Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Round Cell Sarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Round Cell Sarcoma because of ATM and AR gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Round Cell Sarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Cherry” or “Include fruit Bayberry in my diet” or “Should I reduce consumption of vegetable Bell Pepper” or “Can I take Caffeine and Bayberry supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ROUND CELL SARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Round Cell Sarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR ROUND CELL SARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Round Cell Sarcoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Round Cell Sarcoma from cBioPortal. 42.1% of males and 57.9% of females were the distribution of gender in these clinical studies. From a patient sample size of 38; the top genes with mutations and other abnormalities for Round Cell Sarcoma include genes PIK3CA, ATM, RB1, TERT and AR. The occurrence frequency distribution for these genes respectively is 5.6%, 5.6%, 5.6%, 5.6% and 5.6%. These tumor genetic details of Round Cell Sarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Round Cell Sarcoma.
Significance of Nutrition for Round Cell Sarcoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Round Cell Sarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Cherry includes active ingredients Isorhamnetin, Quercetin, Glucaric Acid, Beta-sitosterol, Oleic Acid and others. And Bayberry contains active ingredients Myricetin, Gallic Acid, Beta-carotene, Lupeol, Linalool and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Round Cell Sarcoma, activation or inhibition of selected biochemical pathways like DNA Repair, PI3K-AKT-MTOR Signaling, Hypoxia, Oncogenic Histone Methylation plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Round Cell Sarcoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ROUND CELL SARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Round Cell Sarcoma undergoing chemotherapy treatment
In Round Cell Sarcoma – the genes PIK3CA, ATM, RB1, TERT and AR have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Round Cell Sarcoma are DNA Repair, PI3K-AKT-MTOR Signaling and others. Doxorubicin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers DNA Repair, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Black-eyed Pea or Lima Bean?
Pulses are an important part of many diets. The active ingredients contained in Black-eyed Pea are Beta-carotene, Daidzein, Oleic Acid, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Lima Bean are Oleic Acid, Vitamin C, Genistein, Linoleic Acid, Vitamin A and others.
Daidzein can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling.
Genistein can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Round Cell Sarcoma with chemotherapy Doxorubicin – Foods like Black-eyed Pea are recommended compared to Lima Bean. This is because the active ingredients Genistein and Folic Acid in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Daidzein and Vitamin C contained in Black-eyed Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BLACK-EYED PEA IS RECOMMENDED OVER LIMA BEAN FOR ROUND CELL SARCOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more vegetables, Arrowroot or Bell Pepper?
Vegetables are an important part of many diets. The active ingredients contained in Arrowroot are Quercetin, Beta-carotene, Vanillic Acid, Chlorogenic Acid, Protocatechuic Acid among others. While the active ingredients contained in Bell Pepper are Isorhamnetin, Vitamin E, Oleic Acid, Linolenic Acid, Vitamin C and others.
Quercetin can manipulate biochemical pathways DNA Repair and PI3K-AKT-MTOR Signaling. Beta-carotene has biological action on biochemical pathways DNA Repair and PI3K-AKT-MTOR Signaling.
Capsaicin can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Round Cell Sarcoma with chemotherapy Doxorubicin – Foods like Arrowroot are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Folic Acid in Bell Pepper interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Beta-carotene contained in Arrowroot support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARROWROOT IS RECOMMENDED OVER BELL PEPPER FOR ROUND CELL SARCOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more fruits, Bayberry or Cherry?
Fruits are an important part of many diets. The active ingredients contained in Bayberry are Myricetin, Gallic Acid, Beta-carotene, Lupeol, Linalool among others. While the active ingredients contained in Cherry are Isorhamnetin, Quercetin, Glucaric Acid, Beta-sitosterol, Oleic Acid and others.
Beta-caryophyllene can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Myricetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling.
Shikimic Acid can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Genistein has biological action on biochemical pathways DNA Repair. And so on.
When treating Round Cell Sarcoma with chemotherapy Doxorubicin – Foods like Bayberry are recommended compared to Cherry. This is because the active ingredients Shikimic Acid and Genistein in Cherry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-caryophyllene and Myricetin contained in Bayberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BAYBERRY IS RECOMMENDED OVER CHERRY FOR ROUND CELL SARCOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more nuts, Almond or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Salicylic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Oleic Acid, Linolenic Acid, Folic Acid, Lecithin and others.
Beta-sitosterol can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways DNA Repair and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Round Cell Sarcoma with chemotherapy Doxorubicin – Foods like Almond are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Quercetin contained in Almond support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER BRAZIL NUT FOR ROUND CELL SARCOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Round Cell Sarcoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ATM and AR are two genes whose abnormalities are risk factors for Round Cell Sarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Round Cell Sarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Round Cell Sarcoma gene ATM has causative impact on biological pathways like DNA Repair and Cell Cycle Checkpoints. And AR has a causative impact on biological pathways like Androgen Signaling and Cytoskeletal Dynamics. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ATM and AR should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ATM and AR should be avoided.
Eat more pulses, Scarlet Bean or Fava Bean?
The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Fava Bean are Daidzein, Beta-sitosterol, Vitamin C, Oleic Acid, Cianidanol and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and Apoptosis.
Ferulic Acid can manipulate biochemical pathways DNA Repair. Genistein has biological action on biochemical pathways DNA Repair. And so on.
For genetic risk of Round Cell Sarcoma due to abnormalities in genes ATM and AR – Foods like Scarlet Bean are recommended compared to Fava Bean. This is because the active ingredients Ferulic Acid and Genistein in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF ROUND CELL SARCOMA DUE TO GENES ATM AND AR
Eat more vegetables, Jicama or Beetroot?
The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Beetroot are Vitamin E, Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Vitamin B3 has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis.
Vitamin E can manipulate biochemical pathways DNA Repair. Folic Acid has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and Apoptosis. And so on.
For genetic risk of Round Cell Sarcoma due to abnormalities in genes ATM and AR – Foods like Jicama are recommended compared to Beetroot. This is because the active ingredients Vitamin E and Folic Acid in Beetroot further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER BEETROOT FOR REDUCING THE GENETIC RISK OF ROUND CELL SARCOMA DUE TO GENES ATM AND AR
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Kiwi or Cranberry?
The active ingredients contained in Kiwi are Vitamin C, Fisetin, Chlorogenic Acid, Quercetin, Vitamin A among others. While the active ingredients contained in Cranberry are Resveratrol, Vitamin C, Ellagic Acid, Hyperoside, P-coumaric Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Fisetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints.
Resveratrol can manipulate biochemical pathways DNA Repair. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Round Cell Sarcoma due to abnormalities in genes ATM and AR – Foods like Kiwi are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Ellagic Acid in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Fisetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: KIWI IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF ROUND CELL SARCOMA DUE TO GENES ATM AND AR
Eat more nuts, Hazelnut or Macadamia Nut?
The active ingredients contained in Hazelnut are Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid, Quercetin among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Folic Acid, Myristic Acid and others.
Quercetin can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Cell Cycle Checkpoints.
Palmitic Acid can manipulate biochemical pathways Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling and DNA Repair. Lauric Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Round Cell Sarcoma due to abnormalities in genes ATM and AR – Foods like Hazelnut are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Quercetin and Vitamin A contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER MACADAMIA NUT FOR REDUCING THE GENETIC RISK OF ROUND CELL SARCOMA DUE TO GENES ATM AND AR
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Round Cell Sarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
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Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.