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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Therapy-related Myeloid Neoplasms!

Aug 1, 2023

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Introduction

Foods for Therapy-related Myeloid Neoplasms should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.



A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Therapy-related Myeloid Neoplasms does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Therapy-related Myeloid Neoplasms?

For example does it matter if vegetable Cauliflower is consumed more compared to Kohlrabi? Does it make any difference if fruit Pummelo is preferred over Pomegranate? Also if similar choices are made for nuts/seeds like Black Walnut over Chestnut and for pulses like Black-eyed Pea over Hyacinth Bean. And if what I eat matters – then how does one identify foods which are recommended for Therapy-related Myeloid Neoplasms and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Therapy-related Myeloid Neoplasms!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Therapy-related Myeloid Neoplasms can be characterized by a unique set of biochemical pathways - the signature pathways of Therapy-related Myeloid Neoplasms. Biochemical pathways like Suppressive Histone Methylation, Cell Cycle, Oncogenic Cancer Epigenetics, RAS-RAF Signaling are part of the signature definition of Therapy-related Myeloid Neoplasms.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Pummelo contains active ingredients Apigenin, Curcumin, Lupeol, Lycopene, Quercetin. And Pomegranate contains active ingredients Apigenin, Cinnamic Acid, Curcumin, Lupeol, Quercetin and possibly others.

A common mistake made when deciding and choosing foods to eat for Therapy-related Myeloid Neoplasms – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Therapy-related Myeloid Neoplasms.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Personalized nutrition for cancers like Therapy-related Myeloid Neoplasms consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Therapy-related Myeloid Neoplasms biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

All cancers like Therapy-related Myeloid Neoplasms can be characterized by a unique set of biochemical pathways – the signature pathways of Therapy-related Myeloid Neoplasms. Biochemical pathways like Suppressive Histone Methylation, Cell Cycle, Oncogenic Cancer Epigenetics, RAS-RAF Signaling are part of the signature definition of Therapy-related Myeloid Neoplasms. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Therapy-related Myeloid Neoplasms need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Therapy-related Myeloid Neoplasms when taking cancer treatment Decitabine, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

TP53, DNMT3A, FLT3, IDH1 and NRAS are the top ranked reported genes for Therapy-related Myeloid Neoplasms. TP53 is reported in 17.9 % of the representative patients across all clinical trials. And DNMT3A is reported in 12.6 %. The combined population patient data cover ages from to . 45.2 % of the patient data are identified as men. The Therapy-related Myeloid Neoplasms biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Therapy related Myeloid Neoplasms!

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CAULIFLOWER or KOHLRABI?

Vegetable Cauliflower contains many active ingredients or bioactives such as Curcumin, Lupeol, Beta-sitosterol, Isoliquiritigenin, Daidzein. These active ingredients manipulate various biochemical pathways like Cell Cycle, Apoptosis, WNT Beta Catenin Signaling and MAPK Signaling and others. Cauliflower is recommended for Therapy-related Myeloid Neoplasms when ongoing cancer treatment is Decitabine. This is because Cauliflower modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Decitabine.

Some of the active ingredients or bioactives in vegetable Kohlrabi are Curcumin, Lupeol, Quercetin, Beta-sitosterol, Kaempferol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and Oncogenic Cancer Epigenetics and others. Kohlrabi is not recommended for Therapy-related Myeloid Neoplasms when ongoing cancer treatment is Decitabine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CAULIFLOWER IS RECOMMENDED OVER KOHLRABI FOR Therapy-related Myeloid Neoplasms AND TREATMENT Decitabine.

Choose Fruit POMEGRANATE or PUMMELO?

Fruit Pomegranate contains many active ingredients or bioactives such as Apigenin, Cinnamic Acid, Curcumin, Lupeol, Quercetin. These active ingredients manipulate various biochemical pathways like Cell Cycle, Apoptosis, Chromatin Remodeling and MAPK Signaling and others. Pomegranate is recommended for Therapy-related Myeloid Neoplasms when ongoing cancer treatment is Decitabine. This is because Pomegranate modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Decitabine.

