Which Foods are Recommended for High-grade B-cell Lymphoma?

Highlights

No two cancers are the same, nor are they treated the same, and neither should nutrition be the same for everyone. Nutrition includes foods like pulses, vegetables, fruits, nuts, oils, herbs and spices. Also nutrition includes supplements which are high concentrations of foods or high concentrations of individual ingredients found in foods. For cancers like High-grade B-cell Lymphoma when undergoing chemotherapy or when you determine you have a genetic risk for developing High-grade B-cell Lymphoma because of MYC and ID3 gene mutations, a very important question is “What foods should I avoid and what foods are recommended specifically for me?”. The other related question is “What nutritional supplements should I avoid?”.

There is no one answer to this question for cancers such as High-grade B-cell Lymphoma which can be found through internet searches. The answer to the question is “It Depends” because the nutrition plan needs to be personalized for you. Nutrition should depend on the cancer indication, genetic information, adult or pediatric, staging, primary or secondary, advanced, metastatic, relapsed or refractory, ongoing treatments if any, nutritional supplements being taken, age and factors like gender, weight, height, lifestyle, allergies and food preferences.

In short – the process to answer questions like “Should I Avoid eating fruit Apricot” or “Include fruit Pomegranate in my diet” or “Should I reduce consumption of vegetable Jute” or “Can I take Thunder God and Artemisinine supplements” is not as simple as internet searches. The process is very complex and answers are based on knowhow of genetics, action of treatments, active ingredients in foods and their associated biological action. Finally the answer to the nutrition question needs to be personalized for you.

RECOMMENDATION: PERSONALIZE YOUR FOODS AND SUPPLEMENTS TO HIGH-GRADE B-CELL LYMPHOMA, TREATMENTS, GENETIC INFORMATION, AND OTHER CONDITIONS.

The overall objective of personalized nutrition for High-grade B-cell Lymphoma is to minimize foods and nutritional supplements which have adverse interactions with cancer molecular drivers and ongoing treatments. And identify those foods and supplements which have a beneficial action. Whenever there are changes in treatments or diagnosis – it is important to remember that your foods and supplements need re-evaluation. And the answers to the nutrition question could be different based on the new context.

RECOMMENDATION: UPDATE YOUR NUTRITION FOR HIGH-GRADE B-CELL LYMPHOMA, WHEN TREATMENTS, DISEASE STATUS AND OTHER CONDITIONS CHANGE.

About High-grade B-cell Lymphoma

cBioPortal is one source of collection of cancer patient data from clinical trials across 350 plus cancer indications. The data from each clinical trial includes the clinical trial name and study details like number of patients, ages, gender, ethnicity, treatments, tumor site, genetic aberrations found and analysis of all the data. The cBioPortal for Cancer Genomics was originally developed at Memorial Sloan Kettering Cancer Center (MSK). The public cBioPortal site is hosted by the Center for Molecular Oncology at MSK – https://www.cbioportal.org/about.

Following key highlights are derived from clinical data for High-grade B-cell Lymphoma from cBioPortal. From a patient sample size of 34; the top genes with mutations and other abnormalities for High-grade B-cell Lymphoma include genes MYC, TP53, KMT2D, ID3 and PCBP1. The occurrence frequency distribution for these genes respectively is 38.1%, 23.8%, 23.8%, 19.0% and 14.3%. These tumor genetic details of High-grade B-cell Lymphoma are mapped to molecular biochemical pathway drivers of cancer thereby providing definition of characteristic features of High-grade B-cell Lymphoma.

Significance of Nutrition for High-grade B-cell Lymphoma

All foods and nutritional supplements consist of a collection of one or more active chemical ingredients in different proportions and quantities. The action of some active ingredients in a food can have adverse interactions while other active ingredients in the same food may be supportive from the context of High-grade B-cell Lymphoma. Hence the same food has good and not-so-good actions and analysis of combined effect will be needed to come up with a personalized nutrition plan.

For example Apricot includes active ingredients Quercetin, Beta-sitosterol, Vitamin C, Oleic Acid, Salicylic Acid and others. And Pomegranate contains active ingredients Apigenin, Ellagic Acid, Betulinic Acid, Beta-sitosterol, Gallic Acid and others. It is likely that some of these active ingredients of the same food could have opposing effects and hence it is recommended to identify recommended foods based on analysis of all high quantity ingredients contained in foods.

For cancers like High-grade B-cell Lymphoma, activation or inhibition of selected biochemical pathways like RAS-RAF Signaling, Cell Cycle, PI3K-AKT-MTOR Signaling, MAPK Signaling plays an important role in driving cancer growth. Similarly different treatments work via different molecular actions which should never be canceled out by your foods and supplements. The foods and nutritional supplements contain different active ingredients each of which have a specific molecular action on different biochemical pathways. Hence, eating some foods and nutritional supplements would be recommended with a specific treatment of High-grade B-cell Lymphoma, while eating some other foods and supplements may not be recommended.

