Highlights
No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Lung Cancer In The Never Smokers when undergoing chemotherapy or when you determine you have a genetic risk for developing Lung Cancer In The Never Smokers because of EGFR and SETD2 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.
There is no one answer to this question for cancers such as Lung Cancer In The Never Smokers which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.
In short – the process to answer questions like “Should I Avoid eating fruit Roselle” or “Include fruit Saskatoon Berry in my diet” or “Should I reduce consumption of vegetable Parsnip” or “Can I take D-limonene and Modified Citrus Pectin supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.
RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO LUNG CANCER IN THE NEVER SMOKERS, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.
The overall objective of personalized nutrition for Lung Cancer In The Never Smokers is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.
RECOMMENDATION: UPDATE YOUR NUTRITION FOR LUNG CANCER IN THE NEVER SMOKERS, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.
About Lung Cancer In The Never Smokers
cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.
Following key highlights are derived from clinical data for Lung Cancer In The Never Smokers from cBioPortal. The patients enrolled in the studies for Lung Cancer In The Never Smokers are in ages between 21 to 86 with an average age of 68. 24.6% of males and 75.4% of females were the distribution of gender in these clinical studies. From a patient sample size of 232; the top genes with mutations and other abnormalities for Lung Cancer In The Never Smokers include genes EGFR, TP53, KRAS, MUC16 and SETD2. The occurrence frequency distribution for these genes respectively is 28.6%, 15.6%, 7.4%, 5.2% and 4.3%. These tumor genetic details of Lung Cancer In The Never Smokers are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Lung Cancer In The Never Smokers.
Significance of Nutrition for Lung Cancer In The Never Smokers
All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Lung Cancer In The Never Smokers. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.
For example Roselle includes active ingredients Vitamin E, Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid and others. And Saskatoon Berry contains active ingredients Quercetin, Delphinidin and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.
For cancers like Lung Cancer In The Never Smokers, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Apoptosis, PI3K-AKT-MTOR Signaling, Growth Factor Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Lung Cancer In The Never Smokers, while eating some other foods and supplements may not be recommended.
One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.
RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR LUNG CANCER IN THE NEVER SMOKERS – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.
Foods for Lung Cancer In The Never Smokers undergoing chemotherapy treatment
In Lung Cancer In The Never Smokers – the genes EGFR, TP53, KRAS, MUC16 and SETD2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Lung Cancer In The Never Smokers are RAS-RAF Signaling, Apoptosis, NFKB Signaling and others. Erlotinib is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Apoptosis, NFKB Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.
RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.
Eat more pulses, Winged Bean or Common Bean?
Pulses are an important part of many diets. The active ingredients contained in Winged Bean are Betulinic Acid, Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Common Bean are Delphinidin, Apigenin, Gamma-linolenic Acid, Genistein, Linolenic Acid and others.
Betulinic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, MYC Signaling and WNT Beta Catenin Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling and Extracellular Matrix Remodelling. Apigenin has biological action on biochemical pathways Epithelial to Mesenchymal Transition, TGFB Signaling and PI3K-AKT-MTOR Signaling. And so on.
When treating Lung Cancer In The Never Smokers with chemotherapy Erlotinib – Foods like Winged Bean are recommended compared to Common Bean. This is because the active ingredients Vitamin A and Apigenin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER COMMON BEAN FOR LUNG CANCER IN THE NEVER SMOKERS ON TREATMENT WITH CHEMOTHERAPY ERLOTINIB FOR SOME CONDITIONS.
Eat more vegetables, Kohlrabi or Parsnip?
Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Beta-sitosterol, Linolenic Acid, Vitamin C, Indole-3-carbinol, Oleic Acid among others. While the active ingredients contained in Parsnip are Quercetin, Angelicin, Linolenic Acid, Vitamin C, Psoralen and others.
Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Apoptosis. Brassinin has biological action on biochemical pathways Extracellular Matrix Remodelling, MYC Signaling and WNT Beta Catenin Signaling.
Ferulic Acid can manipulate biochemical pathways Growth Factor Signaling. Myristicin has biological action on biochemical pathways Apoptosis. And so on.
