Which Foods are Recommended for Sarcomatoid Carcinoma Of The Lung?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Sarcomatoid Carcinoma Of The Lung when undergoing chemotherapy or when you determine you have a genetic risk for developing Sarcomatoid Carcinoma Of The Lung because of RNF43 and MET gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Sarcomatoid Carcinoma Of The Lung which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Huckleberry” or “Include fruit Orange in my diet” or “Should I reduce consumption of vegetable Radish” or “Can I take Curcumin and Modified Citrus Pectin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO SARCOMATOID CARCINOMA OF THE LUNG, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Sarcomatoid Carcinoma Of The Lung is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR SARCOMATOID CARCINOMA OF THE LUNG, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Sarcomatoid Carcinoma Of The Lung

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Sarcomatoid Carcinoma Of The Lung from cBioPortal. 60.0% of males and 40.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 15; the top genes with mutations and other abnormalities for Sarcomatoid Carcinoma Of The Lung include genes TP53, RNF43, MET, NRAS and KRAS. The occurrence frequency distribution for these genes respectively is 45.5%, 18.2%, 18.2%, 18.2% and 18.2%. These tumor genetic details of Sarcomatoid Carcinoma Of The Lung are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Sarcomatoid Carcinoma Of The Lung.

Significance of Nutrition for Sarcomatoid Carcinoma Of The Lung

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Sarcomatoid Carcinoma Of The Lung. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Huckleberry includes active ingredients Quercetin, Resveratrol, Ferulic Acid, P-coumaric Acid, Vitamin C and others. And Orange contains active ingredients D-limonene, Modified Citrus Pectin, Linalool, Hesperidin, Auraptene and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Sarcomatoid Carcinoma Of The Lung, activation or inhibition of selected biochemical pathways like Growth Factor Signaling, DNA Repair, PI3K-AKT-MTOR Signaling, Apoptosis plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Sarcomatoid Carcinoma Of The Lung, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR SARCOMATOID CARCINOMA OF THE LUNG – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Sarcomatoid Carcinoma Of The Lung undergoing chemotherapy treatment

In Sarcomatoid Carcinoma Of The Lung – the genes TP53, RNF43, MET, NRAS and KRAS have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Sarcomatoid Carcinoma Of The Lung are Growth Factor Signaling, DNA Repair, Mismatch Repair and others. Pembrolizumab is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Growth Factor Signaling, DNA Repair, Mismatch Repair so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Winged Bean or Soy Bean?

Pulses are an important part of many diets. The active ingredients contained in Winged Bean are Betulinic Acid, Linolenic Acid, Oleic Acid, Vitamin C, Linoleic Acid among others. While the active ingredients contained in Soy Bean are Quercetin, Vitamin E, Lupeol, Daidzein, Beta-sitosterol and others.

Betulinic Acid can manipulate biochemical pathways MYC Signaling, Myeloid-derived Suppressor Cells and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, Myeloid-derived Suppressor Cells and PI3K-AKT-MTOR Signaling.

Genistein can manipulate biochemical pathways DNA Repair. Lecithin has biological action on biochemical pathways MYC Signaling, Myeloid-derived Suppressor Cells and PI3K-AKT-MTOR Signaling. And so on.

When treating Sarcomatoid Carcinoma Of The Lung with chemotherapy Pembrolizumab – Foods like Winged Bean are recommended compared to Soy Bean. This is because the active ingredients Genistein and Lecithin in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER SOY BEAN FOR SARCOMATOID CARCINOMA OF THE LUNG ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.

Eat more vegetables, Bamboo or Radish?

Vegetables are an important part of many diets. The active ingredients contained in Bamboo are Protocatechuic Acid, Beta-sitosterol, Ferulic Acid, P-coumaric Acid, Beta-carotene among others. While the active ingredients contained in Radish are Quercetin, Beta-sitosterol, P-coumaric Acid, Linolenic Acid, Vitamin C and others.

Ferulic Acid can manipulate biochemical pathways Myeloid-derived Suppressor Cells, Growth Factor Signaling and DNA Repair. Protocatechuic Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Myeloid-derived Suppressor Cells.

Pelargonidin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Salicylic Acid has biological action on biochemical pathways Mismatch Repair. And so on.

When treating Sarcomatoid Carcinoma Of The Lung with chemotherapy Pembrolizumab – Foods like Bamboo are recommended compared to Radish. This is because the active ingredients Pelargonidin and Salicylic Acid in Radish interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ferulic Acid and Protocatechuic Acid contained in Bamboo support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: BAMBOO IS RECOMMENDED OVER RADISH FOR SARCOMATOID CARCINOMA OF THE LUNG ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.

Eat more fruits, Orange or Huckleberry?

Fruits are an important part of many diets. The active ingredients contained in Orange are D-limonene, Modified Citrus Pectin, Linalool, Hesperidin, Auraptene among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, Ferulic Acid, P-coumaric Acid, Vitamin C and others.

D-limonene can manipulate biochemical pathways MYC Signaling, Growth Factor Signaling and Myeloid-derived Suppressor Cells. Glucaric Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and Myeloid-derived Suppressor Cells.

