Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Therapy-related Myeloid Neoplasms when undergoing chemotherapy or when you determine you have a genetic risk for developing Therapy-related Myeloid Neoplasms because of FLT3 and IDH1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Therapy-related Myeloid Neoplasms which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Apricot” or “Include fruit Salmonberry in my diet” or “Should I reduce consumption of vegetable Celery” or “Can I take Guggul and Apigenin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO THERAPY-RELATED MYELOID NEOPLASMS, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Therapy-related Myeloid Neoplasms is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR THERAPY-RELATED MYELOID NEOPLASMS, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Therapy-related Myeloid Neoplasms from cBioPortal. 45.2% of males and 54.8% of females were the distribution of gender in these clinical studies. From a patient sample size of 102; the top genes with mutations and other abnormalities for Therapy-related Myeloid Neoplasms include genes TP53, DNMT3A, FLT3, IDH1 and NRAS. The occurrence frequency distribution for these genes respectively is 17.9%, 12.6%, 10.5%, 10.5% and 9.5%. These tumor genetic details of Therapy-related Myeloid Neoplasms are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Therapy-related Myeloid Neoplasms.
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Therapy-related Myeloid Neoplasms. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Apricot includes active ingredients Quercetin, Modified Citrus Pectin, Beta-sitosterol, Vitamin C, Linolenic Acid and others. And Salmonberry contains active ingredients Protocatechuic Acid, P-coumaric Acid, Vanillic Acid, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Therapy-related Myeloid Neoplasms, activation or inhibition of selected biochemical pathways like Oncogenic Cancer Epigenetics, Chromatin Remodeling, RAS-RAF Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Therapy-related Myeloid Neoplasms, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR THERAPY-RELATED MYELOID NEOPLASMS – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
In Therapy-related Myeloid Neoplasms – the genes TP53, DNMT3A, FLT3, IDH1 and NRAS have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Therapy-related Myeloid Neoplasms are Oncogenic Cancer Epigenetics, Chromatin Remodeling, JAK-STAT Signaling and others. Cytarabine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Oncogenic Cancer Epigenetics, Chromatin Remodeling, JAK-STAT Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Scarlet Bean or Moth Bean?
Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Linolenic Acid, Genistein, Stigmasterol among others. While the active ingredients contained in Moth Bean are Beta-sitosterol, Linolenic Acid, Stigmasterol, Oleic Acid, Linoleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Chromatin Remodeling and MYC Signaling. Vitamin C has biological action on biochemical pathways WNT Beta Catenin Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Oleic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling, MYC Signaling and MAPK Signaling. And so on.
When treating Therapy-related Myeloid Neoplasms with chemotherapy Cytarabine – Foods like Scarlet Bean are recommended compared to Moth Bean. This is because the active ingredients Oleic Acid and Folic Acid in Moth Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER MOTH BEAN FOR THERAPY-RELATED MYELOID NEOPLASMS ON TREATMENT WITH CHEMOTHERAPY CYTARABINE FOR SOME CONDITIONS.
Eat more vegetables, Arugula or Celery?
Vegetables are an important part of many diets. The active ingredients contained in Arugula are Kaempferol, Esculin, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Kaempferol, Luteolin, Angelicin and others.
Kaempferol can manipulate biochemical pathways NFKB Signaling, JAK-STAT Signaling and WNT Beta Catenin Signaling. Vitamin A has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Inflammation.
Luteolin can manipulate biochemical pathways MYC Signaling and WNT Beta Catenin Signaling. Cynaroside has biological action on biochemical pathways MAPK Signaling. And so on.
When treating Therapy-related Myeloid Neoplasms with chemotherapy Cytarabine – Foods like Arugula are recommended compared to Celery. This is because the active ingredients Luteolin and Cynaroside in Celery interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Vitamin A contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CELERY FOR THERAPY-RELATED MYELOID NEOPLASMS ON TREATMENT WITH CHEMOTHERAPY CYTARABINE FOR SOME CONDITIONS.
Eat more fruits, Salmonberry or Apricot?
Fruits are an important part of many diets. The active ingredients contained in Salmonberry are Protocatechuic Acid, P-coumaric Acid, Vanillic Acid, Vitamin A among others. While the active ingredients contained in Apricot are Quercetin, Modified Citrus Pectin, Beta-sitosterol, Vitamin C, Linolenic Acid and others.
Protocatechuic Acid can manipulate biochemical pathways NFKB Signaling, JAK-STAT Signaling and MYC Signaling. P-coumaric Acid has biological action on biochemical pathways Chromatin Remodeling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Rutin can manipulate biochemical pathways WNT Beta Catenin Signaling and Oncogenic Cancer Epigenetics. Salicylic Acid has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.
When treating Therapy-related Myeloid Neoplasms with chemotherapy Cytarabine – Foods like Salmonberry are recommended compared to Apricot. This is because the active ingredients Rutin and Salicylic Acid in Apricot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Protocatechuic Acid and P-coumaric Acid contained in Salmonberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SALMONBERRY IS RECOMMENDED OVER APRICOT FOR THERAPY-RELATED MYELOID NEOPLASMS ON TREATMENT WITH CHEMOTHERAPY CYTARABINE FOR SOME CONDITIONS.
