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What Foods are Recommended for Cancer?
is a very common question. Personalized Nutrition Plans are foods and supplements which are personalized to a cancer indication, genes, any treatments and lifestyle conditions.

Foods for Infiltrating Ductal Carcinoma!

Jul 20, 2023

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Introduction

Foods for Infiltrating Ductal Carcinoma should be personalized for each individual and also must adapt when cancer treatment or tumor genetic change. The personalization and adaptation must consider all the active ingredients or bioactives contained in different foods with respect to cancer tissue biology, genetics, treatments, lifestyle conditions and diet preferences. Hence while nutrition is one of the very important decisions for a cancer patient and individual at risk of cancer to make – how to choose foods to eat is not an easy task.

Infiltrating ductal carcinoma (IDC) is the most common type of breast cancer, characterized by cancer cells that have spread from the milk ducts into the surrounding breast tissue. Accurate coding using the ICD-10 system ensures proper documentation of infiltrating ductal carcinoma in medical records. IDC is typically detected through a breast biopsy and is graded based on the characteristics of the cancer cells. Symptoms may include a lump, changes in breast shape or size, nipple discharge, or skin changes. The prognosis for infiltrating ductal carcinoma varies depending on the grade, stage, and other factors, but early detection and treatment can significantly improve outcomes. Treatment options for IDC include surgery, radiation therapy, chemotherapy, hormonal therapy, or targeted therapies, depending on the specific case. The ability to cure infiltrating ductal carcinoma depends on various factors, including the stage of the cancer. Survival rates differ based on individual factors and responses to treatment. Understanding the causes of infiltrating ductal carcinoma is actively researched, with genetic and environmental factors playing a role. Regular breast self-exams and screening mammograms can aid in early detection. Awareness of the symptoms is crucial for timely diagnosis and intervention. Proper treatment for infiltrating ductal carcinoma is essential for improving outcomes and reducing the risk of recurrence. As infiltrating ductal carcinoma can progress, appropriate staging and monitoring are necessary. Overall, early detection, comprehensive treatment, and ongoing research are key in managing infiltrating ductal carcinoma and providing the best possible care for patients.



For Infiltrating Ductal Carcinoma does it matter what vegetables, fruits, nuts, seeds one eats?

A very common nutrition question asked by cancer patients and individuals at-genetic risk of cancer is – for cancers like Infiltrating Ductal Carcinoma does it matter what foods I eat and which I do not? Or if I follow a plant-based diet is that enough for cancer like Infiltrating Ductal Carcinoma?

For example does it matter if vegetable Giant Butterbur is consumed more compared to Arrowroot? Does it make any difference if fruit Grapefruit is preferred over Java Plum? Also if similar choices are made for nuts/seeds like Butternut over European Chestnut and for pulses like Hyacinth Bean over Pigeon Pea. And if what I eat matters – then how does one identify foods which are recommended for Infiltrating Ductal Carcinoma and is it the same answer for everyone with the same diagnosis or genetic risk?

Yes! Foods you eat matters for Infiltrating Ductal Carcinoma!

Food recommendations may not be the same for everyone and can be different even for the same diagnosis and genetic risk.

All cancers like Infiltrating Ductal Carcinoma can be characterized by a unique set of biochemical pathways - the signature pathways of Infiltrating Ductal Carcinoma. Biochemical pathways like Oncogenic Cancer Epigenetics, Chromatin Remodeling, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Infiltrating Ductal Carcinoma.

All foods (vegetables, fruits, nuts, seeds, pulses, oils etc.) and nutritional supplements are made up of more than one active molecular ingredient or bio-actives in different proportions and quantities. Each active ingredient has a unique mechanism of action – which can be activation or inhibition of different biochemical pathways. Simply stated foods and supplements which are recommended are those which do not cause an increase of molecular drivers of cancer but reduce them. Else those foods should not be recommended. Foods contain multiple active ingredients – hence when evaluating foods and supplements you need to consider the impact of all active ingredients cumulatively rather than individually.

For example Grapefruit contains active ingredients Formononetin, Lupeol, Curcumin, Catechol, Phloretin. And Java Plum contains active ingredients Formononetin, Lupeol, Curcumin, Myricetin, Ellagic Acid and possibly others.

