Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Neuroendocrine Tumors Of The Stomach when undergoing chemotherapy or when you determine you have a genetic risk for developing Neuroendocrine Tumors Of The Stomach because of NTRK3 and ARID5B gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Neuroendocrine Tumors Of The Stomach which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Lingonberry” or “Include fruit Date in my diet” or “Should I reduce consumption of vegetable Chayote” or “Can I take Echinacea and Turmeric supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO NEUROENDOCRINE TUMORS OF THE STOMACH, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Neuroendocrine Tumors Of The Stomach is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR NEUROENDOCRINE TUMORS OF THE STOMACH, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Neuroendocrine Tumors Of The Stomach
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Neuroendocrine Tumors Of The Stomach from cBioPortal. 57.1% of males and 42.9% of females were the distribution of gender in these clinical studies. From a patient sample size of 7; the top genes with mutations and other abnormalities for Neuroendocrine Tumors Of The Stomach include genes TP53, NTRK3, ARID5B, CREBBP and ERBB4. The occurrence frequency distribution for these genes respectively is 100.0%, 50.0%, 50.0%, 50.0% and 50.0%. These tumor genetic details of Neuroendocrine Tumors Of The Stomach are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Neuroendocrine Tumors Of The Stomach.
Significance of Nutrition for Neuroendocrine Tumors Of The Stomach
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Neuroendocrine Tumors Of The Stomach. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Lingonberry includes active ingredients Oleic Acid, Hyperoside, Vitamin C, Quercetin, Linolenic Acid and others. And Date contains active ingredients Apigenin, Lupeol, Oleic Acid, Beta-sitosterol, Protocatechuic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Neuroendocrine Tumors Of The Stomach, activation or inhibition of selected biochemical pathways like Growth Factor Signaling, PI3K-AKT-MTOR Signaling, Cell Cycle Checkpoints, Apoptosis plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Neuroendocrine Tumors Of The Stomach, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR NEUROENDOCRINE TUMORS OF THE STOMACH – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Neuroendocrine Tumors Of The Stomach undergoing chemotherapy treatment
In Neuroendocrine Tumors Of The Stomach – the genes TP53, NTRK3, ARID5B, CREBBP and ERBB4 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Neuroendocrine Tumors Of The Stomach are Growth Factor Signaling, PI3K-AKT-MTOR Signaling and others. Gemcitabine is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Growth Factor Signaling, PI3K-AKT-MTOR Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Lima Bean?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Oleic Acid, Vitamin C, Quercetin, Linolenic Acid, Vitexin among others. While the active ingredients contained in Lima Bean are Oleic Acid, Vitamin C, Genistein, Linoleic Acid, Vitamin A and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, P53 Signaling and Growth Factor Signaling. Quercetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and P53 Signaling.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Neuroendocrine Tumors Of The Stomach with chemotherapy Gemcitabine – Foods like Mung Bean are recommended compared to Lima Bean. This is because the active ingredients Linoleic Acid and Folic Acid in Lima Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Quercetin contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER LIMA BEAN FOR NEUROENDOCRINE TUMORS OF THE STOMACH ON TREATMENT WITH CHEMOTHERAPY GEMCITABINE FOR SOME CONDITIONS.
Eat more vegetables, Arugula or Chayote?
Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Chayote are Oleic Acid, Vitamin C, Linolenic Acid, Linoleic Acid, Folic Acid and others.
Kaempferol can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Neuroendocrine Tumors Of The Stomach with chemotherapy Gemcitabine – Foods like Arugula are recommended compared to Chayote. This is because the active ingredients Linoleic Acid and Folic Acid in Chayote interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Vitamin A contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CHAYOTE FOR NEUROENDOCRINE TUMORS OF THE STOMACH ON TREATMENT WITH CHEMOTHERAPY GEMCITABINE FOR SOME CONDITIONS.
Eat more fruits, Date or Lingonberry?
Fruits are an important part of many diets. The active ingredients contained in Date are Apigenin, Lupeol, Oleic Acid, Beta-sitosterol, Protocatechuic Acid among others. While the active ingredients contained in Lingonberry are Oleic Acid, Hyperoside, Vitamin C, Quercetin, Linolenic Acid and others.
Apigenin can manipulate biochemical pathways MYC Signaling, P53 Signaling and PI3K-AKT-MTOR Signaling. Lupeol has biological action on biochemical pathways Growth Factor Signaling, MYC Signaling and P53 Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
When treating Neuroendocrine Tumors Of The Stomach with chemotherapy Gemcitabine – Foods like Date are recommended compared to Lingonberry. This is because the active ingredients Resveratrol and Linoleic Acid in Lingonberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Apigenin and Lupeol contained in Date support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: DATE IS RECOMMENDED OVER LINGONBERRY FOR NEUROENDOCRINE TUMORS OF THE STOMACH ON TREATMENT WITH CHEMOTHERAPY GEMCITABINE FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Chestnut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Cianidanol, Linolenic Acid, Delphinidin among others. While the active ingredients contained in Chestnut are Ellagic Acid, Oleic Acid, Vitamin C, Quercetin, Linolenic Acid and others.