Resveratrol can manipulate biochemical pathways DNA Repair. Pelargonidin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

When treating Sarcomatoid Carcinoma Of The Lung with chemotherapy Pembrolizumab – Foods like Orange are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients D-limonene and Glucaric Acid contained in Orange support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ORANGE IS RECOMMENDED OVER HUCKLEBERRY FOR SARCOMATOID CARCINOMA OF THE LUNG ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Peanut?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Beta-sitosterol, Ferulic Acid, Vanillic Acid and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Myeloid-derived Suppressor Cells and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling, Myeloid-derived Suppressor Cells and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways MYC Signaling, Myeloid-derived Suppressor Cells and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

When treating Sarcomatoid Carcinoma Of The Lung with chemotherapy Pembrolizumab – Foods like Pine Nut are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PEANUT FOR SARCOMATOID CARCINOMA OF THE LUNG ON TREATMENT WITH CHEMOTHERAPY PEMBROLIZUMAB FOR SOME CONDITIONS.

Foods for Genetic Risk of Sarcomatoid Carcinoma Of The Lung

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. RNF43 and MET are two genes whose abnormalities are risk factors for Sarcomatoid Carcinoma Of The Lung. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Sarcomatoid Carcinoma Of The Lung can be used as a guide for coming up with a recommended personalized nutrition plan. For Sarcomatoid Carcinoma Of The Lung gene RNF43 has causative impact on biological pathways like . And MET has a causative impact on biological pathways like Adherens junction, Cytoskeletal Dynamics and MAPK Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like RNF43 and MET should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes RNF43 and MET should be avoided.

Eat more pulses, Scarlet Bean or Lima Bean?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Lima Bean are Oleic Acid, Vitamin C, Genistein, Linoleic Acid, Vitamin A and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling and Extracellular Matrix Remodelling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.

For genetic risk of Sarcomatoid Carcinoma Of The Lung due to abnormalities in genes RNF43 and MET – Foods like Scarlet Bean are recommended compared to Lima Bean. This is because the active ingredients Vitamin A and Linoleic Acid in Lima Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER LIMA BEAN FOR REDUCING THE GENETIC RISK OF SARCOMATOID CARCINOMA OF THE LUNG DUE TO GENES RNF43 AND MET

Eat more vegetables, Jicama or Lotus?

The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Lotus are Quercetin, Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Vitamin B3 has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MYC Signaling.

Fisetin can manipulate biochemical pathways MYC Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.

For genetic risk of Sarcomatoid Carcinoma Of The Lung due to abnormalities in genes RNF43 and MET – Foods like Jicama are recommended compared to Lotus. This is because the active ingredients Fisetin and Linoleic Acid in Lotus further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER LOTUS FOR REDUCING THE GENETIC RISK OF SARCOMATOID CARCINOMA OF THE LUNG DUE TO GENES RNF43 AND MET

Eat more fruits, Feijoa or Lingonberry?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Lingonberry are Quercetin, Hyperoside, Resveratrol, Oleic Acid, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Lycopene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Resveratrol can manipulate biochemical pathways P53 Signaling. Fraxin has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.

For genetic risk of Sarcomatoid Carcinoma Of The Lung due to abnormalities in genes RNF43 and MET – Foods like Feijoa are recommended compared to Lingonberry. This is because the active ingredients Resveratrol and Fraxin in Lingonberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER LINGONBERRY FOR REDUCING THE GENETIC RISK OF SARCOMATOID CARCINOMA OF THE LUNG DUE TO GENES RNF43 AND MET

Eat more nuts, Almond or Acorn?

The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Quercitrin, Vitamin B3 and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Extracellular Matrix Remodelling, Growth Factor Signaling and Cell Cycle Checkpoints.

Beta-carotene can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways Extracellular Matrix Remodelling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Sarcomatoid Carcinoma Of The Lung due to abnormalities in genes RNF43 and MET – Foods like Almond are recommended compared to Acorn. This is because the active ingredients Beta-carotene and Vitamin A in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF SARCOMATOID CARCINOMA OF THE LUNG DUE TO GENES RNF43 AND MET

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Sarcomatoid Carcinoma Of The Lung by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

• Tmb Mskcc 2018
• Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients.
• Betulinic acid impairs metastasis and reduces immunosuppressive cells in breast cancer models.
• Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
• BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells.
• Role of the lipid-regulated NF-κB/IL-6/STAT3 axis in alpha-naphthyl isothiocyanate-induced liver injury.
• D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
• Dietary D-glucarate effects on the biomarkers of inflammation during early post-initiation stages of benzo[a]pyrene-induced lung tumorigenesis in A/J mice.
• Pelargonidin reduces the TPA induced transformation of mouse epidermal cells -potential involvement of Nrf2 promoter demethylation.
• Ferulic Acid Exerts Anti-Angiogenic and Anti-Tumor Activity by Targeting Fibroblast Growth Factor Receptor 1-Mediated Angiogenesis.
• Naturally occurring phenolic acids modulate TPA-induced activation of EGFR, AP-1, and STATs in mouse epidermis.
• β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
• Research progress on the anticancer effects of vitamin K2.
• Sequential protooncogene expression in regenerating kidney following acute renal injury.
• Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
• Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells.
• Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
• Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
• Fraxin Alleviates LPS-Induced ARDS by Downregulating Inflammatory Responses and Oxidative Damages and Reducing Pulmonary Vascular Permeability.
• Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells.
• Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
• β-carotene Inhibits Expression of c-Myc and Cyclin E in Helicobacter pylori-infected Gastric Epithelial Cells.
• HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
• Analysis and bioactive evaluation of the compounds absorbed into blood after oral administration of the extracts of Vaccinium vitis-idaea in rat.
• Fisetin: a dietary antioxidant for health promotion.