Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Urothelial Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Urothelial Carcinoma because of RB1 and KMT2D gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Urothelial Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Bilberry” or “Include fruit Nance in my diet” or “Should I reduce consumption of vegetable Jute” or “Can I take Dim and Birch supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO UROTHELIAL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Urothelial Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR UROTHELIAL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Urothelial Carcinoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Urothelial Carcinoma from cBioPortal. 69.8% of males and 30.2% of females were the distribution of gender in these clinical studies. From a patient sample size of 45; the top genes with mutations and other abnormalities for Urothelial Carcinoma include genes KMT2D, TP53, TERT, PIK3CA and RB1. The occurrence frequency distribution for these genes respectively is 56.7%, 53.3%, 43.3%, 23.3% and 16.7%. These tumor genetic details of Urothelial Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Urothelial Carcinoma.
Significance of Nutrition for Urothelial Carcinoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Urothelial Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Bilberry includes active ingredients Quercetin, Resveratrol, Myricetin, P-coumaric Acid, Caffeic Acid and others. And Nance contains active ingredients Vitamin C, Betulin, Vitamin A and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Urothelial Carcinoma, activation or inhibition of selected biochemical pathways like Oncogenic Cancer Epigenetics, MAPK Signaling, PI3K-AKT-MTOR Signaling, Oncogenic Histone Methylation plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Urothelial Carcinoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR UROTHELIAL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Urothelial Carcinoma undergoing chemotherapy treatment
In Urothelial Carcinoma – the genes KMT2D, TP53, TERT, PIK3CA and RB1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Urothelial Carcinoma are Oncogenic Cancer Epigenetics, MAPK Signaling, Angiogenesis and others. Doxorubicin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Oncogenic Cancer Epigenetics, MAPK Signaling, Angiogenesis so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Adzuki Bean?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Daidzein, Lupeol, Beta-sitosterol, Vitamin C, Oleic Acid among others. While the active ingredients contained in Adzuki Bean are Isoliquiritigenin, Genistein, Glucaric Acid, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Oxidative Stress, MYC Signaling and WNT Beta Catenin Signaling.
Isoliquiritigenin can manipulate biochemical pathways Oxidative Stress. Genistein has biological action on biochemical pathways DNA Repair and Oxidative Stress. And so on.
When treating Urothelial Carcinoma with chemotherapy Doxorubicin – Foods like Common Pea are recommended compared to Adzuki Bean. This is because the active ingredients Isoliquiritigenin and Genistein in Adzuki Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER ADZUKI BEAN FOR UROTHELIAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more vegetables, Okra or Jute?
Vegetables are an important part of many diets. The active ingredients contained in Okra are Quercetin, Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Jute are Quercetin, Vitamin C, Oleic Acid, Linolenic Acid, Kaempferol and others.
Vitamin A can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin K has biological action on biochemical pathways MYC Signaling, Vitamin D Signaling and Cell Cycle Checkpoints.
Quercetin can manipulate biochemical pathways Oxidative Stress. Kaempferol has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Urothelial Carcinoma with chemotherapy Doxorubicin – Foods like Okra are recommended compared to Jute. This is because the active ingredients Quercetin and Kaempferol in Jute interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin A and Vitamin K contained in Okra support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: OKRA IS RECOMMENDED OVER JUTE FOR UROTHELIAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more fruits, Nance or Bilberry?
Fruits are an important part of many diets. The active ingredients contained in Nance are Vitamin C, Betulin, Vitamin A among others. While the active ingredients contained in Bilberry are Quercetin, Resveratrol, Myricetin, P-coumaric Acid, Caffeic Acid and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Oxidative Stress. Betulin has biological action on biochemical pathways Cell Survival, MYC Signaling and MAPK Signaling.
Delphinidin can manipulate biochemical pathways Oxidative Stress. Chlorogenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Urothelial Carcinoma with chemotherapy Doxorubicin – Foods like Nance are recommended compared to Bilberry. This is because the active ingredients Delphinidin and Chlorogenic Acid in Bilberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Betulin contained in Nance support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: NANCE IS RECOMMENDED OVER BILBERRY FOR UROTHELIAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Acorn?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Linolenic Acid, Cianidanol, Delphinidin among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Beta-carotene, Gallic Acid and others.
