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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Which Foods are Recommended for Low-grade Glioma?

Jul 31, 2022

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Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Low-grade Glioma when undergoing chemotherapy or when you determine you have a genetic risk for developing Low-grade Glioma because of SETD2 and IDH1 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Low-grade Glioma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Peach” or “Include fruit Blueberry in my diet” or “Should I reduce consumption of vegetable Beetroot” or “Can I take Chamomile and Spirulina supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO LOW-GRADE GLIOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Low-grade Glioma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR LOW-GRADE GLIOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.



About Low-grade Glioma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Low-grade Glioma from cBioPortal. The patients enrolled in the studies for Low-grade Glioma are in ages between 2 to 26 with an average age of 10. 58.5% of males and 41.5% of females were the distribution of gender in these clinical studies. From a patient sample size of 94; the top genes with mutations and other abnormalities for Low-grade Glioma include genes TP53, ATRX, IDH1, TERT and SETD2. The occurrence frequency distribution for these genes respectively is 44.4%, 33.3%, 33.3%, 22.2% and 22.2%. These tumor genetic details of Low-grade Glioma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Low-grade Glioma.

Significance of Nutrition for Low-grade Glioma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Low-grade Glioma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Peach includes active ingredients Fisetin, Oleic Acid, Linolenic Acid, Vitamin C, Beta-sitosterol and others. And Blueberry contains active ingredients Cianidanol, Quercetin, Vitamin E, Delphinidin, Eugenol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Low-grade Glioma, activation or inhibition of selected biochemical pathways like Growth Factor Signaling, Cell Cycle, Apoptosis, Cell Cycle Checkpoints plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Low-grade Glioma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

For cancers like Low-grade Glioma, activation or inhibition of selected biochemical pathways like Growth Factor Signaling, Cell Cycle, Apoptosis, Cell Cycle Checkpoints plays an important role in driving cancer growth.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR LOW-GRADE GLIOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Low-grade Glioma undergoing chemotherapy treatment

In Low-grade Glioma – the genes TP53, ATRX, IDH1, TERT and SETD2 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Low-grade Glioma are Growth Factor Signaling, Cell Cycle, Hypoxia and others. Capmatinib is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers Growth Factor Signaling, Cell Cycle, Hypoxia so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Pigeon Pea?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Oleic Acid, Linolenic Acid, Vitamin C, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Pigeon Pea are Oleic Acid, Linolenic Acid, Vitamin C, Genistein, Linoleic Acid and others.

Vitamin C can manipulate biochemical pathways Growth Factor Signaling, Cell Cycle and MYC Signaling. Beta-sitosterol has biological action on biochemical pathways P53 Signaling, PI3K-AKT-MTOR Signaling and Hypoxia.

Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and RAS-RAF Signaling. And so on.

When treating Low-grade Glioma with chemotherapy Capmatinib – Foods like Scarlet Bean are recommended compared to Pigeon Pea. This is because the active ingredients Linoleic Acid and Folic Acid in Pigeon Pea interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER PIGEON PEA FOR LOW-GRADE GLIOMA ON TREATMENT WITH CHEMOTHERAPY CAPMATINIB FOR SOME CONDITIONS.

Eat more vegetables, Arugula or Beetroot?

Vegetables are an important part of many diets. The active ingredients contained in Arugula are Esculin, Kaempferol, Vitamin A, Vitamin K, Erysolin among others. While the active ingredients contained in Beetroot are Vitamin E, Oleic Acid, Linolenic Acid, Vitamin C, Beta-sitosterol and others.

Kaempferol can manipulate biochemical pathways RAS-RAF Signaling, Cell Cycle and Hypoxia. Vitamin A has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Cell Cycle.

Linoleic Acid can manipulate biochemical pathways Growth Factor Signaling. Folic Acid has biological action on biochemical pathways MYC Signaling, P53 Signaling and RAS-RAF Signaling. And so on.

When treating Low-grade Glioma with chemotherapy Capmatinib – Foods like Arugula are recommended compared to Beetroot. This is because the active ingredients Linoleic Acid and Folic Acid in Beetroot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Kaempferol and Vitamin A contained in Arugula support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER BEETROOT FOR LOW-GRADE GLIOMA ON TREATMENT WITH CHEMOTHERAPY CAPMATINIB FOR SOME CONDITIONS.

?Which Foods are Recommended for Low grade Glioma?

Eat more fruits, Blueberry or Peach?

Fruits are an important part of many diets. The active ingredients contained in Blueberry are Cianidanol, Quercetin, Vitamin E, Delphinidin, Eugenol among others. While the active ingredients contained in Peach are Fisetin, Oleic Acid, Linolenic Acid, Vitamin C, Beta-sitosterol and others.

Cianidanol can manipulate biochemical pathways Growth Factor Signaling, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Cell Cycle, PI3K-AKT-MTOR Signaling and Hypoxia.

Fisetin can manipulate biochemical pathways MYC Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.

