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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Prostate Small Cell Carcinoma!

Jul 28, 2023

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Introduction

Foods for Prostate Small Cell Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.



For Prostate Small Cell Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Prostate Small Cell Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Prostate Small Cell Carcinoma?

For example does it matter if vegetable Calabash is consumed more compared to Turnip? Does it make any difference if fruit Nanking Cherry is preferred over Highbush Blueberry? Also if similar choices are made for nuts/seeds like Chestnut over European Chestnut and for pulses like Chickpea over Catjang Pea. And if what I eat matters – then how does one identify foods which are recommended for Prostate Small Cell Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Prostate Small Cell Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Prostate Small Cell Carcinoma can be characterized by a unique set of biochemical pathways - the signature pathways of Prostate Small Cell Carcinoma. Biochemical pathways like Oncogenic Histone Methylation, Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints are part of the signature definition of Prostate Small Cell Carcinoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Nanking Cherry contains active ingredients Curcumin, Apigenin, Daidzein, Caffeine, Formononetin. And Highbush Blueberry contains active ingredients Curcumin, Ellagic Acid, Cianidanol, Apigenin, Daidzein and possibly others.

A common mistake made when deciding and choosing foods to eat for Prostate Small Cell Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Prostate Small Cell Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Prostate Small Cell Carcinoma?

Personalized nutrition for cancers like Prostate Small Cell Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Prostate Small Cell Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Prostate Small Cell Carcinoma

All cancers like Prostate Small Cell Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Prostate Small Cell Carcinoma. Biochemical pathways like Oncogenic Histone Methylation, Oncogenic Cancer Epigenetics, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints are part of the signature definition of Prostate Small Cell Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Prostate Small Cell Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Prostate Small Cell Carcinoma when taking cancer treatment Abiraterone Acetate, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

APC, PIK3CD, BRCA2, CREBBP and DNMT3B are the top ranked reported genes for Prostate Small Cell Carcinoma. APC is reported in 100.0 % of the representative patients across all clinical trials. And PIK3CD is reported in 100.0 %. The combined population patient data cover ages from to . 100.0 % of the patient data are identified as men. The Prostate Small Cell Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Prostate Small Cell Carcinoma!

Food and Supplements for Prostate Small Cell Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable CALABASH or TURNIP?

Vegetable Calabash contains many active ingredients or bioactives such as Curcumin, Apigenin, Daidzein, Formononetin, Salicylic Acid. These active ingredients manipulate various biochemical pathways like DNA Repair, Histone/Protein Acetylation, PI3K-AKT-MTOR Signaling and MYC Signaling and others. Calabash is recommended for Prostate Small Cell Carcinoma when ongoing cancer treatment is Abiraterone Acetate. This is because Calabash modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Abiraterone Acetate.

Some of the active ingredients or bioactives in vegetable Turnip are Curcumin, Ellagic Acid, Daidzein, Formononetin, Salicylic Acid. These active ingredients manipulate various biochemical pathways like DNA Repair and Growth Factor Signaling and others. Turnip is not recommended for Prostate Small Cell Carcinoma when ongoing cancer treatment is Abiraterone Acetate because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE CALABASH IS RECOMMENDED OVER TURNIP FOR Prostate Small Cell Carcinoma AND TREATMENT Abiraterone Acetate.

Choose Fruit HIGHBUSH BLUEBERRY or NANKING CHERRY?

Fruit Highbush Blueberry contains many active ingredients or bioactives such as Curcumin, Ellagic Acid, Cianidanol, Apigenin, Daidzein. These active ingredients manipulate various biochemical pathways like Growth Factor Signaling, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics and others. Highbush Blueberry is recommended for Prostate Small Cell Carcinoma when ongoing cancer treatment is Abiraterone Acetate. This is because Highbush Blueberry modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Abiraterone Acetate.

Some of the active ingredients or bioactives in fruit Nanking Cherry are Curcumin, Apigenin, Daidzein, Caffeine, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair, PI3K-AKT-MTOR Signaling and MYC Signaling and others. Nanking Cherry is not recommended for Prostate Small Cell Carcinoma when ongoing cancer treatment is Abiraterone Acetate because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT HIGHBUSH BLUEBERRY IS RECOMMENDED OVER NANKING CHERRY FOR Prostate Small Cell Carcinoma AND TREATMENT Abiraterone Acetate.

Choose Nut CHESTNUT or EUROPEAN CHESTNUT?

Chestnut contains many active ingredients or bioactives such as Curcumin, Ellagic Acid, Apigenin, Daidzein, Caffeine. These active ingredients manipulate various biochemical pathways like Growth Factor Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling and others. Chestnut is recommended for Prostate Small Cell Carcinoma when ongoing cancer treatment is Abiraterone Acetate. This is because Chestnut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Abiraterone Acetate.

Some of the active ingredients or bioactives in European Chestnut are Curcumin, Ellagic Acid, Apigenin, Daidzein, Formononetin. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and MYC Signaling and others. European Chestnut is not recommended for Prostate Small Cell Carcinoma when ongoing cancer treatment is Abiraterone Acetate because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

CHESTNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Prostate Small Cell Carcinoma AND TREATMENT Abiraterone Acetate.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Prostate Small Cell Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable GIANT BUTTERBUR or CHINESE MUSTARD?

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Formononetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Histone/Protein Acetylation, P53 Signaling and Angiogenesis and others. Giant Butterbur is recommended for risk of Prostate Small Cell Carcinoma when associated genetic risk is APC. This is because Giant Butterbur increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Chinese Mustard are Curcumin, Apigenin, Quercetin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like DNA Repair and PI3K-AKT-MTOR Signaling and others. Chinese Mustard is not recommended when risk of Prostate Small Cell Carcinoma when associated genetic risk is APC because it increases the signature pathways of it.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER CHINESE MUSTARD FOR APC GENETIC RISK OF CANCER.

Choose Fruit JAVA PLUM or COMMON CHOKECHERRY?

Fruit Java Plum contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Formononetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Stem Cell Signaling, Histone/Protein Acetylation and P53 Signaling and others. Java Plum is recommended for risk of Prostate Small Cell Carcinoma when associated genetic risk is APC. This is because Java Plum increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Common Chokecherry are Curcumin, Apigenin, Lupeol, Formononetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like TGFB Signaling and Angiogenesis and others. Common Chokecherry is not recommended when risk of Prostate Small Cell Carcinoma when associated genetic risk is APC because it increases the signature pathways of it.

FRUIT JAVA PLUM IS RECOMMENDED OVER COMMON CHOKECHERRY FOR APC GENETIC RISK OF CANCER.

Choose Nut CHIA or HICKORY NUT?

Chia contains many active ingredients or bioactives such as Curcumin, Apigenin, Lupeol, Formononetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like TGFB Signaling, Histone/Protein Acetylation, Angiogenesis and DNA Repair and others. Chia is recommended for risk of Prostate Small Cell Carcinoma when associated genetic risk is APC. This is because Chia increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Hickory Nut are Curcumin, Apigenin, Lupeol, Formononetin, Beta-sitosterol. These active ingredients manipulate various biochemical pathways like DNA Repair, TGFB Signaling and WNT Beta Catenin Signaling and others. Hickory Nut is not recommended when risk of Prostate Small Cell Carcinoma when associated genetic risk is APC because it increases the signature pathways of it.

CHIA IS RECOMMENDED OVER HICKORY NUT FOR APC GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Prostate Small Cell Carcinoma. Prostate Small Cell Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Prostate Small Cell Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Calabash contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Prostate Small Cell Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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