Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Metaplastic Breast Cancer when undergoing chemotherapy or when you determine you have a genetic risk for developing Metaplastic Breast Cancer because of EPHA7 and TP53 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Metaplastic Breast Cancer which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Lingonberry” or “Include fruit Apple in my diet” or “Should I reduce consumption of vegetable Yardlong Bean” or “Can I take Curcumin and Birch supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO METAPLASTIC BREAST CANCER, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Metaplastic Breast Cancer is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR METAPLASTIC BREAST CANCER, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Metaplastic Breast Cancer
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Metaplastic Breast Cancer from cBioPortal. From a patient sample size of 38; the top genes with mutations and other abnormalities for Metaplastic Breast Cancer include genes TP53, PIK3CA, TERT, EPHA7 and KMT2C. The occurrence frequency distribution for these genes respectively is 59.3%, 18.5%, 11.1%, 7.4% and 7.4%. These tumor genetic details of Metaplastic Breast Cancer are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Metaplastic Breast Cancer.
Significance of Nutrition for Metaplastic Breast Cancer
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Metaplastic Breast Cancer. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Lingonberry includes active ingredients Quercetin, Hyperoside, Caffeic Acid, Resveratrol, Oleic Acid and others. And Apple contains active ingredients Fisetin, Caffeic Acid, Phloretin, Rhamnetin, Chlorogenic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Metaplastic Breast Cancer, activation or inhibition of selected biochemical pathways like Apoptosis, MAPK Signaling, Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Metaplastic Breast Cancer, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR METAPLASTIC BREAST CANCER – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Metaplastic Breast Cancer undergoing chemotherapy treatment
In Metaplastic Breast Cancer – the genes TP53, PIK3CA, TERT, EPHA7 and KMT2C have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Metaplastic Breast Cancer are Apoptosis, MAPK Signaling, Extracellular Matrix Remodelling and others. Oxaliplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Apoptosis, MAPK Signaling, Extracellular Matrix Remodelling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Common Pea or Pigeon Pea?
Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Pigeon Pea are Oleic Acid, Linolenic Acid, Vitamin C, Linoleic Acid, Vitamin A and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, Cell Cycle and RUNX Signaling. Vitamin C has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Oxidative Stress.
Genistein can manipulate biochemical pathways DNA Repair and Oxidative Stress. Oleic Acid has biological action on biochemical pathways Extracellular Matrix Remodelling. And so on.
When treating Metaplastic Breast Cancer with chemotherapy Oxaliplatin – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Genistein and Oleic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR METAPLASTIC BREAST CANCER ON TREATMENT WITH CHEMOTHERAPY OXALIPLATIN FOR SOME CONDITIONS.
Eat more vegetables, Bamboo or Yardlong Bean?
Vegetables are an important part of many diets. The active ingredients contained in Bamboo are Caffeic Acid, Ferulic Acid, Beta-sitosterol, Protocatechuic Acid, Chlorogenic Acid among others. While the active ingredients contained in Yardlong Bean are Oleic Acid, Linolenic Acid, Vitamin C, Linoleic Acid, Vitamin A and others.
Ferulic Acid can manipulate biochemical pathways Apoptosis, Extracellular Matrix Remodelling and DNA Repair. Caffeic Acid has biological action on biochemical pathways Nucleotide Metabolism, Cell Cycle and MAPK Signaling.
Oleic Acid can manipulate biochemical pathways Extracellular Matrix Remodelling. Linolenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Metaplastic Breast Cancer with chemotherapy Oxaliplatin – Foods like Bamboo are recommended compared to Yardlong Bean. This is because the active ingredients Oleic Acid and Linolenic Acid in Yardlong Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ferulic Acid and Caffeic Acid contained in Bamboo support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: BAMBOO IS RECOMMENDED OVER YARDLONG BEAN FOR METAPLASTIC BREAST CANCER ON TREATMENT WITH CHEMOTHERAPY OXALIPLATIN FOR SOME CONDITIONS.
Eat more fruits, Apple or Lingonberry?
Fruits are an important part of many diets. The active ingredients contained in Apple are Fisetin, Caffeic Acid, Phloretin, Rhamnetin, Chlorogenic Acid among others. While the active ingredients contained in Lingonberry are Quercetin, Hyperoside, Caffeic Acid, Resveratrol, Oleic Acid and others.
Glucaric Acid can manipulate biochemical pathways Apoptosis, Extracellular Matrix Remodelling and Cell Cycle. Fisetin has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle.
Quercetin can manipulate biochemical pathways Oxidative Stress. Hyperoside has biological action on biochemical pathways Oxidative Stress. And so on.
When treating Metaplastic Breast Cancer with chemotherapy Oxaliplatin – Foods like Apple are recommended compared to Lingonberry. This is because the active ingredients Quercetin and Hyperoside in Lingonberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Glucaric Acid and Fisetin contained in Apple support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: APPLE IS RECOMMENDED OVER LINGONBERRY FOR METAPLASTIC BREAST CANCER ON TREATMENT WITH CHEMOTHERAPY OXALIPLATIN FOR SOME CONDITIONS.
