Which Foods are Recommended for Monoclonal Gammopathy Of Undetermined Significance?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Monoclonal Gammopathy Of Undetermined Significance when undergoing chemotherapy or when you determine you have a genetic risk for developing Monoclonal Gammopathy Of Undetermined Significance because of LATS2 and LCP1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Monoclonal Gammopathy Of Undetermined Significance which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Pummelo” or “Include fruit Rowanberry in my diet” or “Should I reduce consumption of vegetable Rhubarb” or “Can I take Kaempferol and Apigenin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Monoclonal Gammopathy Of Undetermined Significance is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Monoclonal Gammopathy Of Undetermined Significance

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Monoclonal Gammopathy Of Undetermined Significance from cBioPortal. The top genes with mutations and other abnormalities for Monoclonal Gammopathy Of Undetermined Significance include genes LATS2, LCP1, IRS2, CUL4A and RB1. The occurrence frequency distribution for these genes respectively is 30.3%, 30.3%, 30.3%, 30.3% and 30.3%. These tumor genetic details of Monoclonal Gammopathy Of Undetermined Significance are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Monoclonal Gammopathy Of Undetermined Significance.

Significance of Nutrition for Monoclonal Gammopathy Of Undetermined Significance

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Monoclonal Gammopathy Of Undetermined Significance. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Pummelo includes active ingredients Hesperetin, Beta-sitosterol, Naringin, Vitamin C, Chlorogenic Acid and others. And Rowanberry contains active ingredients Quercetin, Chlorogenic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Monoclonal Gammopathy Of Undetermined Significance, activation or inhibition of selected biochemical pathways like NFKB Signaling, Angiogenesis, PI3K-AKT-MTOR Signaling, Hypoxia plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Monoclonal Gammopathy Of Undetermined Significance, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Monoclonal Gammopathy Of Undetermined Significance undergoing chemotherapy treatment

In Monoclonal Gammopathy Of Undetermined Significance – the genes LATS2, LCP1, IRS2, CUL4A and RB1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Monoclonal Gammopathy Of Undetermined Significance are NFKB Signaling, Angiogenesis, Hypoxia and others. Lenalidomide is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers NFKB Signaling, Angiogenesis, Hypoxia so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Kaempferol, Daidzein, Beta-sitosterol, Lupeol, Vitamin C among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Genistein, Vitamin A and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Glucocorticoid Signaling and Microtubule Dynamics. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and WNT Beta Catenin Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Angiogenesis. And so on.

When treating Monoclonal Gammopathy Of Undetermined Significance with chemotherapy Lenalidomide – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Vitamin A and Linoleic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE ON TREATMENT WITH CHEMOTHERAPY LENALIDOMIDE FOR SOME CONDITIONS.

Eat more vegetables, Arugula or Rhubarb?

Vegetables are an important part of many diets. The active ingredients contained in Arugula are Kaempferol, Esculin, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Rhubarb are Quercetin, Rhein, Vitamin E, Chrysophanol, Vitamin C and others.

Kaempferol can manipulate biochemical pathways NFKB Signaling, Microtubule Dynamics and Cell Cycle. Vitamin K has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and NFKB Signaling.

Rutin can manipulate biochemical pathways WNT Beta Catenin Signaling and Microtubule Dynamics. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

When treating Monoclonal Gammopathy Of Undetermined Significance with chemotherapy Lenalidomide – Foods like Arugula are recommended compared to Rhubarb. This is because the active ingredients Rutin and Vitamin A in Rhubarb interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Vitamin K contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER RHUBARB FOR MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE ON TREATMENT WITH CHEMOTHERAPY LENALIDOMIDE FOR SOME CONDITIONS.

Eat more fruits, Rowanberry or Pummelo?

Fruits are an important part of many diets. The active ingredients contained in Rowanberry are Quercetin, Chlorogenic Acid among others. While the active ingredients contained in Pummelo are Hesperetin, Beta-sitosterol, Naringin, Vitamin C, Chlorogenic Acid and others.

Chlorogenic Acid can manipulate biochemical pathways NFKB Signaling, Glucocorticoid Signaling and Microtubule Dynamics. Quercetin has biological action on biochemical pathways JAK-STAT Signaling, Cell Cycle and Cell Survival.

Naringetol can manipulate biochemical pathways WNT Beta Catenin Signaling and Microtubule Dynamics. Hesperetin has biological action on biochemical pathways WNT Beta Catenin Signaling and Microtubule Dynamics. And so on.

When treating Monoclonal Gammopathy Of Undetermined Significance with chemotherapy Lenalidomide – Foods like Rowanberry are recommended compared to Pummelo. This is because the active ingredients Naringetol and Hesperetin in Pummelo interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Chlorogenic Acid and Quercetin contained in Rowanberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ROWANBERRY IS RECOMMENDED OVER PUMMELO FOR MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE ON TREATMENT WITH CHEMOTHERAPY LENALIDOMIDE FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Pumpkin Seeds?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Linolenic Acid, Oleic Acid, Vitamin A among others. While the active ingredients contained in Pumpkin Seeds are Beta-sitosterol, Linolenic Acid, Oleic Acid, Gamma-linolenic Acid, Salicylic Acid and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Glucocorticoid Signaling and Microtubule Dynamics. Vitamin K has biological action on biochemical pathways MYC Signaling, Cell Cycle and PI3K-AKT-MTOR Signaling.

