Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Retroperitoneal Seminoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Retroperitoneal Seminoma because of KIT and RAC1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Retroperitoneal Seminoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Bilberry” or “Include fruit Feijoa in my diet” or “Should I reduce consumption of vegetable Purslane” or “Can I take Birch and Lavender supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO RETROPERITONEAL SEMINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Retroperitoneal Seminoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR RETROPERITONEAL SEMINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Retroperitoneal Seminoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Retroperitoneal Seminoma from cBioPortal. The top genes with mutations and other abnormalities for Retroperitoneal Seminoma include genes KIT, KRAS, NRAS, RAC1 and KMT2D. The occurrence frequency distribution for these genes respectively is 22.3%, 18.9%, 6.1%, 5.8% and 4.8%. These tumor genetic details of Retroperitoneal Seminoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Retroperitoneal Seminoma.
Significance of Nutrition for Retroperitoneal Seminoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Retroperitoneal Seminoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Bilberry includes active ingredients Quercetin, Resveratrol, Myricetin, P-coumaric Acid, Caffeic Acid and others. And Feijoa contains active ingredients Lycopene, Vitamin C, Casuarinin, Folic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Retroperitoneal Seminoma, activation or inhibition of selected biochemical pathways like Cell Cycle, RUNX Signaling, PI3K-AKT-MTOR Signaling, RAS-RAF Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Retroperitoneal Seminoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR RETROPERITONEAL SEMINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Retroperitoneal Seminoma undergoing chemotherapy treatment
In Retroperitoneal Seminoma – the genes KIT, KRAS, NRAS, RAC1 and KMT2D have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Retroperitoneal Seminoma are Cell Cycle, RUNX Signaling, Notch Signaling and others. Cisplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, RUNX Signaling, Notch Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Linoleic Acid, Genistein among others. While the active ingredients contained in Pigeon Pea are Linoleic Acid, Genistein, Vitamin C, Linolenic Acid, Oleic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Inositol Phosphate Signaling, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and WNT Beta Catenin Signaling.
Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
When treating Retroperitoneal Seminoma with chemotherapy Cisplatin – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Vitamin A in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR RETROPERITONEAL SEMINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more vegetables, Jicama or Purslane?
Vegetables are an important part of many diets. The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Purslane are Linoleic Acid, Vitamin C, Linolenic Acid, Oleic Acid, Vitamin A and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Beta-carotene has biological action on biochemical pathways NFKB Signaling, DNA Repair and WNT Beta Catenin Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Citric Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Retroperitoneal Seminoma with chemotherapy Cisplatin – Foods like Jicama are recommended compared to Purslane. This is because the active ingredients Vitamin A and Citric Acid in Purslane interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-carotene contained in Jicama support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER PURSLANE FOR RETROPERITONEAL SEMINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more fruits, Feijoa or Bilberry?
Fruits are an important part of many diets. The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Bilberry are Quercetin, Resveratrol, Myricetin, P-coumaric Acid, Caffeic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Cell Cycle and MYC Signaling. Lycopene has biological action on biochemical pathways NFKB Signaling, JAK-STAT Signaling and WNT Beta Catenin Signaling.
Chlorogenic Acid can manipulate biochemical pathways Oxidative Stress. Arbutin has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Retroperitoneal Seminoma with chemotherapy Cisplatin – Foods like Feijoa are recommended compared to Bilberry. This is because the active ingredients Chlorogenic Acid and Arbutin in Bilberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Lycopene contained in Feijoa support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER BILBERRY FOR RETROPERITONEAL SEMINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Eat more nuts, Hazelnut or Macadamia Nut?
Nuts are an important part of many diets. The active ingredients contained in Hazelnut are Quercetin, Vitamin E, Linoleic Acid, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Palmitic Acid, Lauric Acid, Myristic Acid, Folic Acid and others.
Quercetin can manipulate biochemical pathways Inositol Phosphate Signaling, NFKB Signaling and Apoptosis. Vitamin E has biological action on biochemical pathways DNA Repair, Cell Cycle and MYC Signaling.
Palmitic Acid can manipulate biochemical pathways WNT Beta Catenin Signaling, NFKB Signaling and MAPK Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and NFKB Signaling. And so on.
