Bitter Melon or Yam?

Vegetables are an important part of many diets. The active ingredients contained in Bitter Melon are Vitamin C, Beta-sitosterol, Cucurbitacin E, Oleic Acid, Cianidanol among others. While the active ingredients contained in Yam are Vitamin C, Beta-sitosterol, Oleic Acid, Linolenic Acid, Dioscin and others.

Vitamin C can manipulate biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, DNA Repair and Cell Survival.

Citric Acid can manipulate biochemical pathways Oxidative Stress. Dioscin has biological action on biochemical pathways Notch Signaling and Oxidative Stress. And so on.

When treating Ocular Melanoma with chemotherapy Radiation – Foods like Bitter Melon are recommended compared to Yam. This is because the active ingredients Citric Acid and Dioscin in Yam interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Bitter Melon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: BITTER MELON IS RECOMMENDED OVER YAM FOR OCULAR MELANOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Persimmon or Quince?

Fruits are an important part of many diets. The active ingredients contained in Persimmon are Quercetin, Fisetin, Lupeol, Betulinic Acid, Vitamin C among others. While the active ingredients contained in Quince are Vitamin C, Oleic Acid, Chlorogenic Acid, Modified Citrus Pectin, Linoleic Acid and others.

Vitamin C can manipulate biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling. Lycopene has biological action on biochemical pathways NFKB Signaling, JAK-STAT Signaling and Cell Survival.

Quercitrin can manipulate biochemical pathways Oxidative Stress. Chlorogenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Ocular Melanoma with chemotherapy Radiation – Foods like Persimmon are recommended compared to Quince. This is because the active ingredients Quercitrin and Chlorogenic Acid in Quince interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Lycopene contained in Persimmon support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PERSIMMON IS RECOMMENDED OVER QUINCE FOR OCULAR MELANOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Pumpkin Seeds?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Pumpkin Seeds are Beta-sitosterol, Salicylic Acid, Stigmasterol, Gamma-linolenic Acid, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, DNA Repair and Cell Cycle. Vitamin K has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and NFKB Signaling.

Gamma-linolenic Acid can manipulate biochemical pathways Oxidative Stress. Lecithin has biological action on biochemical pathways NFKB Signaling, JAK-STAT Signaling and MYC Signaling. And so on.

When treating Ocular Melanoma with chemotherapy Radiation – Foods like Pine Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Gamma-linolenic Acid and Lecithin in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR OCULAR MELANOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Ocular Melanoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. GNAQ and GNA11 are two genes whose abnormalities are risk factors for Ocular Melanoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Ocular Melanoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Ocular Melanoma gene GNAQ has causative impact on biological pathways like G-protein-coupled Receptor Signaling, Cytoskeletal Dynamics and Reproductive Hormone Signaling. And GNA11 has a causative impact on biological pathways like Cytoskeletal Dynamics, cGMP Signaling and Reproductive Hormone Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like GNAQ and GNA11 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes GNAQ and GNA11 should be avoided.

Eat more pulses, Soy Bean or Yellow Wax Bean?

The active ingredients contained in Soy Bean are Fisetin, Quercetin, Caffeic Acid, 7-8-dihydroxyflavone, Oleic Acid among others. While the active ingredients contained in Yellow Wax Bean are Cianidanol, Ferulic Acid, Vitamin C, Butyric Acid, Folic Acid and others.

Aescin can manipulate biochemical pathways G-protein-coupled Receptor Signaling. Fisetin has biological action on biochemical pathways Phospholipase Signaling, MAPK Signaling and Platelet aggregation.

Palmitic Acid can manipulate biochemical pathways mRNA Splicing and MAPK Signaling. Butyric Acid has biological action on biochemical pathways mRNA Splicing. And so on.

For genetic risk of Ocular Melanoma due to abnormalities in genes GNAQ and GNA11 – Foods like Soy Bean are recommended compared to Yellow Wax Bean. This is because the active ingredients Palmitic Acid and Butyric Acid in Yellow Wax Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Aescin and Fisetin contained in Soy Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SOY BEAN IS RECOMMENDED OVER YELLOW WAX BEAN FOR REDUCING THE GENETIC RISK OF OCULAR MELANOMA DUE TO GENES GNAQ AND GNA11

Eat more vegetables, Lotus or Bell Pepper?

The active ingredients contained in Lotus are Fisetin, Quercetin, Linoleic Acid, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Bell Pepper are Isorhamnetin, Linolenic Acid, Oleic Acid, Vitamin C, Vitamin E and others.

Fisetin can manipulate biochemical pathways Phospholipase Signaling, MAPK Signaling and Platelet aggregation. Vitamin C has biological action on biochemical pathways MAPK Signaling.

Capsaicin can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways MAPK Signaling. And so on.

