Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Unclassified Renal Cell Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Unclassified Renal Cell Carcinoma because of NF2 and BAP1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Unclassified Renal Cell Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Pummelo” or “Include fruit Pomegranate in my diet” or “Should I reduce consumption of vegetable Yardlong Bean” or “Can I take Birch and Spirulina supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO UNCLASSIFIED RENAL CELL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Unclassified Renal Cell Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR UNCLASSIFIED RENAL CELL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Unclassified Renal Cell Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Unclassified Renal Cell Carcinoma from cBioPortal. The patients enrolled in the studies for Unclassified Renal Cell Carcinoma are in ages between 12 to 84 with an average age of 60. 63.6% of males and 36.4% of females were the distribution of gender in these clinical studies. From a patient sample size of 168; the top genes with mutations and other abnormalities for Unclassified Renal Cell Carcinoma include genes SETD2, NF2, BAP1, KMT2C and MTOR. The occurrence frequency distribution for these genes respectively is 16.4%, 16.4%, 11.9%, 9.0% and 7.5%. These tumor genetic details of Unclassified Renal Cell Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Unclassified Renal Cell Carcinoma.
Significance of Nutrition for Unclassified Renal Cell Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Unclassified Renal Cell Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Pummelo includes active ingredients Beta-sitosterol, Vitamin C, Naringin, Oleic Acid, Chlorogenic Acid and others. And Pomegranate contains active ingredients Ellagic Acid, Apigenin, Betulinic Acid, Beta-sitosterol, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Unclassified Renal Cell Carcinoma, activation or inhibition of selected biochemical pathways like Oncogenic Cancer Epigenetics, Suppressive Histone Methylation, PI3K-AKT-MTOR Signaling, Oncogenic Histone Methylation plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Unclassified Renal Cell Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR UNCLASSIFIED RENAL CELL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Unclassified Renal Cell Carcinoma undergoing chemotherapy treatment
In Unclassified Renal Cell Carcinoma – the genes SETD2, NF2, BAP1, KMT2C and MTOR have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Unclassified Renal Cell Carcinoma are Oncogenic Cancer Epigenetics, Suppressive Histone Methylation, Growth Factor Signaling and others. Ipilimumab is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Oncogenic Cancer Epigenetics, Suppressive Histone Methylation, Growth Factor Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Beta-sitosterol, Daidzein, Vitamin C, Oleic Acid among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Oleic Acid, Linolenic Acid, Genistein, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, WNT Beta Catenin Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways Suppressive Histone Methylation, Oncogenic Cancer Epigenetics and Angiogenesis.
Genistein can manipulate biochemical pathways Chromatin Remodeling and DNA Repair. Linoleic Acid has biological action on biochemical pathways Angiogenesis. And so on.
When treating Unclassified Renal Cell Carcinoma with chemotherapy Ipilimumab – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Linoleic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR UNCLASSIFIED RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY IPILIMUMAB FOR SOME CONDITIONS.
Eat more vegetables, Cabbage or Yardlong Bean?
Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Quercetin, Benzyl Isothiocyanate, Beta-sitosterol, Vitamin C, Isorhamnetin among others. While the active ingredients contained in Yardlong Bean are Vitamin C, Oleic Acid, Linolenic Acid, Vitamin A, Linoleic Acid and others.
Vitamin C can manipulate biochemical pathways Suppressive Histone Methylation, MYC Signaling and WNT Beta Catenin Signaling. Glucaric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and MYC Signaling.
Linoleic Acid can manipulate biochemical pathways Angiogenesis. Folic Acid has biological action on biochemical pathways MYC Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Unclassified Renal Cell Carcinoma with chemotherapy Ipilimumab – Foods like Cabbage are recommended compared to Yardlong Bean. This is because the active ingredients Linoleic Acid and Folic Acid in Yardlong Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CABBAGE IS RECOMMENDED OVER YARDLONG BEAN FOR UNCLASSIFIED RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY IPILIMUMAB FOR SOME CONDITIONS.
Eat more fruits, Pomegranate or Pummelo?
Fruits are an important part of many diets. The active ingredients contained in Pomegranate are Ellagic Acid, Apigenin, Betulinic Acid, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Pummelo are Beta-sitosterol, Vitamin C, Naringin, Oleic Acid, Chlorogenic Acid and others.