When treating Lung Cancer In The Never Smokers with chemotherapy Erlotinib – Foods like Kohlrabi are recommended compared to Parsnip. This is because the active ingredients Ferulic Acid and Myristicin in Parsnip interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Brassinin contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER PARSNIP FOR LUNG CANCER IN THE NEVER SMOKERS ON TREATMENT WITH CHEMOTHERAPY ERLOTINIB FOR SOME CONDITIONS.
Eat more fruits, Saskatoon Berry or Roselle?
Fruits are an important part of many diets. The active ingredients contained in Saskatoon Berry are Quercetin, Delphinidin among others. While the active ingredients contained in Roselle are Vitamin E, Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid and others.
Delphinidin can manipulate biochemical pathways NFKB Signaling, Extracellular Matrix Remodelling and Growth Factor Signaling. Quercetin has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Apoptosis and TGFB Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling and Extracellular Matrix Remodelling. Oleic Acid has biological action on biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Extracellular Matrix Remodelling. And so on.
When treating Lung Cancer In The Never Smokers with chemotherapy Erlotinib – Foods like Saskatoon Berry are recommended compared to Roselle. This is because the active ingredients Vitamin A and Oleic Acid in Roselle interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Delphinidin and Quercetin contained in Saskatoon Berry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: SASKATOON BERRY IS RECOMMENDED OVER ROSELLE FOR LUNG CANCER IN THE NEVER SMOKERS ON TREATMENT WITH CHEMOTHERAPY ERLOTINIB FOR SOME CONDITIONS.
Eat more nuts, Pecan Nut or Peanut?
Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Delphinidin, Cianidanol, Vitamin E, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Gamma-linolenic Acid, Beta-sitosterol, Linolenic Acid and others.
Delphinidin can manipulate biochemical pathways NFKB Signaling, Extracellular Matrix Remodelling and Growth Factor Signaling. Cianidanol has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling.
Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling and Extracellular Matrix Remodelling. Lecithin has biological action on biochemical pathways NFKB Signaling, MYC Signaling and MAPK Signaling. And so on.
When treating Lung Cancer In The Never Smokers with chemotherapy Erlotinib – Foods like Pecan Nut are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Delphinidin and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.
RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER PEANUT FOR LUNG CANCER IN THE NEVER SMOKERS ON TREATMENT WITH CHEMOTHERAPY ERLOTINIB FOR SOME CONDITIONS.
Foods for Genetic Risk of Lung Cancer In The Never Smokers
One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. EGFR and SETD2 are two genes whose abnormalities are risk factors for Lung Cancer In The Never Smokers. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Lung Cancer In The Never Smokers can be used as a guide for coming up with a recommended personalized nutrition plan. For Lung Cancer In The Never Smokers gene EGFR has causative impact on biological pathways like Cytoskeletal Dynamics, Growth Factor Signaling and Antigen Presentation. And SETD2 has a causative impact on biological pathways like Oncogenic Histone Methylation. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like EGFR and SETD2 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes EGFR and SETD2 should be avoided.
Eat more pulses, Common Pea or Pigeon Pea?
The active ingredients contained in Common Pea are Genistein, Delphinidin, Lupeol, Daidzein, Vitamin C among others. While the active ingredients contained in Pigeon Pea are Genistein, Vitamin C, Linolenic Acid, Oleic Acid, Linoleic Acid and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. And so on.
For genetic risk of Lung Cancer In The Never Smokers due to abnormalities in genes EGFR and SETD2 – Foods like Common Pea are recommended compared to Pigeon Pea. This is because the active ingredients Linoleic Acid and Folic Acid in Pigeon Pea further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER PIGEON PEA FOR REDUCING THE GENETIC RISK OF LUNG CANCER IN THE NEVER SMOKERS DUE TO GENES EGFR AND SETD2
Eat more vegetables, Cassava or Carob?
The active ingredients contained in Cassava are Vitamin C, Beta-sitosterol, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Carob are Quercetin, Myricetin, Gallic Acid, Palmitic Acid, Phloroglucinol and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Palmitic Acid can manipulate biochemical pathways Growth Factor Signaling. Myricetin has biological action on biochemical pathways Oncogenic Histone Methylation. And so on.
