Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Soft Tissue Myoepithelial Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Soft Tissue Myoepithelial Carcinoma because of COL4A4 and PHLPP1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Soft Tissue Myoepithelial Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Pummelo” or “Include fruit Pitanga in my diet” or “Should I reduce consumption of vegetable Carrot” or “Can I take Curcumin and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SOFT TISSUE MYOEPITHELIAL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Soft Tissue Myoepithelial Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR SOFT TISSUE MYOEPITHELIAL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Soft Tissue Myoepithelial Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Soft Tissue Myoepithelial Carcinoma from cBioPortal. The patients enrolled in the studies for Soft Tissue Myoepithelial Carcinoma are in ages between 49 to 65 with an average age of 57. 60.0% of males and 40.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 9; the top genes with mutations and other abnormalities for Soft Tissue Myoepithelial Carcinoma include genes COL4A4, PHLPP1, SMARCB1, RYR1 and ABAT. The occurrence frequency distribution for these genes respectively is 28.6%, 28.6%, 28.6%, 28.6% and 14.3%. These tumor genetic details of Soft Tissue Myoepithelial Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Soft Tissue Myoepithelial Carcinoma.
Significance of Nutrition for Soft Tissue Myoepithelial Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Soft Tissue Myoepithelial Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Pummelo includes active ingredients Linolenic Acid, Naringin, Naringenin, Beta-sitosterol, Hesperetin and others. And Pitanga contains active ingredients Quercetin, Vitamin C, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Soft Tissue Myoepithelial Carcinoma, activation or inhibition of selected biochemical pathways like RUNX Signaling, MAPK Signaling, Extracellular Matrix Remodelling, Small Molecule Transport plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Soft Tissue Myoepithelial Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SOFT TISSUE MYOEPITHELIAL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Soft Tissue Myoepithelial Carcinoma undergoing chemotherapy treatment
In Soft Tissue Myoepithelial Carcinoma – the genes COL4A4, PHLPP1, SMARCB1, RYR1 and ABAT have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Soft Tissue Myoepithelial Carcinoma are RUNX Signaling, MAPK Signaling, Extracellular Matrix Remodelling and others. Carboplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RUNX Signaling, MAPK Signaling, Extracellular Matrix Remodelling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Linolenic Acid, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Pigeon Pea are Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Vitamin C has biological action on biochemical pathways P53 Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Linolenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Soft Tissue Myoepithelial Carcinoma with chemotherapy Carboplatin – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Linolenic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR SOFT TISSUE MYOEPITHELIAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more vegetables, Jicama or Carrot?
Vegetables are an important part of many diets. The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Carrot are Quercetin, D-limonene, Vitamin E, Lupeol, Luteolin and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Beta-carotene has biological action on biochemical pathways Extracellular Matrix Remodelling, DNA Repair and P53 Signaling.
Gamma-linolenic Acid can manipulate biochemical pathways Oxidative Stress. Osthole has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Soft Tissue Myoepithelial Carcinoma with chemotherapy Carboplatin – Foods like Jicama are recommended compared to Carrot. This is because the active ingredients Gamma-linolenic Acid and Osthole in Carrot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-carotene contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER CARROT FOR SOFT TISSUE MYOEPITHELIAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more fruits, Pitanga or Pummelo?
Fruits are an important part of many diets. The active ingredients contained in Pitanga are Quercetin, Vitamin C, Vitamin A among others. While the active ingredients contained in Pummelo are Linolenic Acid, Naringin, Naringenin, Beta-sitosterol, Hesperetin and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Quercetin has biological action on biochemical pathways Extracellular Matrix Remodelling, DNA Repair and JAK-STAT Signaling.
Naringin can manipulate biochemical pathways Oxidative Stress. Naringenin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Soft Tissue Myoepithelial Carcinoma with chemotherapy Carboplatin – Foods like Pitanga are recommended compared to Pummelo. This is because the active ingredients Naringin and Naringenin in Pummelo interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Quercetin contained in Pitanga support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PITANGA IS RECOMMENDED OVER PUMMELO FOR SOFT TISSUE MYOEPITHELIAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Linolenic Acid, Beta-sitosterol, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Beta-carotene, Gallic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Cell Cycle.
Gallic Acid can manipulate biochemical pathways Oxidative Stress. Quercitrin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Soft Tissue Myoepithelial Carcinoma with chemotherapy Carboplatin – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Gallic Acid and Quercitrin in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR SOFT TISSUE MYOEPITHELIAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Soft Tissue Myoepithelial Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. COL4A4 and PHLPP1 are two genes whose abnormalities are risk factors for Soft Tissue Myoepithelial Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Soft Tissue Myoepithelial Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Soft Tissue Myoepithelial Carcinoma gene COL4A4 has causative impact on biological pathways like Extracellular Matrix Remodelling, Epithelial to Mesenchymal Transition and Focal Adhesion. And PHLPP1 has a causative impact on biological pathways like PI3K-AKT-MTOR Signaling, Inositol Phosphate Signaling and Focal Adhesion. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like COL4A4 and PHLPP1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes COL4A4 and PHLPP1 should be avoided.
Eat more pulses, Common Bean or Yellow Wax Bean?