Betulinic Acid can manipulate biochemical pathways JAK-STAT Signaling, MYC Signaling and WNT Beta Catenin Signaling. Gallic Acid has biological action on biochemical pathways DNA Repair, Angiogenesis and PI3K-AKT-MTOR Signaling.
Naringetol can manipulate biochemical pathways WNT Beta Catenin Signaling. Hesperetin has biological action on biochemical pathways WNT Beta Catenin Signaling. And so on.
When treating Unclassified Renal Cell Carcinoma with chemotherapy Ipilimumab – Foods like Pomegranate are recommended compared to Pummelo. This is because the active ingredients Naringetol and Hesperetin in Pummelo interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Gallic Acid contained in Pomegranate support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER PUMMELO FOR UNCLASSIFIED RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY IPILIMUMAB FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Oleic Acid, Vitamin E, Delphinidin, Linolenic Acid, Cianidanol among others. While the active ingredients contained in Brazil Nut are Oleic Acid, Vitamin E, Linolenic Acid, Folic Acid, Lecithin and others.
Vitamin E can manipulate biochemical pathways MYC Signaling, DNA Repair and Angiogenesis. Delphinidin has biological action on biochemical pathways G-protein-coupled Receptor Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling, MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Unclassified Renal Cell Carcinoma with chemotherapy Ipilimumab – Foods like Pecan Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Delphinidin contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER BRAZIL NUT FOR UNCLASSIFIED RENAL CELL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY IPILIMUMAB FOR SOME CONDITIONS.
Foods for Genetic Risk of Unclassified Renal Cell Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NF2 and BAP1 are two genes whose abnormalities are risk factors for Unclassified Renal Cell Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Unclassified Renal Cell Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Unclassified Renal Cell Carcinoma gene NF2 has causative impact on biological pathways like Hippo Signaling, Cytoskeletal Dynamics and Growth Factor Signaling. And BAP1 has a causative impact on biological pathways like DNA Repair. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NF2 and BAP1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NF2 and BAP1 should be avoided.
Eat more pulses, Scarlet Bean or Common Bean?
The active ingredients contained in Scarlet Bean are Vitamin C, Beta-sitosterol, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Oleic Acid, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and MYC Signaling.
Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways P53 Signaling, MYC Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Unclassified Renal Cell Carcinoma due to abnormalities in genes NF2 and BAP1 – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF UNCLASSIFIED RENAL CELL CARCINOMA DUE TO GENES NF2 AND BAP1
Eat more vegetables, Cassava or Celery?
The active ingredients contained in Cassava are Vitamin C, Beta-sitosterol, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Celery are Apigenin, Vitamin C, Quercetin, Oleic Acid, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and MYC Signaling.
Cynaroside can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Chrysin has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Unclassified Renal Cell Carcinoma due to abnormalities in genes NF2 and BAP1 – Foods like Cassava are recommended compared to Celery. This is because the active ingredients Cynaroside and Chrysin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF UNCLASSIFIED RENAL CELL CARCINOMA DUE TO GENES NF2 AND BAP1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Huckleberry?
The active ingredients contained in Feijoa are Vitamin C, Lycopene, Casuarinin, Folic Acid among others. While the active ingredients contained in Huckleberry are Resveratrol, Vitamin C, Quercetin, Caffeic Acid, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Lycopene has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Hypoxia and MYC Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Unclassified Renal Cell Carcinoma due to abnormalities in genes NF2 and BAP1 – Foods like Feijoa are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF UNCLASSIFIED RENAL CELL CARCINOMA DUE TO GENES NF2 AND BAP1
Eat more nuts, Hazelnut or Acorn?
The active ingredients contained in Hazelnut are Quercetin, Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Acorn are Vitamin C, Quercetin, Beta-sitosterol, Beta-carotene, Quercitrin and others.
Quercetin can manipulate biochemical pathways MYC Signaling, P53 Signaling and Cell Cycle Checkpoints. Vitamin E has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Hypoxia and MYC Signaling.
Vitamin B3 can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin B2 has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.
For genetic risk of Unclassified Renal Cell Carcinoma due to abnormalities in genes NF2 and BAP1 – Foods like Hazelnut are recommended compared to Acorn. This is because the active ingredients Vitamin B3 and Vitamin B2 in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin E contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF UNCLASSIFIED RENAL CELL CARCINOMA DUE TO GENES NF2 AND BAP1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Unclassified Renal Cell Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Pan Origimed 2020
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.