Which Foods are Recommended for Adenoid Cystic Carcinoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Adenoid Cystic Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Adenoid Cystic Carcinoma because of NOTCH1 and ACTB gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Adenoid Cystic Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Cranberry” or “Include fruit Feijoa in my diet” or “Should I reduce consumption of vegetable Beetroot” or “Can I take Birch and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO ADENOID CYSTIC CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Adenoid Cystic Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR ADENOID CYSTIC CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Adenoid Cystic Carcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Adenoid Cystic Carcinoma from cBioPortal. The patients enrolled in the studies for Adenoid Cystic Carcinoma are in ages between 18 to 88 with an average age of 55. 50.5% of males and 49.5% of females were the distribution of gender in these clinical studies. From a patient sample size of 1189; the top genes with mutations and other abnormalities for Adenoid Cystic Carcinoma include genes NOTCH1, ACTB, KDM6A, SMARCA2 and BCOR. The occurrence frequency distribution for these genes respectively is 4.5%, 4.1%, 3.8%, 3.4% and 3.1%. These tumor genetic details of Adenoid Cystic Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Adenoid Cystic Carcinoma.

Significance of Nutrition for Adenoid Cystic Carcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Adenoid Cystic Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Cranberry includes active ingredients Quercetin, Ellagic Acid, Myricetin, Resveratrol, Hyperoside and others. And Feijoa contains active ingredients Lycopene, Vitamin C, Casuarinin, Folic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Adenoid Cystic Carcinoma, activation or inhibition of selected biochemical pathways like Cell Cycle, C-type Lectin Receptor Signaling, PI3K-AKT-MTOR Signaling, Focal Adhesion plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Adenoid Cystic Carcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR ADENOID CYSTIC CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Adenoid Cystic Carcinoma undergoing chemotherapy treatment

In Adenoid Cystic Carcinoma – the genes NOTCH1, ACTB, KDM6A, SMARCA2 and BCOR have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Adenoid Cystic Carcinoma are Cell Cycle, C-type Lectin Receptor Signaling, RUNX Signaling and others. Cisplatin is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Cell Cycle, C-type Lectin Receptor Signaling, RUNX Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Lupeol, Daidzein, Beta-sitosterol, Vitamin C, Linolenic Acid among others. While the active ingredients contained in Pigeon Pea are Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid, Vitamin A and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Cell Cycle, MYC Signaling and WNT Beta Catenin Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Genistein has biological action on biochemical pathways DNA Repair and Oxidative Stress. And so on.

When treating Adenoid Cystic Carcinoma with chemotherapy Cisplatin – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Vitamin A and Genistein in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR ADENOID CYSTIC CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more vegetables, Cabbage or Beetroot?

Vegetables are an important part of many diets. The active ingredients contained in Cabbage are Quercetin, Benzyl Isothiocyanate, Beta-sitosterol, Isorhamnetin, Vitamin C among others. While the active ingredients contained in Beetroot are Vitamin E, Beta-sitosterol, Vitamin C, Linolenic Acid, Oleic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Cell Cycle. Glucaric Acid has biological action on biochemical pathways NFKB Signaling, Inositol Phosphate Signaling and Cell Survival.

Vitamin E can manipulate biochemical pathways Oxidative Stress. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

When treating Adenoid Cystic Carcinoma with chemotherapy Cisplatin – Foods like Cabbage are recommended compared to Beetroot. This is because the active ingredients Vitamin E and Vitamin A in Beetroot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Glucaric Acid contained in Cabbage support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CABBAGE IS RECOMMENDED OVER BEETROOT FOR ADENOID CYSTIC CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more fruits, Feijoa or Cranberry?

Fruits are an important part of many diets. The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Cranberry are Quercetin, Ellagic Acid, Myricetin, Resveratrol, Hyperoside and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and Cell Cycle. Lycopene has biological action on biochemical pathways NFKB Signaling, JAK-STAT Signaling and Cell Survival.

Quercetin can manipulate biochemical pathways Oxidative Stress. Ellagic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, WNT Beta Catenin Signaling and MYC Signaling. And so on.

When treating Adenoid Cystic Carcinoma with chemotherapy Cisplatin – Foods like Feijoa are recommended compared to Cranberry. This is because the active ingredients Quercetin and Ellagic Acid in Cranberry interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Lycopene contained in Feijoa support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER CRANBERRY FOR ADENOID CYSTIC CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Pumpkin Seeds?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Linolenic Acid, Oleic Acid, Cianidanol, Linoleic Acid among others. While the active ingredients contained in Pumpkin Seeds are Beta-sitosterol, Linolenic Acid, Oleic Acid, Stigmasterol, Salicylic Acid and others.

