Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Small Cell Carcinoma Of The Ovary when undergoing chemotherapy or when you determine you have a genetic risk for developing Small Cell Carcinoma Of The Ovary because of SMARCA4 and JAK3 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Small Cell Carcinoma Of The Ovary which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Grape” or “Include fruit Graviola in my diet” or “Should I reduce consumption of vegetable Radish” or “Can I take Buckthorn and Apigenin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SMALL CELL CARCINOMA OF THE OVARY, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Small Cell Carcinoma Of The Ovary is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR SMALL CELL CARCINOMA OF THE OVARY, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Small Cell Carcinoma Of The Ovary
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Small Cell Carcinoma Of The Ovary from cBioPortal. The patients enrolled in the studies for Small Cell Carcinoma Of The Ovary are in ages between 18 to 42 with an average age of 26.From a patient sample size of 13; the top genes with mutations and other abnormalities for Small Cell Carcinoma Of The Ovary include genes SMARCA4, TP53, ASXL1, JAK3 and NOTCH2. The occurrence frequency distribution for these genes respectively is 91.7%, 8.3%, 8.3%, 8.3% and 8.3%. These tumor genetic details of Small Cell Carcinoma Of The Ovary are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Small Cell Carcinoma Of The Ovary.
Significance of Nutrition for Small Cell Carcinoma Of The Ovary
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Small Cell Carcinoma Of The Ovary. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Grape includes active ingredients Lupeol, Vitamin E, Linolenic Acid, Beta-sitosterol, Pterostilbene and others. And Graviola contains active ingredients Emodin, Lycopene, Vitamin E, Daidzein, Beta-sitosterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Small Cell Carcinoma Of The Ovary, activation or inhibition of selected biochemical pathways like Apoptosis, JAK-STAT Signaling, Chromatin Remodeling, Oncogenic Cancer Epigenetics plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Small Cell Carcinoma Of The Ovary, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SMALL CELL CARCINOMA OF THE OVARY – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Small Cell Carcinoma Of The Ovary undergoing chemotherapy treatment
In Small Cell Carcinoma Of The Ovary – the genes SMARCA4, TP53, ASXL1, JAK3 and NOTCH2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Small Cell Carcinoma Of The Ovary are Apoptosis, JAK-STAT Signaling and others. Carboplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Apoptosis, JAK-STAT Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Hyacinth Bean or Soy Bean?
Pulses are an important part of many diets. The active ingredients contained in Hyacinth Bean are Palmitic Acid, Vitamin C, Genistein, Myristic Acid, Folic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Stigmasterol, Vitamin E, Daidzein, Linolenic Acid and others.
Palmitic Acid can manipulate biochemical pathways MYC Signaling, P53 Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways MYC Signaling, P53 Signaling and Apoptosis.
Lecithin can manipulate biochemical pathways MYC Signaling and JAK-STAT Signaling. Fisetin has biological action on biochemical pathways MYC Signaling. And so on.
When treating Small Cell Carcinoma Of The Ovary with chemotherapy Carboplatin – Foods like Hyacinth Bean are recommended compared to Soy Bean. This is because the active ingredients Lecithin and Fisetin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Palmitic Acid and Vitamin C contained in Hyacinth Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: HYACINTH BEAN IS RECOMMENDED OVER SOY BEAN FOR SMALL CELL CARCINOMA OF THE OVARY ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more vegetables, Arugula or Radish?
Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Radish are Beta-sitosterol, Linolenic Acid, Quercetin, Vitamin C, P-coumaric Acid and others.
Kaempferol can manipulate biochemical pathways JAK-STAT Signaling. Vitamin A has biological action on biochemical pathways MYC Signaling and Apoptosis.
Pelargonidin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways P53 Signaling, Apoptosis and JAK-STAT Signaling. And so on.
When treating Small Cell Carcinoma Of The Ovary with chemotherapy Carboplatin – Foods like Arugula are recommended compared to Radish. This is because the active ingredients Pelargonidin and Folic Acid in Radish interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Vitamin A contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER RADISH FOR SMALL CELL CARCINOMA OF THE OVARY ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more fruits, Graviola or Grape?
Fruits are an important part of many diets. The active ingredients contained in Graviola are Emodin, Lycopene, Vitamin E, Daidzein, Beta-sitosterol among others. While the active ingredients contained in Grape are Lupeol, Vitamin E, Linolenic Acid, Beta-sitosterol, Pterostilbene and others.
Emodin can manipulate biochemical pathways MYC Signaling, P53 Signaling and Apoptosis. Cinnamic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and Apoptosis.
Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling. And so on.
When treating Small Cell Carcinoma Of The Ovary with chemotherapy Carboplatin – Foods like Graviola are recommended compared to Grape. This is because the active ingredients Resveratrol and Pelargonidin in Grape interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Emodin and Cinnamic Acid contained in Graviola support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: GRAVIOLA IS RECOMMENDED OVER GRAPE FOR SMALL CELL CARCINOMA OF THE OVARY ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Cianidanol, Linoleic Acid, Oleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid and others.