Eat more nuts, Walnut or Pumpkin Seeds?
Nuts are an important part of many diets. The active ingredients contained in Walnut are Ellagic Acid, Quercetin, D-limonene, Vitamin E, Carvacrol among others. While the active ingredients contained in Pumpkin Seeds are Beta-sitosterol, Stigmasterol, Oleic Acid, Linolenic Acid, Salicylic Acid and others.
Ellagic Acid can manipulate biochemical pathways Apoptosis, Extracellular Matrix Remodelling and JAK-STAT Signaling. D-limonene has biological action on biochemical pathways Cell Cycle, MAPK Signaling and PI3K-AKT-MTOR Signaling.
Gamma-linolenic Acid can manipulate biochemical pathways Oxidative Stress. Lecithin has biological action on biochemical pathways JAK-STAT Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Metaplastic Breast Cancer with chemotherapy Oxaliplatin – Foods like Walnut are recommended compared to Pumpkin Seeds. This is because the active ingredients Gamma-linolenic Acid and Lecithin in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Ellagic Acid and D-limonene contained in Walnut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: WALNUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR METAPLASTIC BREAST CANCER ON TREATMENT WITH CHEMOTHERAPY OXALIPLATIN FOR SOME CONDITIONS.
Foods for Genetic Risk of Metaplastic Breast Cancer
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. EPHA7 and TP53 are two genes whose abnormalities are risk factors for Metaplastic Breast Cancer. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Metaplastic Breast Cancer can be used as a guide for coming up with a recommended personalized nutrition plan. For Metaplastic Breast Cancer gene EPHA7 has causative impact on biological pathways like . And TP53 has a causative impact on biological pathways like Cell Cycle Checkpoints and Apoptosis. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like EPHA7 and TP53 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes EPHA7 and TP53 should be avoided.
Eat more pulses, Mung Bean or Soy Bean?
The active ingredients contained in Mung Bean are Quercetin, Vitamin C, Linolenic Acid, Genistein, Oleic Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Quercetin, Daidzein, Beta-sitosterol, Vitamin E and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Stigmasterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.
Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Metaplastic Breast Cancer due to abnormalities in genes EPHA7 and TP53 – Foods like Mung Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Stigmasterol contained in Mung Bean together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: MUNG BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF METAPLASTIC BREAST CANCER DUE TO GENES EPHA7 AND TP53
Eat more vegetables, Jicama or Celery?
The active ingredients contained in Jicama are Vitamin C, Beta-carotene, Vitamin B3, Vitamin A, Folic Acid among others. While the active ingredients contained in Celery are Apigenin, Quercetin, Vitamin C, Linolenic Acid, Oleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Beta-carotene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Oncogenic Cancer Epigenetics.
Cynaroside can manipulate biochemical pathways Oncogenic Cancer Epigenetics. Luteolin has biological action on biochemical pathways MYC Signaling. And so on.
For genetic risk of Metaplastic Breast Cancer due to abnormalities in genes EPHA7 and TP53 – Foods like Jicama are recommended compared to Celery. This is because the active ingredients Cynaroside and Luteolin in Celery further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-carotene contained in Jicama together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: JICAMA IS RECOMMENDED OVER CELERY FOR REDUCING THE GENETIC RISK OF METAPLASTIC BREAST CANCER DUE TO GENES EPHA7 AND TP53
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Date or Cranberry?
The active ingredients contained in Date are Apigenin, Lupeol, Quercetin, Protocatechuic Acid, Beta-sitosterol among others. While the active ingredients contained in Cranberry are Ellagic Acid, Quercetin, Resveratrol, Hyperoside, Vitamin C and others.
Apigenin can manipulate biochemical pathways Apoptosis, EPHRIN Signaling and MYC Signaling. Lupeol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics. And so on.
For genetic risk of Metaplastic Breast Cancer due to abnormalities in genes EPHA7 and TP53 – Foods like Date are recommended compared to Cranberry. This is because the active ingredients Resveratrol and Myricetin in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Apigenin and Lupeol contained in Date together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: DATE IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF METAPLASTIC BREAST CANCER DUE TO GENES EPHA7 AND TP53
Eat more nuts, Pine Nut or Brazil Nut?
The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Brazil Nut are Vitamin E, Linolenic Acid, Oleic Acid, Lecithin, Folic Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin K has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.
Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, P53 Signaling and Cell Cycle Checkpoints. And so on.
For genetic risk of Metaplastic Breast Cancer due to abnormalities in genes EPHA7 and TP53 – Foods like Pine Nut are recommended compared to Brazil Nut. This is because the active ingredients Lecithin and Folic Acid in Brazil Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: PINE NUT IS RECOMMENDED OVER BRAZIL NUT FOR REDUCING THE GENETIC RISK OF METAPLASTIC BREAST CANCER DUE TO GENES EPHA7 AND TP53
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Metaplastic Breast Cancer by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
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- HyperFoods/food_compound_original.csv at master • warcraft12321/HyperFoods • GitHub
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.