Which Foods are Recommended for Adamantinoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Adamantinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Adamantinoma because of FZD1 and BMPR2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Adamantinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Grape” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Olive” or “Can I take Neem Extract and Dan Shen supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ADAMANTINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Adamantinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ADAMANTINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Adamantinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Adamantinoma from cBioPortal. 60.0% of males and 40.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 5; the top genes with mutations and other abnormalities for Adamantinoma include genes FZD1, BMPR2, PI4KB, MAP3K21 and KDM6A. The occurrence frequency distribution for these genes respectively is 20.0%, 20.0%, 20.0%, 20.0% and 20.0%. These tumor genetic details of Adamantinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Adamantinoma.

Adamantinoma is a rare, low-grade, slow-growing, malignant bone tumor. It most often develops in individuals between the age of 20 and 50 years and it is more common in men. It may be located in several bones, with most cases in the long tubular bones and the most common location being in the tibia. Adamantinoma may be of two types: classic adamantinoma and differentiated adamantinoma, with the latter developing in younger patients up to 20 years of age. The main symptom reported by patients is pain and swelling. The initial symptoms are non-specific and depend on the location of the tumor. Many patients may live with the above symptoms for many years without proceeding to a medical examination. Adamantinoma can cause pathological fractures and the tumor can metastasize, mainly to the adjacent lymph nodes and the lungs. Treatment of adamantinoma includes extensive resection and reconstruction of bone defect. Patients with adamantinoma have a high 5-year survival rate of 95%-98.8%, although the biological behavior of this tumor is unpredictable, and recurrence presents with a more progressive behavior. When adamantinoma metastasizes, targeted multi-kinase inhibitors may prolong survival. Additionally, supportive care with the right nutrition (foods and natural supplements) can improve the patients’ well-being. (Ref: Varvarousis DN et al, in vivo, 2021;
https://www.ncbi.nlm.nih.gov/books/NBK538175/)

Significance of Nutrition for Adamantinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Adamantinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Grape includes active ingredients Beta-sitosterol, Lupeol, Vitamin C, Berberine, Resveratrol and others. And Partridgeberry contains active ingredients Beta-sitosterol, Resveratrol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Adamantinoma, activation or inhibition of selected biochemical pathways like Notch Signaling, Chromatin Remodeling, Epithelial to Mesenchymal Transition, Oxidative Stress plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Adamantinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ADAMANTINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Adamantinoma undergoing chemotherapy treatment

In Adamantinoma – the genes FZD1, BMPR2, PI4KB, MAP3K21 and KDM6A have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Adamantinoma are Notch Signaling, Chromatin Remodeling, Epithelial to Mesenchymal Transition and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Notch Signaling, Chromatin Remodeling, Epithelial to Mesenchymal Transition so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Hyacinth Bean or Lima Bean?

Pulses are an important part of many diets. The active ingredients contained in Hyacinth Bean are Vitamin C, Palmitic Acid, Myristic Acid, Genistein among others. While the active ingredients contained in Lima Bean are Vitamin C, Oleic Acid, Vitamin A, Linoleic Acid, Genistein and others.

Palmitic Acid can manipulate biochemical pathways Oxidative Stress. Vitamin C has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Oxidative Stress.

Genistein can manipulate biochemical pathways Oxidative Stress. Vitamin A has biological action on biochemical pathways Notch Signaling. And so on.

When treating Adamantinoma with chemotherapy Radiation – Foods like Hyacinth Bean are recommended compared to Lima Bean. This is because the active ingredients Genistein and Vitamin A in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Palmitic Acid and Vitamin C contained in Hyacinth Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: HYACINTH BEAN IS RECOMMENDED OVER LIMA BEAN FOR ADAMANTINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Turnip or Olive?

Vegetables are an important part of many diets. The active ingredients contained in Turnip are Sulforaphane, Vitamin C, Indole-3-carbinol, Vitamin A among others. While the active ingredients contained in Olive are Caffeic Acid, Cinnamic Acid, Lupeol, Betulinic Acid, Corosolic Acid and others.

Sulforaphane can manipulate biochemical pathways Chromatin Remodeling and Oxidative Stress. Indole-3-carbinol has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Oxidative Stress.

Cinnamic Acid can manipulate biochemical pathways Oxidative Stress. Hydroxytyrosol has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Adamantinoma with chemotherapy Radiation – Foods like Turnip are recommended compared to Olive. This is because the active ingredients Cinnamic Acid and Hydroxytyrosol in Olive interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Sulforaphane and Indole-3-carbinol contained in Turnip support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: TURNIP IS RECOMMENDED OVER OLIVE FOR ADAMANTINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Partridgeberry or Grape?

Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Beta-sitosterol, Resveratrol, Stigmasterol among others. While the active ingredients contained in Grape are Beta-sitosterol, Lupeol, Vitamin C, Berberine, Resveratrol and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Chromatin Remodeling and Oxidative Stress. Resveratrol has biological action on biochemical pathways Notch Signaling.

Geraniin can manipulate biochemical pathways Oxidative Stress. Pelargonidin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Adamantinoma with chemotherapy Radiation – Foods like Partridgeberry are recommended compared to Grape. This is because the active ingredients Geraniin and Pelargonidin in Grape interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Resveratrol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER GRAPE FOR ADAMANTINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Macadamia Nut or Walnut?