A common mistake made when deciding and choosing foods to eat for Infiltrating Ductal Carcinoma – is to evaluate only selected active ingredients contained in foods and ignore the rest. Because different active ingredients contained in foods may have opposing effects on cancer drivers – you cannot cherry pick active ingredients in foods and supplements for making a nutrition decision for Infiltrating Ductal Carcinoma.

YES – FOOD CHOICES MATTER FOR CANCER. NUTRITION DECISIONS MUST CONSIDER ALL ACTIVE INGREDIENTS OF FOODS.

Skills Needed for Nutrition Personalization for Infiltrating Ductal Carcinoma?

Personalized nutrition for cancers like Infiltrating Ductal Carcinoma consists of recommended foods / supplements; not recommended foods / supplements with example recipes which prioritize use of recommended foods. An example of personalized nutrition can be seen at this link.

Deciding which foods are recommended or not is extremely complicated, requiring expertise in Infiltrating Ductal Carcinoma biology, food science, genetics, biochemistry along with good understanding of how cancer treatments work and associated vulnerabilities by which the treatments could stop being effective.

MINIMUM KNOWLEDGE EXPERTISE NEEDED FOR NUTRITION PERSONALIZATION FOR CANCER ARE: CANCER BIOLOGY, FOOD SCIENCE, CANCER TREATMENTS AND GENETICS.

Foods to Eat After Cancer Diagnosis!

No two cancers are the same. Go beyond the common nutrition guidelines for everyone and make personalized decisions about food and supplements with confidence.

Characteristics of cancers like Infiltrating Ductal Carcinoma

All cancers like Infiltrating Ductal Carcinoma can be characterized by a unique set of biochemical pathways – the signature pathways of Infiltrating Ductal Carcinoma. Biochemical pathways like Oncogenic Cancer Epigenetics, Chromatin Remodeling, PI3K-AKT-MTOR Signaling, MAPK Signaling are part of the signature definition of Infiltrating Ductal Carcinoma. Each individual’s cancer genetics can be different and hence their specific cancer signature could be unique.

The treatments which are effective for Infiltrating Ductal Carcinoma need to be cognizant of the associated signature biochemical pathways for each cancer patient and individual at genetic risk. Therefore different treatments with different mechanisms of actions are effective for different patients. Similarly and for the same reasons foods and supplements need to be personalized for each individual. Hence some foods and supplements are recommended for Infiltrating Ductal Carcinoma when taking cancer treatment Pembrolizumab, and some foods and supplements are not recommended.

Sources like cBioPortal and many others provide population representative patient anonymized data from clinical trials for all cancer indications. This data consists of clinical trial study details like sample size / number of patients, age groups, gender, ethnicity, treatments, tumor site and any genetic mutations.

PIK3CA, TP53, MUC16, KMT2C and AKT1 are the top ranked reported genes for Infiltrating Ductal Carcinoma. PIK3CA is reported in 28.0 % of the representative patients across all clinical trials. And TP53 is reported in 25.6 %. The combined population patient data cover ages from 31 to 92. 0.0 % of the patient data are identified as men. The Infiltrating Ductal Carcinoma biology along with reported genetics together define the population represented signature biochemical pathways for this cancer. If the individual cancer tumor genetics or genes contributing to the risk are also known then that should also be used for nutrition personalization.

NUTRITION CHOICES SHOULD MATCH WITH EACH INDIVIDUAL’S CANCER SIGNATURE.

Foods for Infiltrating Ductal Carcinoma!

Food and Supplements for Infiltrating Ductal Carcinoma

For Cancer Patients

Cancer patients on treatment or on palliative care need to make decisions on food and supplements – for the needed dietary calories, for managing any treatment side effects and also for improved cancer management. All plant-based foods are not equal and choosing and prioritizing foods which are personalized and customized to ongoing cancer treatment is important and complicated. Here are some examples providing guidelines for making nutrition decisions.

