Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Myeloid Sarcoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Myeloid Sarcoma because of ARAF and BRCC3 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Myeloid Sarcoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Fig” or “Include fruit Orange in my diet” or “Should I reduce consumption of vegetable Celery” or “Can I take Licorice and Cardamom supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MYELOID SARCOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Myeloid Sarcoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR MYELOID SARCOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Myeloid Sarcoma
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Myeloid Sarcoma from cBioPortal. 75.0% of males and 25.0% of females were the distribution of gender in these clinical studies. From a patient sample size of 10; the top genes with mutations and other abnormalities for Myeloid Sarcoma include genes ARAF, IDH1, BRCC3, FLT3 and GNB1. The occurrence frequency distribution for these genes respectively is 11.1%, 11.1%, 11.1%, 11.1% and 11.1%. These tumor genetic details of Myeloid Sarcoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Myeloid Sarcoma.
Significance of Nutrition for Myeloid Sarcoma
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Myeloid Sarcoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Fig includes active ingredients Vitamin C, Lupeol, Bergapten, Angelicin, Beta-sitosterol and others. And Orange contains active ingredients D-limonene, Vicenin 2, Linalool, Vitamin C, Oleic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Myeloid Sarcoma, activation or inhibition of selected biochemical pathways like MAPK Signaling, PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics, RAS-RAF Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Myeloid Sarcoma, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MYELOID SARCOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Myeloid Sarcoma undergoing chemotherapy treatment
In Myeloid Sarcoma – the genes ARAF, IDH1, BRCC3, FLT3 and GNB1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Myeloid Sarcoma are MAPK Signaling, PI3K-AKT-MTOR Signaling, JAK-STAT Signaling and others. Somatostatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers MAPK Signaling, PI3K-AKT-MTOR Signaling, JAK-STAT Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Mung Bean or Soy Bean?
Pulses are an important part of many diets. The active ingredients contained in Mung Bean are Kaempferol, Quercetin, Vitamin C, Oleic Acid, Genistein among others. While the active ingredients contained in Soy Bean are Quercetin, Vitamin C, Lupeol, Daidzein, Oleic Acid and others.
Kaempferol can manipulate biochemical pathways JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics, MAPK Signaling and JAK-STAT Signaling.
Lecithin can manipulate biochemical pathways JAK-STAT Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Myeloid Sarcoma with chemotherapy Somatostatin – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Lecithin and Folic Acid in Soy Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Quercetin contained in Mung Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR MYELOID SARCOMA ON TREATMENT WITH CHEMOTHERAPY SOMATOSTATIN FOR SOME CONDITIONS.
Eat more vegetables, Arugula or Celery?
Vegetables are an important part of many diets. The active ingredients contained in Arugula are Kaempferol, Esculin, Vitamin A, Vitamin K among others. While the active ingredients contained in Celery are Apigenin, Kaempferol, Quercetin, Luteolin, Vitamin C and others.
Kaempferol can manipulate biochemical pathways JAK-STAT Signaling and PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling.
Cynaroside can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Myeloid Sarcoma with chemotherapy Somatostatin – Foods like Arugula are recommended compared to Celery. This is because the active ingredients Cynaroside and Folic Acid in Celery interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Vitamin A contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ARUGULA IS RECOMMENDED OVER CELERY FOR MYELOID SARCOMA ON TREATMENT WITH CHEMOTHERAPY SOMATOSTATIN FOR SOME CONDITIONS.
Eat more fruits, Orange or Fig?
Fruits are an important part of many diets. The active ingredients contained in Orange are D-limonene, Vicenin 2, Linalool, Vitamin C, Oleic Acid among others. While the active ingredients contained in Fig are Vitamin C, Lupeol, Bergapten, Angelicin, Beta-sitosterol and others.
D-limonene can manipulate biochemical pathways MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin C has biological action on biochemical pathways Oncogenic Cancer Epigenetics, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Lauric Acid can manipulate biochemical pathways MAPK Signaling and PI3K-AKT-MTOR Signaling. Myristic Acid has biological action on biochemical pathways MAPK Signaling. And so on.
When treating Myeloid Sarcoma with chemotherapy Somatostatin – Foods like Orange are recommended compared to Fig. This is because the active ingredients Lauric Acid and Myristic Acid in Fig interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients D-limonene and Vitamin C contained in Orange support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: ORANGE IS RECOMMENDED OVER FIG FOR MYELOID SARCOMA ON TREATMENT WITH CHEMOTHERAPY SOMATOSTATIN FOR SOME CONDITIONS.
Eat more nuts, Pine Nut or Brazil Nut?
Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Oleic Acid, Vitamin E, Beta-sitosterol, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Brazil Nut are Oleic Acid, Vitamin E, Linolenic Acid, Lecithin, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling. Vitamin K has biological action on biochemical pathways PI3K-AKT-MTOR Signaling.