Vitamin E can manipulate biochemical pathways MYC Signaling, P53 Signaling and Apoptosis. Cianidanol has biological action on biochemical pathways MYC Signaling, P53 Signaling and Apoptosis.
Lecithin can manipulate biochemical pathways MYC Signaling and JAK-STAT Signaling. Folic Acid has biological action on biochemical pathways P53 Signaling, Apoptosis and MYC Signaling. And so on.
When treating Small Cell Carcinoma Of The Ovary with chemotherapy Carboplatin – Foods like Pecan Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER BRAZIL NUT FOR SMALL CELL CARCINOMA OF THE OVARY ON TREATMENT WITH CHEMOTHERAPY CARBOPLATIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Small Cell Carcinoma Of The Ovary
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. SMARCA4 and JAK3 are two genes whose abnormalities are risk factors for Small Cell Carcinoma Of The Ovary. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Small Cell Carcinoma Of The Ovary can be used as a guide for coming up with a recommended personalized nutrition plan. For Small Cell Carcinoma Of The Ovary gene SMARCA4 has causative impact on biological pathways like Androgen Signaling, Chromatin Remodeling and Epithelial to Mesenchymal Transition. And JAK3 has a causative impact on biological pathways like Chemokine Signaling, Hematopoiesis and Cytokine Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like SMARCA4 and JAK3 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes SMARCA4 and JAK3 should be avoided.
Eat more pulses, Mung Bean or Common Bean?
The active ingredients contained in Mung Bean are Quercetin, Oleic Acid, Stigmasterol, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Oleic Acid, Vitamin C, Linolenic Acid and others.
Quercetin can manipulate biochemical pathways Apoptosis, JAK-STAT Signaling and MYC Signaling. Stigmasterol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, JAK-STAT Signaling and P53 Signaling. And so on.
For genetic risk of Small Cell Carcinoma Of The Ovary due to abnormalities in genes SMARCA4 and JAK3 – Foods like Mung Bean are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Stigmasterol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF SMALL CELL CARCINOMA OF THE OVARY DUE TO GENES SMARCA4 AND JAK3
Eat more vegetables, Cluster Bean or Chicory?
The active ingredients contained in Cluster Bean are Beta-sitosterol, Oleic Acid, Stigmasterol, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Betulinic Acid, Lupeol, Quercetin and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Stigmasterol has biological action on biochemical pathways JAK-STAT Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Luteolin can manipulate biochemical pathways MYC Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, JAK-STAT Signaling and P53 Signaling. And so on.
For genetic risk of Small Cell Carcinoma Of The Ovary due to abnormalities in genes SMARCA4 and JAK3 – Foods like Cluster Bean are recommended compared to Chicory. This is because the active ingredients Luteolin and Folic Acid in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Stigmasterol contained in Cluster Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CLUSTER BEAN IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF SMALL CELL CARCINOMA OF THE OVARY DUE TO GENES SMARCA4 AND JAK3
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Cherimoya or Raspberry?
The active ingredients contained in Cherimoya are Beta-sitosterol, Oleic Acid, Stigmasterol, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Raspberry are Quercetin, Resveratrol, Ellagic Acid, Vitamin C, Salicylic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Stigmasterol has biological action on biochemical pathways JAK-STAT Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
For genetic risk of Small Cell Carcinoma Of The Ovary due to abnormalities in genes SMARCA4 and JAK3 – Foods like Cherimoya are recommended compared to Raspberry. This is because the active ingredients Ellagic Acid and Resveratrol in Raspberry further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Stigmasterol contained in Cherimoya together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CHERIMOYA IS RECOMMENDED OVER RASPBERRY FOR REDUCING THE GENETIC RISK OF SMALL CELL CARCINOMA OF THE OVARY DUE TO GENES SMARCA4 AND JAK3
Eat more nuts, Almond or Peanut?
The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Stigmasterol and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways JAK-STAT Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Small Cell Carcinoma Of The Ovary due to abnormalities in genes SMARCA4 and JAK3 – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF SMALL CELL CARCINOMA OF THE OVARY DUE TO GENES SMARCA4 AND JAK3
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Small Cell Carcinoma Of The Ovary by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
- Recurrent SMARCA4 mutations in small cell carcinoma of the ovary.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Actions of calcitonin gene-related peptide on rat spinal dorsal horn neurons.
- Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Comparison of Myo-Monitor centric position to centric relation and centric occlusion.
- Cinnamic Acid (CINN) Induces Apoptosis and Proliferation in Human Nasopharyngeal Carcinoma Cells.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- Flavonoids as receptor tyrosine kinase FLT3 inhibitors.
- Increased mean serum thyrotropin in apparently euthyroid hypercholesterolemic patients: does it mean occult hypothyroidism?
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Apoptosis induction by gamma-tocotrienol in human hepatoma Hep3B cells.
- Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
- Stigmasterol isolated from marine microalgae Navicula incerta induces apoptosis in human hepatoma HepG2 cells.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.