Vitamin E can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Cianidanol has biological action on biochemical pathways Cell Survival, MYC Signaling and P53 Signaling.
Quercetin can manipulate biochemical pathways Oxidative Stress. Beta-carotene has biological action on biochemical pathways MAPK Signaling and Notch Signaling. And so on.
When treating Urothelial Carcinoma with chemotherapy Doxorubicin – Foods like Pecan Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Beta-carotene in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER ACORN FOR UROTHELIAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY DOXORUBICIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Urothelial Carcinoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. RB1 and KMT2D are two genes whose abnormalities are risk factors for Urothelial Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Urothelial Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Urothelial Carcinoma gene RB1 has causative impact on biological pathways like Cell Cycle Checkpoints, DNA Repair and Cell Cycle. And KMT2D has a causative impact on biological pathways like Oncogenic Histone Methylation and Amino Acid Metabolism. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like RB1 and KMT2D should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes RB1 and KMT2D should be avoided.
Eat more pulses, Scarlet Bean or Soy Bean?
The active ingredients contained in Scarlet Bean are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Soy Bean are Quercetin, Lupeol, Daidzein, Vitamin E, Beta-sitosterol and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Urothelial Carcinoma due to abnormalities in genes RB1 and KMT2D – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF UROTHELIAL CARCINOMA DUE TO GENES RB1 AND KMT2D
Eat more vegetables, Jicama or Carob?
The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Carob are Quercetin, Myricetin, Palmitic Acid, Phloroglucinol, Gallic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin B3 has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Palmitic Acid can manipulate biochemical pathways Chromatin Remodeling and MAPK Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Urothelial Carcinoma due to abnormalities in genes RB1 and KMT2D – Foods like Jicama are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Folic Acid in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF UROTHELIAL CARCINOMA DUE TO GENES RB1 AND KMT2D
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Cranberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Ellagic Acid, Quercetin, Resveratrol, Hyperoside, Myricetin and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling and Cell Cycle Checkpoints. Resveratrol has biological action on biochemical pathways P53 Signaling. And so on.
For genetic risk of Urothelial Carcinoma due to abnormalities in genes RB1 and KMT2D – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Resveratrol in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF UROTHELIAL CARCINOMA DUE TO GENES RB1 AND KMT2D
Eat more nuts, Hazelnut or Peanut?
The active ingredients contained in Hazelnut are Quercetin, Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Vitamin C and others.
Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Myricitrin has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Urothelial Carcinoma due to abnormalities in genes RB1 and KMT2D – Foods like Hazelnut are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Myricitrin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF UROTHELIAL CARCINOMA DUE TO GENES RB1 AND KMT2D
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Urothelial Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Impact 2017
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- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH.
- Isoliquiritigenin, an Orally Available Natural FLT3 Inhibitor from Licorice, Exhibits Selective Anti-Acute Myeloid Leukemia Efficacy In Vitro and In Vivo.
- BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
- Trends in congenital heart disease in Dallas County births. 1971-1984.
- Delphinidin, an anthocyanidin in pigmented fruits and vegetables, protects human HaCaT keratinocytes and mouse skin against UVB-mediated oxidative stress and apoptosis.
- Natural Polyphenol Chlorogenic Acid Protects Against Acetaminophen-Induced Hepatotoxicity by Activating ERK/Nrf2 Antioxidative Pathway.
- Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
- Research progress on the anticancer effects of vitamin K2.
- Small-molecule inhibitors of NADPH oxidase 4.
- Gamma-tocotrienol-induced apoptosis in human gastric cancer SGC-7901 cells is associated with a suppression in mitogen-activated protein kinase signalling.
- (+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-alpha in LPS-stimulated macrophages.
- Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines.
- Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells.
- Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
- Sequential protooncogene expression in regenerating kidney following acute renal injury.
- Myricitrin blocks activation of NF-κB and MAPK signaling pathways to protect nigrostriatum neuron in LPS-stimulated mice.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.