When treating Retroperitoneal Seminoma with chemotherapy Cisplatin – Foods like Hazelnut are recommended compared to Macadamia Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Quercetin and Vitamin E contained in Hazelnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER MACADAMIA NUT FOR RETROPERITONEAL SEMINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Retroperitoneal Seminoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. KIT and RAC1 are two genes whose abnormalities are risk factors for Retroperitoneal Seminoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Retroperitoneal Seminoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Retroperitoneal Seminoma gene KIT has causative impact on biological pathways like MAPK Signaling, Growth Factor Signaling and PI3K-AKT-MTOR Signaling. And RAC1 has a causative impact on biological pathways like Cytoskeletal Dynamics, Adherens junction and Angiogenesis. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like KIT and RAC1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes KIT and RAC1 should be avoided.
Eat more pulses, Winged Bean or Fava Bean?
The active ingredients contained in Winged Bean are Betulinic Acid, Oleic Acid, Vitamin C, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Fava Bean are Daidzein, Quercetin, Beta-sitosterol, Cianidanol, Butein and others.
Betulinic Acid can manipulate biochemical pathways Apoptosis, MYC Signaling and MAPK Signaling. Vitamin C has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oxidative Stress and RAS-RAF Signaling.
Cianidanol can manipulate biochemical pathways Oxidative Stress. Betulin has biological action on biochemical pathways Cytoskeletal Dynamics. And so on.
For genetic risk of Retroperitoneal Seminoma due to abnormalities in genes KIT and RAC1 – Foods like Winged Bean are recommended compared to Fava Bean. This is because the active ingredients Cianidanol and Betulin in Fava Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER FAVA BEAN FOR REDUCING THE GENETIC RISK OF RETROPERITONEAL SEMINOMA DUE TO GENES KIT AND RAC1
Eat more vegetables, Cassava or Chicory?
The active ingredients contained in Cassava are Beta-sitosterol, Oleic Acid, Vitamin C, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Chicory are Protocatechuic Acid, Apigenin, Lupeol, Betulinic Acid, Quercetin and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and MAPK Signaling. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oxidative Stress and MYC Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Protocatechuic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
For genetic risk of Retroperitoneal Seminoma due to abnormalities in genes KIT and RAC1 – Foods like Cassava are recommended compared to Chicory. This is because the active ingredients Vitamin A and Protocatechuic Acid in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF RETROPERITONEAL SEMINOMA DUE TO GENES KIT AND RAC1
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Apple or Lingonberry?
The active ingredients contained in Apple are Modified Citrus Pectin, Cianidanol, Glucaric Acid, Phloretin, Rhamnetin among others. While the active ingredients contained in Lingonberry are Resveratrol, Quercetin, Hyperoside, Oleic Acid, Vitamin C and others.
Glucaric Acid can manipulate biochemical pathways Apoptosis, MYC Signaling and MAPK Signaling. Modified Citrus Pectin has biological action on biochemical pathways Growth Factor Signaling, PI3K-AKT-MTOR Signaling and RAS-RAF Signaling.
Hyperoside can manipulate biochemical pathways Oxidative Stress. Quercitrin has biological action on biochemical pathways Oxidative Stress. And so on.
For genetic risk of Retroperitoneal Seminoma due to abnormalities in genes KIT and RAC1 – Foods like Apple are recommended compared to Lingonberry. This is because the active ingredients Hyperoside and Quercitrin in Lingonberry further promote the effects of genes on the biochemical pathways. While the active ingredients Glucaric Acid and Modified Citrus Pectin contained in Apple together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: APPLE IS RECOMMENDED OVER LINGONBERRY FOR REDUCING THE GENETIC RISK OF RETROPERITONEAL SEMINOMA DUE TO GENES KIT AND RAC1
Eat more nuts, Pine Nut or Acorn?
The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Oleic Acid, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Gallic Acid, Quercitrin and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Apoptosis and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Gallic Acid can manipulate biochemical pathways Cell Junctions and Oxidative Stress. Quercitrin has biological action on biochemical pathways Oxidative Stress. And so on.
For genetic risk of Retroperitoneal Seminoma due to abnormalities in genes KIT and RAC1 – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Gallic Acid and Quercitrin in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF RETROPERITONEAL SEMINOMA DUE TO GENES KIT AND RAC1
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Retroperitoneal Seminoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
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- Hyperoside Induces Breast Cancer Cells Apoptosis via ROS-Mediated NF-κB Signaling Pathway.
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- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- Pectin – Wikipedia
- Pectin and Pectin-Based Composite Materials: Beyond Food Texture.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.