Choose Vegetable GIANT BUTTERBUR or ARROWROOT

Vegetable Giant Butterbur contains many active ingredients or bioactives such as Formononetin, Lupeol, Curcumin, Myricetin, Caffeine. These active ingredients manipulate various biochemical pathways like JAK-STAT Signaling, WNT Beta Catenin Signaling, Myeloid-derived Suppressor Cells and PI3K-AKT-MTOR Signaling and others. Giant Butterbur is recommended for Infiltrating Ductal Carcinoma when ongoing cancer treatment is Pembrolizumab. This is because Giant Butterbur modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Pembrolizumab.

Some of the active ingredients or bioactives in vegetable Arrowroot are Quercetin, Formononetin, Lupeol, Curcumin, Myricetin. These active ingredients manipulate various biochemical pathways like DNA Repair and G-protein-coupled Receptor Signaling and others. Arrowroot is not recommended for Infiltrating Ductal Carcinoma when ongoing cancer treatment is Pembrolizumab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

VEGETABLE GIANT BUTTERBUR IS RECOMMENDED OVER ARROWROOT FOR Infiltrating Ductal Carcinoma AND TREATMENT Pembrolizumab.

Choose Fruit JAVA PLUM or GRAPEFRUIT

Fruit Java Plum contains many active ingredients or bioactives such as Formononetin, Lupeol, Curcumin, Myricetin, Ellagic Acid. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, PPAR Signaling and PI3K-AKT-MTOR Signaling and others. Java Plum is recommended for Infiltrating Ductal Carcinoma when ongoing cancer treatment is Pembrolizumab. This is because Java Plum modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Pembrolizumab.

Some of the active ingredients or bioactives in fruit Grapefruit are Formononetin, Lupeol, Curcumin, Catechol, Phloretin. These active ingredients manipulate various biochemical pathways like PPAR Signaling and others. Grapefruit is not recommended for Infiltrating Ductal Carcinoma when ongoing cancer treatment is Pembrolizumab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

FRUIT JAVA PLUM IS RECOMMENDED OVER GRAPEFRUIT FOR Infiltrating Ductal Carcinoma AND TREATMENT Pembrolizumab.

Choose Nut BUTTERNUT or EUROPEAN CHESTNUT

Butternut contains many active ingredients or bioactives such as Formononetin, Lupeol, Curcumin, Myricetin, Caffeine. These active ingredients manipulate various biochemical pathways like WNT Beta Catenin Signaling, MYC Signaling, Angiogenesis and PI3K-AKT-MTOR Signaling and others. Butternut is recommended for Infiltrating Ductal Carcinoma when ongoing cancer treatment is Pembrolizumab. This is because Butternut modifies those biochemical pathways which have been scientifically reported to sensitize the effect of Pembrolizumab.

Some of the active ingredients or bioactives in European Chestnut are Quercetin, Formononetin, Lupeol, Curcumin, Myricetin. These active ingredients manipulate various biochemical pathways like DNA Repair and G-protein-coupled Receptor Signaling and others. European Chestnut is not recommended for Infiltrating Ductal Carcinoma when ongoing cancer treatment is Pembrolizumab because it modifies those biochemical pathways which make the cancer treatment resistant or less responsive.

BUTTERNUT IS RECOMMENDED OVER EUROPEAN CHESTNUT FOR Infiltrating Ductal Carcinoma AND TREATMENT Pembrolizumab.

For Individuals with Genetic Risk of Cancer

The question asked by individuals who have genetic risk of Infiltrating Ductal Carcinoma or familial history is “What Should I Eat Differently from Before?” and how they should choose foods and supplements to manage risks of the disease. Since for cancer risk there is nothing actionable in terms of treatment – decisions of foods and supplements become important and one of the very few actionable things which can be done. All plant-based foods are not equal and based on identified genetics and pathway signature – the choices of food and supplements should be personalized.

Choose Vegetable BITTER GOURD or BROCCOLI

Vegetable Bitter Gourd contains many active ingredients or bioactives such as Apigenin, Catechol, Curcumin, Lupeol, Formononetin. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Hypoxia, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Bitter Gourd is recommended for risk of Infiltrating Ductal Carcinoma when associated genetic risk is AKT1. This is because Bitter Gourd increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in vegetable Broccoli are Quercetin, Resveratrol, Catechol, Curcumin, Lupeol. These active ingredients manipulate various biochemical pathways like P53 Signaling and PI3K-AKT-MTOR Signaling and others. Broccoli is not recommended when risk of Infiltrating Ductal Carcinoma when associated genetic risk is AKT1 because it increases the signature pathways of it.