Eat more nuts, Pistachio or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Pistachio are Beta-sitosterol, Resveratrol, Linolenic Acid, Vitamin E, Stigmasterol among others. While the active ingredients contained in Peanut are Quercetin, Beta-sitosterol, Vitamin B3, Vitamin C, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Chromatin Remodeling and MYC Signaling. Resveratrol has biological action on biochemical pathways JAK-STAT Signaling, PI3K-AKT-MTOR Signaling and Inflammation.
Lecithin can manipulate biochemical pathways NFKB Signaling, JAK-STAT Signaling and MYC Signaling. Oleic Acid has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.
When treating Therapy-related Myeloid Neoplasms with chemotherapy Cytarabine – Foods like Pistachio are recommended compared to Peanut. This is because the active ingredients Lecithin and Oleic Acid in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Resveratrol contained in Pistachio support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PISTACHIO IS RECOMMENDED OVER PEANUT FOR THERAPY-RELATED MYELOID NEOPLASMS ON TREATMENT WITH CHEMOTHERAPY CYTARABINE FOR SOME CONDITIONS.
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. FLT3 and IDH1 are two genes whose abnormalities are risk factors for Therapy-related Myeloid Neoplasms. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Therapy-related Myeloid Neoplasms can be used as a guide for coming up with a recommended personalized nutrition plan. For Therapy-related Myeloid Neoplasms gene FLT3 has causative impact on biological pathways like Hypoxia, JAK-STAT Signaling and MAPK Signaling. And IDH1 has a causative impact on biological pathways like Oncogenic Cancer Epigenetics, Glutathione Metabolism and Hypoxia. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like FLT3 and IDH1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes FLT3 and IDH1 should be avoided.
Eat more pulses, Mung Bean or Soy Bean?
The active ingredients contained in Mung Bean are Quercetin, Kaempferol, Vitamin C, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Soy Bean are Quercetin, Lupeol, Vitamin C, Vitamin E, Daidzein and others.
Quercetin can manipulate biochemical pathways JAK-STAT Signaling, MYC Signaling and Cell Cycle Checkpoints. Kaempferol has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Hypoxia.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, JAK-STAT Signaling and MAPK Signaling. And so on.
For genetic risk of Therapy-related Myeloid Neoplasms due to abnormalities in genes FLT3 and IDH1 – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Kaempferol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF THERAPY-RELATED MYELOID NEOPLASMS DUE TO GENES FLT3 AND IDH1
Eat more vegetables, Asparagus or Chicory?
The active ingredients contained in Asparagus are Quercetin, Kaempferol, Vitamin C, Isorhamnetin, Oleic Acid among others. While the active ingredients contained in Chicory are Apigenin, Quercetin, Kaempferol, Luteolin, Lupeol and others.
Quercetin can manipulate biochemical pathways JAK-STAT Signaling, MYC Signaling and Cell Cycle Checkpoints. Kaempferol has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Hypoxia.
Luteolin can manipulate biochemical pathways MYC Signaling. Esculetin has biological action on biochemical pathways Hypoxia. And so on.
For genetic risk of Therapy-related Myeloid Neoplasms due to abnormalities in genes FLT3 and IDH1 – Foods like Asparagus are recommended compared to Chicory. This is because the active ingredients Luteolin and Esculetin in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Kaempferol contained in Asparagus together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ASPARAGUS IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF THERAPY-RELATED MYELOID NEOPLASMS DUE TO GENES FLT3 AND IDH1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Elderberry or Strawberry?
The active ingredients contained in Elderberry are Quercetin, Kaempferol, Lupeol, Vitamin C, Betulinic Acid among others. While the active ingredients contained in Strawberry are Ellagic Acid, Lupeol, Vitamin C, Oleic Acid, Linolenic Acid and others.
Quercetin can manipulate biochemical pathways JAK-STAT Signaling, MYC Signaling and Cell Cycle Checkpoints. Kaempferol has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Hypoxia.
Fisetin can manipulate biochemical pathways MYC Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Therapy-related Myeloid Neoplasms due to abnormalities in genes FLT3 and IDH1 – Foods like Elderberry are recommended compared to Strawberry. This is because the active ingredients Fisetin and Ellagic Acid in Strawberry further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Kaempferol contained in Elderberry together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ELDERBERRY IS RECOMMENDED OVER STRAWBERRY FOR REDUCING THE GENETIC RISK OF THERAPY-RELATED MYELOID NEOPLASMS DUE TO GENES FLT3 AND IDH1
Eat more nuts, Almond or Acorn?
The active ingredients contained in Almond are Quercetin, Vitamin E, Oleic Acid, Linolenic Acid, Beta-sitosterol among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Beta-sitosterol, Gallic Acid, Beta-carotene and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways JAK-STAT Signaling, MAPK Signaling and Oncogenic Cancer Epigenetics.
Beta-carotene can manipulate biochemical pathways MAPK Signaling. Vitamin B2 has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.
For genetic risk of Therapy-related Myeloid Neoplasms due to abnormalities in genes FLT3 and IDH1 – Foods like Almond are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Vitamin B2 in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF THERAPY-RELATED MYELOID NEOPLASMS DUE TO GENES FLT3 AND IDH1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Therapy-related Myeloid Neoplasms by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.