Lecithin can manipulate biochemical pathways NFKB Signaling, JAK-STAT Signaling and MYC Signaling. Cucurbitacin I has biological action on biochemical pathways MYC Signaling and NFKB Signaling. And so on.

When treating Monoclonal Gammopathy Of Undetermined Significance with chemotherapy Lenalidomide – Foods like Pine Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Lecithin and Cucurbitacin I in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE ON TREATMENT WITH CHEMOTHERAPY LENALIDOMIDE FOR SOME CONDITIONS.

Foods for Genetic Risk of Monoclonal Gammopathy Of Undetermined Significance

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. LATS2 and LCP1 are two genes whose abnormalities are risk factors for Monoclonal Gammopathy Of Undetermined Significance. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Monoclonal Gammopathy Of Undetermined Significance can be used as a guide for coming up with a recommended personalized nutrition plan. For Monoclonal Gammopathy Of Undetermined Significance gene LATS2 has causative impact on biological pathways like Hippo Signaling. And LCP1 has a causative impact on biological pathways like T-Cell Receptor Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like LATS2 and LCP1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes LATS2 and LCP1 should be avoided.

Eat more pulses, Scarlet Bean or Lima Bean?

The active ingredients contained in Scarlet Bean are Oleic Acid, Vitamin C, Linolenic Acid, Stigmasterol, Beta-sitosterol among others. While the active ingredients contained in Lima Bean are Oleic Acid, Vitamin C, Genistein, Linoleic Acid, Vitamin A and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Stigmasterol has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways FOXO Signaling. And so on.

For genetic risk of Monoclonal Gammopathy Of Undetermined Significance due to abnormalities in genes LATS2 and LCP1 – Foods like Scarlet Bean are recommended compared to Lima Bean. This is because the active ingredients Vitamin A and Linoleic Acid in Lima Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Stigmasterol contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER LIMA BEAN FOR REDUCING THE GENETIC RISK OF MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE DUE TO GENES LATS2 AND LCP1

Eat more vegetables, Mexican Groundcherry or Chinese Mustard?

The active ingredients contained in Mexican Groundcherry are Vitamin C, Vitamin B3 among others. While the active ingredients contained in Chinese Mustard are Quercetin, Kaempferol, Isorhamnetin, Indole-3-carbinol, Vitamin A and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Vitamin B3 has biological action on biochemical pathways FOXO Signaling, DNA Repair and Hypoxia.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, RAS-RAF Signaling and MAPK Signaling. And so on.

For genetic risk of Monoclonal Gammopathy Of Undetermined Significance due to abnormalities in genes LATS2 and LCP1 – Foods like Mexican Groundcherry are recommended compared to Chinese Mustard. This is because the active ingredients Vitamin A and Folic Acid in Chinese Mustard further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Mexican Groundcherry together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MEXICAN GROUNDCHERRY IS RECOMMENDED OVER CHINESE MUSTARD FOR REDUCING THE GENETIC RISK OF MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE DUE TO GENES LATS2 AND LCP1

Eat more fruits, Feijoa or Huckleberry?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Huckleberry are Quercetin, Resveratrol, Vitamin C, Chlorogenic Acid, Caffeic Acid and others.

Vitamin C can manipulate biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. Lycopene has biological action on biochemical pathways FOXO Signaling, Hypoxia and RAS-RAF Signaling.

Resveratrol can manipulate biochemical pathways FOXO Signaling. Caffeic Acid has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Monoclonal Gammopathy Of Undetermined Significance due to abnormalities in genes LATS2 and LCP1 – Foods like Feijoa are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Caffeic Acid in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE DUE TO GENES LATS2 AND LCP1

Eat more nuts, Almond or Acorn?

The active ingredients contained in Almond are Quercetin, Oleic Acid, Vitamin E, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Acorn are Quercetin, Vitamin C, Gallic Acid, Beta-sitosterol, Vitamin B3 and others.

Beta-sitosterol can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Quercetin has biological action on biochemical pathways FOXO Signaling, MAPK Signaling and Hypoxia.

Gallic Acid can manipulate biochemical pathways DNA Repair. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Monoclonal Gammopathy Of Undetermined Significance due to abnormalities in genes LATS2 and LCP1 – Foods like Almond are recommended compared to Acorn. This is because the active ingredients Gallic Acid and Vitamin A in Acorn further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER ACORN FOR REDUCING THE GENETIC RISK OF MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE DUE TO GENES LATS2 AND LCP1

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Monoclonal Gammopathy Of Undetermined Significance by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

References

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