Vitamin E can manipulate biochemical pathways MYC Signaling, P53 Signaling and Growth Factor Signaling. Cianidanol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, MYC Signaling and P53 Signaling.
Ellagic Acid can manipulate biochemical pathways MYC Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.
When treating Neuroendocrine Tumors Of The Stomach with chemotherapy Gemcitabine – Foods like Pecan Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Linoleic Acid in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CHESTNUT FOR NEUROENDOCRINE TUMORS OF THE STOMACH ON TREATMENT WITH CHEMOTHERAPY GEMCITABINE FOR SOME CONDITIONS.
Foods for Genetic Risk of Neuroendocrine Tumors Of The Stomach
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NTRK3 and ARID5B are two genes whose abnormalities are risk factors for Neuroendocrine Tumors Of The Stomach. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Neuroendocrine Tumors Of The Stomach can be used as a guide for coming up with a recommended personalized nutrition plan. For Neuroendocrine Tumors Of The Stomach gene NTRK3 has causative impact on biological pathways like Growth Factor Signaling and RAS-RAF Signaling. And ARID5B has a causative impact on biological pathways like Suppressive Histone Methylation. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NTRK3 and ARID5B should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NTRK3 and ARID5B should be avoided.
Eat more pulses, Common Pea or Soy Bean?
The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Linolenic Acid, Vitamin C among others. While the active ingredients contained in Soy Bean are Lupeol, Vitamin E, Daidzein, Beta-sitosterol, Linolenic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Neuroendocrine Tumors Of The Stomach due to abnormalities in genes NTRK3 and ARID5B – Foods like Common Pea are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF NEUROENDOCRINE TUMORS OF THE STOMACH DUE TO GENES NTRK3 AND ARID5B
Eat more vegetables, Giant Butterbur or Carob?
The active ingredients contained in Giant Butterbur are Beta-sitosterol, Vitamin C, Vitamin B3, Melatonin, Kaempferol among others. While the active ingredients contained in Carob are Quercetin, Myricetin, Palmitic Acid, Gallic Acid, Phloroglucinol and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-sitosterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Palmitic Acid can manipulate biochemical pathways MAPK Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Neuroendocrine Tumors Of The Stomach due to abnormalities in genes NTRK3 and ARID5B – Foods like Giant Butterbur are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Folic Acid in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF NEUROENDOCRINE TUMORS OF THE STOMACH DUE TO GENES NTRK3 AND ARID5B
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Lemon?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Lemon are D-limonene, Diosmetin, Vitamin C, Hesperidin, Eucalyptol and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Myrcene can manipulate biochemical pathways Extracellular Matrix Remodelling. Syringin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Neuroendocrine Tumors Of The Stomach due to abnormalities in genes NTRK3 and ARID5B – Foods like Feijoa are recommended compared to Lemon. This is because the active ingredients Myrcene and Syringin in Lemon further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER LEMON FOR REDUCING THE GENETIC RISK OF NEUROENDOCRINE TUMORS OF THE STOMACH DUE TO GENES NTRK3 AND ARID5B
Eat more nuts, Almond or Brazil Nut?
The active ingredients contained in Almond are Vitamin E, Beta-sitosterol, Linolenic Acid, Stigmasterol, Quercetin among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin E has biological action on biochemical pathways Cell Cycle Checkpoints, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Neuroendocrine Tumors Of The Stomach due to abnormalities in genes NTRK3 and ARID5B – Foods like Almond are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin E contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF NEUROENDOCRINE TUMORS OF THE STOMACH DUE TO GENES NTRK3 AND ARID5B
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Neuroendocrine Tumors Of The Stomach by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Msk Met 2021
- Vitamin C enhances epigenetic modifications induced by 5-azacytidine and cell cycle arrest in the hepatocellular carcinoma cell lines HLE and Huh7.
- Inhibitors of the epidermal growth factor receptor in apple juice extract.
- Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Flavonoids as receptor tyrosine kinase FLT3 inhibitors.
- Retinol decreases beta-catenin protein levels in retinoic acid-resistant colon cancer cell lines.
- Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression.
- Cytotoxicity and apoptosis induction in human breast adenocarcinoma MCF-7 cells by (+)-cyanidan-3-ol.
- Identification of ellagic acid as potent inhibitor of protein kinase CK2: a successful example of a virtual screening application.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Lycopene metabolite, apo-10′-lycopenoic acid, inhibits diethylnitrosamine-initiated, high fat diet-promoted hepatic inflammation and tumorigenesis in mice.
- Myrcene, an Aromatic Volatile Compound, Ameliorates Human Skin Extrinsic Aging via Regulation of MMPs Production.
- Syringin prevents bone loss in ovariectomized mice via TRAF6 mediated inhibition of NF-κB and stimulation of PI3K/AKT.
- Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 (human acute monocytic leukemia cell) cells.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
- HyperFoods/food_compound_original.csv at master • warcraft12321/HyperFoods • GitHub
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.