One common mistake when finding foods to eat or not – is to consider only a few active ingredients contained in foods based on internet searches and ignore the rest. Because different active ingredients contained in foods may have opposing effects on relevant biochemical pathways – it is recommended to consider all the high quantity active ingredients that are present in significant and much larger than trace amounts in the food.

RECOMMENDATION: TO FIND RECOMMENDED AND NON-RECOMMENDED FOODS FOR HIGH-GRADE B-CELL LYMPHOMA – CONSIDER HIGH QUANTITY ACTIVE INGREDIENTS CONTAINED IN FOODS.

Foods for High-grade B-cell Lymphoma undergoing chemotherapy treatment

In High-grade B-cell Lymphoma – the genes MYC, TP53, KMT2D, ID3 and PCBP1 have high occurrences of genomic abnormalities. Not all of these genes necessarily are relevant for cancer – though they have been reported. Some of these genes directly or indirectly end up manipulating different cancer related biochemical biological pathways. Some of the pathways which are relevant drivers for High-grade B-cell Lymphoma are RAS-RAF Signaling, Cell Cycle, Notch Signaling and others. Radiation is one of the chemotherapies used for cancer treatment. The intent of treatment is to negate or cancel out effects of biochemical pathway drivers RAS-RAF Signaling, Cell Cycle, Notch Signaling so as to reduce disease progression and inhibit growth. Those foods whose combined action of active ingredients support treatment action and do not enhance disease drivers are recommended foods and supplements which will be included in personalized nutrition. And similarly – those foods whose combined action of active ingredients is not supportive of treatment action but end up promoting disease drives will not be recommended in your personalized nutrition plan.

RECOMMENDATION: AVOID SUPPLEMENTS AND FOODS WHICH ARE NOT SUPPORTIVE OF CANCER TREATMENT ACTION AND RATHER ENHANCE DISEASE DRIVERS.

Eat more pulses, Scarlet Bean or Common Bean?

Pulses are an important part of many diets. The active ingredients contained in Scarlet Bean are Beta-sitosterol, Vitamin C, Oleic Acid, Linolenic Acid, Stigmasterol among others. While the active ingredients contained in Common Bean are Apigenin, Vitamin C, Oleic Acid, Esculin, P-coumaric Acid and others.

Beta-sitosterol can manipulate biochemical pathways NFKB Signaling, Cell Cycle and Cell Survival. Vitamin C has biological action on biochemical pathways MYC Signaling, MAPK Signaling and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways Notch Signaling. Apigenin has biological action on biochemical pathways DNA Repair. And so on.

When treating High-grade B-cell Lymphoma with chemotherapy Radiation – Foods like Scarlet Bean are recommended compared to Common Bean. This is because the active ingredients Vitamin A and Apigenin in Common Bean interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Beta-sitosterol and Vitamin C contained in Scarlet Bean support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: SCARLET BEAN IS RECOMMENDED OVER COMMON BEAN FOR HIGH-GRADE B-CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more vegetables, Kohlrabi or Jute?

Vegetables are an important part of many diets. The active ingredients contained in Kohlrabi are Beta-sitosterol, Vitamin C, Oleic Acid, Brassinin, Linolenic Acid among others. While the active ingredients contained in Jute are Quercetin, Vitamin C, Oleic Acid, Linolenic Acid, Kaempferol and others.

Vitamin C can manipulate biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling. Brassinin has biological action on biochemical pathways NFKB Signaling, Cell Survival and PI3K-AKT-MTOR Signaling.

Vitamin A can manipulate biochemical pathways Notch Signaling. Vitamin B3 has biological action on biochemical pathways Angiogenesis. And so on.

When treating High-grade B-cell Lymphoma with chemotherapy Radiation – Foods like Kohlrabi are recommended compared to Jute. This is because the active ingredients Vitamin A and Vitamin B3 in Jute interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin C and Brassinin contained in Kohlrabi support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: KOHLRABI IS RECOMMENDED OVER JUTE FOR HIGH-GRADE B-CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more fruits, Pomegranate or Apricot?

Fruits are an important part of many diets. The active ingredients contained in Pomegranate are Apigenin, Ellagic Acid, Betulinic Acid, Beta-sitosterol, Gallic Acid among others. While the active ingredients contained in Apricot are Quercetin, Beta-sitosterol, Vitamin C, Oleic Acid, Salicylic Acid and others.

