Which Foods are Recommended for Infiltrating Ductal Carcinoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like Infiltrating Ductal Carcinoma when undergoing chemotherapy or when you determine you have a genetic risk for developing Infiltrating Ductal Carcinoma because of AKT1 and PIK3CA gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as Infiltrating Ductal Carcinoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Quince” or “Include fruit Partridgeberry in my diet” or “Should I reduce consumption of vegetable Prairie Turnip” or “Can I take Thunder God and Dim supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO INFILTRATING DUCTAL CARCINOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for Infiltrating Ductal Carcinoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR INFILTRATING DUCTAL CARCINOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About Infiltrating Ductal Carcinoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for Infiltrating Ductal Carcinoma from cBioPortal. The patients enrolled in the studies for Infiltrating Ductal Carcinoma are in ages between 31 to 92 with an average age of 48.From a patient sample size of 82; the top genes with mutations and other abnormalities for Infiltrating Ductal Carcinoma include genes PIK3CA, TP53, MUC16, KMT2C and AKT1. The occurrence frequency distribution for these genes respectively is 28.0%, 25.6%, 7.3%, 7.3% and 6.1%. These tumor genetic details of Infiltrating Ductal Carcinoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of Infiltrating Ductal Carcinoma.

Significance of Nutrition for Infiltrating Ductal Carcinoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of Infiltrating Ductal Carcinoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Quince includes active ingredients Vitamin C, Chlorogenic Acid, Oleic Acid, Modified Citrus Pectin, Quercitrin and others. And Partridgeberry contains active ingredients Resveratrol, Beta-sitosterol, Stigmasterol and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like Infiltrating Ductal Carcinoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, mRNA Splicing, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of Infiltrating Ductal Carcinoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR INFILTRATING DUCTAL CARCINOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for Infiltrating Ductal Carcinoma undergoing chemotherapy treatment

In Infiltrating Ductal Carcinoma – the genes PIK3CA, TP53, MUC16, KMT2C and AKT1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for Infiltrating Ductal Carcinoma are RAS-RAF Signaling, mRNA Splicing, DNA Repair and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, mRNA Splicing, DNA Repair so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Common Pea or Lentils?

Pulses are an important part of many diets. The active ingredients contained in Common Pea are Beta-sitosterol, Daidzein, Lupeol, Linolenic Acid, Kaempferol among others. While the active ingredients contained in Lentils are Ellagic Acid, Isoliquiritigenin, Beta-sitosterol, Daidzein, Linolenic Acid and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Vitamin C has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Ellagic Acid can manipulate biochemical pathways Epithelial to Mesenchymal Transition, Heat Stress Response and MYC Signaling. Isoliquiritigenin has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Infiltrating Ductal Carcinoma with chemotherapy Radiation – Foods like Common Pea are recommended compared to Lentils. This is because the active ingredients Ellagic Acid and Isoliquiritigenin in Lentils interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Common Pea support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: COMMON PEA IS RECOMMENDED OVER LENTILS FOR INFILTRATING DUCTAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Cassava or Prairie Turnip?

Vegetables are an important part of many diets. The active ingredients contained in Cassava are Beta-sitosterol, Linolenic Acid, Vitamin C, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Prairie Turnip are Selenium, Vitexin, Folic Acid and others.

Vitamin C can manipulate biochemical pathways Epithelial to Mesenchymal Transition, MYC Signaling and MAPK Signaling. Beta-sitosterol has biological action on biochemical pathways NFKB Signaling, Glucocorticoid Signaling and Oxidative Stress.

Selenium can manipulate biochemical pathways Heat Stress Response and Oxidative Stress. Vitexin has biological action on biochemical pathways Microtubule Dynamics and Oxidative Stress. And so on.

When treating Infiltrating Ductal Carcinoma with chemotherapy Radiation – Foods like Cassava are recommended compared to Prairie Turnip. This is because the active ingredients Selenium and Vitexin in Prairie Turnip interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Beta-sitosterol contained in Cassava support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: CASSAVA IS RECOMMENDED OVER PRAIRIE TURNIP FOR INFILTRATING DUCTAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Partridgeberry or Quince?

Fruits are an important part of many diets. The active ingredients contained in Partridgeberry are Resveratrol, Beta-sitosterol, Stigmasterol among others. While the active ingredients contained in Quince are Vitamin C, Chlorogenic Acid, Oleic Acid, Modified Citrus Pectin, Quercitrin and others.

Resveratrol can manipulate biochemical pathways NFKB Signaling, Microtubule Dynamics and JAK-STAT Signaling. Beta-sitosterol has biological action on biochemical pathways Epithelial to Mesenchymal Transition, Glucocorticoid Signaling and Oxidative Stress.

Quercitrin can manipulate biochemical pathways Oxidative Stress. Chlorogenic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Infiltrating Ductal Carcinoma with chemotherapy Radiation – Foods like Partridgeberry are recommended compared to Quince. This is because the active ingredients Quercitrin and Chlorogenic Acid in Quince interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Resveratrol and Beta-sitosterol contained in Partridgeberry support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PARTRIDGEBERRY IS RECOMMENDED OVER QUINCE FOR INFILTRATING DUCTAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pine Nut or Acorn?

Nuts are an important part of many diets. The active ingredients contained in Pine Nut are Beta-sitosterol, Vitamin E, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Acorn are Quercetin, Beta-sitosterol, Vitamin C, Gallic Acid, Vitamin B3 and others.