The active ingredients contained in Common Bean are Apigenin, Oleic Acid, Gamma-linolenic Acid, Genistein, Esculin among others. While the active ingredients contained in Yellow Wax Bean are Cianidanol, Vitamin C, Butyric Acid, Ferulic Acid, Astragalin and others.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Apigenin has biological action on biochemical pathways G-protein-coupled Receptor Signaling, EPHRIN Signaling and PI3K-AKT-MTOR Signaling.
Palmitic Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling and Post Translation Modification. Cianidanol has biological action on biochemical pathways Complement Cascade. And so on.
For genetic risk of Soft Tissue Myoepithelial Carcinoma due to abnormalities in genes COL4A4 and PHLPP1 – Foods like Common Bean are recommended compared to Yellow Wax Bean. This is because the active ingredients Palmitic Acid and Cianidanol in Yellow Wax Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin A and Apigenin contained in Common Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON BEAN IS RECOMMENDED OVER YELLOW WAX BEAN FOR REDUCING THE GENETIC RISK OF SOFT TISSUE MYOEPITHELIAL CARCINOMA DUE TO GENES COL4A4 AND PHLPP1
Eat more vegetables, Artichoke or Cluster Bean?
The active ingredients contained in Artichoke are Apigenin, Naringenin, Chlorogenic Acid, Cynaroside, Vitamin C among others. While the active ingredients contained in Cluster Bean are Oleic Acid, Beta-sitosterol, Vitamin C, Stigmasterol, Linolenic Acid and others.
Vitamin K can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Apigenin has biological action on biochemical pathways G-protein-coupled Receptor Signaling, EPHRIN Signaling and PI3K-AKT-MTOR Signaling.
Linolenic Acid can manipulate biochemical pathways Complement Cascade. Linoleic Acid has biological action on biochemical pathways Complement Cascade. And so on.
For genetic risk of Soft Tissue Myoepithelial Carcinoma due to abnormalities in genes COL4A4 and PHLPP1 – Foods like Artichoke are recommended compared to Cluster Bean. This is because the active ingredients Linolenic Acid and Linoleic Acid in Cluster Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin K and Apigenin contained in Artichoke together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ARTICHOKE IS RECOMMENDED OVER CLUSTER BEAN FOR REDUCING THE GENETIC RISK OF SOFT TISSUE MYOEPITHELIAL CARCINOMA DUE TO GENES COL4A4 AND PHLPP1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Pomegranate or Malus (crab Apple)?
The active ingredients contained in Pomegranate are Apigenin, Ellagic Acid, Epigallocatechin Gallate, Beta-sitosterol, Betulinic Acid among others. While the active ingredients contained in Malus (crab Apple) are Oleic Acid, Vitamin C, Linolenic Acid, 7-4′-dihydroxyflavone, Linoleic Acid and others.
Betulinic Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Ursolic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling.
Linolenic Acid can manipulate biochemical pathways Complement Cascade. Linoleic Acid has biological action on biochemical pathways Complement Cascade. And so on.
For genetic risk of Soft Tissue Myoepithelial Carcinoma due to abnormalities in genes COL4A4 and PHLPP1 – Foods like Pomegranate are recommended compared to Malus (crab Apple). This is because the active ingredients Linolenic Acid and Linoleic Acid in Malus (crab Apple) further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Ursolic Acid contained in Pomegranate together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER MALUS (CRAB APPLE) FOR REDUCING THE GENETIC RISK OF SOFT TISSUE MYOEPITHELIAL CARCINOMA DUE TO GENES COL4A4 AND PHLPP1
Eat more nuts, Chestnut or Cashew Nut?
The active ingredients contained in Chestnut are Ellagic Acid, Quercetin, Oleic Acid, Betulin, Vitamin C among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Vitamin C, Butyric Acid, Gallic Acid, Vitamin K and others.
Ellagic Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling, Post Translation Modification and EPHRIN Signaling. Betulin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling.
Lauric Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways Post Translation Modification. And so on.
For genetic risk of Soft Tissue Myoepithelial Carcinoma due to abnormalities in genes COL4A4 and PHLPP1 – Foods like Chestnut are recommended compared to Cashew Nut. This is because the active ingredients Lauric Acid and Myristic Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Ellagic Acid and Betulin contained in Chestnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CHESTNUT IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF SOFT TISSUE MYOEPITHELIAL CARCINOMA DUE TO GENES COL4A4 AND PHLPP1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Soft Tissue Myoepithelial Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
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- Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex.
- Natural products as a gold mine for selective matrix metalloproteinases inhibitors.
- β-Carotene suppresses osteoclastogenesis and bone resorption by suppressing NF-κB signaling pathway.
- Research on Rett syndrome: strategy and preliminary results.
- Osthole prevents tamoxifen-induced liver injury in mice.
- Research progress on the anticancer effects of vitamin K2.
- Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats.
- Quercetin and quercitrin protect against cytokine‑induced injuries in RINm5F β-cells via the mitochondrial pathway and NF-κB signaling.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
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- Thrombin inhibitory activity of some polyphenolic compounds.
- Pentacyclic Triterpenoids Inhibit IKKβ Mediated Activation of NF-κB Pathway: In Silico and In Vitro Evidences.
- Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
- Betulin Inhibits Lung Metastasis by Inducing Cell Cycle Arrest, Autophagy, and Apoptosis of Metastatic Colorectal Cancer Cells.
- Functional Expression and Characterization of Human Myristoylated-Arf1 in Nanodisc Membrane Mimetics.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.