Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Skin Adnexal Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Skin Adnexal Carcinoma because of CARD11 and KIT gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Skin Adnexal Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Gooseberry” or “Include fruit Currant in my diet” or “Should I reduce consumption of vegetable Beetroot” or “Can I take Myricetin and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SKIN ADNEXAL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Skin Adnexal Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR SKIN ADNEXAL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Skin Adnexal Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Skin Adnexal Carcinoma from cBioPortal. 33.3% of males and 66.7% of females were the distribution of gender in these clinical studies. From a patient sample size of 6; the top genes with mutations and other abnormalities for Skin Adnexal Carcinoma include genes CARD11, TERT, KIT, IGF1R and AXL. The occurrence frequency distribution for these genes respectively is 50.0%, 50.0%, 50.0%, 50.0% and 50.0%. These tumor genetic details of Skin Adnexal Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Skin Adnexal Carcinoma.
Significance of Nutrition for Skin Adnexal Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Skin Adnexal Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Gooseberry includes active ingredients Beta-sitosterol, Vitamin C, Linolenic Acid, Gallic Acid, Oleic Acid and others. And Currant contains active ingredients Quercetin, Delphinidin, Myricetin, Beta-sitosterol, Vitamin C and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Skin Adnexal Carcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Growth Factor Signaling, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Skin Adnexal Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SKIN ADNEXAL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Skin Adnexal Carcinoma undergoing chemotherapy treatment
In Skin Adnexal Carcinoma – the genes CARD11, TERT, KIT, IGF1R and AXL have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Skin Adnexal Carcinoma are RAS-RAF Signaling, Growth Factor Signaling, Microtubule Dynamics and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Growth Factor Signaling, Microtubule Dynamics so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Delphinidin, Daidzein, Lupeol, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Genistein, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Microtubule Dynamics. Vitamin C has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Angiogenesis.
Genistein can manipulate biochemical pathways DNA Repair. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
When treating Skin Adnexal Carcinoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Oleic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR SKIN ADNEXAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more vegetables, Kohlrabi or Beetroot?
Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Beta-sitosterol, Vitamin C, Brassinin, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Beetroot are Beta-sitosterol, Vitamin E, Vitamin C, Linolenic Acid, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and PI3K-AKT-MTOR Signaling. Brassinin has biological action on biochemical pathways NFKB Signaling, JAK-STAT Signaling and Angiogenesis.
Oleic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Linoleic Acid has biological action on biochemical pathways Angiogenesis and Epithelial to Mesenchymal Transition. And so on.
When treating Skin Adnexal Carcinoma with chemotherapy Radiation – Foods like Kohlrabi are recommended compared to Beetroot. This is because the active ingredients Oleic Acid and Linoleic Acid in Beetroot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Brassinin contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER BEETROOT FOR SKIN ADNEXAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more fruits, Currant or Gooseberry?
Fruits are an important part of many diets. The active ingredients contained in Currant are Quercetin, Delphinidin, Myricetin, Beta-sitosterol, Vitamin C among others. While the active ingredients contained in Gooseberry are Beta-sitosterol, Vitamin C, Linolenic Acid, Gallic Acid, Oleic Acid and others.
Delphinidin can manipulate biochemical pathways NFKB Signaling, DNA Repair and Growth Factor Signaling. Vitamin C has biological action on biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and PI3K-AKT-MTOR Signaling.
Rutin can manipulate biochemical pathways Microtubule Dynamics. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
When treating Skin Adnexal Carcinoma with chemotherapy Radiation – Foods like Currant are recommended compared to Gooseberry. This is because the active ingredients Rutin and Oleic Acid in Gooseberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Delphinidin and Vitamin C contained in Currant support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: CURRANT IS RECOMMENDED OVER GOOSEBERRY FOR SKIN ADNEXAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Delphinidin, Vitamin E, Linolenic Acid, Cianidanol, Oleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid and others.
Delphinidin can manipulate biochemical pathways NFKB Signaling, DNA Repair and Growth Factor Signaling. Vitamin E has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Notch Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways NFKB Signaling, JAK-STAT Signaling and MYC Signaling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition. And so on.
When treating Skin Adnexal Carcinoma with chemotherapy Radiation – Foods like Pecan Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Oleic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Delphinidin and Vitamin E contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER BRAZIL NUT FOR SKIN ADNEXAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.
