Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Juvenile Myelomonocytic Leukemia when undergoing chemotherapy or when you determine you have a genetic risk for developing Juvenile Myelomonocytic Leukemia because of PTPN11 and NRAS gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Juvenile Myelomonocytic Leukemia which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Raspberry” or “Include fruit Sapota in my diet” or “Should I reduce consumption of vegetable Bell Pepper” or “Can I take Guggul and D-limonene supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO JUVENILE MYELOMONOCYTIC LEUKEMIA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Juvenile Myelomonocytic Leukemia is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR JUVENILE MYELOMONOCYTIC LEUKEMIA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Juvenile Myelomonocytic Leukemia
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Juvenile Myelomonocytic Leukemia from cBioPortal. The top genes with mutations and other abnormalities for Juvenile Myelomonocytic Leukemia include genes PTPN11, NRAS, NF1, KRAS and SH2B3. The occurrence frequency distribution for these genes respectively is 37.4%, 35.8%, 35.8%, 18.9% and 15.1%. These tumor genetic details of Juvenile Myelomonocytic Leukemia are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Juvenile Myelomonocytic Leukemia.
Significance of Nutrition for Juvenile Myelomonocytic Leukemia
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Juvenile Myelomonocytic Leukemia. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Raspberry includes active ingredients Ellagic Acid, Resveratrol, Vitamin C, Salicylic Acid, Gallic Acid and others. And Sapota contains active ingredients Lycopene, Vitamin C, Oleic Acid, Beta-sitosterol, Linolenic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Juvenile Myelomonocytic Leukemia, activation or inhibition of selected biochemical pathways like Suppressive Histone Methylation, Noncoding RNA Signaling, RAS-RAF Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Juvenile Myelomonocytic Leukemia, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR JUVENILE MYELOMONOCYTIC LEUKEMIA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Juvenile Myelomonocytic Leukemia undergoing chemotherapy treatment
In Juvenile Myelomonocytic Leukemia – the genes PTPN11, NRAS, NF1, KRAS and SH2B3 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Juvenile Myelomonocytic Leukemia are Suppressive Histone Methylation, Noncoding RNA Signaling, Oncogenic Cancer Epigenetics and others. Azacitidine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Suppressive Histone Methylation, Noncoding RNA Signaling, Oncogenic Cancer Epigenetics so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Winged Bean or Black-eyed Pea?
Pulses are an important part of many diets. The active ingredients contained in Winged Bean are Vitamin C, Betulinic Acid, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Black-eyed Pea are Vitamin C, Daidzein, Oleic Acid, Genistein, Linolenic Acid and others.
Betulinic Acid can manipulate biochemical pathways MAPK Signaling, MYC Signaling and Oncogenic Cancer Epigenetics. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MAPK Signaling and MYC Signaling.
Beta-carotene can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling. And so on.
When treating Juvenile Myelomonocytic Leukemia with chemotherapy Azacitidine – Foods like Winged Bean are recommended compared to Black-eyed Pea. This is because the active ingredients Beta-carotene and Folic Acid in Black-eyed Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER BLACK-EYED PEA FOR JUVENILE MYELOMONOCYTIC LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY AZACITIDINE FOR SOME CONDITIONS.
Eat more vegetables, Turnip or Bell Pepper?
Vegetables are an important part of many diets. The active ingredients contained in Turnip are Sulforaphane, Vitamin C, Indole-3-carbinol, Vitamin A, Vitamin K among others. While the active ingredients contained in Bell Pepper are Vitamin C, Oleic Acid, Vitamin E, Linolenic Acid, Isorhamnetin and others.
Sulforaphane can manipulate biochemical pathways MAPK Signaling, MYC Signaling and Oncogenic Cancer Epigenetics. Indole-3-carbinol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.
Capsaicin can manipulate biochemical pathways MAPK Signaling and MYC Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MAPK Signaling and MYC Signaling. And so on.
When treating Juvenile Myelomonocytic Leukemia with chemotherapy Azacitidine – Foods like Turnip are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Folic Acid in Bell Pepper interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Sulforaphane and Indole-3-carbinol contained in Turnip support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: TURNIP IS RECOMMENDED OVER BELL PEPPER FOR JUVENILE MYELOMONOCYTIC LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY AZACITIDINE FOR SOME CONDITIONS.
Eat more fruits, Sapota or Raspberry?
Fruits are an important part of many diets. The active ingredients contained in Sapota are Lycopene, Vitamin C, Oleic Acid, Beta-sitosterol, Linolenic Acid among others. While the active ingredients contained in Raspberry are Ellagic Acid, Resveratrol, Vitamin C, Salicylic Acid, Gallic Acid and others.
Lycopene can manipulate biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, MYC Signaling and PI3K-AKT-MTOR Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Quercetin has biological action on biochemical pathways Noncoding RNA Signaling and Suppressive Histone Methylation. And so on.