Beta-sitosterol can manipulate biochemical pathways Epithelial to Mesenchymal Transition, NFKB Signaling and Glucocorticoid Signaling. Vitamin K has biological action on biochemical pathways MYC Signaling, PI3K-AKT-MTOR Signaling and Inflammation.

Quercetin can manipulate biochemical pathways Oxidative Stress. Gallic Acid has biological action on biochemical pathways Oxidative Stress. And so on.

When treating Infiltrating Ductal Carcinoma with chemotherapy Radiation – Foods like Pine Nut are recommended compared to Acorn. This is because the active ingredients Quercetin and Gallic Acid in Acorn interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin K contained in Pine Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PINE NUT IS RECOMMENDED OVER ACORN FOR INFILTRATING DUCTAL CARCINOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of Infiltrating Ductal Carcinoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. AKT1 and PIK3CA are two genes whose abnormalities are risk factors for Infiltrating Ductal Carcinoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of Infiltrating Ductal Carcinoma can be used as a guide for coming up with a recommended personalized nutrition plan. For Infiltrating Ductal Carcinoma gene AKT1 has causative impact on biological pathways like Autophagy, PI3K-AKT-MTOR Signaling and Angiogenesis. And PIK3CA has a causative impact on biological pathways like Angiogenesis and Hematopoiesis. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like AKT1 and PIK3CA should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes AKT1 and PIK3CA should be avoided.

Eat more pulses, Winged Bean or Moth Bean?

The active ingredients contained in Winged Bean are Betulinic Acid, Linolenic Acid, Oleic Acid, Vitamin C, Linoleic Acid among others. While the active ingredients contained in Moth Bean are Linolenic Acid, Beta-sitosterol, Oleic Acid, Stigmasterol, Linoleic Acid and others.

Betulinic Acid can manipulate biochemical pathways Apoptosis, MYC Signaling and P53 Signaling. Vitamin C has biological action on biochemical pathways Growth Factor Signaling, Cell Cycle Checkpoints and MAPK Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.

For genetic risk of Infiltrating Ductal Carcinoma due to abnormalities in genes AKT1 and PIK3CA – Foods like Winged Bean are recommended compared to Moth Bean. This is because the active ingredients Vitamin A and Linoleic Acid in Moth Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Betulinic Acid and Vitamin C contained in Winged Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: WINGED BEAN IS RECOMMENDED OVER MOTH BEAN FOR REDUCING THE GENETIC RISK OF INFILTRATING DUCTAL CARCINOMA DUE TO GENES AKT1 AND PIK3CA

Eat more vegetables, Jicama or Lotus?

The active ingredients contained in Jicama are Vitamin C, Vitamin B3, Beta-carotene, Vitamin A, Folic Acid among others. While the active ingredients contained in Lotus are Quercetin, Linolenic Acid, Beta-sitosterol, Oleic Acid, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Vitamin B3 has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and PI3K-AKT-MTOR Signaling.

Fisetin can manipulate biochemical pathways MYC Signaling. Linoleic Acid has biological action on biochemical pathways Growth Factor Signaling. And so on.

For genetic risk of Infiltrating Ductal Carcinoma due to abnormalities in genes AKT1 and PIK3CA – Foods like Jicama are recommended compared to Lotus. This is because the active ingredients Fisetin and Linoleic Acid in Lotus further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Vitamin B3 contained in Jicama together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: JICAMA IS RECOMMENDED OVER LOTUS FOR REDUCING THE GENETIC RISK OF INFILTRATING DUCTAL CARCINOMA DUE TO GENES AKT1 AND PIK3CA

Eat more fruits, Feijoa or Peach?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Peach are Modified Citrus Pectin, Linolenic Acid, Beta-sitosterol, Oleic Acid, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Lycopene has biological action on biochemical pathways P53 Signaling, Cell Cycle Checkpoints and MAPK Signaling.

Fisetin can manipulate biochemical pathways MYC Signaling. Vitamin A has biological action on biochemical pathways PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Infiltrating Ductal Carcinoma due to abnormalities in genes AKT1 and PIK3CA – Foods like Feijoa are recommended compared to Peach. This is because the active ingredients Fisetin and Vitamin A in Peach further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER PEACH FOR REDUCING THE GENETIC RISK OF INFILTRATING DUCTAL CARCINOMA DUE TO GENES AKT1 AND PIK3CA

Eat more nuts, Hazelnut or Peanut?

The active ingredients contained in Hazelnut are Quercetin, Vitamin E, Linolenic Acid, Oleic Acid, Linoleic Acid among others. While the active ingredients contained in Peanut are Quercetin, Vitamin E, Linolenic Acid, Beta-sitosterol, Oleic Acid and others.

Vitamin E can manipulate biochemical pathways Apoptosis, Growth Factor Signaling and MYC Signaling. Myricitrin has biological action on biochemical pathways MAPK Signaling, PI3K-AKT-MTOR Signaling and MYC Signaling.

Vitamin A can manipulate biochemical pathways PI3K-AKT-MTOR Signaling. Lecithin has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of Infiltrating Ductal Carcinoma due to abnormalities in genes AKT1 and PIK3CA – Foods like Hazelnut are recommended compared to Peanut. This is because the active ingredients Vitamin A and Lecithin in Peanut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Myricitrin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER PEANUT FOR REDUCING THE GENETIC RISK OF INFILTRATING DUCTAL CARCINOMA DUE TO GENES AKT1 AND PIK3CA

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for Infiltrating Ductal Carcinoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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