For genetic risk of Lung Cancer In The Never Smokers due to abnormalities in genes EGFR and SETD2 – Foods like Cassava are recommended compared to Carob. This is because the active ingredients Palmitic Acid and Myricetin in Carob further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: CASSAVA IS RECOMMENDED OVER CAROB FOR REDUCING THE GENETIC RISK OF LUNG CANCER IN THE NEVER SMOKERS DUE TO GENES EGFR AND SETD2
Foods to Eat After Cancer Diagnosis!
No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.
Eat more fruits, Feijoa or Huckleberry?
The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Huckleberry are Quercetin, Delphinidin, P-coumaric Acid, Vitamin C, Resveratrol and others.
Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Lycopene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Resveratrol can manipulate biochemical pathways P53 Signaling. Pelargonidin has biological action on biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. And so on.
For genetic risk of Lung Cancer In The Never Smokers due to abnormalities in genes EGFR and SETD2 – Foods like Feijoa are recommended compared to Huckleberry. This is because the active ingredients Resveratrol and Pelargonidin in Huckleberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: FEIJOA IS RECOMMENDED OVER HUCKLEBERRY FOR REDUCING THE GENETIC RISK OF LUNG CANCER IN THE NEVER SMOKERS DUE TO GENES EGFR AND SETD2
Eat more nuts, Almond or Cashew Nut?
The active ingredients contained in Almond are Quercetin, Vitamin E, Beta-sitosterol, Linolenic Acid, Oleic Acid among others. While the active ingredients contained in Cashew Nut are Vitamin C, Beta-sitosterol, Gallic Acid, Palmitic Acid, Butyric Acid and others.
Beta-sitosterol can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Quercetin has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.
Palmitic Acid can manipulate biochemical pathways Growth Factor Signaling. Lauric Acid has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Growth Factor Signaling. And so on.
For genetic risk of Lung Cancer In The Never Smokers due to abnormalities in genes EGFR and SETD2 – Foods like Almond are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Beta-sitosterol and Quercetin contained in Almond together have a canceling effect of genes on the biochemical pathways.
RECOMMENDATION: ALMOND IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF LUNG CANCER IN THE NEVER SMOKERS DUE TO GENES EGFR AND SETD2
In Summary
An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.
“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.
The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.
You can get started NOW and design a personalized nutrition plan for Lung Cancer In The Never Smokers by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.
What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.
The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.
Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.
References
- Lung Nci 2022
- Genomic and evolutionary classification of lung cancer in never smokers.
- Betulinic Acid Suppresses Breast Cancer Metastasis by Targeting GRP78-Mediated Glycolysis and ER Stress Apoptotic Pathway.
- Vitamin C kills thyroid cancer cells through ROS-dependent inhibition of MAPK/ERK and PI3K/AKT pathways via distinct mechanisms.
- Vitamin A regulates Akt signaling through the phospholipid fatty acid composition.
- Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin.
- Identification of new potent phthalazine derivatives with VEGFR-2 and EGFR kinase inhibitory activity.
- Inhibitors of the epidermal growth factor receptor in apple juice extract.
- Oleic acid-induced ANGPTL4 enhances head and neck squamous cell carcinoma anoikis resistance and metastasis via up-regulation of fibronectin.
- Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade.
- Modulation of HER2 expression by ferulic acid on human breast cancer MCF7 cells.
- Myristicin from nutmeg induces apoptosis via the mitochondrial pathway and down regulates genes of the DNA damage response pathways in human leukaemia K562 cells.
- Molecular docking analysis of Cianidanol fromGinkgo biloba with HER2+ breast cancer target.
- The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras.
- β-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.
- Role of phospholipase D in migration and invasion induced by linoleic acid in breast cancer cells.
- Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells.
- Lycopene Inhibits Activation of Epidermal Growth Factor Receptor and Expression of Cyclooxygenase-2 in Gastric Cancer Cells.
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase.
- Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway.
- EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice.
- Inhibitors of histone demethylases.
- Clinical pharmacodynamics of antihistamines.
- HyperFoods: Machine intelligent mapping of cancer-beating molecules in foods.
Personalized Nutrition for Cancer!
Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.