When treating Juvenile Myelomonocytic Leukemia with chemotherapy Azacitidine – Foods like Sapota are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Quercetin in Raspberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Lycopene and Beta-sitosterol contained in Sapota support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SAPOTA IS RECOMMENDED OVER RASPBERRY FOR JUVENILE MYELOMONOCYTIC LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY AZACITIDINE FOR SOME CONDITIONS.
Eat more nuts, Hazelnut or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Oleic Acid, Vitamin E, Linolenic Acid, Linoleic Acid, Quercetin among others. While the active ingredients contained in Brazil Nut are Oleic Acid, Vitamin E, Linolenic Acid, Lecithin, Folic Acid and others.
Vitamin E can manipulate biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. Myricitrin has biological action on biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MAPK Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Juvenile Myelomonocytic Leukemia with chemotherapy Azacitidine – Foods like Hazelnut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Myricitrin contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER BRAZIL NUT FOR JUVENILE MYELOMONOCYTIC LEUKEMIA ON TREATMENT WITH CHEMOTHERAPY AZACITIDINE FOR SOME CONDITIONS.
Foods for Genetic Risk of Juvenile Myelomonocytic Leukemia
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. PTPN11 and NRAS are two genes whose abnormalities are risk factors for Juvenile Myelomonocytic Leukemia. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Juvenile Myelomonocytic Leukemia can be used as a guide for coming up with a recommended personalized nutrition plan. For Juvenile Myelomonocytic Leukemia gene PTPN11 has causative impact on biological pathways like Angiogenesis and C-type Lectin Receptor Signaling. And NRAS has a causative impact on biological pathways like G-protein-coupled Receptor Signaling, Growth Factor Signaling and RAS-RAF Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like PTPN11 and NRAS should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes PTPN11 and NRAS should be avoided.
Eat more pulses, Mung Bean or Adzuki Bean?
The active ingredients contained in Mung Bean are Quercetin, Oleic Acid, Linolenic Acid, Vitamin C, Vitexin among others. While the active ingredients contained in Adzuki Bean are Isoliquiritigenin, Glucaric Acid, Genistein, Folic Acid and others.
Vitamin C can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. Vitexin has biological action on biochemical pathways P53 Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.
Folic Acid can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. And so on.
For genetic risk of Juvenile Myelomonocytic Leukemia due to abnormalities in genes PTPN11 and NRAS – Foods like Mung Bean are recommended compared to Adzuki Bean. This is because the active ingredients Folic Acid in Adzuki Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitexin contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER ADZUKI BEAN FOR REDUCING THE GENETIC RISK OF JUVENILE MYELOMONOCYTIC LEUKEMIA DUE TO GENES PTPN11 AND NRAS
Eat more vegetables, Arugula or Radish?
The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Radish are Quercetin, Beta-sitosterol, Oleic Acid, Linolenic Acid, Vitamin C and others.
Kaempferol can manipulate biochemical pathways Cell Cycle Checkpoints, RAS-RAF Signaling and PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways MYC Signaling, Apoptosis and Cell Cycle Checkpoints.
Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MAPK Signaling, RAS-RAF Signaling and P53 Signaling. And so on.
For genetic risk of Juvenile Myelomonocytic Leukemia due to abnormalities in genes PTPN11 and NRAS – Foods like Arugula are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish further promote the effects of genes on the biochemical pathways. While the active ingredients Kaempferol and Vitamin A contained in Arugula together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER RADISH FOR REDUCING THE GENETIC RISK OF JUVENILE MYELOMONOCYTIC LEUKEMIA DUE TO GENES PTPN11 AND NRAS
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Orange or Cranberry?
The active ingredients contained in Orange are D-limonene, Linalool, Modified Citrus Pectin, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Cranberry are Ellagic Acid, Quercetin, Myricetin, Resveratrol, Hyperoside and others.
D-limonene can manipulate biochemical pathways MAPK Signaling, Cell Cycle Checkpoints and RAS-RAF Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
For genetic risk of Juvenile Myelomonocytic Leukemia due to abnormalities in genes PTPN11 and NRAS – Foods like Orange are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients D-limonene and Vitamin C contained in Orange together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ORANGE IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF JUVENILE MYELOMONOCYTIC LEUKEMIA DUE TO GENES PTPN11 AND NRAS
Eat more nuts, Almond or Macadamia Nut?
The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Cell Cycle Checkpoints, P53 Signaling and MYC Signaling. Vitamin E has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Apoptosis.
Palmitic Acid can manipulate biochemical pathways MAPK Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and MAPK Signaling. And so on.
For genetic risk of Juvenile Myelomonocytic Leukemia due to abnormalities in genes PTPN11 and NRAS – Foods like Almond are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF JUVENILE MYELOMONOCYTIC LEUKEMIA DUE TO GENES PTPN11 AND NRAS
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Juvenile Myelomonocytic Leukemia by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.