When treating Low-grade Glioma with chemotherapy Capmatinib – Foods like Blueberry are recommended compared to Peach. This is because the active ingredients Fisetin and Linoleic Acid in Peach interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Cianidanol and Vitamin C contained in Blueberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: BLUEBERRY IS RECOMMENDED OVER PEACH FOR LOW-GRADE GLIOMA ON TREATMENT WITH CHEMOTHERAPY CAPMATINIB FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Chestnut?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Cianidanol, Vitamin E, Delphinidin, Oleic Acid, Linolenic Acid among others. While the active ingredients contained in Chestnut are Ellagic Acid, Quercetin, Oleic Acid, Linolenic Acid, Vitamin C and others.

Cianidanol can manipulate biochemical pathways Growth Factor Signaling, MYC Signaling and P53 Signaling. Vitamin E has biological action on biochemical pathways Cell Cycle, PI3K-AKT-MTOR Signaling and Hypoxia.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.

When treating Low-grade Glioma with chemotherapy Capmatinib – Foods like Pecan Nut are recommended compared to Chestnut. This is because the active ingredients Ellagic Acid and Linoleic Acid in Chestnut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Cianidanol and Vitamin E contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER CHESTNUT FOR LOW-GRADE GLIOMA ON TREATMENT WITH CHEMOTHERAPY CAPMATINIB FOR SOME CONDITIONS.

Foods for Genetic Risk of Low-grade Glioma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. SETD2 and IDH1 are two genes whose abnormalities are risk factors for Low-grade Glioma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Low-grade Glioma can be used as a guide for coming up with a recommended personalized nutrition plan. For Low-grade Glioma gene SETD2 has causative impact on biological pathways like Oncogenic Histone Methylation. And IDH1 has a causative impact on biological pathways like Oncogenic Cancer Epigenetics, Glutathione Metabolism and Hypoxia. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like SETD2 and IDH1 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes SETD2 and IDH1 should be avoided.

Eat more pulses, Common Pea or Common Bean?

The active ingredients contained in Common Pea are Lupeol, Daidzein, Vitamin C, Beta-sitosterol, Oleic Acid among others. While the active ingredients contained in Common Bean are Apigenin, Esculin, Vitamin C, Oleic Acid, Linolenic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and Hypoxia.

Pelargonidin can manipulate biochemical pathways MYC Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of Low-grade Glioma due to abnormalities in genes SETD2 and IDH1 – Foods like Common Pea are recommended compared to Common Bean. This is because the active ingredients Pelargonidin and Folic Acid in Common Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Common Pea together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER COMMON BEAN FOR REDUCING THE GENETIC RISK OF LOW-GRADE GLIOMA DUE TO GENES SETD2 AND IDH1

Eat more vegetables, Giant Butterbur or Chicory?

The active ingredients contained in Giant Butterbur are Vitamin C, Beta-sitosterol, Vitamin B3, Melatonin, Kaempferol among others. While the active ingredients contained in Chicory are Apigenin, Esculin, Lupeol, Vitamin C, Betulinic Acid and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Beta-sitosterol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and Hypoxia.

Luteolin can manipulate biochemical pathways MYC Signaling. Esculetin has biological action on biochemical pathways Hypoxia. And so on.

For genetic risk of Low-grade Glioma due to abnormalities in genes SETD2 and IDH1 – Foods like Giant Butterbur are recommended compared to Chicory. This is because the active ingredients Luteolin and Esculetin in Chicory further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Beta-sitosterol contained in Giant Butterbur together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: GIANT BUTTERBUR IS RECOMMENDED OVER CHICORY FOR REDUCING THE GENETIC RISK OF LOW-GRADE GLIOMA DUE TO GENES SETD2 AND IDH1

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Eat more fruits, Kiwi or Cranberry?

The active ingredients contained in Kiwi are Vitamin C, Quercetin, Fisetin, Chlorogenic Acid, Vitamin A among others. While the active ingredients contained in Cranberry are Resveratrol, Vitamin C, Ellagic Acid, Hyperoside, Quercetin and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Quercetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and Hypoxia.

Ellagic Acid can manipulate biochemical pathways MYC Signaling. Myricetin has biological action on biochemical pathways Oncogenic Cancer Epigenetics and Oncogenic Histone Methylation. And so on.

For genetic risk of Low-grade Glioma due to abnormalities in genes SETD2 and IDH1 – Foods like Kiwi are recommended compared to Cranberry. This is because the active ingredients Ellagic Acid and Myricetin in Cranberry further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Quercetin contained in Kiwi together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: KIWI IS RECOMMENDED OVER CRANBERRY FOR REDUCING THE GENETIC RISK OF LOW-GRADE GLIOMA DUE TO GENES SETD2 AND IDH1

Eat more nuts, Hazelnut or Peanut?

The active ingredients contained in Hazelnut are Vitamin E, Oleic Acid, Quercetin, Linolenic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Vitamin C, Vitamin E, Beta-sitosterol, Oleic Acid, Quercetin and others.

Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. Quercetin has biological action on biochemical pathways PI3K-AKT-MTOR Signaling, Oncogenic Cancer Epigenetics and Hypoxia.

Lecithin can manipulate biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. Folic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, Apoptosis and MYC Signaling. And so on.

For genetic risk of Low-grade Glioma due to abnormalities in genes SETD2 and IDH1 – Foods like Hazelnut are recommended compared to Peanut. This is because the active ingredients Lecithin and Folic Acid in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF LOW-GRADE GLIOMA DUE TO GENES SETD2 AND IDH1


In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Low-grade Glioma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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References

Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.


Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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