Lecithin can manipulate biochemical pathways JAK-STAT Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways JAK-STAT Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Myeloid Sarcoma with chemotherapy Somatostatin – Foods like Pine Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER BRAZIL NUT FOR MYELOID SARCOMA ON TREATMENT WITH CHEMOTHERAPY SOMATOSTATIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Myeloid Sarcoma
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. ARAF and BRCC3 are two genes whose abnormalities are risk factors for Myeloid Sarcoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Myeloid Sarcoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Myeloid Sarcoma gene ARAF has causative impact on biological pathways like MAPK Signaling, RAS-RAF Signaling and Cytoskeletal Dynamics. And BRCC3 has a causative impact on biological pathways like DNA Repair and NFKB Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like ARAF and BRCC3 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes ARAF and BRCC3 should be avoided.
Eat more pulses, Scarlet Bean or Pigeon Pea?
The active ingredients contained in Scarlet Bean are Vitamin C, Oleic Acid, Beta-sitosterol, Stigmasterol, Genistein among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Oleic Acid, Genistein, Linolenic Acid, Linoleic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Beta-sitosterol has biological action on biochemical pathways Oncogenic Cancer Epigenetics, MYC Signaling and PI3K-AKT-MTOR Signaling.
Linolenic Acid can manipulate biochemical pathways Complement Cascade. Linoleic Acid has biological action on biochemical pathways Complement Cascade. And so on.
For genetic risk of Myeloid Sarcoma due to abnormalities in genes ARAF and BRCC3 – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Linolenic Acid and Linoleic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF MYELOID SARCOMA DUE TO GENES ARAF AND BRCC3
Eat more vegetables, Jicama or Olive?
The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Olive are Protocatechuic Acid, Quercetin, Caffeic Acid, Esculin, Lupeol and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin B3 has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling.
Corosolic Acid can manipulate biochemical pathways MYC Signaling and MAPK Signaling. Maslinic Acid has biological action on biochemical pathways MAPK Signaling. And so on.
For genetic risk of Myeloid Sarcoma due to abnormalities in genes ARAF and BRCC3 – Foods like Jicama are recommended compared to Olive. This is because the active ingredients Corosolic Acid and Maslinic Acid in Olive further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER OLIVE FOR REDUCING THE GENETIC RISK OF MYELOID SARCOMA DUE TO GENES ARAF AND BRCC3
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Blackberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Blackberry are Myricetin, Ellagic Acid, Quercetin, Kaempferol, Gallic Acid and others.
Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Lycopene has biological action on biochemical pathways RAS-RAF Signaling, MYC Signaling and MAPK Signaling.
Cianidanol can manipulate biochemical pathways Complement Cascade. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics and Oncogenic Histone Methylation. And so on.
For genetic risk of Myeloid Sarcoma due to abnormalities in genes ARAF and BRCC3 – Foods like Feijoa are recommended compared to Blackberry. This is because the active ingredients Cianidanol and Myricetin in Blackberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER BLACKBERRY FOR REDUCING THE GENETIC RISK OF MYELOID SARCOMA DUE TO GENES ARAF AND BRCC3
Eat more nuts, Almond or Peanut?
The active ingredients contained in Almond are Quercetin, Vitamin E, Oleic Acid, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Peanut are Quercetin, Vitamin C, Vitamin E, Oleic Acid, Beta-sitosterol and others.
Beta-sitosterol can manipulate biochemical pathways MYC Signaling, Oncogenic Cancer Epigenetics and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways MAPK Signaling, RAS-RAF Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling, RAS-RAF Signaling and MAPK Signaling. Gamma-linolenic Acid has biological action on biochemical pathways Complement Cascade. And so on.
For genetic risk of Myeloid Sarcoma due to abnormalities in genes ARAF and BRCC3 – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Lecithin and Gamma-linolenic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF MYELOID SARCOMA DUE TO GENES ARAF AND BRCC3
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Myeloid Sarcoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Mds Mskcc 2020
- Genomic Classification and Prognosis in Acute Myeloid Leukemia.
- Functional genomic landscape of acute myeloid leukaemia.
- Clinical and biological implications of driver mutations in myelodysplastic syndromes.
- Flavonoids as receptor tyrosine kinase FLT3 inhibitors.
- Protein kinase and HDAC inhibitors from the endophytic fungus Epicoccum nigrum.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- Sequential protooncogene expression in regenerating kidney following acute renal injury.
- D-Limonene modulates inflammation, oxidative stress and Ras-ERK pathway to inhibit murine skin tumorigenesis.
- The synergy of Vitamin C with decitabine activates TET2 in leukemic cells and significantly improves overall survival in elderly patients with acute myeloid leukemia.
- Clinical pharmacodynamics of antihistamines.
- Sequence homology of surface membrane proteins of Babesia rodhaini.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
- Research progress on the anticancer effects of vitamin K2.
- Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex.
- Lycopene differentially induces quiescence and apoptosis in androgen-responsive and -independent prostate cancer cell lines.
- Thrombin inhibitory activity of some polyphenolic compounds.
- Inhibitors of histone demethylases.
- Concurrent acetylation of FoxO1/3a and p53 due to sirtuins inhibition elicit Bim/PUMA mediated mitochondrial dysfunction and apoptosis in berberine-treated HepG2 cells.
- Corosolic acid induces cell cycle arrest and cell apoptosis in human retinoblastoma Y-79 cells via disruption of MELK-FoxM1 signaling.
- The natural triterpene maslinic acid induces apoptosis in HT29 colon cancer cells by a JNK-p53-dependent mechanism.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.