Betulinic Acid can manipulate biochemical pathways NFKB Signaling, Cell Cycle and Cell Survival. Gallic Acid has biological action on biochemical pathways DNA Repair, Notch Signaling and MYC Signaling.

Epicatechin can manipulate biochemical pathways Angiogenesis. Linoleic Acid has biological action on biochemical pathways Angiogenesis. And so on.

When treating High-grade B-cell Lymphoma with chemotherapy Radiation – Foods like Pomegranate are recommended compared to Apricot. This is because the active ingredients Epicatechin and Linoleic Acid in Apricot interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Betulinic Acid and Gallic Acid contained in Pomegranate support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: POMEGRANATE IS RECOMMENDED OVER APRICOT FOR HIGH-GRADE B-CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Eat more nuts, Pecan Nut or Macadamia Nut?

Nuts are an important part of many diets. The active ingredients contained in Pecan Nut are Vitamin E, Oleic Acid, Linolenic Acid, Cianidanol, Vitamin A among others. While the active ingredients contained in Macadamia Nut are Beta-sitosterol, Myristic Acid, Palmitic Acid, Lauric Acid, Folic Acid and others.

Vitamin E can manipulate biochemical pathways NFKB Signaling, DNA Repair and Cell Cycle. Cianidanol has biological action on biochemical pathways Cell Survival, MYC Signaling and MAPK Signaling.

Myristic Acid can manipulate biochemical pathways Cell Cycle, MYC Signaling and MAPK Signaling. Palmitic Acid has biological action on biochemical pathways NFKB Signaling, Angiogenesis and MAPK Signaling. And so on.

When treating High-grade B-cell Lymphoma with chemotherapy Radiation – Foods like Pecan Nut are recommended compared to Macadamia Nut. This is because the active ingredients Myristic Acid and Palmitic Acid in Macadamia Nut interferes with treatment action by canceling out the biochemical pathways through which the chemotherapy works. While the active ingredients Vitamin E and Cianidanol contained in Pecan Nut support the treatment action by enhancing the biochemical pathway effect through which the chemotherapy works.

RECOMMENDATION: PECAN NUT IS RECOMMENDED OVER MACADAMIA NUT FOR HIGH-GRADE B-CELL LYMPHOMA ON TREATMENT WITH CHEMOTHERAPY RADIATION FOR SOME CONDITIONS.

Foods for Genetic Risk of High-grade B-cell Lymphoma

One of the ways to assess risk of cancer is by checking for presence of genetic abnormalities in a set of genes. There is prior information on a list of genes whose mutations and other aberrations can play a role in risk to different cancers. MYC and ID3 are two genes whose abnormalities are risk factors for High-grade B-cell Lymphoma. In such a cancer risk situation – while there are typically no treatments which a physician can prescribe – the various biochemical pathways which are potentially molecular drivers of High-grade B-cell Lymphoma can be used as a guide for coming up with a recommended personalized nutrition plan. For High-grade B-cell Lymphoma gene MYC has causative impact on biological pathways like Noncoding RNA Signaling and MAPK Signaling. And ID3 has a causative impact on biological pathways like TGFB Signaling. Foods and nutritional supplements which have molecular action to cancel out biochemical pathways effects of genes like MYC and ID3 should be included in a personalized nutrition plan. And those foods and supplements which promote the effects of genes MYC and ID3 should be avoided.

Eat more pulses, Yellow Wax Bean or Soy Bean?

The active ingredients contained in Yellow Wax Bean are Vitamin C, Palmitic Acid, Vitamin A, Ferulic Acid, Butyric Acid among others. While the active ingredients contained in Soy Bean are Lupeol, Daidzein, Vitamin E, Beta-sitosterol, Vitamin C and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Vitamin D Signaling. Ferulic Acid has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.

Aescin can manipulate biochemical pathways Cell Cycle Checkpoints. Lecithin has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of High-grade B-cell Lymphoma due to abnormalities in genes MYC and ID3 – Foods like Yellow Wax Bean are recommended compared to Soy Bean. This is because the active ingredients Aescin and Lecithin in Soy Bean further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Ferulic Acid contained in Yellow Wax Bean together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: YELLOW WAX BEAN IS RECOMMENDED OVER SOY BEAN FOR REDUCING THE GENETIC RISK OF HIGH-GRADE B-CELL LYMPHOMA DUE TO GENES MYC AND ID3

Eat more vegetables, Arugula or Bell Pepper?

The active ingredients contained in Arugula are Esculin, Vitamin A, Vitamin K, Kaempferol, Erysolin among others. While the active ingredients contained in Bell Pepper are Vitamin E, Vitamin C, P-coumaric Acid, Capsaicin, Linolenic Acid and others.