Nuts are an important part of many diets. The active ingredients contained in Macadamia Nut are Beta-sitosterol, Lauric Acid, Palmitic Acid, Myristic Acid among others. While the active ingredients contained in Walnut are Myricetin, Beta-sitosterol, Carvacrol, Betulinic Acid, Juglone and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Chromatin Remodeling and Oxidative Stress. Lauric Acid has biological action on biochemical pathways Oxidative Stress.

Myricetin can manipulate biochemical pathways Oxidative Stress. Juglone has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Adamantinoma with chemotherapy Radiation – Foods like Macadamia Nut are recommended compared to Walnut. This is because the active ingredients Myricetin and Juglone in Walnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Lauric Acid contained in Macadamia Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: MACADAMIA NUT IS RECOMMENDED OVER WALNUT FOR ADAMANTINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Adamantinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. FZD1 and BMPR2 are two genes whose abnormalities are risk factors for Adamantinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Adamantinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Adamantinoma gene FZD1 has causative impact on biological pathways like Noncoding RNA Signaling and PI3K-AKT-MTOR Signaling. And BMPR2 has a causative impact on biological pathways like TGFB Signaling, Hematopoiesis and Cytokine Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like FZD1 and BMPR2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes FZD1 and BMPR2 should be avoided.

Eat more pulses, Mung Bean or Lentils?

The active ingredients contained in Mung Bean are Vitamin C, Stigmasterol, Linolenic Acid, Vitamin A, Oleic Acid among others. While the active ingredients contained in Lentils are Ellagic Acid, Vitamin C, Isoliquiritigenin, Daidzein, Beta-sitosterol and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition and Oxidative Stress. Stigmasterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Oxidative Stress.

Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition. Isoliquiritigenin has biological action on biochemical pathways Oxidative Stress. And so on.

For genetic risk of Adamantinoma due to abnormalities in genes FZD1 and BMPR2 – Foods like Mung Bean are recommended compared to Lentils. This is because the active ingredients Ellagic Acid and Isoliquiritigenin in Lentils further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Stigmasterol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER LENTILS FOR REDUCING THE GENETIC RISK OF ADAMANTINOMA DUE TO GENES FZD1 AND BMPR2

Eat more vegetables, Giant Butterbur or Rhubarb?

The active ingredients contained in Giant Butterbur are Vitamin C, Beta-sitosterol, Melatonin, Vitamin A, Vitamin B3 among others. While the active ingredients contained in Rhubarb are Chrysophanol, Vitamin C, Gallic Acid, Linolenic Acid, Vitamin A and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition and Oxidative Stress. Beta-sitosterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition and Oxidative Stress.

Rutin can manipulate biochemical pathways Oxidative Stress. Chrysophanol has biological action on biochemical pathways Chromatin Remodeling. And so on.

For genetic risk of Adamantinoma due to abnormalities in genes FZD1 and BMPR2 – Foods like Giant Butterbur are recommended compared to Rhubarb. This is because the active ingredients Rutin and Chrysophanol in Rhubarb further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER RHUBARB FOR REDUCING THE GENETIC RISK OF ADAMANTINOMA DUE TO GENES FZD1 AND BMPR2

Eat more fruits, Raspberry or Blueberry?

The active ingredients contained in Raspberry are Ellagic Acid, Vitamin C, Resveratrol, Gallic Acid, Vitamin A among others. While the active ingredients contained in Blueberry are Eugenol, Caffeic Acid, Vitamin C, Resveratrol, Ferulic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition and Oxidative Stress. Resveratrol has biological action on biochemical pathways Notch Signaling.

Gallic Acid can manipulate biochemical pathways Oxidative Stress. Cianidanol has biological action on biochemical pathways Oxidative Stress. And so on.

For genetic risk of Adamantinoma due to abnormalities in genes FZD1 and BMPR2 – Foods like Raspberry are recommended compared to Blueberry. This is because the active ingredients Gallic Acid and Cianidanol in Blueberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Resveratrol contained in Raspberry together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: RASPBERRY IS RECOMMENDED OVER BLUEBERRY FOR REDUCING THE GENETIC RISK OF ADAMANTINOMA DUE TO GENES FZD1 AND BMPR2

Eat more nuts, Cashew Nut or Peanut?

The active ingredients contained in Cashew Nut are Vitamin C, Lauric Acid, Palmitic Acid, Beta-sitosterol, Gallic Acid among others. While the active ingredients contained in Peanut are Vitamin C, Stigmasterol, Ferulic Acid, Beta-sitosterol, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition and Oxidative Stress. Lauric Acid has biological action on biochemical pathways Oxidative Stress.

Vitamin A can manipulate biochemical pathways Notch Signaling. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.

For genetic risk of Adamantinoma due to abnormalities in genes FZD1 and BMPR2 – Foods like Cashew Nut are recommended compared to Peanut. This is because the active ingredients Vitamin A and Citric Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lauric Acid contained in Cashew Nut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: CASHEW NUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF ADAMANTINOMA DUE TO GENES FZD1 AND BMPR2

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Adamantinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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