For genetic risk of Ocular Melanoma due to abnormalities in genes GNAQ and GNA11 – Foods like Lotus are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Folic Acid in Bell Pepper further promote the effects of genes on the biochemical pathways. While the active ingredients Fisetin and Vitamin C contained in Lotus together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: LOTUS IS RECOMMENDED OVER BELL PEPPER FOR REDUCING THE GENETIC RISK OF OCULAR MELANOMA DUE TO GENES GNAQ AND GNA11

Eat more fruits, Kiwi or Fig?

The active ingredients contained in Kiwi are Fisetin, Quercetin, Chlorogenic Acid, Vitamin C among others. While the active ingredients contained in Fig are Lupeol, Psoralen, Rutin, Vitamin C, Lauric Acid and others.

Vitamin C can manipulate biochemical pathways MAPK Signaling. Fisetin has biological action on biochemical pathways Phospholipase Signaling, Platelet aggregation and G-protein-coupled Receptor Signaling.

Lauric Acid can manipulate biochemical pathways MAPK Signaling. Myristic Acid has biological action on biochemical pathways G-protein-coupled Receptor Signaling and MAPK Signaling. And so on.

For genetic risk of Ocular Melanoma due to abnormalities in genes GNAQ and GNA11 – Foods like Kiwi are recommended compared to Fig. This is because the active ingredients Lauric Acid and Myristic Acid in Fig further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Fisetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: KIWI IS RECOMMENDED OVER FIG FOR REDUCING THE GENETIC RISK OF OCULAR MELANOMA DUE TO GENES GNAQ AND GNA11

Eat more nuts, Chestnut or Brazil Nut?

The active ingredients contained in Chestnut are Ellagic Acid, Quercetin, Gallic Acid, Betulin, Linoleic Acid among others. While the active ingredients contained in Brazil Nut are Linolenic Acid, Oleic Acid, Vitamin E, Lecithin, Folic Acid and others.

Ellagic Acid can manipulate biochemical pathways MAPK Signaling, G-protein-coupled Receptor Signaling and Platelet aggregation. Gallic Acid has biological action on biochemical pathways MAPK Signaling.

Lecithin can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways MAPK Signaling. And so on.

For genetic risk of Ocular Melanoma due to abnormalities in genes GNAQ and GNA11 – Foods like Chestnut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Ellagic Acid and Gallic Acid contained in Chestnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CHESTNUT IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF OCULAR MELANOMA DUE TO GENES GNAQ AND GNA11

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Ocular Melanoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Mixed Allen 2018
• Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer.
• Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines.
• Genomic and Functional Approaches to Understanding Cancer Aneuploidy.
• Driver Fusions and Their Implications in the Development and Treatment of Human Cancers.
• An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics.
• Oncogenic Signaling Pathways in The Cancer Genome Atlas.
• Microbiome analyses of blood and tissues suggest cancer diagnostic approach.
• Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics.
• Landscape of Microsatellite Instability Across 39 Cancer Types.
• Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
• Reactive oxygen species-mediated activation of AMP-activated protein kinase and c-Jun N-terminal kinase plays a critical role in beta-sitosterol-induced apoptosis in multiple myeloma U266 cells.
• Small-molecule inhibitors of NADPH oxidase 4.
• Topical (+)-catechin emulsified gel prevents DMBA/TPA-induced squamous cell carcinoma of the skin by modulating antioxidants and inflammatory biomarkers in BALB/c mice.
• Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines.
• Quercetin and quercitrin protect against cytokine‑induced injuries in RINm5F β-cells via the mitochondrial pathway and NF-κB signaling.
• Natural Polyphenol Chlorogenic Acid Protects Against Acetaminophen-Induced Hepatotoxicity by Activating ERK/Nrf2 Antioxidative Pathway.
• Effect of dioscin on promoting liver regeneration via activating Notch1/Jagged1 signal pathway.
• Research progress on the anticancer effects of vitamin K2.
• Research on Rett syndrome: strategy and preliminary results.
• The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
• Fisetin targets YB-1/RSK axis independent of its effect on ERK signaling: insights from in vitro and in vivo melanoma models.
• Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
• SRSF2 is required for sodium butyrate-mediated p21(WAF1) induction and premature senescence in human lung carcinoma cell lines.
• Clinical pharmacodynamics of antihistamines.
• Identification of covalently bound amino-terminal myristic acid in endothelial nitric oxide synthase.
• Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner.
• Sequential protooncogene expression in regenerating kidney following acute renal injury.
• Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
• Gallic acid indanone and mangiferin xanthone are strong determinants of immunosuppressive anti-tumour effects of Mangifera indica L. bark in MDA-MB231 breast cancer cells.
• HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
• Fisetin: a dietary antioxidant for health promotion.