Foods for Genetic Risk of Skin Adnexal Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. CARD11 and KIT are two genes whose abnormalities are risk factors for Skin Adnexal Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Skin Adnexal Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Skin Adnexal Carcinoma gene CARD11 has causative impact on biological pathways like T-Cell Receptor Signaling and NFKB Signaling. And KIT has a causative impact on biological pathways like MAPK Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like CARD11 and KIT should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes CARD11 and KIT should be avoided.
Eat more pulses, Scarlet Bean or Fava Bean?
The active ingredients contained in Scarlet Bean are Oleic Acid, Genistein, Vitamin C, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Fava Bean are Quercetin, Daidzein, Oleic Acid, Caffeic Acid, Genistein and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Stigmasterol has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Quercetin can manipulate biochemical pathways DNA Repair. Ferulic Acid has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Skin Adnexal Carcinoma due to abnormalities in genes CARD11 and KIT – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Quercetin and Ferulic Acid in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Stigmasterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF SKIN ADNEXAL CARCINOMA DUE TO GENES CARD11 AND KIT
Eat more vegetables, Jicama or Chinese Mustard?
The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Vitamin A, Beta-carotene, Folic Acid among others. While the active ingredients contained in Chinese Mustard are Quercetin, Isorhamnetin, Kaempferol, Indole-3-carbinol, Vitamin A and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin B3 has biological action on biochemical pathways NFKB Signaling and MYC Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Skin Adnexal Carcinoma due to abnormalities in genes CARD11 and KIT – Foods like Jicama are recommended compared to Chinese Mustard. This is because the active ingredients Vitamin A and Quercetin in Chinese Mustard further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER CHINESE MUSTARD FOR REDUCING THE GENETIC RISK OF SKIN ADNEXAL CARCINOMA DUE TO GENES CARD11 AND KIT
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Grape or Huckleberry?
The active ingredients contained in Grape are Resveratrol, Lupeol, Oleic Acid, Chlorogenic Acid, Vitamin E among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, Chlorogenic Acid, Caffeic Acid, Vitamin C and others.
Resveratrol can manipulate biochemical pathways NFKB Signaling, DNA Repair and MYC Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Quercetin can manipulate biochemical pathways DNA Repair. Pelargonidin has biological action on biochemical pathways MYC Signaling, NFKB Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Skin Adnexal Carcinoma due to abnormalities in genes CARD11 and KIT – Foods like Grape are recommended compared to Huckleberry. This is because the active ingredients Quercetin and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Resveratrol and Vitamin C contained in Grape together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GRAPE IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF SKIN ADNEXAL CARCINOMA DUE TO GENES CARD11 AND KIT
Eat more nuts, Almond or Pumpkin Seeds?
The active ingredients contained in Almond are Quercetin, Oleic Acid, Vitamin E, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Pumpkin Seeds are Oleic Acid, Linolenic Acid, Stigmasterol, Gamma-linolenic Acid, Beta-sitosterol and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, NFKB Signaling and Oncogenic Cancer Epigenetics. Vitamin E has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, NFKB Signaling and MAPK Signaling. Cucurbitacin I has biological action on biochemical pathways EPHRIN Signaling, MYC Signaling and NFKB Signaling. And so on.
For genetic risk of Skin Adnexal Carcinoma due to abnormalities in genes CARD11 and KIT – Foods like Almond are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Cucurbitacin I in Pumpkin Seeds further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER PUMPKIN SEEDS FOR REDUCING THE GENETIC RISK OF SKIN ADNEXAL CARCINOMA DUE TO GENES CARD11 AND KIT
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Skin Adnexal Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
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- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- Identification of new potent phthalazine derivatives with VEGFR-2 and EGFR kinase inhibitory activity.
- Brassinin inhibits STAT3 signaling pathway through modulation of PIAS-3 and SOCS-3 expression and sensitizes human lung cancer xenograft in nude mice to paclitaxel.
- Linoleic acid enhances angiogenesis through suppression of angiostatin induced by plasminogen activator inhibitor 1.
- Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Stigmasterol Causes Ovarian Cancer Cell Apoptosis by Inducing Endoplasmic Reticulum and Mitochondrial Dysfunction.
- [Basic formulation of the tasks of special education in rehabilitating the physically handicapped].
- Legionella pneumophila serogroup 12 pneumonia in a renal transplant recipient: case report and environmental observations.
- Spongiapyridine and related spongians isolated from an Indonesian Spongia sp.
- Pelargonidin reduces the TPA induced transformation of mouse epidermal cells -potential involvement of Nrf2 promoter demethylation.
- Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Cucurbitacin-I induces hypertrophy in H9c2 cardiomyoblasts through activation of autophagy via MEK/ERK1/2 signaling pathway.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.