Vitamin K can manipulate biochemical pathways MYC Signaling, Vitamin D Signaling and Cell Cycle Checkpoints. Kaempferol has biological action on biochemical pathways PI3K-AKT-MTOR Signaling and Cell Cycle Checkpoints.

Linolenic Acid can manipulate biochemical pathways Vitamin D Signaling. Folic Acid has biological action on biochemical pathways Apoptosis, MYC Signaling and Cell Cycle Checkpoints. And so on.

For genetic risk of High-grade B-cell Lymphoma due to abnormalities in genes MYC and ID3 – Foods like Arugula are recommended compared to Bell Pepper. This is because the active ingredients Linolenic Acid and Folic Acid in Bell Pepper further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin K and Kaempferol contained in Arugula together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: ARUGULA IS RECOMMENDED OVER BELL PEPPER FOR REDUCING THE GENETIC RISK OF HIGH-GRADE B-CELL LYMPHOMA DUE TO GENES MYC AND ID3

Eat more fruits, Feijoa or Fig?

The active ingredients contained in Feijoa are Lycopene, Vitamin C, Casuarinin, Folic Acid among others. While the active ingredients contained in Fig are Lupeol, Beta-sitosterol, Vitamin C, Psoralen, Bergapten and others.

Vitamin C can manipulate biochemical pathways Apoptosis, MYC Signaling and Vitamin D Signaling. Lycopene has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and Amino Acid Metabolism.

Palmitic Acid can manipulate biochemical pathways Chromatin Remodeling. Lauric Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of High-grade B-cell Lymphoma due to abnormalities in genes MYC and ID3 – Foods like Feijoa are recommended compared to Fig. This is because the active ingredients Palmitic Acid and Lauric Acid in Fig further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin C and Lycopene contained in Feijoa together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: FEIJOA IS RECOMMENDED OVER FIG FOR REDUCING THE GENETIC RISK OF HIGH-GRADE B-CELL LYMPHOMA DUE TO GENES MYC AND ID3

Eat more nuts, Hazelnut or Cashew Nut?

The active ingredients contained in Hazelnut are Vitamin E, Linoleic Acid, Linolenic Acid, Vitamin A, Oleic Acid among others. While the active ingredients contained in Cashew Nut are Beta-sitosterol, Vitamin C, Palmitic Acid, Butyric Acid, Gallic Acid and others.

Vitamin E can manipulate biochemical pathways Apoptosis, MYC Signaling and Vitamin D Signaling. Quercetin has biological action on biochemical pathways Cell Cycle Checkpoints, PI3K-AKT-MTOR Signaling and MYC Signaling.

Palmitic Acid can manipulate biochemical pathways Chromatin Remodeling. Lauric Acid has biological action on biochemical pathways MYC Signaling and PI3K-AKT-MTOR Signaling. And so on.

For genetic risk of High-grade B-cell Lymphoma due to abnormalities in genes MYC and ID3 – Foods like Hazelnut are recommended compared to Cashew Nut. This is because the active ingredients Palmitic Acid and Lauric Acid in Cashew Nut further promote the effects of genes on the biochemical pathways. While the active ingredients Vitamin E and Quercetin contained in Hazelnut together have a canceling effect of genes on the biochemical pathways.

RECOMMENDATION: HAZELNUT IS RECOMMENDED OVER CASHEW NUT FOR REDUCING THE GENETIC RISK OF HIGH-GRADE B-CELL LYMPHOMA DUE TO GENES MYC AND ID3

In Summary

An important thing to remember is that cancer treatments may not be the same for everyone – and neither should your nutrition be. Nutrition which includes food and nutritional supplements is a very effective tool controlled by you.

“What should I eat?” is the most frequently asked question in the context of cancer. The answer calculation is complex and depends upon cancer type, underlying genomics, current treatments, any allergies, lifestyle information, and factors like BMI.

The addon personalized nutrition plan recommends foods and supplements which minimizes adverse nutrition interactions and encourages support to treatments.

You can get started NOW and design a personalized nutrition plan for High-grade B-cell Lymphoma by answering questions on type of cancer, current treatments, supplements, allergies, age group, gender, and lifestyle information.

What food you eat and which supplements you take is a decision you make. Your decision should include consideration of the cancer gene mutations, which cancer, ongoing treatments and supplements, any allergies, lifestyle information, weight, height and habits.

The nutrition planning for cancer from addon is not based on internet searches. It automates the decision making for you based on molecular science implemented by our scientists and software engineers. Irrespective of whether you care to understand the underlying biochemical molecular pathways or not - for nutrition planning for cancer that understanding is needed.

Get started NOW with your nutrition planning by answering questions on the name of cancer, genetic mutations, ongoing treatments and supplements, any allergies, habits, lifestyle, age group and gender.

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