Some of the active ingredients or bioactives in fruit Pummelo are Apigenin, Curcumin, Lupeol, Lycopene, Quercetin. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and Oncogenic Cancer Epigenetics and others. Pummelo is not recommended for Therapy-related Myeloid Neoplasms when ongoing cancer treatment is Decitabine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT POMEGRANATE IS RECOMMENDED OVER PUMMELO FOR Therapy-related Myeloid Neoplasms AND TREATMENT Decitabine.

Choose Nut BLACK WALNUT or CHESTNUT?

Black Walnut contains many active ingredients or bioactives such as Apigenin, Curcumin, Lupeol, Quercetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like Cell Cycle, Apoptosis, MAPK Signaling and PI3K-AKT-MTOR Signaling and others. Black Walnut is recommended for Therapy-related Myeloid Neoplasms when ongoing cancer treatment is Decitabine. This is because Black Walnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Decitabine.

Some of the active ingredients or bioactives in Chestnut are Apigenin, Curcumin, Lupeol, Lycopene, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling and Oncogenic Cancer Epigenetics and others. Chestnut is not recommended for Therapy-related Myeloid Neoplasms when ongoing cancer treatment is Decitabine because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BLACK WALNUT IS RECOMMENDED OVER CHESTNUT FOR Therapy-related Myeloid Neoplasms AND TREATMENT Decitabine.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Therapy-related Myeloid Neoplasms or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or JERUSALEM ARTICHOKE?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Apigenin, Curcumin, Myricetin, Isoliquiritigenin, Lycopene. These active ingredients manipulate various biochemical pathways like Hypoxia, P53 Signaling, MAPK Signaling and Cell Cycle Checkpoints and others. Giant Butterbur is recommended for risk of Therapy-related Myeloid Neoplasms when associated genetic risk is DNMT3A. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Jerusalem Artichoke are Apigenin, Curcumin, Myricetin, Isoliquiritigenin, Kaempferol. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and MYC Signaling and others. Jerusalem Artichoke is not recommended when risk of Therapy-related Myeloid Neoplasms when associated genetic risk is DNMT3A because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER JERUSALEM ARTICHOKE FOR DNMT3A GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or LIME?

Fruit Red Raspberry contains many active ingredients or bioactives such as Curcumin, Quercetin, Ellagic Acid, Isoliquiritigenin, Formononetin. These active ingredients manipulate various biochemical pathways like Hypoxia, P53 Signaling and MAPK Signaling and others. Red Raspberry is recommended for risk of Therapy-related Myeloid Neoplasms when associated genetic risk is DNMT3A. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Lime are Curcumin, Isoliquiritigenin, Lycopene, Formononetin, Lupeol. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints and MYC Signaling and others. Lime is not recommended when risk of Therapy-related Myeloid Neoplasms when associated genetic risk is DNMT3A because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER LIME FOR DNMT3A GENETIC RISK OF CANCER.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT?

Butternut contains many active ingredients or bioactives such as Apigenin, Curcumin, Myricetin, Isoliquiritigenin, Lycopene. These active ingredients manipulate various biochemical pathways like Hypoxia, P53 Signaling, MAPK Signaling and Cell Cycle Checkpoints and others. Butternut is recommended for risk of Therapy-related Myeloid Neoplasms when associated genetic risk is DNMT3A. This is because Butternut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in European Chestnut are Apigenin, Curcumin, Quercetin, Ellagic Acid, Myricetin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and MYC Signaling and others. European Chestnut is not recommended when risk of Therapy-related Myeloid Neoplasms when associated genetic risk is DNMT3A because it increases the signature pathways of it.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR DNMT3A GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Therapy-related Myeloid Neoplasms. Therapy-related Myeloid Neoplasms patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Therapy-related Myeloid Neoplasms, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Cauliflower contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Therapy-related Myeloid Neoplasms?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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