Cianidanol can manipulate biochemical pathways NFKB Signaling, Apoptosis and DNA Repair. Delphinidin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and C-type Lectin Receptor Signaling.

Gamma-linolenic Acid can manipulate biochemical pathways Oxidative Stress. Lecithin has biological action on biochemical pathways NFKB Signaling, JAK-STAT Signaling and MYC Signaling. And so on.

When treating Adenoid Cystic Carcinoma with chemotherapy Cisplatin – Foods like Pecan Nut are recommended compared to Pumpkin Seeds. This is because the active ingredients Gamma-linolenic Acid and Lecithin in Pumpkin Seeds interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Cianidanol and Delphinidin contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PUMPKIN SEEDS FOR ADENOID CYSTIC CARCINOMA ON TREATMENT WITH CHEMOTHERAPY CISPLATIN FOR SOME CONDITIONS.

Foods for Genetic Risk of Adenoid Cystic Carcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. NOTCH1 and ACTB are two genes whose abnormalities are risk factors for Adenoid Cystic Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Adenoid Cystic Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Adenoid Cystic Carcinoma gene NOTCH1 has causative impact on biological pathways like Notch Signaling and RUNX Signaling. And ACTB has a causative impact on biological pathways like Cytoskeletal Dynamics and Focal Adhesion. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like NOTCH1 and ACTB should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes NOTCH1 and ACTB should be avoided.

Eat more pulses, Scarlet Bean or Soy Bean?

The active ingredients contained in Scarlet Bean are Beta-sitosterol, Linolenic Acid, Oleic Acid, Vitamin C, Stigmasterol among others. While the active ingredients contained in Soy Bean are Vitamin E, Lupeol, Daidzein, Beta-sitosterol, Linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Adenoid Cystic Carcinoma due to abnormalities in genes NOTCH1 and ACTB – Foods like Scarlet Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF ADENOID CYSTIC CARCINOMA DUE TO GENES NOTCH1 AND ACTB

Eat more vegetables, Milk Thistle or Bell Pepper?

The active ingredients contained in Milk Thistle are Vitamin E, Silibinin, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Bell Pepper are Vitamin E, Capsaicin, Linolenic Acid, Oleic Acid, Vitamin C and others.

Silibinin can manipulate biochemical pathways Apoptosis, Notch Signaling and MYC Signaling. Oleic Acid has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Capsaicin can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Adenoid Cystic Carcinoma due to abnormalities in genes NOTCH1 and ACTB – Foods like Milk Thistle are recommended compared to Bell Pepper. This is because the active ingredients Capsaicin and Vitamin A in Bell Pepper further promote the effects of genes on the biochemical pathways. While the active ingredients Silibinin and Oleic Acid contained in Milk Thistle together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: MILK THISTLE IS RECOMMENDED OVER BELL PEPPER FOR REDUCING THE GENETIC RISK OF ADENOID CYSTIC CARCINOMA DUE TO GENES NOTCH1 AND ACTB

Eat more fruits, Blueberry or Cloudberry?

The active ingredients contained in Blueberry are Vitamin E, Eugenol, Resveratrol, Hyperoside, Vitamin C among others. While the active ingredients contained in Cloudberry are Ellagic Acid, Vitamin C, Urolithin B, Vitamin A and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Cianidanol has biological action on biochemical pathways Cell Cycle Checkpoints, RUNX Signaling and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Ellagic Acid has biological action on biochemical pathways MYC Signaling. And so on.

For genetic risk of Adenoid Cystic Carcinoma due to abnormalities in genes NOTCH1 and ACTB – Foods like Blueberry are recommended compared to Cloudberry. This is because the active ingredients Vitamin A and Ellagic Acid in Cloudberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Cianidanol contained in Blueberry together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: BLUEBERRY IS RECOMMENDED OVER CLOUDBERRY FOR REDUCING THE GENETIC RISK OF ADENOID CYSTIC CARCINOMA DUE TO GENES NOTCH1 AND ACTB

Eat more nuts, Almond or Peanut?

The active ingredients contained in Almond are Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid, Stigmasterol among others. While the active ingredients contained in Peanut are Vitamin E, Rhamnetin, Beta-sitosterol, Linolenic Acid, Oleic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Stigmasterol has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Apoptosis.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Adenoid Cystic Carcinoma due to abnormalities in genes NOTCH1 and ACTB – Foods like Almond are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Stigmasterol contained in Almond together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ALMOND IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF ADENOID CYSTIC CARCINOMA DUE TO GENES NOTCH1 AND ACTB

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Adenoid Cystic Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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