VEGETABLE BITTER GOURD IS RECOMMENDED OVER BROCCOLI FOR AKT1 GENETIC RISK OF CANCER.

Choose Fruit RED RASPBERRY or PUMMELO

Fruit Red Raspberry contains many active ingredients or bioactives such as Quercetin, Catechol, Curcumin, Ellagic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints, Hypoxia, MYC Signaling and PI3K-AKT-MTOR Signaling and others. Red Raspberry is recommended for risk of Infiltrating Ductal Carcinoma when associated genetic risk is AKT1. This is because Red Raspberry increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in fruit Pummelo are Quercetin, Apigenin, Catechol, Curcumin, Lupeol. These active ingredients manipulate various biochemical pathways like Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling and others. Pummelo is not recommended when risk of Infiltrating Ductal Carcinoma when associated genetic risk is AKT1 because it increases the signature pathways of it.

FRUIT RED RASPBERRY IS RECOMMENDED OVER PUMMELO FOR AKT1 GENETIC RISK OF CANCER.

Choose Nut COMMON WALNUT or CHESTNUT

Common Walnut contains many active ingredients or bioactives such as Quercetin, Catechol, Curcumin, Ellagic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like Hypoxia, Insulin Signaling and PI3K-AKT-MTOR Signaling and others. Common Walnut is recommended for risk of Infiltrating Ductal Carcinoma when associated genetic risk is AKT1. This is because Common Walnut increases those biochemical pathways which counteract the signature drivers of it.

Some of the active ingredients or bioactives in Chestnut are Apigenin, Catechol, Curcumin, Ellagic Acid, Lupeol. These active ingredients manipulate various biochemical pathways like PI3K-AKT-MTOR Signaling and others. Chestnut is not recommended when risk of Infiltrating Ductal Carcinoma when associated genetic risk is AKT1 because it increases the signature pathways of it.

COMMON WALNUT IS RECOMMENDED OVER CHESTNUT FOR AKT1 GENETIC RISK OF CANCER.


In Conclusion

Foods and Supplements chosen are important decisions for cancers like Infiltrating Ductal Carcinoma. Infiltrating Ductal Carcinoma patients and individuals with genetic-risk always have this question: “What foods and nutritional supplements are recommended for me and which are not?” There is a common belief which is a misconception that all plant-based foods could be beneficial or not but would not be harmful. Certain foods and supplements can interfere with cancer treatments or promote molecular pathway drivers of cancer.

There are different types of cancer indications like Infiltrating Ductal Carcinoma, each with different tumor genetics with further genomic variations across each individual. Further every cancer treatment and chemotherapy has a unique mechanism of action. Each food like Giant Butterbur contains various bioactives in different quantities, which have an impact on different and distinct sets of biochemical pathways. The definition of personalized nutrition is individualized food recommendations for the cancer indication, treatments, genetics, lifestyle and other factors. Nutrition personalization decisions for cancer require knowledge of cancer biology, food science and an understanding of different chemotherapy treatments. Finally when there are treatment changes or new genomics is identified – the nutrition personalization needs re-evaluation.

The addon nutrition personalization solution makes the decision making easy and removes all the guesswork in answering the question, “What foods should I choose or not choose for Infiltrating Ductal Carcinoma?”. The addon multi-disciplinary team includes cancer physicians, clinical scientists, software engineers and data scientists.


Personalized Nutrition for Cancer!

Cancer changes with time. Customize and modify your nutrition based on cancer indication, treatments, lifestyle, food preferences, allergies and other factors.

References

Scientifically Reviewed by: Dr. Cogle

Christopher R. Cogle, M.D. is a tenured professor at the University of Florida, Chief Medical Officer of Florida Medicaid, and Director of the Florida Health Policy Leadership Academy at the Bob Graham Center for Public Service.

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